Panos Zanos, Scott M Thompson, Ronald S Duman, Carlos A Zarate, Todd D Gould. CNS Drugs 2018
Times Cited: 97
Times Cited: 97
Times Cited
Times Co-cited
Similarity
Antidepressant effects of ketamine in depressed patients.
R M Berman, A Cappiello, A Anand, D A Oren, G R Heninger, D S Charney, J H Krystal. Biol Psychiatry 2000
R M Berman, A Cappiello, A Anand, D A Oren, G R Heninger, D S Charney, J H Krystal. Biol Psychiatry 2000
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NMDAR inhibition-independent antidepressant actions of ketamine metabolites.
Panos Zanos, Ruin Moaddel, Patrick J Morris, Polymnia Georgiou, Jonathan Fischell, Greg I Elmer, Manickavasagom Alkondon, Peixiong Yuan, Heather J Pribut, Nagendra S Singh,[...]. Nature 2016
Panos Zanos, Ruin Moaddel, Patrick J Morris, Polymnia Georgiou, Jonathan Fischell, Greg I Elmer, Manickavasagom Alkondon, Peixiong Yuan, Heather J Pribut, Nagendra S Singh,[...]. Nature 2016
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A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression.
Carlos A Zarate, Jaskaran B Singh, Paul J Carlson, Nancy E Brutsche, Rezvan Ameli, David A Luckenbaugh, Dennis S Charney, Husseini K Manji. Arch Gen Psychiatry 2006
Carlos A Zarate, Jaskaran B Singh, Paul J Carlson, Nancy E Brutsche, Rezvan Ameli, David A Luckenbaugh, Dennis S Charney, Husseini K Manji. Arch Gen Psychiatry 2006
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mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists.
Nanxin Li, Boyoung Lee, Rong-Jian Liu, Mounira Banasr, Jason M Dwyer, Masaaki Iwata, Xiao-Yuan Li, George Aghajanian, Ronald S Duman. Science 2010
Nanxin Li, Boyoung Lee, Rong-Jian Liu, Mounira Banasr, Jason M Dwyer, Masaaki Iwata, Xiao-Yuan Li, George Aghajanian, Ronald S Duman. Science 2010
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NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses.
Anita E Autry, Megumi Adachi, Elena Nosyreva, Elisa S Na, Maarten F Los, Peng-fei Cheng, Ege T Kavalali, Lisa M Monteggia. Nature 2011
Anita E Autry, Megumi Adachi, Elena Nosyreva, Elisa S Na, Maarten F Los, Peng-fei Cheng, Ege T Kavalali, Lisa M Monteggia. Nature 2011
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Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants.
Ronald S Duman, George K Aghajanian, Gerard Sanacora, John H Krystal. Nat Med 2016
Ronald S Duman, George K Aghajanian, Gerard Sanacora, John H Krystal. Nat Med 2016
31
29
A randomized add-on trial of an N-methyl-D-aspartate antagonist in treatment-resistant bipolar depression.
Nancy Diazgranados, Lobna Ibrahim, Nancy E Brutsche, Andrew Newberg, Phillip Kronstein, Sami Khalife, William A Kammerer, Zenaide Quezado, David A Luckenbaugh, Giacomo Salvadore,[...]. Arch Gen Psychiatry 2010
Nancy Diazgranados, Lobna Ibrahim, Nancy E Brutsche, Andrew Newberg, Phillip Kronstein, Sami Khalife, William A Kammerer, Zenaide Quezado, David A Luckenbaugh, Giacomo Salvadore,[...]. Arch Gen Psychiatry 2010
28
Cellular mechanisms underlying the antidepressant effects of ketamine: role of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors.
Sungho Maeng, Carlos A Zarate, Jing Du, Robert J Schloesser, Joseph McCammon, Guang Chen, Husseini K Manji. Biol Psychiatry 2008
Sungho Maeng, Carlos A Zarate, Jing Du, Robert J Schloesser, Joseph McCammon, Guang Chen, Husseini K Manji. Biol Psychiatry 2008
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Antidepressant efficacy of ketamine in treatment-resistant major depression: a two-site randomized controlled trial.
