A citation-based method for searching scientific literature

Antonio Cuadrado, Gina Manda, Ahmed Hassan, María José Alcaraz, Coral Barbas, Andreas Daiber, Pietro Ghezzi, Rafael León, Manuela G López, Baldo Oliva, Marta Pajares, Ana I Rojo, Natalia Robledinos-Antón, Angela M Valverde, Emre Guney, Harald H H W Schmidt. Pharmacol Rev 2018
Times Cited: 211







List of co-cited articles
984 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity


Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases.
Antonio Cuadrado, Ana I Rojo, Geoffrey Wells, John D Hayes, Sharon P Cousin, William L Rumsey, Otis C Attucks, Stephen Franklin, Anna-Liisa Levonen, Thomas W Kensler,[...]. Nat Rev Drug Discov 2019
343
31

Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription.
Eri H Kobayashi, Takafumi Suzuki, Ryo Funayama, Takeshi Nagashima, Makiko Hayashi, Hiroki Sekine, Nobuyuki Tanaka, Takashi Moriguchi, Hozumi Motohashi, Keiko Nakayama,[...]. Nat Commun 2016
602
18

The Nrf2 regulatory network provides an interface between redox and intermediary metabolism.
John D Hayes, Albena T Dinkova-Kostova. Trends Biochem Sci 2014
967
18

Role of nrf2 in oxidative stress and toxicity.
Qiang Ma. Annu Rev Pharmacol Toxicol 2013
18

Nrf2 signaling pathway: Pivotal roles in inflammation.
Syed Minhaj Uddin Ahmed, Lin Luo, Akhileshwar Namani, Xiu Jun Wang, Xiuwen Tang. Biochim Biophys Acta Mol Basis Dis 2017
597
17

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1.
Masaaki Komatsu, Hirofumi Kurokawa, Satoshi Waguri, Keiko Taguchi, Akira Kobayashi, Yoshinobu Ichimura, Yu-Shin Sou, Izumi Ueno, Ayako Sakamoto, Kit I Tong,[...]. Nat Cell Biol 2010
14

The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis.
Masayuki Yamamoto, Thomas W Kensler, Hozumi Motohashi. Physiol Rev 2018
395
13

An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements.
K Itoh, T Chiba, S Takahashi, T Ishii, K Igarashi, Y Katoh, T Oyake, N Hayashi, K Satoh, I Hatayama,[...]. Biochem Biophys Res Commun 1997
13

Dissecting molecular cross-talk between Nrf2 and NF-κB response pathways.
Joanna D Wardyn, Amy H Ponsford, Christopher M Sanderson. Biochem Soc Trans 2015
427
13

NRF2 and the Hallmarks of Cancer.
Montserrat Rojo de la Vega, Eli Chapman, Donna D Zhang. Cancer Cell 2018
412
12

Activators and Inhibitors of NRF2: A Review of Their Potential for Clinical Development.
Natalia Robledinos-Antón, Raquel Fernández-Ginés, Gina Manda, Antonio Cuadrado. Oxid Med Cell Longev 2019
145
12

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain.
K Itoh, N Wakabayashi, Y Katoh, T Ishii, K Igarashi, J D Engel, M Yamamoto. Genes Dev 1999
11

The emerging role of Nrf2 in mitochondrial function.
Albena T Dinkova-Kostova, Andrey Y Abramov. Free Radic Biol Med 2015
405
10

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants.
Albena T Dinkova-Kostova, W David Holtzclaw, Robert N Cole, Ken Itoh, Nobunao Wakabayashi, Yasutake Katoh, Masayuki Yamamoto, Paul Talalay. Proc Natl Acad Sci U S A 2002
10

Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis.
Deepti Malhotra, Elodie Portales-Casamar, Anju Singh, Siddhartha Srivastava, David Arenillas, Christine Happel, Casper Shyr, Nobunao Wakabayashi, Thomas W Kensler, Wyeth W Wasserman,[...]. Nucleic Acids Res 2010
482
9

Modulating NRF2 in Disease: Timing Is Everything.
Matthew Dodson, Montserrat Rojo de la Vega, Aram B Cholanians, Cody J Schmidlin, Eli Chapman, Donna D Zhang. Annu Rev Pharmacol Toxicol 2019
103
9

