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Times Cited: 57
Times Cited: 57
Times Cited
Times Co-cited
Similarity
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Small nucleoli are a cellular hallmark of longevity.
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Drosophila RNA polymerase III repressor Maf1 controls body size and developmental timing by modulating tRNAiMet synthesis and systemic insulin signaling.
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Intestinal barrier dysfunction links metabolic and inflammatory markers of aging to death in Drosophila.
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Maf1-dependent transcriptional regulation of tRNAs prevents genomic instability and is associated with extended lifespan.
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Maf1 is an essential mediator of diverse signals that repress RNA polymerase III transcription.
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Rapamycin fed late in life extends lifespan in genetically heterogeneous mice.
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Extending healthy life span--from yeast to humans.
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The adult Drosophila posterior midgut is maintained by pluripotent stem cells.
Benjamin Ohlstein, Allan Spradling. Nature 2006
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Evidence that stem cells reside in the adult Drosophila midgut epithelium.
Craig A Micchelli, Norbert Perrimon. Nature 2006
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Structural basis of RNA polymerase III transcription initiation.
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Promoting health and longevity through diet: from model organisms to humans.
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Facing up to the global challenges of ageing.
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mTOR associates with TFIIIC, is found at tRNA and 5S rRNA genes, and targets their repressor Maf1.
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Recessive mutations in POLR1C cause a leukodystrophy by impairing biogenesis of RNA polymerase III.
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Mutations in genes encoding subunits of RNA polymerases I and III cause Treacher Collins syndrome.
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General repression of RNA polymerase III transcription is triggered by protein phosphatase type 2A-mediated dephosphorylation of Maf1.
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Maf1p, a negative effector of RNA polymerase III in Saccharomyces cerevisiae.
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Reduced expression of MYC increases longevity and enhances healthspan.
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Genetics: influence of TOR kinase on lifespan in C. elegans.
Tibor Vellai, Krisztina Takacs-Vellai, Yue Zhang, Attila L Kovacs, László Orosz, Fritz Müller. Nature 2003
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Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein.
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Nucleolar expansion and elevated protein translation in premature aging.
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Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.