James W Murrough, Dan V Iosifescu, Lee C Chang, Rayan K Al Jurdi, Charles E Green, Andrew M Perez, Syed Iqbal, Sarah Pillemer, Alexandra Foulkes, Asim Shah,[...]. Am J Psychiatry 2013
James W Murrough, Dan V Iosifescu, Lee C Chang, Rayan K Al Jurdi, Charles E Green, Andrew M Perez, Syed Iqbal, Sarah Pillemer, Alexandra Foulkes, Asim Shah,[...]. Am J Psychiatry 2013
27
Replication of ketamine's antidepressant efficacy in bipolar depression: a randomized controlled add-on trial.
Carlos A Zarate, Nancy E Brutsche, Lobna Ibrahim, Jose Franco-Chaves, Nancy Diazgranados, Anibal Cravchik, Jessica Selter, Craig A Marquardt, Victoria Liberty, David A Luckenbaugh. Biol Psychiatry 2012
Carlos A Zarate, Nancy E Brutsche, Lobna Ibrahim, Jose Franco-Chaves, Nancy Diazgranados, Anibal Cravchik, Jessica Selter, Craig A Marquardt, Victoria Liberty, David A Luckenbaugh. Biol Psychiatry 2012
26
Glutamate N-methyl-D-aspartate receptor antagonists rapidly reverse behavioral and synaptic deficits caused by chronic stress exposure.
Nanxin Li, Rong-Jian Liu, Jason M Dwyer, Mounira Banasr, Boyoung Lee, Hyeon Son, Xiao-Yuan Li, George Aghajanian, Ronald S Duman. Biol Psychiatry 2011
Nanxin Li, Rong-Jian Liu, Jason M Dwyer, Mounira Banasr, Boyoung Lee, Hyeon Son, Xiao-Yuan Li, George Aghajanian, Ronald S Duman. Biol Psychiatry 2011
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Ketamine and Other NMDA Antagonists: Early Clinical Trials and Possible Mechanisms in Depression.
D Jeffrey Newport, Linda L Carpenter, William M McDonald, James B Potash, Mauricio Tohen, Charles B Nemeroff. Am J Psychiatry 2015
D Jeffrey Newport, Linda L Carpenter, William M McDonald, James B Potash, Mauricio Tohen, Charles B Nemeroff. Am J Psychiatry 2015
25
Efficacy and Safety of Intranasal Esketamine Adjunctive to Oral Antidepressant Therapy in Treatment-Resistant Depression: A Randomized Clinical Trial.
Ella J Daly, Jaskaran B Singh, Maggie Fedgchin, Kimberly Cooper, Pilar Lim, Richard C Shelton, Michael E Thase, Andrew Winokur, Luc Van Nueten, Husseini Manji,[...]. JAMA Psychiatry 2018
Ella J Daly, Jaskaran B Singh, Maggie Fedgchin, Kimberly Cooper, Pilar Lim, Richard C Shelton, Michael E Thase, Andrew Winokur, Luc Van Nueten, Husseini Manji,[...]. JAMA Psychiatry 2018
25
Efficacy and Safety of Intranasal Esketamine for the Rapid Reduction of Symptoms of Depression and Suicidality in Patients at Imminent Risk for Suicide: Results of a Double-Blind, Randomized, Placebo-Controlled Study.
Carla M Canuso, Jaskaran B Singh, Maggie Fedgchin, Larry Alphs, Rosanne Lane, Pilar Lim, Christine Pinter, David Hough, Gerard Sanacora, Husseini Manji,[...]. Am J Psychiatry 2018
Carla M Canuso, Jaskaran B Singh, Maggie Fedgchin, Larry Alphs, Rosanne Lane, Pilar Lim, Christine Pinter, David Hough, Gerard Sanacora, Husseini Manji,[...]. Am J Psychiatry 2018
25
The Effect of a Single Dose of Intravenous Ketamine on Suicidal Ideation: A Systematic Review and Individual Participant Data Meta-Analysis.