SCF/{beta}-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner.
Patricia Rada, Ana I Rojo, Sudhir Chowdhry, Michael McMahon, John D Hayes, Antonio Cuadrado. Mol Cell Biol 2011
440
9

Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling.
Shih-Ching Lo, Xuchu Li, Michael T Henzl, Lesa J Beamer, Mark Hannink. EMBO J 2006
298
9

Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2.
Akira Kobayashi, Moon-Il Kang, Hiromi Okawa, Makiko Ohtsuji, Yukari Zenke, Tomoki Chiba, Kazuhiko Igarashi, Masayuki Yamamoto. Mol Cell Biol 2004
9

Bardoxolone methyl and kidney function in CKD with type 2 diabetes.
Pablo E Pergola, Philip Raskin, Robert D Toto, Colin J Meyer, J Warren Huff, Eric B Grossman, Melissa Krauth, Stacey Ruiz, Paul Audhya, Heidi Christ-Schmidt,[...]. N Engl J Med 2011
598
8

Transcription factor NFE2L2/NRF2 is a regulator of macroautophagy genes.
Marta Pajares, Natalia Jiménez-Moreno, Ángel J García-Yagüe, Maribel Escoll, María L de Ceballos, Fred Van Leuven, Alberto Rábano, Masayuki Yamamoto, Ana I Rojo, Antonio Cuadrado. Autophagy 2016
168
8

p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription.
Ashish Jain, Trond Lamark, Eva Sjøttem, Kenneth Bowitz Larsen, Jane Atesoh Awuh, Aud Øvervatn, Michael McMahon, John D Hayes, Terje Johansen. J Biol Chem 2010
844
8




Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex.
Donna D Zhang, Shih-Ching Lo, Janet V Cross, Dennis J Templeton, Mark Hannink. Mol Cell Biol 2004
842
8

The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligase.
Sara B Cullinan, John D Gordan, Jianping Jin, J Wade Harper, J Alan Diehl. Mol Cell Biol 2004
679
8

Antioxidants in Translational Medicine.
Harald H H W Schmidt, Roland Stocker, Claudia Vollbracht, Gøran Paulsen, Dennis Riley, Andreas Daiber, Antonio Cuadrado. Antioxid Redox Signal 2015
143
7

Repression of the Antioxidant NRF2 Pathway in Premature Aging.
Nard Kubben, Weiqi Zhang, Lixia Wang, Ty C Voss, Jiping Yang, Jing Qu, Guang-Hui Liu, Tom Misteli. Cell 2016
250
7

Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes.
Annika S Axelsson, Emily Tubbs, Brig Mecham, Shaji Chacko, Hannah A Nenonen, Yunzhao Tang, Jed W Fahey, Jonathan M J Derry, Claes B Wollheim, Nils Wierup,[...]. Sci Transl Med 2017
125
7

Keap1 degradation by autophagy for the maintenance of redox homeostasis.
Keiko Taguchi, Nanako Fujikawa, Masaaki Komatsu, Tetsuro Ishii, Michiaki Unno, Takaaki Akaike, Hozumi Motohashi, Masayuki Yamamoto. Proc Natl Acad Sci U S A 2012
278
7

Characterizations of Three Major Cysteine Sensors of Keap1 in Stress Response.
Ryota Saito, Takafumi Suzuki, Keiichiro Hiramoto, Soichiro Asami, Eriko Naganuma, Hiromi Suda, Tatsuro Iso, Hirotaka Yamamoto, Masanobu Morita, Liam Baird,[...]. Mol Cell Biol 2015
118
7

Structural and functional characterization of Nrf2 degradation by the glycogen synthase kinase 3/β-TrCP axis.
Patricia Rada, Ana I Rojo, Nathalie Evrard-Todeschi, Nadia G Innamorato, Axelle Cotte, Tomasz Jaworski, Julio C Tobón-Velasco, Herman Devijver, María Flor García-Mayoral, Fred Van Leuven,[...]. Mol Cell Biol 2012
194
7

Keap1 recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site molecular recognition model.
Kit I Tong, Yasutake Katoh, Hideki Kusunoki, Ken Itoh, Toshiyuki Tanaka, Masayuki Yamamoto. Mol Cell Biol 2006
443
7

