A citation-based method for searching scientific literature

Sunisa Thongsom, Wipa Suginta, Kyung Jin Lee, Han Choe, Chutima Talabnin. Apoptosis 2017
Times Cited: 48







List of co-cited articles
230 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity


Overview of the therapeutic potential of piplartine (piperlongumine).
Daniel P Bezerra, Claudia Pessoa, Manoel O de Moraes, Nicolau Saker-Neto, Edilberto R Silveira, Leticia V Costa-Lotufo. Eur J Pharm Sci 2013
165
33

Piperlongumine inhibits lung tumor growth via inhibition of nuclear factor kappa B signaling pathway.
Jie Zheng, Dong Ju Son, Sun Mi Gu, Ju Rang Woo, Young Wan Ham, Hee Pom Lee, Wun Jae Kim, Jae Kyung Jung, Jin Tae Hong. Sci Rep 2016
51
27

Selective killing of cancer cells by a small molecule targeting the stress response to ROS.
Lakshmi Raj, Takao Ide, Aditi U Gurkar, Michael Foley, Monica Schenone, Xiaoyu Li, Nicola J Tolliday, Todd R Golub, Steven A Carr, Alykhan F Shamji,[...]. Nature 2011
750
27

Piperlongumine selectively kills cancer cells and increases cisplatin antitumor activity in head and neck cancer.
Jong-Lyel Roh, Eun Hye Kim, Jin Young Park, Ji Won Kim, Minsu Kwon, Byung-Heon Lee. Oncotarget 2014
67
27

Piperlongumine Induces Reactive Oxygen Species (ROS)-Dependent Downregulation of Specificity Protein Transcription Factors.
Keshav Karki, Erik Hedrick, Ravi Kasiappan, Un-Ho Jin, Stephen Safe. Cancer Prev Res (Phila) 2017
48
25

Piperlongumine selectively kills hepatocellular carcinoma cells and preferentially inhibits their invasion via ROS-ER-MAPKs-CHOP.
Yong Chen, Ju Mei Liu, Xin Xin Xiong, Xin Yao Qiu, Feng Pan, Di Liu, Shu Jue Lan, Si Jin, Shang Bin Yu, Xiao Qian Chen. Oncotarget 2015
62
22

Piperlongumine induces apoptotic and autophagic death of the primary myeloid leukemia cells from patients via activation of ROS-p38/JNK pathways.
Xin-xin Xiong, Ju-mei Liu, Xin-yao Qiu, Feng Pan, Shang-bin Yu, Xiao-qian Chen. Acta Pharmacol Sin 2015
44
25

Piperlongumine induces apoptosis and autophagy in human lung cancer cells through inhibition of PI3K/Akt/mTOR pathway.
Feng Wang, Yong Mao, Qingjun You, Dong Hua, Dongyan Cai. Int J Immunopathol Pharmacol 2015
61
20

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
Dunyaporn Trachootham, Jerome Alexandre, Peng Huang. Nat Rev Drug Discov 2009
20

Piperlongumine as a direct TrxR1 inhibitor with suppressive activity against gastric cancer.
Peng Zou, Yiqun Xia, Jiansong Ji, Weiqian Chen, Jinsan Zhang, Xi Chen, Vinothkumar Rajamanickam, Gaozhi Chen, Zhe Wang, Lingfeng Chen,[...]. Cancer Lett 2016
79
20

Piperlongumine suppresses bladder cancer invasion via inhibiting epithelial mesenchymal transition and F-actin reorganization.
Di Liu, Xin Yao Qiu, Xi Wu, Dian Xing Hu, Chun Yang Li, Shang Bin Yu, Feng Pan, Xiao Qian Chen. Biochem Biophys Res Commun 2017
21
47

Drug-repositioning screening identified piperlongumine as a direct STAT3 inhibitor with potent activity against breast cancer.
U Bharadwaj, T K Eckols, M Kolosov, M M Kasembeli, A Adam, D Torres, X Zhang, L E Dobrolecki, W Wei, M T Lewis,[...]. Oncogene 2015
109
18