Samuel T Wilkinson, Elizabeth D Ballard, Michael H Bloch, Sanjay J Mathew, James W Murrough, Adriana Feder, Peter Sos, Gang Wang, Carlos A Zarate, Gerard Sanacora. Am J Psychiatry 2018
Samuel T Wilkinson, Elizabeth D Ballard, Michael H Bloch, Sanjay J Mathew, James W Murrough, Adriana Feder, Peter Sos, Gang Wang, Carlos A Zarate, Gerard Sanacora. Am J Psychiatry 2018
24
Rapid resolution of suicidal ideation after a single infusion of an N-methyl-D-aspartate antagonist in patients with treatment-resistant major depressive disorder.
Nancy DiazGranados, Lobna A Ibrahim, Nancy E Brutsche, Rezvan Ameli, Ioline D Henter, David A Luckenbaugh, Rodrigo Machado-Vieira, Carlos A Zarate. J Clin Psychiatry 2010
Nancy DiazGranados, Lobna A Ibrahim, Nancy E Brutsche, Rezvan Ameli, Ioline D Henter, David A Luckenbaugh, Rodrigo Machado-Vieira, Carlos A Zarate. J Clin Psychiatry 2010
23
Ketamine blocks bursting in the lateral habenula to rapidly relieve depression.
Yan Yang, Yihui Cui, Kangning Sang, Yiyan Dong, Zheyi Ni, Shuangshuang Ma, Hailan Hu. Nature 2018
Yan Yang, Yihui Cui, Kangning Sang, Yiyan Dong, Zheyi Ni, Shuangshuang Ma, Hailan Hu. Nature 2018
23
Functional antagonists at the NMDA receptor complex exhibit antidepressant actions.
R Trullas, P Skolnick. Eur J Pharmacol 1990
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22
Ketamine and Ketamine Metabolite Pharmacology: Insights into Therapeutic Mechanisms.
Panos Zanos, Ruin Moaddel, Patrick J Morris, Lace M Riggs, Jaclyn N Highland, Polymnia Georgiou, Edna F R Pereira, Edson X Albuquerque, Craig J Thomas, Carlos A Zarate,[...]. Pharmacol Rev 2018
Panos Zanos, Ruin Moaddel, Patrick J Morris, Lace M Riggs, Jaclyn N Highland, Polymnia Georgiou, Edna F R Pereira, Edson X Albuquerque, Craig J Thomas, Carlos A Zarate,[...]. Pharmacol Rev 2018
22
A randomized controlled trial of intranasal ketamine in major depressive disorder.
Kyle A B Lapidus, Cara F Levitch, Andrew M Perez, Jess W Brallier, Michael K Parides, Laili Soleimani, Adriana Feder, Dan V Iosifescu, Dennis S Charney, James W Murrough. Biol Psychiatry 2014
Kyle A B Lapidus, Cara F Levitch, Andrew M Perez, Jess W Brallier, Michael K Parides, Laili Soleimani, Adriana Feder, Dan V Iosifescu, Dennis S Charney, James W Murrough. Biol Psychiatry 2014
20
Rapid and longer-term antidepressant effects of repeated ketamine infusions in treatment-resistant major depression.
James W Murrough, Andrew M Perez, Sarah Pillemer, Jessica Stern, Michael K Parides, Marije aan het Rot, Katherine A Collins, Sanjay J Mathew, Dennis S Charney, Dan V Iosifescu. Biol Psychiatry 2013
James W Murrough, Andrew M Perez, Sarah Pillemer, Jessica Stern, Michael K Parides, Marije aan het Rot, Katherine A Collins, Sanjay J Mathew, Dennis S Charney, Dan V Iosifescu. Biol Psychiatry 2013
20
R-ketamine: a rapid-onset and sustained antidepressant without psychotomimetic side effects.
C Yang, Y Shirayama, J-c Zhang, Q Ren, W Yao, M Ma, C Dong, K Hashimoto. Transl Psychiatry 2015
C Yang, Y Shirayama, J-c Zhang, Q Ren, W Yao, M Ma, C Dong, K Hashimoto. Transl Psychiatry 2015
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Sustained rescue of prefrontal circuit dysfunction by antidepressant-induced spine formation.
R N Moda-Sava, M H Murdock, P K Parekh, R N Fetcho, B S Huang, T N Huynh, J Witztum, D C Shaver, D L Rosenthal, E J Alway,[...]. Science 2019
R N Moda-Sava, M H Murdock, P K Parekh, R N Fetcho, B S Huang, T N Huynh, J Witztum, D C Shaver, D L Rosenthal, E J Alway,[...]. Science 2019
19
NMDA receptor hypofunction produces opposite effects on prefrontal cortex interneurons and pyramidal neurons.