RXRα inhibits the NRF2-ARE signaling pathway through a direct interaction with the Neh7 domain of NRF2.
Hongyan Wang, Kaihua Liu, Miao Geng, Peng Gao, Xiaoyuan Wu, Yan Hai, Yangxia Li, Yulong Li, Lin Luo, John D Hayes,[...]. Cancer Res 2013
160
7

Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway.
Ralf A Linker, De-Hyung Lee, Sarah Ryan, Anne M van Dam, Rebecca Conrad, Pradeep Bista, Weike Zeng, Xiaoping Hronowsky, Alex Buko, Sowmya Chollate,[...]. Brain 2011
658
7

The Keap1-Nrf2-ARE Pathway As a Potential Preventive and Therapeutic Target: An Update.
Meng-Chen Lu, Jian-Ai Ji, Zheng-Yu Jiang, Qi-Dong You. Med Res Rev 2016
287
7

Placebo-controlled phase 3 study of oral BG-12 for relapsing multiple sclerosis.
Ralf Gold, Ludwig Kappos, Douglas L Arnold, Amit Bar-Or, Gavin Giovannoni, Krzysztof Selmaj, Carlo Tornatore, Marianne T Sweetser, Minhua Yang, Sarah I Sheikh,[...]. N Engl J Med 2012
7

Regulatory flexibility in the Nrf2-mediated stress response is conferred by conformational cycling of the Keap1-Nrf2 protein complex.
Liam Baird, David Llères, Sam Swift, Albena T Dinkova-Kostova. Proc Natl Acad Sci U S A 2013
192
7

Structural basis of Keap1 interactions with Nrf2.
Peter Canning, Fiona J Sorrell, Alex N Bullock. Free Radic Biol Med 2015
196
7

Transcriptional Regulation by Nrf2.
Claudia Tonelli, Iok In Christine Chio, David A Tuveson. Antioxid Redox Signal 2018
469
7

Bardoxolone methyl in type 2 diabetes and stage 4 chronic kidney disease.
Dick de Zeeuw, Tadao Akizawa, Paul Audhya, George L Bakris, Melanie Chin, Heidi Christ-Schmidt, Angie Goldsberry, Mark Houser, Melissa Krauth, Hiddo J Lambers Heerspink,[...]. N Engl J Med 2013
568
6

Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration.
Kira M Holmström, Liam Baird, Ying Zhang, Iain Hargreaves, Annapurna Chalasani, John M Land, Lee Stanyer, Masayuki Yamamoto, Albena T Dinkova-Kostova, Andrey Y Abramov. Biol Open 2013
241
6

Nrf2-MafG heterodimers contribute globally to antioxidant and metabolic networks.
Yosuke Hirotsu, Fumiki Katsuoka, Ryo Funayama, Takeshi Nagashima, Yuichiro Nishida, Keiko Nakayama, James Douglas Engel, Masayuki Yamamoto. Nucleic Acids Res 2012
216
6

Redox regulation by NRF2 in aging and disease.
Cody J Schmidlin, Matthew B Dodson, Lalitha Madhavan, Donna D Zhang. Free Radic Biol Med 2019
122
6

Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis.
Rajesh K Thimmulappa, Hannah Lee, Tirumalai Rangasamy, Sekhar P Reddy, Masayuki Yamamoto, Thomas W Kensler, Shyam Biswal. J Clin Invest 2006
675
6

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.
Evanna L Mills, Dylan G Ryan, Hiran A Prag, Dina Dikovskaya, Deepthi Menon, Zbigniew Zaslona, Mark P Jedrychowski, Ana S H Costa, Maureen Higgins, Emily Hams,[...]. Nature 2018
476
6

A PGAM5-KEAP1-Nrf2 complex is required for stress-induced mitochondrial retrograde trafficking.
Gary B O'Mealey, Kendra S Plafker, William L Berry, Ralf Janknecht, Jefferson Y Chan, Scott M Plafker. J Cell Sci 2017
45
13

Oxidative Stress.
Helmut Sies, Carsten Berndt, Dean P Jones. Annu Rev Biochem 2017
951
6

Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolution.
Keiko Taguchi, Hozumi Motohashi, Masayuki Yamamoto. Genes Cells 2011
872
6


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.