György Szabó, György I Túrós, Sándor Kolok, Mónika Vastag, Zsuzsanna Sánta, Miklós Dékány, György I Lévay, István Greiner, Minami Natsumi, Watanabe Tatsuya, György M Keserű. J Med Chem 2019
Times Cited: 9
Times Cited: 9
Times Cited
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Practical Strategies and Concepts in GPCR Allosteric Modulator Discovery: Recent Advances with Metabotropic Glutamate Receptors.
Craig W Lindsley, Kyle A Emmitte, Corey R Hopkins, Thomas M Bridges, Karen J Gregory, Colleen M Niswender, P Jeffrey Conn. Chem Rev 2016
Craig W Lindsley, Kyle A Emmitte, Corey R Hopkins, Thomas M Bridges, Karen J Gregory, Colleen M Niswender, P Jeffrey Conn. Chem Rev 2016
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Structure-Based Optimization Strategies for G Protein-Coupled Receptor (GPCR) Allosteric Modulators: A Case Study from Analyses of New Metabotropic Glutamate Receptor 5 (mGlu5) X-ray Structures.
John A Christopher, Zoltán Orgován, Miles Congreve, Andrew S Doré, James C Errey, Fiona H Marshall, Jonathan S Mason, Krzysztof Okrasa, Prakash Rucktooa, Maria J Serrano-Vega,[...]. J Med Chem 2019
John A Christopher, Zoltán Orgován, Miles Congreve, Andrew S Doré, James C Errey, Fiona H Marshall, Jonathan S Mason, Krzysztof Okrasa, Prakash Rucktooa, Maria J Serrano-Vega,[...]. J Med Chem 2019
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Metabotropic glutamate receptors: physiology, pharmacology, and disease.
Colleen M Niswender, P Jeffrey Conn. Annu Rev Pharmacol Toxicol 2010
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Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders.
P Jeffrey Conn, Arthur Christopoulos, Craig W Lindsley. Nat Rev Drug Discov 2009
P Jeffrey Conn, Arthur Christopoulos, Craig W Lindsley. Nat Rev Drug Discov 2009
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Structure of class C GPCR metabotropic glutamate receptor 5 transmembrane domain.
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Selective Negative Allosteric Modulation Of Metabotropic Glutamate Receptors – A Structural Perspective of Ligands and Mutants.
Kasper Harpsøe, Vignir Isberg, Benjamin G Tehan, Dahlia Weiss, Angela Arsova, Fiona H Marshall, Hans Bräuner-Osborne, David E Gloriam. Sci Rep 2015
Kasper Harpsøe, Vignir Isberg, Benjamin G Tehan, Dahlia Weiss, Angela Arsova, Fiona H Marshall, Hans Bräuner-Osborne, David E Gloriam. Sci Rep 2015
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Molecular Switches of Allosteric Modulation of the Metabotropic Glutamate 2 Receptor.
Laura Pérez-Benito, Maarten L J Doornbos, Arnau Cordomí, Luc Peeters, Hilde Lavreysen, Leonardo Pardo, Gary Tresadern. Structure 2017
Laura Pérez-Benito, Maarten L J Doornbos, Arnau Cordomí, Luc Peeters, Hilde Lavreysen, Leonardo Pardo, Gary Tresadern. Structure 2017
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CPCCOEt, a noncompetitive metabotropic glutamate receptor 1 antagonist, inhibits receptor signaling without affecting glutamate binding.
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Mechanisms Underlying Allosteric Molecular Switches of Metabotropic Glutamate Receptor 5.
Claudia Llinas Del Torrent, Nil Casajuana-Martin, Leonardo Pardo, Gary Tresadern, Laura Pérez-Benito. J Chem Inf Model 2019
Claudia Llinas Del Torrent, Nil Casajuana-Martin, Leonardo Pardo, Gary Tresadern, Laura Pérez-Benito. J Chem Inf Model 2019
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Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors.
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Structural insights into the activation of metabotropic glutamate receptors.
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Positive and negative modulation of group I metabotropic glutamate receptors.
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Integrated In Silico Fragment-Based Drug Design: Case Study with Allosteric Modulators on Metabotropic Glutamate Receptor 5.
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"Molecular switches" on mGluR allosteric ligands that modulate modes of pharmacology.
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Applying Structure-Based Drug Design Approaches to Allosteric Modulators of GPCRs.
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Major ligand-induced rearrangement of the heptahelical domain interface in a GPCR dimer.
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Discovery of 1,4-disubstituted 3-cyano-2-pyridones: a new class of positive allosteric modulators of the metabotropic glutamate 2 receptor.
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Scaffold hopping from pyridones to imidazo[1,2-a]pyridines. New positive allosteric modulators of metabotropic glutamate 2 receptor.
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Computational analysis of negative and positive allosteric modulator binding and function in metabotropic glutamate receptor 5 (in)activation.
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The non-competitive antagonists 2-methyl-6-(phenylethynyl)pyridine and 7-hydroxyiminocyclopropan[b]chromen-1a-carboxylic acid ethyl ester interact with overlapping binding pockets in the transmembrane region of group I metabotropic glutamate receptors.
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Comparison of the binding pockets of two chemically unrelated allosteric antagonists of the mGlu5 receptor and identification of crucial residues involved in the inverse agonism of MPEP.
Pari Malherbe, Nicole Kratochwil, Andreas Mühlemann, Marie-Thérèse Zenner, Christophe Fischer, Martin Stahl, Paul R Gerber, Georg Jaeschke, Richard H P Porter. J Neurochem 2006
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A novel class of positive allosteric modulators of metabotropic glutamate receptor subtype 1 interact with a site distinct from that of negative allosteric modulators.
Kamondanai Hemstapat, Tomas de Paulis, Yelin Chen, Ashley E Brady, Vandana K Grover, David Alagille, Gilles D Tamagnan, P Jeffrey Conn. Mol Pharmacol 2006
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Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator.
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Fragment and Structure-Based Drug Discovery for a Class C GPCR: Discovery of the mGlu5 Negative Allosteric Modulator HTL14242 (3-Chloro-5-[6-(5-fluoropyridin-2-yl)pyrimidin-4-yl]benzonitrile).
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Analysis of positive and negative allosteric modulation in metabotropic glutamate receptors 4 and 5 with a dual ligand.
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Mutational analysis and molecular modeling of the binding pocket of the metabotropic glutamate 5 receptor negative modulator 2-methyl-6-(phenylethynyl)-pyridine.
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Structural determinants of allosteric antagonism at metabotropic glutamate receptor 2: mechanistic studies with new potent negative allosteric modulators.
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Evidence for the role of metabotropic glutamate (mGlu)2 not mGlu3 receptors in the preclinical antipsychotic pharmacology of the mGlu2/3 receptor agonist (-)-(1R,4S,5S,6S)-4-amino-2-sulfonylbicyclo[3.1.0]hexane-4,6-dicarboxylic acid (LY404039).
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Discovery of the first M5-selective and CNS penetrant negative allosteric modulator (NAM) of a muscarinic acetylcholine receptor: (S)-9b-(4-chlorophenyl)-1-(3,4-difluorobenzoyl)-2,3-dihydro-1H-imidazo[2,1-a]isoindol-5(9bH)-one (ML375).
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Allosteric modulation of seven transmembrane spanning receptors: theory, practice, and opportunities for central nervous system drug discovery.
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Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.