M Kreir, B Van Deuren, S Versweyveld, A De Bondt, I Van den Wyngaert, H Van der Linde, H R Lu, G Teuns, D J Gallacher. Toxicol Appl Pharmacol 2018
Times Cited: 21
Times Cited: 21
Times Cited
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In Vitro Screening for Seizure Liability Using Microelectrode Array Technology.
Jenifer A Bradley, Harry H Luithardt, Monica R Metea, Christopher J Strock. Toxicol Sci 2018
Jenifer A Bradley, Harry H Luithardt, Monica R Metea, Christopher J Strock. Toxicol Sci 2018
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Physiological maturation and drug responses of human induced pluripotent stem cell-derived cortical neuronal networks in long-term culture.
A Odawara, H Katoh, N Matsuda, I Suzuki. Sci Rep 2016
A Odawara, H Katoh, N Matsuda, I Suzuki. Sci Rep 2016
61
Human iPSC-derived neuronal models for in vitro neurotoxicity assessment.
Anke M Tukker, Fiona M J Wijnolts, Aart de Groot, Remco H S Westerink. Neurotoxicology 2018
Anke M Tukker, Fiona M J Wijnolts, Aart de Groot, Remco H S Westerink. Neurotoxicology 2018
57
Toxicological evaluation of convulsant and anticonvulsant drugs in human induced pluripotent stem cell-derived cortical neuronal networks using an MEA system.
A Odawara, N Matsuda, Y Ishibashi, R Yokoi, I Suzuki. Sci Rep 2018
A Odawara, N Matsuda, Y Ishibashi, R Yokoi, I Suzuki. Sci Rep 2018
57
Safety pharmacology investigations on the nervous system: An industry survey.
Simon Authier, Joseph Arezzo, Marcus S Delatte, Mary-Jeanne Kallman, Carrie Markgraf, Dominique Paquette, Michael K Pugsley, Sian Ratcliffe, William S Redfern, Joanne Stevens,[...]. J Pharmacol Toxicol Methods 2016
Simon Authier, Joseph Arezzo, Marcus S Delatte, Mary-Jeanne Kallman, Carrie Markgraf, Dominique Paquette, Michael K Pugsley, Sian Ratcliffe, William S Redfern, Joanne Stevens,[...]. J Pharmacol Toxicol Methods 2016
52
Human induced pluripotent stem cell (hiPSC)-derived neurons respond to convulsant drugs when co-cultured with hiPSC-derived astrocytes.
Misawa Niki Ishii, Koji Yamamoto, Masanobu Shoji, Asano Asami, Yuji Kawamata. Toxicology 2017
Misawa Niki Ishii, Koji Yamamoto, Masanobu Shoji, Asano Asami, Yuji Kawamata. Toxicology 2017
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In vitro Models for Seizure-Liability Testing Using Induced Pluripotent Stem Cells.
Alastair I Grainger, Marianne C King, David A Nagel, H Rheinallt Parri, Michael D Coleman, Eric J Hill. Front Neurosci 2018
Alastair I Grainger, Marianne C King, David A Nagel, H Rheinallt Parri, Michael D Coleman, Eric J Hill. Front Neurosci 2018
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Assessing seizure liability using multi-electrode arrays (MEA).
Jingsong Fan, George Thalody, Jae Kwagh, Elisabeth Burnett, Hong Shi, Geoff Lewen, Shen-Jue Chen, Paul Levesque. Toxicol In Vitro 2019
Jingsong Fan, George Thalody, Jae Kwagh, Elisabeth Burnett, Hong Shi, Geoff Lewen, Shen-Jue Chen, Paul Levesque. Toxicol In Vitro 2019
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Long-term electrophysiological activity and pharmacological response of a human induced pluripotent stem cell-derived neuron and astrocyte co-culture.