Houman Homayoun, Bita Moghaddam. J Neurosci 2007
Houman Homayoun, Bita Moghaddam. J Neurosci 2007
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Effects of intravenous ketamine on explicit and implicit measures of suicidality in treatment-resistant depression.
Rebecca B Price, Matthew K Nock, Dennis S Charney, Sanjay J Mathew. Biol Psychiatry 2009
Rebecca B Price, Matthew K Nock, Dennis S Charney, Sanjay J Mathew. Biol Psychiatry 2009
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Synaptic dysfunction in depression: potential therapeutic targets.
Ronald S Duman, George K Aghajanian. Science 2012
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Antidepressant-relevant concentrations of the ketamine metabolite (2R,6R)-hydroxynorketamine do not block NMDA receptor function.
Eric W Lumsden, Timothy A Troppoli, Scott J Myers, Panos Zanos, Yasco Aracava, Jan Kehr, Jacqueline Lovett, Sukhan Kim, Fu-Hua Wang, Staffan Schmidt,[...]. Proc Natl Acad Sci U S A 2019
Eric W Lumsden, Timothy A Troppoli, Scott J Myers, Panos Zanos, Yasco Aracava, Jan Kehr, Jacqueline Lovett, Sukhan Kim, Fu-Hua Wang, Staffan Schmidt,[...]. Proc Natl Acad Sci U S A 2019
22
Activation of glutamatergic neurotransmission by ketamine: a novel step in the pathway from NMDA receptor blockade to dopaminergic and cognitive disruptions associated with the prefrontal cortex.
B Moghaddam, B Adams, A Verma, D Daly. J Neurosci 1997
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Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: a STAR*D report.
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17
(R)-Ketamine Shows Greater Potency and Longer Lasting Antidepressant Effects Than Its Metabolite (2R,6R)-Hydroxynorketamine.
Chun Yang, Youge Qu, Masahito Abe, Dai Nozawa, Shigeyuki Chaki, Kenji Hashimoto. Biol Psychiatry 2017
Chun Yang, Youge Qu, Masahito Abe, Dai Nozawa, Shigeyuki Chaki, Kenji Hashimoto. Biol Psychiatry 2017
17
Common Neurotransmission Recruited in (R,S)-Ketamine and (2R,6R)-Hydroxynorketamine-Induced Sustained Antidepressant-like Effects.
Thu Ha Pham, Céline Defaix, Xiaoming Xu, Shi-Xian Deng, Nicolas Fabresse, Jean-Claude Alvarez, Donald W Landry, Rebecca A Brachman, Christine A Denny, Alain M Gardier. Biol Psychiatry 2018
Thu Ha Pham, Céline Defaix, Xiaoming Xu, Shi-Xian Deng, Nicolas Fabresse, Jean-Claude Alvarez, Donald W Landry, Rebecca A Brachman, Christine A Denny, Alain M Gardier. Biol Psychiatry 2018
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BDNF release is required for the behavioral actions of ketamine.
Ashley E Lepack, Manabu Fuchikami, Jason M Dwyer, Mounira Banasr, Ronald S Duman. Int J Neuropsychopharmacol 2014
Ashley E Lepack, Manabu Fuchikami, Jason M Dwyer, Mounira Banasr, Ronald S Duman. Int J Neuropsychopharmacol 2014
16
Relationship of ketamine's plasma metabolites with response, diagnosis, and side effects in major depression.
Carlos A Zarate, Nancy Brutsche, Gonzalo Laje, David A Luckenbaugh, Swarajya L Vattem Venkata, Anuradha Ramamoorthy, Ruin Moaddel, Irving W Wainer. Biol Psychiatry 2012
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Effects of a ketamine metabolite on synaptic NMDAR function.
Kanzo Suzuki, Elena Nosyreva, Kevin W Hunt, Ege T Kavalali, Lisa M Monteggia. Nature 2017
Kanzo Suzuki, Elena Nosyreva, Kevin W Hunt, Ege T Kavalali, Lisa M Monteggia. Nature 2017
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A Double-Blind, Randomized, Placebo-Controlled, Dose-Frequency Study of Intravenous Ketamine in Patients With Treatment-Resistant Depression.
