Yi Yang, Han Wu, Xiangjin Kang, Yanhui Liang, Ting Lan, Tianjie Li, Tao Tan, Jiangyun Peng, Quanjun Zhang, Geng An, Yali Liu, Qian Yu, Zhenglai Ma, Ying Lian, Boon Seng Soh, Qingfeng Chen, Ping Liu, Yaoyong Chen, Xiaofang Sun, Rong Li, Xiumei Zhen, Ping Liu, Yang Yu, Xiaoping Li, Yong Fan. Protein Cell 2018
Times Cited: 49
Times Cited: 49
Times Cited
Times Co-cited
Similarity
Specific elimination of mutant mitochondrial genomes in patient-derived cells by mitoTALENs.
Sandra R Bacman, Siôn L Williams, Milena Pinto, Susana Peralta, Carlos T Moraes. Nat Med 2013
Sandra R Bacman, Siôn L Williams, Milena Pinto, Susana Peralta, Carlos T Moraes. Nat Med 2013
55
Genome editing in mitochondria corrects a pathogenic mtDNA mutation in vivo.
Payam A Gammage, Carlo Viscomi, Marie-Lune Simard, Ana S H Costa, Edoardo Gaude, Christopher A Powell, Lindsey Van Haute, Beverly J McCann, Pedro Rebelo-Guiomar, Raffaele Cerutti,[...]. Nat Med 2018
Payam A Gammage, Carlo Viscomi, Marie-Lune Simard, Ana S H Costa, Edoardo Gaude, Christopher A Powell, Lindsey Van Haute, Beverly J McCann, Pedro Rebelo-Guiomar, Raffaele Cerutti,[...]. Nat Med 2018
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MitoTALEN: A General Approach to Reduce Mutant mtDNA Loads and Restore Oxidative Phosphorylation Function in Mitochondrial Diseases.
Masami Hashimoto, Sandra R Bacman, Susana Peralta, Marni J Falk, Anne Chomyn, David C Chan, Sion L Williams, Carlos T Moraes. Mol Ther 2015
Masami Hashimoto, Sandra R Bacman, Susana Peralta, Marni J Falk, Anne Chomyn, David C Chan, Sion L Williams, Carlos T Moraes. Mol Ther 2015
48
MitoTALEN reduces mutant mtDNA load and restores tRNAAla levels in a mouse model of heteroplasmic mtDNA mutation.
Sandra R Bacman, Johanna H K Kauppila, Claudia V Pereira, Nadee Nissanka, Maria Miranda, Milena Pinto, Sion L Williams, Nils-Göran Larsson, James B Stewart, Carlos T Moraes. Nat Med 2018
Sandra R Bacman, Johanna H K Kauppila, Claudia V Pereira, Nadee Nissanka, Maria Miranda, Milena Pinto, Sion L Williams, Nils-Göran Larsson, James B Stewart, Carlos T Moraes. Nat Med 2018
48
Mitochondrially targeted ZFNs for selective degradation of pathogenic mitochondrial genomes bearing large-scale deletions or point mutations.
Payam A Gammage, Joanna Rorbach, Anna I Vincent, Edward J Rebar, Michal Minczuk. EMBO Mol Med 2014
Payam A Gammage, Joanna Rorbach, Anna I Vincent, Edward J Rebar, Michal Minczuk. EMBO Mol Med 2014
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Selective elimination of mitochondrial mutations in the germline by genome editing.
Pradeep Reddy, Alejandro Ocampo, Keiichiro Suzuki, Jinping Luo, Sandra R Bacman, Sion L Williams, Atsushi Sugawara, Daiji Okamura, Yuji Tsunekawa, Jun Wu,[...]. Cell 2015
Pradeep Reddy, Alejandro Ocampo, Keiichiro Suzuki, Jinping Luo, Sandra R Bacman, Sion L Williams, Atsushi Sugawara, Daiji Okamura, Yuji Tsunekawa, Jun Wu,[...]. Cell 2015
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Mitochondrial Genome Engineering: The Revolution May Not Be CRISPR-Ized.
Payam A Gammage, Carlos T Moraes, Michal Minczuk. Trends Genet 2018
Payam A Gammage, Carlos T Moraes, Michal Minczuk. Trends Genet 2018
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TALEN-mediated shift of mitochondrial DNA heteroplasmy in MELAS-iPSCs with m.13513G>A mutation.