A Odawara, Y Saitoh, A H Alhebshi, M Gotoh, I Suzuki. Biochem Biophys Res Commun 2014
A Odawara, Y Saitoh, A H Alhebshi, M Gotoh, I Suzuki. Biochem Biophys Res Commun 2014
42
Seizure liability assessments using the hippocampal tissue slice: Comparison of non-clinical species.
Michael V Accardi, Hai Huang, Simon Authier. J Pharmacol Toxicol Methods 2018
Michael V Accardi, Hai Huang, Simon Authier. J Pharmacol Toxicol Methods 2018
43
Detection of synchronized burst firing in cultured human induced pluripotent stem cell-derived neurons using a 4-step method.
N Matsuda, A Odawara, H Katoh, N Okuyama, R Yokoi, I Suzuki. Biochem Biophys Res Commun 2018
N Matsuda, A Odawara, H Katoh, N Okuyama, R Yokoi, I Suzuki. Biochem Biophys Res Commun 2018
63
[Method for MEA Data Analysis of Drug-treated Rat Primary Neurons and Human iPSC-derived Neurons to Evaluate the Risk of Drug-induced Seizures].
Atsuko Ojima, Norimasa Miyamoto. Yakugaku Zasshi 2018
Atsuko Ojima, Norimasa Miyamoto. Yakugaku Zasshi 2018
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Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework.
David Cook, Dearg Brown, Robert Alexander, Ruth March, Paul Morgan, Gemma Satterthwaite, Menelas N Pangalos. Nat Rev Drug Discov 2014
David Cook, Dearg Brown, Robert Alexander, Ruth March, Paul Morgan, Gemma Satterthwaite, Menelas N Pangalos. Nat Rev Drug Discov 2014
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Towards animal-free neurotoxicity screening: Applicability of hiPSC-derived neuronal models for in vitro seizure liability assessment.
Anke M Tukker, Regina G D M Van Kleef, Fiona M J Wijnolts, Aart De Groot, Remco H S Westerink. ALTEX 2020
Anke M Tukker, Regina G D M Van Kleef, Fiona M J Wijnolts, Aart De Groot, Remco H S Westerink. ALTEX 2020
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Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.
Kazutoshi Takahashi, Shinya Yamanaka. Cell 2006
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Burst and principal components analyses of MEA data for 16 chemicals describe at least three effects classes.
Cina M Mack, Bryant J Lin, James D Turner, Andrew F M Johnstone, Lyle D Burgoon, Timothy J Shafer. Neurotoxicology 2014
Cina M Mack, Bryant J Lin, James D Turner, Andrew F M Johnstone, Lyle D Burgoon, Timothy J Shafer. Neurotoxicology 2014
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Screening for Neurotoxicity with Microelectrode Array.
Jenifer A Bradley, Christopher J Strock. Curr Protoc Toxicol 2019
Jenifer A Bradley, Christopher J Strock. Curr Protoc Toxicol 2019
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Evaluation of multi-well microelectrode arrays for neurotoxicity screening using a chemical training set.
Emma R McConnell, Maxine A McClain, James Ross, William R Lefew, Timothy J Shafer. Neurotoxicology 2012
Emma R McConnell, Maxine A McClain, James Ross, William R Lefew, Timothy J Shafer. Neurotoxicology 2012
23
Microelectrode arrays: a physiologically based neurotoxicity testing platform for the 21st century.
Andrew F M Johnstone, Guenter W Gross, Dieter G Weiss, Olaf H-U Schroeder, Alexandra Gramowski, Timothy J Shafer. Neurotoxicology 2010
Andrew F M Johnstone, Guenter W Gross, Dieter G Weiss, Olaf H-U Schroeder, Alexandra Gramowski, Timothy J Shafer. Neurotoxicology 2010
23
Approaches to seizure risk assessment in preclinical drug discovery.
Alison Easter, M Elizabeth Bell, James R Damewood, William S Redfern, Jean-Pierre Valentin, Matthew J Winter, Carlos Fonck, Russell A Bialecki. Drug Discov Today 2009
Alison Easter, M Elizabeth Bell, James R Damewood, William S Redfern, Jean-Pierre Valentin, Matthew J Winter, Carlos Fonck, Russell A Bialecki. Drug Discov Today 2009
23
Temporally coordinated spiking activity of human induced pluripotent stem cell-derived neurons co-cultured with astrocytes.
