Naoki Yahata, Yuji Matsumoto, Minoru Omi, Naoki Yamamoto, Ryuji Hata. Sci Rep 2017
Times Cited: 34
Times Cited: 34
Times Cited
Times Co-cited
Similarity
Targeted elimination of mutant mitochondrial DNA in MELAS-iPSCs by mitoTALENs.
Yi Yang, Han Wu, Xiangjin Kang, Yanhui Liang, Ting Lan, Tianjie Li, Tao Tan, Jiangyun Peng, Quanjun Zhang, Geng An,[...]. Protein Cell 2018
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MitoTALEN: A General Approach to Reduce Mutant mtDNA Loads and Restore Oxidative Phosphorylation Function in Mitochondrial Diseases.
Masami Hashimoto, Sandra R Bacman, Susana Peralta, Marni J Falk, Anne Chomyn, David C Chan, Sion L Williams, Carlos T Moraes. Mol Ther 2015
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Mitochondrially targeted ZFNs for selective degradation of pathogenic mitochondrial genomes bearing large-scale deletions or point mutations.
Payam A Gammage, Joanna Rorbach, Anna I Vincent, Edward J Rebar, Michal Minczuk. EMBO Mol Med 2014
Payam A Gammage, Joanna Rorbach, Anna I Vincent, Edward J Rebar, Michal Minczuk. EMBO Mol Med 2014
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Specific elimination of mutant mitochondrial genomes in patient-derived cells by mitoTALENs.
Sandra R Bacman, Siôn L Williams, Milena Pinto, Susana Peralta, Carlos T Moraes. Nat Med 2013
Sandra R Bacman, Siôn L Williams, Milena Pinto, Susana Peralta, Carlos T Moraes. Nat Med 2013
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Genome editing in mitochondria corrects a pathogenic mtDNA mutation in vivo.
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Mitochondrial Genome Engineering: The Revolution May Not Be CRISPR-Ized.
Payam A Gammage, Carlos T Moraes, Michal Minczuk. Trends Genet 2018
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Selective elimination of mitochondrial mutations in the germline by genome editing.
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MitoTALEN reduces mutant mtDNA load and restores tRNAAla levels in a mouse model of heteroplasmic mtDNA mutation.
Sandra R Bacman, Johanna H K Kauppila, Claudia V Pereira, Nadee Nissanka, Maria Miranda, Milena Pinto, Sion L Williams, Nils-Göran Larsson, James B Stewart, Carlos T Moraes. Nat Med 2018
Sandra R Bacman, Johanna H K Kauppila, Claudia V Pereira, Nadee Nissanka, Maria Miranda, Milena Pinto, Sion L Williams, Nils-Göran Larsson, James B Stewart, Carlos T Moraes. Nat Med 2018
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Efficient Mitochondrial Genome Editing by CRISPR/Cas9.
Areum Jo, Sangwoo Ham, Gum Hwa Lee, Yun-Il Lee, SangSeong Kim, Yun-Song Lee, Joo-Ho Shin, Yunjong Lee. Biomed Res Int 2015
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mitoTev-TALE: a monomeric DNA editing enzyme to reduce mutant mitochondrial DNA levels.
Claudia V Pereira, Sandra R Bacman, Tania Arguello, Ugne Zekonyte, Sion L Williams, David R Edgell, Carlos T Moraes. EMBO Mol Med 2018
Claudia V Pereira, Sandra R Bacman, Tania Arguello, Ugne Zekonyte, Sion L Williams, David R Edgell, Carlos T Moraes. EMBO Mol Med 2018
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A bacterial cytidine deaminase toxin enables CRISPR-free mitochondrial base editing.
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Near-complete elimination of mutant mtDNA by iterative or dynamic dose-controlled treatment with mtZFNs.
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Prevalence of nuclear and mitochondrial DNA mutations related to adult mitochondrial disease.
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Sequence-specific modification of mitochondrial DNA using a chimeric zinc finger methylase.
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The dynamics of mitochondrial DNA heteroplasmy: implications for human health and disease.
James B Stewart, Patrick F Chinnery. Nat Rev Genet 2015
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Linear mitochondrial DNA is rapidly degraded by components of the replication machinery.
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Gene therapy for mitochondrial disease by delivering restriction endonuclease SmaI into mitochondria.
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Manipulating mitochondrial DNA heteroplasmy by a mitochondrially targeted restriction endonuclease.
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Organ-specific shifts in mtDNA heteroplasmy following systemic delivery of a mitochondria-targeted restriction endonuclease.
S R Bacman, S L Williams, S Garcia, C T Moraes. Gene Ther 2010
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Development of a single-chain, quasi-dimeric zinc-finger nuclease for the selective degradation of mutated human mitochondrial DNA.
Michal Minczuk, Monika A Papworth, Jeffrey C Miller, Michael P Murphy, Aaron Klug. Nucleic Acids Res 2008
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Mitochondrial diseases.
