A citation-based method for searching scientific literature

György Szabó, György I Túrós, Sándor Kolok, Mónika Vastag, Zsuzsanna Sánta, Miklós Dékány, György I Lévay, István Greiner, Minami Natsumi, Watanabe Tatsuya, György M Keserű. J Med Chem 2019
Times Cited: 9







List of co-cited articles
110 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity


Practical Strategies and Concepts in GPCR Allosteric Modulator Discovery: Recent Advances with Metabotropic Glutamate Receptors.
Craig W Lindsley, Kyle A Emmitte, Corey R Hopkins, Thomas M Bridges, Karen J Gregory, Colleen M Niswender, P Jeffrey Conn. Chem Rev 2016
115
55

Structure-Based Optimization Strategies for G Protein-Coupled Receptor (GPCR) Allosteric Modulators: A Case Study from Analyses of New Metabotropic Glutamate Receptor 5 (mGlu5) X-ray Structures.
John A Christopher, Zoltán Orgován, Miles Congreve, Andrew S Doré, James C Errey, Fiona H Marshall, Jonathan S Mason, Krzysztof Okrasa, Prakash Rucktooa, Maria J Serrano-Vega,[...]. J Med Chem 2019
45
55

Metabotropic glutamate receptors: physiology, pharmacology, and disease.
Colleen M Niswender, P Jeffrey Conn. Annu Rev Pharmacol Toxicol 2010
55

Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders.
P Jeffrey Conn, Arthur Christopoulos, Craig W Lindsley. Nat Rev Drug Discov 2009
777
44

Structure of class C GPCR metabotropic glutamate receptor 5 transmembrane domain.
Andrew S Doré, Krzysztof Okrasa, Jayesh C Patel, Maria Serrano-Vega, Kirstie Bennett, Robert M Cooke, James C Errey, Ali Jazayeri, Samir Khan, Ben Tehan,[...]. Nature 2014
292
44

Selective Negative Allosteric Modulation Of Metabotropic Glutamate Receptors – A Structural Perspective of Ligands and Mutants.
Kasper Harpsøe, Vignir Isberg, Benjamin G Tehan, Dahlia Weiss, Angela Arsova, Fiona H Marshall, Hans Bräuner-Osborne, David E Gloriam. Sci Rep 2015
32
44

Molecular Switches of Allosteric Modulation of the Metabotropic Glutamate 2 Receptor.
Laura Pérez-Benito, Maarten L J Doornbos, Arnau Cordomí, Luc Peeters, Hilde Lavreysen, Leonardo Pardo, Gary Tresadern. Structure 2017
35
44

CPCCOEt, a noncompetitive metabotropic glutamate receptor 1 antagonist, inhibits receptor signaling without affecting glutamate binding.
S Litschig, F Gasparini, D Rueegg, N Stoehr, P J Flor, I Vranesic, L Prézeau, J P Pin, C Thomsen, R Kuhn. Mol Pharmacol 1999
281
44

Mechanisms Underlying Allosteric Molecular Switches of Metabotropic Glutamate Receptor 5.
Claudia Llinas Del Torrent, Nil Casajuana-Martin, Leonardo Pardo, Gary Tresadern, Laura Pérez-Benito. J Chem Inf Model 2019
15
44

Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors.
Jean-Philippe Pin, Thierry Galvez, Laurent Prézeau. Pharmacol Ther 2003
454
44

Structural insights into the activation of metabotropic glutamate receptors.
Antoine Koehl, Hongli Hu, Dan Feng, Bingfa Sun, Yan Zhang, Michael J Robertson, Matthew Chu, Tong Sun Kobilka, Toon Laeremans, Jan Steyaert,[...]. Nature 2019
140
44

Positive and negative modulation of group I metabotropic glutamate receptors.
Maksims Vanejevs, Claudia Jatzke, Steffen Renner, Sibylle Müller, Mirko Hechenberger, Tanja Bauer, Anna Klochkova, Ilya Pyatkin, Denis Kazyulkin, Elena Aksenova,[...]. J Med Chem 2008
41
44


"Molecular switches" on mGluR allosteric ligands that modulate modes of pharmacology.
Michael R Wood, Corey R Hopkins, John T Brogan, P Jeffrey Conn, Craig W Lindsley. Biochemistry 2011
126
33

Applying Structure-Based Drug Design Approaches to Allosteric Modulators of GPCRs.
Miles Congreve, Christine Oswald, Fiona H Marshall. Trends Pharmacol Sci 2017
69
33

Molecular determinants of positive allosteric modulation of the human metabotropic glutamate receptor 2.
A Farinha, H Lavreysen, L Peeters, B Russo, S Masure, A A Trabanco, J Cid, G Tresadern. Br J Pharmacol 2015
33
33