Piperlongumine potentiates the effects of gemcitabine in in vitro and in vivo human pancreatic cancer models.
Jiyan Mohammad, Harsharan Dhillon, Shireen Chikara, Sujan Mamidi, Avinash Sreedasyam, Kishore Chittem, Megan Orr, John C Wilkinson, Katie M Reindl. Oncotarget 2017
17
52

Piperlongumine induces apoptosis and synergizes with cisplatin or paclitaxel in human ovarian cancer cells.
Li-Hua Gong, Xiu-Xiu Chen, Huan Wang, Qi-Wei Jiang, Shi-Shi Pan, Jian-Ge Qiu, Xiao-Long Mei, You-Qiu Xue, Wu-Ming Qin, Fei-Yun Zheng,[...]. Oxid Med Cell Longev 2014
63
18

Piperlongumine Induces Apoptosis in Human Melanoma Cells Via Reactive Oxygen Species Mediated Mitochondria Disruption.
Xuejiao Song, Tiantao Gao, Qian Lei, Lidan Zhang, Yuqin Yao, Jingyuan Xiong. Nutr Cancer 2018
18
50

Piperlongumine (piplartine) as a lead compound for anticancer agents - Synthesis and properties of analogues: A mini-review.
Kamil Piska, Agnieszka Gunia-Krzyżak, Paulina Koczurkiewicz, Katarzyna Wójcik-Pszczoła, Elżbieta Pękala. Eur J Med Chem 2018
46
19

Heme oxygenase-1 determines the differential response of breast cancer and normal cells to piperlongumine.
Ha-Na Lee, Hyeon-Ok Jin, Jin-Ah Park, Jin-Hee Kim, Ji-Young Kim, BoRa Kim, Wonki Kim, Sung-Eun Hong, Yun-Han Lee, Yoon Hwan Chang,[...]. Mol Cells 2015
45
20

Piperlongumine, an alkaloid causes inhibition of PI3 K/Akt/mTOR signaling axis to induce caspase-dependent apoptosis in human triple-negative breast cancer cells.
Shweta Shrivastava, Prasad Kulkarni, Dinesh Thummuri, Manish Kumar Jeengar, V G M Naidu, Mallika Alvala, G Bhanuprakash Redddy, Sistla Ramakrishna. Apoptosis 2014
91
16

Piperlongumine inhibits migration of glioblastoma cells via activation of ROS-dependent p38 and JNK signaling pathways.
Qian Rong Liu, Ju Mei Liu, Yong Chen, Xiao Qiang Xie, Xin Xin Xiong, Xin Yao Qiu, Feng Pan, Di Liu, Shang Bin Yu, Xiao Qian Chen. Oxid Med Cell Longev 2014
43
18

Synthesis, cellular evaluation, and mechanism of action of piperlongumine analogs.
Drew J Adams, Mingji Dai, Giovanni Pellegrino, Bridget K Wagner, Andrew M Stern, Alykhan F Shamji, Stuart L Schreiber. Proc Natl Acad Sci U S A 2012
150
16

In vitro and in vivo antitumor effect of 5-FU combined with piplartine and piperine.
Daniel P Bezerra, Fernanda O de Castro, Ana Paula N N Alves, Cláudia Pessoa, Manoel Odorico de Moraes, Edilberto R Silveira, Mary Anne S Lima, Francisca Juliana M Elmiro, Nylane M N de Alencar, Rodney O Mesquita,[...]. J Appl Toxicol 2008
88
16

In vivo growth-inhibition of Sarcoma 180 by piplartine and piperine, two alkaloid amides from Piper.
D P Bezerra, F O Castro, A P N N Alves, C Pessoa, M O Moraes, E R Silveira, M A S Lima, F J M Elmiro, L V Costa-Lotufo. Braz J Med Biol Res 2006
107
16

Modulation of oxidative stress as an anticancer strategy.
Chiara Gorrini, Isaac S Harris, Tak W Mak. Nat Rev Drug Discov 2013
16

