Thomas H Massey, Lesley Jones. Dis Model Mech 2018
Times Cited: 44
Times Cited: 44
Times Cited
Times Co-cited
Similarity
40
38
DNA repair pathways underlie a common genetic mechanism modulating onset in polyglutamine diseases.
Conceição Bettencourt, Davina Hensman-Moss, Michael Flower, Sarah Wiethoff, Alexis Brice, Cyril Goizet, Giovanni Stevanin, Georgios Koutsis, Georgia Karadima, Marios Panas,[...]. Ann Neurol 2016
Conceição Bettencourt, Davina Hensman-Moss, Michael Flower, Sarah Wiethoff, Alexis Brice, Cyril Goizet, Giovanni Stevanin, Georgios Koutsis, Georgia Karadima, Marios Panas,[...]. Ann Neurol 2016
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Huntington disease.
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Disease-associated repeat instability and mismatch repair.
Monika H M Schmidt, Christopher E Pearson. DNA Repair (Amst) 2016
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DNA repair in the trinucleotide repeat disorders.
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Huntingtin is a scaffolding protein in the ATM oxidative DNA damage response complex.
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Mismatch repair genes Mlh1 and Mlh3 modify CAG instability in Huntington's disease mice: genome-wide and candidate approaches.
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20
FAN1 modifies Huntington's disease progression by stabilizing the expanded HTT CAG repeat.
Robert Goold, Michael Flower, Davina Hensman Moss, Chris Medway, Alison Wood-Kaczmar, Ralph Andre, Pamela Farshim, Gill P Bates, Peter Holmans, Lesley Jones,[...]. Hum Mol Genet 2019
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20
Inactivation of PNKP by mutant ATXN3 triggers apoptosis by activating the DNA damage-response pathway in SCA3.
Rui Gao, Yongping Liu, Anabela Silva-Fernandes, Xiang Fang, Adriana Paulucci-Holthauzen, Arpita Chatterjee, Hang L Zhang, Tohru Matsuura, Sanjeev Choudhary, Tetsuo Ashizawa,[...]. PLoS Genet 2015
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18
Intergenerational and striatal CAG repeat instability in Huntington's disease knock-in mice involve different DNA repair genes.
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Pms2 is a genetic enhancer of trinucleotide CAG.CTG repeat somatic mosaicism: implications for the mechanism of triplet repeat expansion.
Mário Gomes-Pereira, M Teresa Fortune, Laura Ingram, John P McAbney, Darren G Monckton. Hum Mol Genet 2004
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Motor neuron disease-associated loss of nuclear TDP-43 is linked to DNA double-strand break repair defects.
Joy Mitra, Erika N Guerrero, Pavana M Hegde, Nicole F Liachko, Haibo Wang, Velmarini Vasquez, Junling Gao, Arvind Pandey, J Paul Taylor, Brian C Kraemer,[...]. Proc Natl Acad Sci U S A 2019
Joy Mitra, Erika N Guerrero, Pavana M Hegde, Nicole F Liachko, Haibo Wang, Velmarini Vasquez, Junling Gao, Arvind Pandey, J Paul Taylor, Brian C Kraemer,[...]. Proc Natl Acad Sci U S A 2019
18
Activation of the DNA damage response in vivo in synucleinopathy models of Parkinson's disease.
Chiara Milanese, Silvia Cerri, Ayse Ulusoy, Simona V Gornati, Audrey Plat, Sylvia Gabriels, Fabio Blandini, Donato A Di Monte, Jan H Hoeijmakers, Pier G Mastroberardino. Cell Death Dis 2018
Chiara Milanese, Silvia Cerri, Ayse Ulusoy, Simona V Gornati, Audrey Plat, Sylvia Gabriels, Fabio Blandini, Donato A Di Monte, Jan H Hoeijmakers, Pier G Mastroberardino. Cell Death Dis 2018
18
Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice.
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DNA Damage Repair in Huntington's Disease and Other Neurodegenerative Diseases.
T Maiuri, C E Suart, C L K Hung, K J Graham, C A Barba Bazan, R Truant. Neurotherapeutics 2019
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Mutant huntingtin impairs PNKP and ATXN3, disrupting DNA repair and transcription.