Jaskaran B Singh, Maggie Fedgchin, Ella J Daly, Peter De Boer, Kimberly Cooper, Pilar Lim, Christine Pinter, James W Murrough, Gerard Sanacora, Richard C Shelton,[...]. Am J Psychiatry 2016
Jaskaran B Singh, Maggie Fedgchin, Ella J Daly, Peter De Boer, Kimberly Cooper, Pilar Lim, Christine Pinter, James W Murrough, Gerard Sanacora, Richard C Shelton,[...]. Am J Psychiatry 2016
16
Disinhibition of CA1 pyramidal cells by low-dose ketamine and other antagonists with rapid antidepressant efficacy.
Allie J Widman, Lori L McMahon. Proc Natl Acad Sci U S A 2018
Allie J Widman, Lori L McMahon. Proc Natl Acad Sci U S A 2018
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Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans. Psychotomimetic, perceptual, cognitive, and neuroendocrine responses.
J H Krystal, L P Karper, J P Seibyl, G K Freeman, R Delaney, J D Bremner, G R Heninger, M B Bowers, D S Charney. Arch Gen Psychiatry 1994
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15
GluN2B-containing NMDA receptors regulate depression-like behavior and are critical for the rapid antidepressant actions of ketamine.
Oliver H Miller, Lingling Yang, Chih-Chieh Wang, Elizabeth A Hargroder, Yihui Zhang, Eric Delpire, Benjamin J Hall. Elife 2014
Oliver H Miller, Lingling Yang, Chih-Chieh Wang, Elizabeth A Hargroder, Yihui Zhang, Eric Delpire, Benjamin J Hall. Elife 2014
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Transiently increased glutamate cycling in rat PFC is associated with rapid onset of antidepressant-like effects.
G M I Chowdhury, J Zhang, M Thomas, M Banasr, X Ma, B Pittman, L Bristow, E Schaeffer, R S Duman, D L Rothman,[...]. Mol Psychiatry 2017
G M I Chowdhury, J Zhang, M Thomas, M Banasr, X Ma, B Pittman, L Bristow, E Schaeffer, R S Duman, D L Rothman,[...]. Mol Psychiatry 2017
15
Attenuation of Antidepressant Effects of Ketamine by Opioid Receptor Antagonism.
Nolan R Williams, Boris D Heifets, Christine Blasey, Keith Sudheimer, Jaspreet Pannu, Heather Pankow, Jessica Hawkins, Justin Birnbaum, David M Lyons, Carolyn I Rodriguez,[...]. Am J Psychiatry 2018
Nolan R Williams, Boris D Heifets, Christine Blasey, Keith Sudheimer, Jaspreet Pannu, Heather Pankow, Jessica Hawkins, Justin Birnbaum, David M Lyons, Carolyn I Rodriguez,[...]. Am J Psychiatry 2018
15
Safety and efficacy of repeated-dose intravenous ketamine for treatment-resistant depression.
Marije aan het Rot, Katherine A Collins, James W Murrough, Andrew M Perez, David L Reich, Dennis S Charney, Sanjay J Mathew. Biol Psychiatry 2010
Marije aan het Rot, Katherine A Collins, James W Murrough, Andrew M Perez, David L Reich, Dennis S Charney, Sanjay J Mathew. Biol Psychiatry 2010
15
Activity-dependent brain-derived neurotrophic factor signaling is required for the antidepressant actions of (2R,6R)-hydroxynorketamine.
Kenichi Fukumoto, Manoela V Fogaça, Rong-Jian Liu, Catharine Duman, Taro Kato, Xiao-Yuan Li, Ronald S Duman. Proc Natl Acad Sci U S A 2019
Kenichi Fukumoto, Manoela V Fogaça, Rong-Jian Liu, Catharine Duman, Taro Kato, Xiao-Yuan Li, Ronald S Duman. Proc Natl Acad Sci U S A 2019
15
Adjunctive Lanicemine (AZD6765) in Patients with Major Depressive Disorder and History of Inadequate Response to Antidepressants: A Randomized, Placebo-Controlled Study.