Tasuku Kayama, Ikuro Suzuki, Aoi Odawara, Takuya Sasaki, Yuji Ikegaya. Biochem Biophys Res Commun 2018
Tasuku Kayama, Ikuro Suzuki, Aoi Odawara, Takuya Sasaki, Yuji Ikegaya. Biochem Biophys Res Commun 2018
27
Neurotoxicity screening of (illicit) drugs using novel methods for analysis of microelectrode array (MEA) recordings.
L Hondebrink, A H A Verboven, W S Drega, S Schmeink, M W G D M de Groot, R G D M van Kleef, F M J Wijnolts, A de Groot, J Meulenbelt, R H S Westerink. Neurotoxicology 2016
L Hondebrink, A H A Verboven, W S Drega, S Schmeink, M W G D M de Groot, R G D M van Kleef, F M J Wijnolts, A de Groot, J Meulenbelt, R H S Westerink. Neurotoxicology 2016
23
Cortical cultures coupled to micro-electrode arrays: a novel approach to perform in vitro excitotoxicity testing.
Monica Frega, Valentina Pasquale, Mariateresa Tedesco, Manuela Marcoli, Andrea Contestabile, Marina Nanni, Laura Bonzano, Guido Maura, Michela Chiappalone. Neurotoxicol Teratol 2012
Monica Frega, Valentina Pasquale, Mariateresa Tedesco, Manuela Marcoli, Andrea Contestabile, Marina Nanni, Laura Bonzano, Guido Maura, Michela Chiappalone. Neurotoxicol Teratol 2012
23
New in vitro phenotypic assay for epilepsy: fluorescent measurement of synchronized neuronal calcium oscillations.
Nathalie Pacico, Ana Mingorance-Le Meur. PLoS One 2014
Nathalie Pacico, Ana Mingorance-Le Meur. PLoS One 2014
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Human cerebral cortex development from pluripotent stem cells to functional excitatory synapses.
Yichen Shi, Peter Kirwan, James Smith, Hugh P C Robinson, Frederick J Livesey. Nat Neurosci 2012
Yichen Shi, Peter Kirwan, James Smith, Hugh P C Robinson, Frederick J Livesey. Nat Neurosci 2012
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Comparison of the acute inhibitory effects of Tetrodotoxin (TTX) in rat and human neuronal networks for risk assessment purposes.
Emma E J Kasteel, Remco H S Westerink. Toxicol Lett 2017
Emma E J Kasteel, Remco H S Westerink. Toxicol Lett 2017
19
Pharmacological validation of a semi-automated in vitro hippocampal brain slice assay for assessment of seizure liability.
A Easter, T H Sharp, J-P Valentin, C E Pollard. J Pharmacol Toxicol Methods 2007
A Easter, T H Sharp, J-P Valentin, C E Pollard. J Pharmacol Toxicol Methods 2007
19
Induction of long-term potentiation and depression phenomena in human induced pluripotent stem cell-derived cortical neurons.
A Odawara, H Katoh, N Matsuda, I Suzuki. Biochem Biophys Res Commun 2016
A Odawara, H Katoh, N Matsuda, I Suzuki. Biochem Biophys Res Commun 2016
23
Comparative neurotoxicity screening in human iPSC-derived neural stem cells, neurons and astrocytes.
Ying Pei, Jun Peng, Mamta Behl, Nisha S Sipes, Keith R Shockley, Mahendra S Rao, Raymond R Tice, Xianmin Zeng. Brain Res 2016
Ying Pei, Jun Peng, Mamta Behl, Nisha S Sipes, Keith R Shockley, Mahendra S Rao, Raymond R Tice, Xianmin Zeng. Brain Res 2016
19
Directed differentiation of human pluripotent stem cells to cerebral cortex neurons and neural networks.