Major ligand-induced rearrangement of the heptahelical domain interface in a GPCR dimer.
Li Xue, Xavier Rovira, Pauline Scholler, Han Zhao, Jianfeng Liu, Jean-Philippe Pin, Philippe Rondard. Nat Chem Biol 2015
120
33

Discovery of 1,4-disubstituted 3-cyano-2-pyridones: a new class of positive allosteric modulators of the metabotropic glutamate 2 receptor.
Jose María Cid, Guillaume Duvey, Gary Tresadern, Vanthea Nhem, Rocco Furnari, Philippe Cluzeau, Juan Antonio Vega, Ana Isabel de Lucas, Encarnación Matesanz, José Manuel Alonso,[...]. J Med Chem 2012
23
33

Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor.
N Kunishima, Y Shimada, Y Tsuji, T Sato, M Yamamoto, T Kumasaka, S Nakanishi, H Jingami, K Morikawa. Nature 2000
938
33

Identification of specific ligand-receptor interactions that govern binding and cooperativity of diverse modulators to a common metabotropic glutamate receptor 5 allosteric site.
Karen J Gregory, Elizabeth D Nguyen, Chrysa Malosh, Jeffrey L Mendenhall, Jessica Z Zic, Brittney S Bates, Meredith J Noetzel, Emma F Squire, Eric M Turner, Jerri M Rook,[...]. ACS Chem Neurosci 2014
39
33

Scaffold hopping from pyridones to imidazo[1,2-a]pyridines. New positive allosteric modulators of metabotropic glutamate 2 receptor.
Gary Tresadern, Jose María Cid, Gregor J Macdonald, Juan Antonio Vega, Ana Isabel de Lucas, Aránzazu García, Encarnación Matesanz, María Lourdes Linares, Daniel Oehlrich, Hilde Lavreysen,[...]. Bioorg Med Chem Lett 2010
49
33

Computational analysis of negative and positive allosteric modulator binding and function in metabotropic glutamate receptor 5 (in)activation.
James A R Dalton, Xavier Gómez-Santacana, Amadeu Llebaria, Jesús Giraldo. J Chem Inf Model 2014
22
33


Investigating metabotropic glutamate receptor 5 allosteric modulator cooperativity, affinity, and agonism: enriching structure-function studies and structure-activity relationships.
Karen J Gregory, Meredith J Noetzel, Jerri M Rook, Paige N Vinson, Shaun R Stauffer, Alice L Rodriguez, Kyle A Emmitte, Ya Zhou, Aspen C Chun, Andrew S Felts,[...]. Mol Pharmacol 2012
68
33

Comparison of the binding pockets of two chemically unrelated allosteric antagonists of the mGlu5 receptor and identification of crucial residues involved in the inverse agonism of MPEP.
Pari Malherbe, Nicole Kratochwil, Andreas Mühlemann, Marie-Thérèse Zenner, Christophe Fischer, Martin Stahl, Paul R Gerber, Georg Jaeschke, Richard H P Porter. J Neurochem 2006
57
33

A novel class of positive allosteric modulators of metabotropic glutamate receptor subtype 1 interact with a site distinct from that of negative allosteric modulators.
Kamondanai Hemstapat, Tomas de Paulis, Yelin Chen, Ashley E Brady, Vandana K Grover, David Alagille, Gilles D Tamagnan, P Jeffrey Conn. Mol Pharmacol 2006
52
33

Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator.
Huixian Wu, Chong Wang, Karen J Gregory, Gye Won Han, Hyekyung P Cho, Yan Xia, Colleen M Niswender, Vsevolod Katritch, Jens Meiler, Vadim Cherezov,[...]. Science 2014
370
33

Fragment and Structure-Based Drug Discovery for a Class C GPCR: Discovery of the mGlu5 Negative Allosteric Modulator HTL14242 (3-Chloro-5-[6-(5-fluoropyridin-2-yl)pyrimidin-4-yl]benzonitrile).
John A Christopher, Sarah J Aves, Kirstie A Bennett, Andrew S Doré, James C Errey, Ali Jazayeri, Fiona H Marshall, Krzysztof Okrasa, Maria J Serrano-Vega, Benjamin G Tehan,[...]. J Med Chem 2015
105
33


Mutational analysis and molecular modeling of the binding pocket of the metabotropic glutamate 5 receptor negative modulator 2-methyl-6-(phenylethynyl)-pyridine.
Pari Malherbe, Nicole Kratochwil, Marie-Thérèse Zenner, Jenny Piussi, Catherine Diener, Claudia Kratzeisen, Christophe Fischer, Richard H P Porter. Mol Pharmacol 2003
126
33

Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
José María Cid, Gary Tresadern, Guillaume Duvey, Robert Lütjens, Terry Finn, Jean-Philippe Rocher, Sonia Poli, Juan Antonio Vega, Ana Isabel de Lucas, Encarnación Matesanz,[...]. J Med Chem 2014
37
33