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18
18
A genetic association study of glutamine-encoding DNA sequence structures, somatic CAG expansion, and DNA repair gene variants, with Huntington disease clinical outcomes.
Marc Ciosi, Alastair Maxwell, Sarah A Cumming, Davina J Hensman Moss, Asma M Alshammari, Michael D Flower, Alexandra Durr, Blair R Leavitt, Raymund A C Roos, Peter Holmans,[...]. EBioMedicine 2019
Marc Ciosi, Alastair Maxwell, Sarah A Cumming, Davina J Hensman Moss, Asma M Alshammari, Michael D Flower, Alexandra Durr, Blair R Leavitt, Raymund A C Roos, Peter Holmans,[...]. EBioMedicine 2019
18
A slipped-CAG DNA-binding small molecule induces trinucleotide-repeat contractions in vivo.
Masayuki Nakamori, Gagan B Panigrahi, Stella Lanni, Terence Gall-Duncan, Hideki Hayakawa, Hana Tanaka, Jennifer Luo, Takahiro Otabe, Jinxing Li, Akihiro Sakata,[...]. Nat Genet 2020
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OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells.
Irina V Kovtun, Yuan Liu, Magnar Bjoras, Arne Klungland, Samuel H Wilson, Cynthia T McMurray. Nature 2007
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DNA triplet repeat expansion and mismatch repair.
Ravi R Iyer, Anna Pluciennik, Marek Napierala, Robert D Wells. Annu Rev Biochem 2015
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DNA instability in postmitotic neurons.
Roman Gonitel, Hilary Moffitt, Kirupa Sathasivam, Ben Woodman, Peter J Detloff, Richard L M Faull, Gillian P Bates. Proc Natl Acad Sci U S A 2008
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Increased nuclear DNA damage precedes mitochondrial dysfunction in peripheral blood mononuclear cells from Huntington's disease patients.
Georgina Askeland, Zaneta Dosoudilova, Marie Rodinova, Jiri Klempir, Irena Liskova, Anna Kuśnierczyk, Magnar Bjørås, Gaute Nesse, Arne Klungland, Hana Hansikova,[...]. Sci Rep 2018
Georgina Askeland, Zaneta Dosoudilova, Marie Rodinova, Jiri Klempir, Irena Liskova, Anna Kuśnierczyk, Magnar Bjørås, Gaute Nesse, Arne Klungland, Hana Hansikova,[...]. Sci Rep 2018
31
Identification of genetic variants associated with Huntington's disease progression: a genome-wide association study.
Davina J Hensman Moss, Antonio F Pardiñas, Douglas Langbehn, Kitty Lo, Blair R Leavitt, Raymund Roos, Alexandra Durr, Simon Mead, Peter Holmans, Lesley Jones,[...]. Lancet Neurol 2017
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15
FAN1 protects against repeat expansions in a Fragile X mouse model.
Xiao-Nan Zhao, Karen Usdin. DNA Repair (Amst) 2018
Xiao-Nan Zhao, Karen Usdin. DNA Repair (Amst) 2018
21
Targeting ATM ameliorates mutant Huntingtin toxicity in cell and animal models of Huntington's disease.
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The DNA damage response: making it safe to play with knives.
Alberto Ciccia, Stephen J Elledge. Mol Cell 2010
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Mutant huntingtin impairs Ku70-mediated DNA repair.
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13
The RNA-binding protein fused in sarcoma (FUS) functions downstream of poly(ADP-ribose) polymerase (PARP) in response to DNA damage.
Adam S Mastrocola, Sang Hwa Kim, Anthony T Trinh, Lance A Rodenkirch, Randal S Tibbetts. J Biol Chem 2013
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13
C9orf72 expansion disrupts ATM-mediated chromosomal break repair.
Callum Walker, Saul Herranz-Martin, Evangelia Karyka, Chunyan Liao, Katherine Lewis, Waheba Elsayed, Vera Lukashchuk, Shih-Chieh Chiang, Swagat Ray, Padraig J Mulcahy,[...]. Nat Neurosci 2017
Callum Walker, Saul Herranz-Martin, Evangelia Karyka, Chunyan Liao, Katherine Lewis, Waheba Elsayed, Vera Lukashchuk, Shih-Chieh Chiang, Swagat Ray, Padraig J Mulcahy,[...]. Nat Neurosci 2017
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The Emerging Role of DNA Damage in the Pathogenesis of the C9orf72 Repeat Expansion in Amyotrophic Lateral Sclerosis.