Yichen Shi, Peter Kirwan, Frederick J Livesey. Nat Protoc 2012
Yichen Shi, Peter Kirwan, Frederick J Livesey. Nat Protoc 2012
19
Multi-well microelectrode array recordings detect neuroactivity of ToxCast compounds.
Pablo Valdivia, Matt Martin, William R LeFew, James Ross, Keith A Houck, Timothy J Shafer. Neurotoxicology 2014
Pablo Valdivia, Matt Martin, William R LeFew, James Ross, Keith A Houck, Timothy J Shafer. Neurotoxicology 2014
19
Seizures and neurodegeneration induced by 4-aminopyridine in rat hippocampus in vivo: role of glutamate- and GABA-mediated neurotransmission and of ion channels.
F Peña, R Tapia. Neuroscience 2000
F Peña, R Tapia. Neuroscience 2000
19
Neuronal medium that supports basic synaptic functions and activity of human neurons in vitro.
Cedric Bardy, Mark van den Hurk, Tameji Eames, Cynthia Marchand, Ruben V Hernandez, Mariko Kellogg, Mark Gorris, Ben Galet, Vanessa Palomares, Joshua Brown,[...]. Proc Natl Acad Sci U S A 2015
Cedric Bardy, Mark van den Hurk, Tameji Eames, Cynthia Marchand, Ruben V Hernandez, Mariko Kellogg, Mark Gorris, Ben Galet, Vanessa Palomares, Joshua Brown,[...]. Proc Natl Acad Sci U S A 2015
19
Is the time right for in vitro neurotoxicity testing using human iPSC-derived neurons?
Anke M Tukker, Martje W G D M de Groot, Fiona M J Wijnolts, Emma E J Kasteel, Laura Hondebrink, Remco H S Westerink. ALTEX 2016
Anke M Tukker, Martje W G D M de Groot, Fiona M J Wijnolts, Emma E J Kasteel, Laura Hondebrink, Remco H S Westerink. ALTEX 2016
19
Revealing neuronal function through microelectrode array recordings.
Marie Engelene J Obien, Kosmas Deligkaris, Torsten Bullmann, Douglas J Bakkum, Urs Frey. Front Neurosci 2015
Marie Engelene J Obien, Kosmas Deligkaris, Torsten Bullmann, Douglas J Bakkum, Urs Frey. Front Neurosci 2015
19
Drug safety sciences and the bottleneck in drug development.
P B Watkins. Clin Pharmacol Ther 2011
P B Watkins. Clin Pharmacol Ther 2011
19
Electrical Responses and Spontaneous Activity of Human iPS-Derived Neuronal Networks Characterized for 3-month Culture with 4096-Electrode Arrays.
Hayder Amin, Alessandro Maccione, Federica Marinaro, Stefano Zordan, Thierry Nieus, Luca Berdondini. Front Neurosci 2016
Hayder Amin, Alessandro Maccione, Federica Marinaro, Stefano Zordan, Thierry Nieus, Luca Berdondini. Front Neurosci 2016
19
Detection of marine neurotoxins in food safety testing using a multielectrode array.
Jonathan Nicolas, Peter J M Hendriksen, Regina G D M van Kleef, Aart de Groot, Toine F H Bovee, Ivonne M C M Rietjens, Remco H S Westerink. Mol Nutr Food Res 2014
Jonathan Nicolas, Peter J M Hendriksen, Regina G D M van Kleef, Aart de Groot, Toine F H Bovee, Ivonne M C M Rietjens, Remco H S Westerink. Mol Nutr Food Res 2014
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Trial watch: phase II and phase III attrition rates 2011-2012.
John Arrowsmith, Philip Miller. Nat Rev Drug Discov 2013
John Arrowsmith, Philip Miller. Nat Rev Drug Discov 2013
19
Using stem cell-derived neurons in drug screening for neurological diseases.