Naoki Yahata, Yuji Matsumoto, Minoru Omi, Naoki Yamamoto, Ryuji Hata. Sci Rep 2017
Naoki Yahata, Yuji Matsumoto, Minoru Omi, Naoki Yamamoto, Ryuji Hata. Sci Rep 2017
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Near-complete elimination of mutant mtDNA by iterative or dynamic dose-controlled treatment with mtZFNs.
Payam A Gammage, Edoardo Gaude, Lindsey Van Haute, Pedro Rebelo-Guiomar, Christopher B Jackson, Joanna Rorbach, Marcin L Pekalski, Alan J Robinson, Marine Charpentier, Jean-Paul Concordet,[...]. Nucleic Acids Res 2016
Payam A Gammage, Edoardo Gaude, Lindsey Van Haute, Pedro Rebelo-Guiomar, Christopher B Jackson, Joanna Rorbach, Marcin L Pekalski, Alan J Robinson, Marine Charpentier, Jean-Paul Concordet,[...]. Nucleic Acids Res 2016
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mitoTev-TALE: a monomeric DNA editing enzyme to reduce mutant mitochondrial DNA levels.
Claudia V Pereira, Sandra R Bacman, Tania Arguello, Ugne Zekonyte, Sion L Williams, David R Edgell, Carlos T Moraes. EMBO Mol Med 2018
Claudia V Pereira, Sandra R Bacman, Tania Arguello, Ugne Zekonyte, Sion L Williams, David R Edgell, Carlos T Moraes. EMBO Mol Med 2018
48
Development of a single-chain, quasi-dimeric zinc-finger nuclease for the selective degradation of mutated human mitochondrial DNA.
Michal Minczuk, Monika A Papworth, Jeffrey C Miller, Michael P Murphy, Aaron Klug. Nucleic Acids Res 2008
Michal Minczuk, Monika A Papworth, Jeffrey C Miller, Michael P Murphy, Aaron Klug. Nucleic Acids Res 2008
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Mitochondrial diseases.
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Gráinne S Gorman, Patrick F Chinnery, Salvatore DiMauro, Michio Hirano, Yasutoshi Koga, Robert McFarland, Anu Suomalainen, David R Thorburn, Massimo Zeviani, Douglass M Turnbull. Nat Rev Dis Primers 2016
30
A bacterial cytidine deaminase toxin enables CRISPR-free mitochondrial base editing.
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28
Gene therapy for mitochondrial disease by delivering restriction endonuclease SmaI into mitochondria.
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Efficient Mitochondrial Genome Editing by CRISPR/Cas9.
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The dynamics of mitochondrial DNA heteroplasmy: implications for human health and disease.
James B Stewart, Patrick F Chinnery. Nat Rev Genet 2015
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Prevalence of nuclear and mitochondrial DNA mutations related to adult mitochondrial disease.
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Sequence and organization of the human mitochondrial genome.
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Manipulating mitochondrial DNA heteroplasmy by a mitochondrially targeted restriction endonuclease.
S Srivastava, C T Moraes. Hum Mol Genet 2001
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Mitochondrial replacement in human oocytes carrying pathogenic mitochondrial DNA mutations.
Eunju Kang, Jun Wu, Nuria Marti Gutierrez, Amy Koski, Rebecca Tippner-Hedges, Karen Agaronyan, Aida Platero-Luengo, Paloma Martinez-Redondo, Hong Ma, Yeonmi Lee,[...]. Nature 2016
Eunju Kang, Jun Wu, Nuria Marti Gutierrez, Amy Koski, Rebecca Tippner-Hedges, Karen Agaronyan, Aida Platero-Luengo, Paloma Martinez-Redondo, Hong Ma, Yeonmi Lee,[...]. Nature 2016
22
A Phenotype-Driven Approach to Generate Mouse Models with Pathogenic mtDNA Mutations Causing Mitochondrial Disease.
Johanna H K Kauppila, Holly L Baines, Ana Bratic, Marie-Lune Simard, Christoph Freyer, Arnaud Mourier, Craig Stamp, Roberta Filograna, Nils-Göran Larsson, Laura C Greaves,[...]. Cell Rep 2016
Johanna H K Kauppila, Holly L Baines, Ana Bratic, Marie-Lune Simard, Christoph Freyer, Arnaud Mourier, Craig Stamp, Roberta Filograna, Nils-Göran Larsson, Laura C Greaves,[...]. Cell Rep 2016
22
Sequence-specific modification of mitochondrial DNA using a chimeric zinc finger methylase.