Anna Konopka, Julie D Atkin. Int J Mol Sci 2018
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R loops stimulate genetic instability of CTG.CAG repeats.
Yunfu Lin, Sharon Y R Dent, John H Wilson, Robert D Wells, Marek Napierala. Proc Natl Acad Sci U S A 2010
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13
Early neuronal accumulation of DNA double strand breaks in Alzheimer's disease.
Niraj M Shanbhag, Mark D Evans, Wenjie Mao, Alissa L Nana, William W Seeley, Anthony Adame, Robert A Rissman, Eliezer Masliah, Lennart Mucke. Acta Neuropathol Commun 2019
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13
Targeting Huntingtin Expression in Patients with Huntington's Disease.
Sarah J Tabrizi, Blair R Leavitt, G Bernhard Landwehrmeyer, Edward J Wild, Carsten Saft, Roger A Barker, Nick F Blair, David Craufurd, Josef Priller, Hugh Rickards,[...]. N Engl J Med 2019
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Interaction of FUS and HDAC1 regulates DNA damage response and repair in neurons.
Wen-Yuan Wang, Ling Pan, Susan C Su, Emma J Quinn, Megumi Sasaki, Jessica C Jimenez, Ian R A Mackenzie, Eric J Huang, Li-Huei Tsai. Nat Neurosci 2013
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RAN Translation in Huntington Disease.
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13
Length of Uninterrupted CAG, Independent of Polyglutamine Size, Results in Increased Somatic Instability, Hastening Onset of Huntington Disease.
Galen E B Wright, Jennifer A Collins, Chris Kay, Cassandra McDonald, Egor Dolzhenko, Qingwen Xia, Kristina Bečanović, Britt I Drögemöller, Alicia Semaka, Charlotte M Nguyen,[...]. Am J Hum Genet 2019
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Mismatch repair gene Msh2 modifies the timing of early disease in Hdh(Q111) striatum.
Vanessa C Wheeler, Lori-Anne Lebel, Vladimir Vrbanac, Allison Teed, Hein te Riele, Marcy E MacDonald. Hum Mol Genet 2003
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MSH3 modifies somatic instability and disease severity in Huntington's and myotonic dystrophy type 1.
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On the wrong DNA track: Molecular mechanisms of repeat-mediated genome instability.
Alexandra N Khristich, Sergei M Mirkin. J Biol Chem 2020
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Triplet repeat mutation length gains correlate with cell-type specific vulnerability in Huntington disease brain.
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13
Somatic expansion of the Huntington's disease CAG repeat in the brain is associated with an earlier age of disease onset.
Meera Swami, Audrey E Hendricks, Tammy Gillis, Tiffany Massood, Jayalakshmi Mysore, Richard H Myers, Vanessa C Wheeler. Hum Mol Genet 2009
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13
Human MutLγ, the MLH1-MLH3 heterodimer, is an endonuclease that promotes DNA expansion.
Lyudmila Y Kadyrova, Vaibhavi Gujar, Vickers Burdett, Paul L Modrich, Farid A Kadyrov. Proc Natl Acad Sci U S A 2020
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Genetic and Functional Analyses Point to FAN1 as the Source of Multiple Huntington Disease Modifier Effects.
Kyung-Hee Kim, Eun Pyo Hong, Jun Wan Shin, Michael J Chao, Jacob Loupe, Tammy Gillis, Jayalakshmi S Mysore, Peter Holmans, Lesley Jones, Michael Orth,[...]. Am J Hum Genet 2020
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XRCC1 mutation is associated with PARP1 hyperactivation and cerebellar ataxia.
Nicolas C Hoch, Hana Hanzlikova, Stuart L Rulten, Martine Tétreault, Emilia Komulainen, Limei Ju, Peter Hornyak, Zhihong Zeng, William Gittens, Stephanie A Rey,[...]. Nature 2017
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11
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.