Positive allosteric modulators of metabotropic glutamate 1 receptor: characterization, mechanism of action, and binding site.
F Knoflach, V Mutel, S Jolidon, J N Kew, P Malherbe, E Vieira, J Wichmann, J A Kemp. Proc Natl Acad Sci U S A 2001
197
33

Molecular mechanism of positive allosteric modulation of the metabotropic glutamate receptor 2 by JNJ-46281222.
Maarten L J Doornbos, Laura Pérez-Benito, Gary Tresadern, Thea Mulder-Krieger, Ilse Biesmans, Andrés A Trabanco, Jose María Cid, Hilde Lavreysen, Adriaan P IJzerman, Laura H Heitman. Br J Pharmacol 2016
30
33

Structural determinants of allosteric antagonism at metabotropic glutamate receptor 2: mechanistic studies with new potent negative allosteric modulators.
L Lundström, C Bissantz, J Beck, J G Wettstein, T J Woltering, J Wichmann, S Gatti. Br J Pharmacol 2011
39
33


Allosteric Modulation Mechanism of the mGluR5 Transmembrane Domain.
Xiaojing Cong, Jean-Baptiste Chéron, Jérôme Golebiowski, Serge Antonczak, Sébastien Fiorucci. J Chem Inf Model 2019
8
37

Structures of the extracellular regions of the group II/III metabotropic glutamate receptors.
Takanori Muto, Daisuke Tsuchiya, Kosuke Morikawa, Hisato Jingami. Proc Natl Acad Sci U S A 2007
267
33


Transposition of three amino acids transforms the human metabotropic glutamate receptor (mGluR)-3-positive allosteric modulation site to mGluR2, and additional characterization of the mGluR2-positive allosteric modulation site.
Blake A Rowe, Hervé Schaffhauser, Sylvia Morales, Laura S Lubbers, Celine Bonnefous, Theodore M Kamenecka, Jeffrey McQuiston, Lorrie P Daggett. J Pharmacol Exp Ther 2008
39
33

Opportunities and challenges in the discovery of allosteric modulators of GPCRs for treating CNS disorders.
P Jeffrey Conn, Craig W Lindsley, Jens Meiler, Colleen M Niswender. Nat Rev Drug Discov 2014
180
22

Organization and functions of mGlu and GABAB receptor complexes.
Jean-Philippe Pin, Bernhard Bettler. Nature 2016
132
22

Discovery of the first M5-selective and CNS penetrant negative allosteric modulator (NAM) of a muscarinic acetylcholine receptor: (S)-9b-(4-chlorophenyl)-1-(3,4-difluorobenzoyl)-2,3-dihydro-1H-imidazo[2,1-a]isoindol-5(9bH)-one (ML375).
Patrick R Gentry, Masaya Kokubo, Thomas M Bridges, Nathan R Kett, Joel M Harp, Hyekyung P Cho, Emery Smith, Peter Chase, Peter S Hodder, Colleen M Niswender,[...]. J Med Chem 2013
33
22

Trends in GPCR drug discovery: new agents, targets and indications.
Alexander S Hauser, Misty M Attwood, Mathias Rask-Andersen, Helgi B Schiöth, David E Gloriam. Nat Rev Drug Discov 2017
22

Allosteric modulation of seven transmembrane spanning receptors: theory, practice, and opportunities for central nervous system drug discovery.
Bruce J Melancon, Corey R Hopkins, Michael R Wood, Kyle A Emmitte, Colleen M Niswender, Arthur Christopoulos, P Jeffrey Conn, Craig W Lindsley. J Med Chem 2012
166
22


Chemical, target, and bioactive properties of allosteric modulation.
Gerard J P van Westen, Anna Gaulton, John P Overington. PLoS Comput Biol 2014
58
22

Activation and allosteric modulation of a muscarinic acetylcholine receptor.
Andrew C Kruse, Aaron M Ring, Aashish Manglik, Jianxin Hu, Kelly Hu, Katrin Eitel, Harald Hübner, Els Pardon, Celine Valant, Patrick M Sexton,[...]. Nature 2013
604
22

Allosteric modulation of G protein-coupled receptors.
Lauren T May, Katie Leach, Patrick M Sexton, Arthur Christopoulos. Annu Rev Pharmacol Toxicol 2007
509
22


Crystal structure of the human beta2 adrenergic G-protein-coupled receptor.
Søren G F Rasmussen, Hee-Jung Choi, Daniel M Rosenbaum, Tong Sun Kobilka, Foon Sun Thian, Patricia C Edwards, Manfred Burghammer, Venkata R P Ratnala, Ruslan Sanishvili, Robert F Fischetti,[...]. Nature 2007
22


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.