Activation of ERK signaling and induction of colon cancer cell death by piperlongumine.
H Randhawa, K Kibble, H Zeng, M P Moyer, K M Reindl. Toxicol In Vitro 2013
67
16


Piperlongumine decreases cell proliferation and the expression of cell cycle-associated proteins by inhibiting Akt pathway in human lung cancer cells.
Jin Sil Seok, Chang Hee Jeong, Michael C Petriello, Han Geuk Seo, Hyunjin Yoo, Kwonho Hong, Sung Gu Han. Food Chem Toxicol 2018
16
50

Piperlongumine Suppresses Proliferation of Human Oral Squamous Cell Carcinoma through Cell Cycle Arrest, Apoptosis and Senescence.
San-Yuan Chen, Geng-Hung Liu, Wen-Ying Chao, Chung-Sheng Shi, Ching-Yen Lin, Yun-Ping Lim, Chieh-Hsiang Lu, Peng-Yeh Lai, Hau-Ren Chen, Ying-Ray Lee. Int J Mol Sci 2016
21
38

Synergistic anticancer activity of doxorubicin and piperlongumine on DU-145 prostate cancer cells - The involvement of carbonyl reductase 1 inhibition.
Kamil Piska, Paulina Koczurkiewicz, Dawid Wnuk, Elżbieta Karnas, Adam Bucki, Katarzyna Wójcik-Pszczoła, Marek Jamrozik, Marta Michalik, Marcin Kołaczkowski, Elżbieta Pękala. Chem Biol Interact 2019
25
32

Piperlongumine inhibits NF-κB activity and attenuates aggressive growth characteristics of prostate cancer cells.
Serge Ginzburg, Konstantin V Golovine, Petr B Makhov, Robert G Uzzo, Alexander Kutikov, Vladimir M Kolenko. Prostate 2014
62
14

Structural and Biochemical Analyses Reveal the Mechanism of Glutathione S-Transferase Pi 1 Inhibition by the Anti-cancer Compound Piperlongumine.
Wayne Harshbarger, Sudershan Gondi, Scott B Ficarro, John Hunter, Durga Udayakumar, Deepak Gurbani, William D Singer, Yan Liu, Lianbo Li, Jarrod A Marto,[...]. J Biol Chem 2017
46
15

Piperlongumine induces gastric cancer cell apoptosis and G2/M cell cycle arrest both in vitro and in vivo.
Chaoqin Duan, Bin Zhang, Chao Deng, Yu Cao, Fan Zhou, Longyun Wu, Min Chen, Shanshan Shen, Guifang Xu, Shu Zhang,[...]. Tumour Biol 2016
33
21

Piperlongumine promotes autophagy via inhibition of Akt/mTOR signalling and mediates cancer cell death.
P Makhov, K Golovine, E Teper, A Kutikov, R Mehrazin, A Corcoran, A Tulin, R G Uzzo, V M Kolenko. Br J Cancer 2014
79
14

Piperlongumine and p53-reactivator APR-246 selectively induce cell death in HNSCC by targeting GSTP1.
Wei Hang, Zhi-Xian Yin, Gang Liu, Qinghua Zeng, Xiang-Feng Shen, Qian-Hui Sun, Dong-Dong Li, Yong-Ping Jian, Yang-He Zhang, Yi-Shu Wang,[...]. Oncogene 2018
28
25


Piperlongumine Suppresses Growth and Sensitizes Pancreatic Tumors to Gemcitabine in a Xenograft Mouse Model by Modulating the NF-kappa B Pathway.
Yongwei Wang, Xiangsong Wu, Yinan Zhou, Hongchi Jiang, Shangha Pan, Bei Sun. Cancer Prev Res (Phila) 2016
35
20

Piperlongumine induces apoptosis and autophagy in leukemic cells through targeting the PI3K/Akt/mTOR and p38 signaling pathways.
Hongfei Wang, Yongqiang Wang, Hongmei Gao, Bing Wang, Lin Dou, Yin Li. Oncol Lett 2018
18
38