Michal Minczuk, Monika A Papworth, Paulina Kolasinska, Michael P Murphy, Aaron Klug. Proc Natl Acad Sci U S A 2006
Michal Minczuk, Monika A Papworth, Paulina Kolasinska, Michael P Murphy, Aaron Klug. Proc Natl Acad Sci U S A 2006
20
Manipulation of mtDNA heteroplasmy in all striated muscles of newborn mice by AAV9-mediated delivery of a mitochondria-targeted restriction endonuclease.
S R Bacman, S L Williams, D Duan, C T Moraes. Gene Ther 2012
S R Bacman, S L Williams, D Duan, C T Moraes. Gene Ther 2012
21
Selective elimination of mutant mitochondrial genomes as therapeutic strategy for the treatment of NARP and MILS syndromes.
M F Alexeyev, N Venediktova, V Pastukh, I Shokolenko, G Bonilla, G L Wilson. Gene Ther 2008
M F Alexeyev, N Venediktova, V Pastukh, I Shokolenko, G Bonilla, G L Wilson. Gene Ther 2008
20
Single-Molecule Analysis of mtDNA Replication Uncovers the Basis of the Common Deletion.
Aaron F Phillips, Armêl R Millet, Marco Tigano, Sonia M Dubois, Hannah Crimmins, Loelia Babin, Marine Charpentier, Marion Piganeau, Erika Brunet, Agnel Sfeir. Mol Cell 2017
Aaron F Phillips, Armêl R Millet, Marco Tigano, Sonia M Dubois, Hannah Crimmins, Loelia Babin, Marine Charpentier, Marion Piganeau, Erika Brunet, Agnel Sfeir. Mol Cell 2017
18
Linear mitochondrial DNA is rapidly degraded by components of the replication machinery.
Viktoriya Peeva, Daniel Blei, Genevieve Trombly, Sarah Corsi, Maciej J Szukszto, Pedro Rebelo-Guiomar, Payam A Gammage, Alexei P Kudin, Christian Becker, Janine Altmüller,[...]. Nat Commun 2018
Viktoriya Peeva, Daniel Blei, Genevieve Trombly, Sarah Corsi, Maciej J Szukszto, Pedro Rebelo-Guiomar, Payam A Gammage, Alexei P Kudin, Christian Becker, Janine Altmüller,[...]. Nat Commun 2018
18
Mitochondrial DNA mutation associated with Leber's hereditary optic neuropathy.
D C Wallace, G Singh, M T Lott, J A Hodge, T G Schurr, A M Lezza, L J Elsas, E K Nikoskelainen. Science 1988
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Metabolic rescue in pluripotent cells from patients with mtDNA disease.
Hong Ma, Clifford D L Folmes, Jun Wu, Robert Morey, Sergio Mora-Castilla, Alejandro Ocampo, Li Ma, Joanna Poulton, Xinjian Wang, Riffat Ahmed,[...]. Nature 2015
Hong Ma, Clifford D L Folmes, Jun Wu, Robert Morey, Sergio Mora-Castilla, Alejandro Ocampo, Li Ma, Joanna Poulton, Xinjian Wang, Riffat Ahmed,[...]. Nature 2015
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Maintenance and Expression of Mammalian Mitochondrial DNA.
Claes M Gustafsson, Maria Falkenberg, Nils-Göran Larsson. Annu Rev Biochem 2016
Claes M Gustafsson, Maria Falkenberg, Nils-Göran Larsson. Annu Rev Biochem 2016
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Biparental Inheritance of Mitochondrial DNA in Humans.
Shiyu Luo, C Alexander Valencia, Jinglan Zhang, Ni-Chung Lee, Jesse Slone, Baoheng Gui, Xinjian Wang, Zhuo Li, Sarah Dell, Jenice Brown,[...]. Proc Natl Acad Sci U S A 2018
Shiyu Luo, C Alexander Valencia, Jinglan Zhang, Ni-Chung Lee, Jesse Slone, Baoheng Gui, Xinjian Wang, Zhuo Li, Sarah Dell, Jenice Brown,[...]. Proc Natl Acad Sci U S A 2018
16
Segregation of mitochondrial DNA heteroplasmy through a developmental genetic bottleneck in human embryos.