Gerard Sanacora, Michael R Johnson, Arif Khan, Sarah D Atkinson, Robert R Riesenberg, Juan P Schronen, Michael A Burke, John M Zajecka, Luis Barra, Hong-Lin Su,[...]. Neuropsychopharmacology 2017
Gerard Sanacora, Michael R Johnson, Arif Khan, Sarah D Atkinson, Robert R Riesenberg, Juan P Schronen, Michael A Burke, John M Zajecka, Luis Barra, Hong-Lin Su,[...]. Neuropsychopharmacology 2017
18
Side-effects associated with ketamine use in depression: a systematic review.
Brooke Short, Joanna Fong, Veronica Galvez, William Shelker, Colleen K Loo. Lancet Psychiatry 2018
Brooke Short, Joanna Fong, Veronica Galvez, William Shelker, Colleen K Loo. Lancet Psychiatry 2018
14
(2R,6R)-hydroxynorketamine rescues chronic stress-induced depression-like behavior through its actions in the midbrain periaqueductal gray.
Dylan Chou, Hsien-Yu Peng, Tzer-Bin Lin, Cheng-Yuan Lai, Ming-Chun Hsieh, Yang-Cheng Wen, An-Sheng Lee, Hsueh-Hsiao Wang, Po-Sheng Yang, Gin-Den Chen,[...]. Neuropharmacology 2018
Dylan Chou, Hsien-Yu Peng, Tzer-Bin Lin, Cheng-Yuan Lai, Ming-Chun Hsieh, Yang-Cheng Wen, An-Sheng Lee, Hsueh-Hsiao Wang, Po-Sheng Yang, Gin-Den Chen,[...]. Neuropharmacology 2018
25
Glutamatergic Neurotransmission: Pathway to Developing Novel Rapid-Acting Antidepressant Treatments.
Bashkim Kadriu, Laura Musazzi, Ioline D Henter, Morgan Graves, Maurizio Popoli, Carlos A Zarate. Int J Neuropsychopharmacol 2019
Bashkim Kadriu, Laura Musazzi, Ioline D Henter, Morgan Graves, Maurizio Popoli, Carlos A Zarate. Int J Neuropsychopharmacol 2019
18
Efficacy and Safety of Flexibly Dosed Esketamine Nasal Spray Combined With a Newly Initiated Oral Antidepressant in Treatment-Resistant Depression: A Randomized Double-Blind Active-Controlled Study.
Vanina Popova, Ella J Daly, Madhukar Trivedi, Kimberly Cooper, Rosanne Lane, Pilar Lim, Christine Mazzucco, David Hough, Michael E Thase, Richard C Shelton,[...]. Am J Psychiatry 2019
Vanina Popova, Ella J Daly, Madhukar Trivedi, Kimberly Cooper, Rosanne Lane, Pilar Lim, Christine Mazzucco, David Hough, Michael E Thase, Richard C Shelton,[...]. Am J Psychiatry 2019
14
A Negative Allosteric Modulator for α5 Subunit-Containing GABA Receptors Exerts a Rapid and Persistent Antidepressant-Like Action without the Side Effects of the NMDA Receptor Antagonist Ketamine in Mice.
Panos Zanos, Mackenzie E Nelson, Jaclyn N Highland, Samuel R Krimmel, Polymnia Georgiou, Todd D Gould, Scott M Thompson. eNeuro 2017
Panos Zanos, Mackenzie E Nelson, Jaclyn N Highland, Samuel R Krimmel, Polymnia Georgiou, Todd D Gould, Scott M Thompson. eNeuro 2017
18
GLYX-13, a NMDA receptor glycine-site functional partial agonist, induces antidepressant-like effects without ketamine-like side effects.
Jeffrey Burgdorf, Xiao-lei Zhang, Katherine L Nicholson, Robert L Balster, J David Leander, Patric K Stanton, Amanda L Gross, Roger A Kroes, Joseph R Moskal. Neuropsychopharmacology 2013
Jeffrey Burgdorf, Xiao-lei Zhang, Katherine L Nicholson, Robert L Balster, J David Leander, Patric K Stanton, Amanda L Gross, Roger A Kroes, Joseph R Moskal. Neuropsychopharmacology 2013
13
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.