Sébastien Herzig, Reuben J Shaw. Nat Rev Mol Cell Biol 2018
Times Cited: 1059
Times Cited: 1059
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AMPK: a nutrient and energy sensor that maintains energy homeostasis.
D Grahame Hardie, Fiona A Ross, Simon A Hawley. Nat Rev Mol Cell Biol 2012
D Grahame Hardie, Fiona A Ross, Simon A Hawley. Nat Rev Mol Cell Biol 2012
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AMPK: Mechanisms of Cellular Energy Sensing and Restoration of Metabolic Balance.
Daniel Garcia, Reuben J Shaw. Mol Cell 2017
Daniel Garcia, Reuben J Shaw. Mol Cell 2017
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AMPK phosphorylation of raptor mediates a metabolic checkpoint.
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Dana M Gwinn, David B Shackelford, Daniel F Egan, Maria M Mihaylova, Annabelle Mery, Debbie S Vasquez, Benjamin E Turk, Reuben J Shaw. Mol Cell 2008
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Metabolism. AMP-activated protein kinase mediates mitochondrial fission in response to energy stress.
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Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin.
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AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1.
Joungmok Kim, Mondira Kundu, Benoit Viollet, Kun-Liang Guan. Nat Cell Biol 2011
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AMPK: Sensing Glucose as well as Cellular Energy Status.
Sheng-Cai Lin, D Grahame Hardie. Cell Metab 2018
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The hallmarks of aging.
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Role of AMP-activated protein kinase in mechanism of metformin action.
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The AMPK signalling pathway coordinates cell growth, autophagy and metabolism.
Maria M Mihaylova, Reuben J Shaw. Nat Cell Biol 2011
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The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation.
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AMPK activators: mechanisms of action and physiological activities.
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AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice.
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AMPK and TOR: The Yin and Yang of Cellular Nutrient Sensing and Growth Control.
Asier González, Michael N Hall, Sheng-Cai Lin, D Grahame Hardie. Cell Metab 2020
Asier González, Michael N Hall, Sheng-Cai Lin, D Grahame Hardie. Cell Metab 2020
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Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy.
Joungmok Kim, Young Chul Kim, Chong Fang, Ryan C Russell, Jeong Hee Kim, Weiliang Fan, Rong Liu, Qing Zhong, Kun-Liang Guan. Cell 2013
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mTOR at the nexus of nutrition, growth, ageing and disease.
Grace Y Liu, David M Sabatini. Nat Rev Mol Cell Biol 2020
Grace Y Liu, David M Sabatini. Nat Rev Mol Cell Biol 2020
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Metabolism of inflammation limited by AMPK and pseudo-starvation.
Luke A J O'Neill, D Grahame Hardie. Nature 2013
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LKB1 is the upstream kinase in the AMP-activated protein kinase cascade.
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A common bicyclic protein kinase cascade inactivates the regulatory enzymes of fatty acid and cholesterol biosynthesis.
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AMP-activated protein kinase inhibits NF-κB signaling and inflammation: impact on healthspan and lifespan.
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Posttranscriptional control of T cell effector function by aerobic glycolysis.
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AMPK: An Energy-Sensing Pathway with Multiple Inputs and Outputs.
D Grahame Hardie, Bethany E Schaffer, Anne Brunet. Trends Cell Biol 2016
D Grahame Hardie, Bethany E Schaffer, Anne Brunet. Trends Cell Biol 2016
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AMPK-dependent degradation of TXNIP upon energy stress leads to enhanced glucose uptake via GLUT1.
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Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release.
Dmitry B Zorov, Magdalena Juhaszova, Steven J Sollott. Physiol Rev 2014
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The glycogen-binding domain on the AMPK beta subunit allows the kinase to act as a glycogen sensor.
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Post-translational regulation of lipogenesis via AMPK-dependent phosphorylation of insulin-induced gene.
Yamei Han, Zhimin Hu, Aoyuan Cui, Zhengshuai Liu, Fengguang Ma, Yaqian Xue, Yuxiao Liu, Feifei Zhang, Zehua Zhao, Yanyan Yu,[...]. Nat Commun 2019
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The Ca2+/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases.
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Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.
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Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK.
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Ferroptosis: mechanisms and links with diseases.
Hong-Fa Yan, Ting Zou, Qing-Zhang Tuo, Shuo Xu, Hua Li, Abdel Ali Belaidi, Peng Lei. Signal Transduct Target Ther 2021
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Benefits of Metformin in Attenuating the Hallmarks of Aging.
Ameya S Kulkarni, Sriram Gubbi, Nir Barzilai. Cell Metab 2020
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Biological Functions of Autophagy Genes: A Disease Perspective.
Beth Levine, Guido Kroemer. Cell 2019
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Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis.
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TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation.
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Age-related changes in AMPK activation: Role for AMPK phosphatases and inhibitory phosphorylation by upstream signaling pathways.
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AMP-activated protein kinase induces a p53-dependent metabolic checkpoint.
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AMP-activated protein kinase: maintaining energy homeostasis at the cellular and whole-body levels.
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Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development.
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Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation.
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Antigen receptor-mediated changes in glucose metabolism in B lymphocytes: role of phosphatidylinositol 3-kinase signaling in the glycolytic control of growth.
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The NLRP3 inflammasome: molecular activation and regulation to therapeutics.
Karen V Swanson, Meng Deng, Jenny P-Y Ting. Nat Rev Immunol 2019
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PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation.
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mTOR- and HIF-1α-mediated aerobic glycolysis as metabolic basis for trained immunity.
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Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets.
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AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network.
Antero Salminen, Kai Kaarniranta. Ageing Res Rev 2012
Antero Salminen, Kai Kaarniranta. Ageing Res Rev 2012
3
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