Vasileios I Floros, Angela Pyle, Sabine Dietmann, Wei Wei, Walfred C W Tang, Naoko Irie, Brendan Payne, Antonio Capalbo, Laila Noli, Jonathan Coxhead,[...]. Nat Cell Biol 2018
Vasileios I Floros, Angela Pyle, Sabine Dietmann, Wei Wei, Walfred C W Tang, Naoko Irie, Brendan Payne, Antonio Capalbo, Laila Noli, Jonathan Coxhead,[...]. Nat Cell Biol 2018
16
The mitochondrial DNA polymerase gamma degrades linear DNA fragments precluding the formation of deletions.
Nadee Nissanka, Sandra R Bacman, Melanie J Plastini, Carlos T Moraes. Nat Commun 2018
Nadee Nissanka, Sandra R Bacman, Melanie J Plastini, Carlos T Moraes. Nat Commun 2018
16
Organ-specific shifts in mtDNA heteroplasmy following systemic delivery of a mitochondria-targeted restriction endonuclease.
S R Bacman, S L Williams, S Garcia, C T Moraes. Gene Ther 2010
S R Bacman, S L Williams, S Garcia, C T Moraes. Gene Ther 2010
16
Rapid directional shift of mitochondrial DNA heteroplasmy in animal tissues by a mitochondrially targeted restriction endonuclease.
Maria Pilar Bayona-Bafaluy, Bas Blits, Brendan J Battersby, Eric A Shoubridge, Carlos T Moraes. Proc Natl Acad Sci U S A 2005
Maria Pilar Bayona-Bafaluy, Bas Blits, Brendan J Battersby, Eric A Shoubridge, Carlos T Moraes. Proc Natl Acad Sci U S A 2005
16
Tissue- and cell-type-specific manifestations of heteroplasmic mtDNA 3243A>G mutation in human induced pluripotent stem cell-derived disease model.
Riikka H Hämäläinen, Tuula Manninen, Hanna Koivumäki, Mikhail Kislin, Timo Otonkoski, Anu Suomalainen. Proc Natl Acad Sci U S A 2013
Riikka H Hämäläinen, Tuula Manninen, Hanna Koivumäki, Mikhail Kislin, Timo Otonkoski, Anu Suomalainen. Proc Natl Acad Sci U S A 2013
16
Gene delivery to mitochondria by targeting modified adenoassociated virus suppresses Leber's hereditary optic neuropathy in a mouse model.
Hong Yu, Rajeshwari D Koilkonda, Tsung-Han Chou, Vittorio Porciatti, Sacide S Ozdemir, Vince Chiodo, Sanford L Boye, Shannon E Boye, William W Hauswirth, Alfred S Lewin,[...]. Proc Natl Acad Sci U S A 2012
Hong Yu, Rajeshwari D Koilkonda, Tsung-Han Chou, Vittorio Porciatti, Sacide S Ozdemir, Vince Chiodo, Sanford L Boye, Shannon E Boye, William W Hauswirth, Alfred S Lewin,[...]. Proc Natl Acad Sci U S A 2012
14
Hypoxia as a therapy for mitochondrial disease.
Isha H Jain, Luca Zazzeron, Rahul Goli, Kristen Alexa, Stephanie Schatzman-Bone, Harveen Dhillon, Olga Goldberger, Jun Peng, Ophir Shalem, Neville E Sanjana,[...]. Science 2016
Isha H Jain, Luca Zazzeron, Rahul Goli, Kristen Alexa, Stephanie Schatzman-Bone, Harveen Dhillon, Olga Goldberger, Jun Peng, Ophir Shalem, Neville E Sanjana,[...]. Science 2016
14
Gene Therapy for Leber Hereditary Optic Neuropathy: Low- and Medium-Dose Visual Results.
John Guy, William J Feuer, Janet L Davis, Vittorio Porciatti, Phillip J Gonzalez, Rajeshwari D Koilkonda, Huijun Yuan, William W Hauswirth, Byron L Lam. Ophthalmology 2017
John Guy, William J Feuer, Janet L Davis, Vittorio Porciatti, Phillip J Gonzalez, Rajeshwari D Koilkonda, Huijun Yuan, William W Hauswirth, Byron L Lam. Ophthalmology 2017
14
Premature ageing in mice expressing defective mitochondrial DNA polymerase.