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Gráinne S Gorman, Patrick F Chinnery, Salvatore DiMauro, Michio Hirano, Yasutoshi Koga, Robert McFarland, Anu Suomalainen, David R Thorburn, Massimo Zeviani, Douglass M Turnbull. Nat Rev Dis Primers 2016
20
Manipulation of mtDNA heteroplasmy in all striated muscles of newborn mice by AAV9-mediated delivery of a mitochondria-targeted restriction endonuclease.
S R Bacman, S L Williams, D Duan, C T Moraes. Gene Ther 2012
S R Bacman, S L Williams, D Duan, C T Moraes. Gene Ther 2012
20
The mitochondrial DNA polymerase gamma degrades linear DNA fragments precluding the formation of deletions.
Nadee Nissanka, Sandra R Bacman, Melanie J Plastini, Carlos T Moraes. Nat Commun 2018
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Single-Molecule Analysis of mtDNA Replication Uncovers the Basis of the Common Deletion.
Aaron F Phillips, Armêl R Millet, Marco Tigano, Sonia M Dubois, Hannah Crimmins, Loelia Babin, Marine Charpentier, Marion Piganeau, Erika Brunet, Agnel Sfeir. Mol Cell 2017
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20
Segregation of mitochondrial DNA heteroplasmy through a developmental genetic bottleneck in human embryos.
Vasileios I Floros, Angela Pyle, Sabine Dietmann, Wei Wei, Walfred C W Tang, Naoko Irie, Brendan Payne, Antonio Capalbo, Laila Noli, Jonathan Coxhead,[...]. Nat Cell Biol 2018
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20
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Rapid directional shift of mitochondrial DNA heteroplasmy in animal tissues by a mitochondrially targeted restriction endonuclease.
Maria Pilar Bayona-Bafaluy, Bas Blits, Brendan J Battersby, Eric A Shoubridge, Carlos T Moraes. Proc Natl Acad Sci U S A 2005
Maria Pilar Bayona-Bafaluy, Bas Blits, Brendan J Battersby, Eric A Shoubridge, Carlos T Moraes. Proc Natl Acad Sci U S A 2005
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Selective elimination of mutant mitochondrial genomes as therapeutic strategy for the treatment of NARP and MILS syndromes.
M F Alexeyev, N Venediktova, V Pastukh, I Shokolenko, G Bonilla, G L Wilson. Gene Ther 2008
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A Phenotype-Driven Approach to Generate Mouse Models with Pathogenic mtDNA Mutations Causing Mitochondrial Disease.
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Metabolic rescue in pluripotent cells from patients with mtDNA disease.
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Genome editing with engineered zinc finger nucleases.
Fyodor D Urnov, Edward J Rebar, Michael C Holmes, H Steve Zhang, Philip D Gregory. Nat Rev Genet 2010
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Mitochondrial DNA mutation associated with Leber's hereditary optic neuropathy.
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The mitochondrial DNA genetic bottleneck: inheritance and beyond.
Haixin Zhang, Stephen P Burr, Patrick F Chinnery. Essays Biochem 2018
Haixin Zhang, Stephen P Burr, Patrick F Chinnery. Essays Biochem 2018
14
Genetic engineering of human pluripotent cells using TALE nucleases.
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Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage.
Alexis C Komor, Yongjoo B Kim, Michael S Packer, John A Zuris, David R Liu. Nature 2016
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14
Modulating mtDNA heteroplasmy by mitochondria-targeted restriction endonucleases in a 'differential multiple cleavage-site' model.
S R Bacman, S L Williams, D Hernandez, C T Moraes. Gene Ther 2007
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Mechanisms of formation and accumulation of mitochondrial DNA deletions in aging neurons.
Hirokazu Fukui, Carlos T Moraes. Hum Mol Genet 2009
Hirokazu Fukui, Carlos T Moraes. Hum Mol Genet 2009
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Mitochondrial DNA genetics and the heteroplasmy conundrum in evolution and disease.
Douglas C Wallace, Dimitra Chalkia. Cold Spring Harb Perspect Biol 2013
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Knock-In Strategy for Editing Human and Zebrafish Mitochondrial DNA Using Mito-CRISPR/Cas9 System.
Wan-Ping Bian, Yan-Ling Chen, Juan-Juan Luo, Chao Wang, Shao-Lin Xie, De-Sheng Pei. ACS Synth Biol 2019
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Disease-causing mitochondrial heteroplasmy segregated within induced pluripotent stem cell clones derived from a patient with MELAS.
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14
Impaired respiratory function in MELAS-induced pluripotent stem cells with high heteroplasmy levels.
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14
Gene delivery to mitochondria by targeting modified adenoassociated virus suppresses Leber's hereditary optic neuropathy in a mouse model.
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14
Human iPSC-Derived Neural Progenitors Are an Effective Drug Discovery Model for Neurological mtDNA Disorders.
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Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies.
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11
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.