Piperlongumine increases sensitivity of colorectal cancer cells to radiation: Involvement of ROS production via dual inhibition of glutathione and thioredoxin systems.
Hui Wang, Heng Jiang, Cyril Corbet, Sven de Mey, Kalun Law, Thierry Gevaert, Olivier Feron, Mark De Ridder. Cancer Lett 2019
32
21

Piplartine induces inhibition of leukemia cell proliferation triggering both apoptosis and necrosis pathways.
Daniel Pereira Bezerra, Gardenia Carmen Gadelha Militão, Fernanda Oliveira de Castro, Cláudia Pessoa, Manoel Odorico de Moraes, Edilberto Rocha Silveira, Mary Anne Sousa Lima, Francisca Juliana Martins Elmiro, Letícia Veras Costa-Lotufo. Toxicol In Vitro 2007
79
12

Designing piperlongumine-directed anticancer agents by an electrophilicity-based prooxidant strategy: A mechanistic investigation.
Wen-Jing Yan, Qi Wang, Cui-Hong Yuan, Fu Wang, Yuan Ji, Fang Dai, Xiao-Ling Jin, Bo Zhou. Free Radic Biol Med 2016
37
16

Piperlongumine selectively kills glioblastoma multiforme cells via reactive oxygen species accumulation dependent JNK and p38 activation.
Ju Mei Liu, Feng Pan, Li Li, Qian Rong Liu, Yong Chen, Xin Xin Xiong, Kejun Cheng, Shang Bin Yu, Zhi Shi, Albert Cheung-Hoi Yu,[...]. Biochem Biophys Res Commun 2013
65
10


JNK signaling pathway is involved in piperlongumine-mediated apoptosis in human colorectal cancer HCT116 cells.
Wen Li, Chuangyu Wen, Haiyan Bai, Xiaoyan Wang, Xiaoli Zhang, Lanlan Huang, Xiangling Yang, Aikichi Iwamoto, Huanliang Liu. Oncol Lett 2015
15
33

Radio-sensitization by Piper longumine of human breast adenoma MDA-MB-231 cells in vitro.
Jian-Xin Yao, Zhi-Feng Yao, Zhan-Feng Li, Yong-Biao Liu. Asian Pac J Cancer Prev 2014
21
23

Piperlongumine derived cyclic sulfonamides (sultams): Synthesis and in vitro exploration for therapeutic potential against HeLa cancer cell lines.
Nitin P Lad, Sarang Kulkarni, Rajiv Sharma, Malcolm Mascarenhas, Mahesh R Kulkarni, Shivaji S Pandit. Eur J Med Chem 2017
13
38

Novel Ligustrazine-Based Analogs of Piperlongumine Potently Suppress Proliferation and Metastasis of Colorectal Cancer Cells in Vitro and in Vivo.
Yu Zou, Di Zhao, Chang Yan, Yanpeng Ji, Jin Liu, Jinyi Xu, Yisheng Lai, Jide Tian, Yihua Zhang, Zhangjian Huang. J Med Chem 2018
24
20

Piperlongumine and immune cytokine TRAIL synergize to promote tumor death.
Jiahe Li, Charles C Sharkey, Michael R King. Sci Rep 2015
26
19



Piperlongumine downregulates the expression of HER family in breast cancer cells.
Hyeon-Ok Jin, Jin-Ah Park, Hyun-Ah Kim, Yoon Hwan Chang, Young Jun Hong, In-Chul Park, Jin Kyung Lee. Biochem Biophys Res Commun 2017
15
33

Piperlongumine inhibits cancer stem cell properties and regulates multiple malignant phenotypes in oral cancer.
Yin-Ju Chen, Chia-Chun Kuo, Lai-Lei Ting, Long-Sheng Lu, Ya-Ching Lu, Ann-Joy Cheng, Yun-Tien Lin, Chien-Ho Chen, Jo-Ting Tsai, Jeng-Fong Chiou. Oncol Lett 2018
9
55


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.