Aleksandra Trifunovic, Anna Wredenberg, Maria Falkenberg, Johannes N Spelbrink, Anja T Rovio, Carl E Bruder, Mohammad Bohlooly-Y, Sebastian Gidlöf, Anders Oldfors, Rolf Wibom,[...]. Nature 2004
Aleksandra Trifunovic, Anna Wredenberg, Maria Falkenberg, Johannes N Spelbrink, Anja T Rovio, Carl E Bruder, Mohammad Bohlooly-Y, Sebastian Gidlöf, Anders Oldfors, Rolf Wibom,[...]. Nature 2004
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Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.
Kazutoshi Takahashi, Shinya Yamanaka. Cell 2006
Kazutoshi Takahashi, Shinya Yamanaka. Cell 2006
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A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity.
Martin Jinek, Krzysztof Chylinski, Ines Fonfara, Michael Hauer, Jennifer A Doudna, Emmanuelle Charpentier. Science 2012
Martin Jinek, Krzysztof Chylinski, Ines Fonfara, Michael Hauer, Jennifer A Doudna, Emmanuelle Charpentier. Science 2012
12
Mitochondrial gene replacement in primate offspring and embryonic stem cells.
Masahito Tachibana, Michelle Sparman, Hathaitip Sritanaudomchai, Hong Ma, Lisa Clepper, Joy Woodward, Ying Li, Cathy Ramsey, Olena Kolotushkina, Shoukhrat Mitalipov. Nature 2009
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12
Mechanisms of formation and accumulation of mitochondrial DNA deletions in aging neurons.
Hirokazu Fukui, Carlos T Moraes. Hum Mol Genet 2009
Hirokazu Fukui, Carlos T Moraes. Hum Mol Genet 2009
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Modifying the Mitochondrial Genome.
Alexander N Patananan, Ting-Hsiang Wu, Pei-Yu Chiou, Michael A Teitell. Cell Metab 2016
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12
The use of mitochondria-targeted endonucleases to manipulate mtDNA.
Sandra R Bacman, Sion L Williams, Milena Pinto, Carlos T Moraes. Methods Enzymol 2014
Sandra R Bacman, Sion L Williams, Milena Pinto, Carlos T Moraes. Methods Enzymol 2014
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mtDNA heteroplasmy level and copy number indicate disease burden in m.3243A>G mitochondrial disease.
John P Grady, Sarah J Pickett, Yi Shiau Ng, Charlotte L Alston, Emma L Blakely, Steven A Hardy, Catherine L Feeney, Alexandra A Bright, Andrew M Schaefer, Gráinne S Gorman,[...]. EMBO Mol Med 2018
John P Grady, Sarah J Pickett, Yi Shiau Ng, Charlotte L Alston, Emma L Blakely, Steven A Hardy, Catherine L Feeney, Alexandra A Bright, Andrew M Schaefer, Gráinne S Gorman,[...]. EMBO Mol Med 2018
12
Progress in mitochondrial replacement therapies.
Mary Herbert, Doug Turnbull. Nat Rev Mol Cell Biol 2018
Mary Herbert, Doug Turnbull. Nat Rev Mol Cell Biol 2018
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mtDNA Variation and Analysis Using Mitomap and Mitomaster.
Marie T Lott, Jeremy N Leipzig, Olga Derbeneva, H Michael Xie, Dimitra Chalkia, Mahdi Sarmady, Vincent Procaccio, Douglas C Wallace. Curr Protoc Bioinformatics 2013
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The mitochondrial DNA genetic bottleneck: inheritance and beyond.
Haixin Zhang, Stephen P Burr, Patrick F Chinnery. Essays Biochem 2018
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Towards clinical application of pronuclear transfer to prevent mitochondrial DNA disease.
Louise A Hyslop, Paul Blakeley, Lyndsey Craven, Jessica Richardson, Norah M E Fogarty, Elpida Fragouli, Mahdi Lamb, Sissy E Wamaitha, Nilendran Prathalingam, Qi Zhang,[...]. Nature 2016
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12
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.