Daniel Little, Robin Ketteler, Paul Gissen, Michael J Devine. Neurobiol Aging 2019
Daniel Little, Robin Ketteler, Paul Gissen, Michael J Devine. Neurobiol Aging 2019
19
Application of micro-electrode arrays (MEAs) as an emerging technology for developmental neurotoxicity: evaluation of domoic acid-induced effects in primary cultures of rat cortical neurons.
Helena T Hogberg, Tomasz Sobanski, Antonio Novellino, Maurice Whelan, Dieter G Weiss, Anna K Bal-Price. Neurotoxicology 2011
Helena T Hogberg, Tomasz Sobanski, Antonio Novellino, Maurice Whelan, Dieter G Weiss, Anna K Bal-Price. Neurotoxicology 2011
19
A multi-laboratory evaluation of microelectrode array-based measurements of neural network activity for acute neurotoxicity testing.
Andrea Vassallo, Michela Chiappalone, Ricardo De Camargos Lopes, Bibiana Scelfo, Antonio Novellino, Enrico Defranchi, Taina Palosaari, Timo Weisschu, Tzutzuy Ramirez, Sergio Martinoia,[...]. Neurotoxicology 2017
Andrea Vassallo, Michela Chiappalone, Ricardo De Camargos Lopes, Bibiana Scelfo, Antonio Novellino, Enrico Defranchi, Taina Palosaari, Timo Weisschu, Tzutzuy Ramirez, Sergio Martinoia,[...]. Neurotoxicology 2017
19
Applicability of hiPSC-Derived Neuronal Cocultures and Rodent Primary Cortical Cultures for In Vitro Seizure Liability Assessment.
Anke M Tukker, Fiona M J Wijnolts, Aart de Groot, Remco H S Westerink. Toxicol Sci 2020
Anke M Tukker, Fiona M J Wijnolts, Aart de Groot, Remco H S Westerink. Toxicol Sci 2020
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Approach to Neurotoxicity using Human iPSC Neurons: Consortium for Safety Assessment using Human iPS Cells.
Takafumi Shirakawa, Ikuro Suzuki. Curr Pharm Biotechnol 2020
Takafumi Shirakawa, Ikuro Suzuki. Curr Pharm Biotechnol 2020
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A multiplexed assay for determination of neurotoxicant effects on spontaneous network activity and viability from microelectrode arrays.
Kathleen Wallace, Jenna D Strickland, Pablo Valdivia, William R Mundy, Timothy J Shafer. Neurotoxicology 2015
Kathleen Wallace, Jenna D Strickland, Pablo Valdivia, William R Mundy, Timothy J Shafer. Neurotoxicology 2015
14
The glia/neuron ratio: how it varies uniformly across brain structures and species and what that means for brain physiology and evolution.
Suzana Herculano-Houzel. Glia 2014
Suzana Herculano-Houzel. Glia 2014
14
Development of micro-electrode array based tests for neurotoxicity: assessment of interlaboratory reproducibility with neuroactive chemicals.
A Novellino, Bibiana Scelfo, T Palosaari, A Price, Tomasz Sobanski, T J Shafer, A F M Johnstone, G W Gross, A Gramowski, O Schroeder,[...]. Front Neuroeng 2011
A Novellino, Bibiana Scelfo, T Palosaari, A Price, Tomasz Sobanski, T J Shafer, A F M Johnstone, G W Gross, A Gramowski, O Schroeder,[...]. Front Neuroeng 2011
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Emerging roles of astrocytes in neural circuit development.
Laura E Clarke, Ben A Barres. Nat Rev Neurosci 2013
Laura E Clarke, Ben A Barres. Nat Rev Neurosci 2013
14
In vitro field potential monitoring on a multi-microelectrode array for the electrophysiological long-term screening of neural stem cell maturation.
Diana Seidel, Heinz-Georg Jahnke, Beate Englich, Mathilde Girard, Andrea A Robitzki. Analyst 2017
Diana Seidel, Heinz-Georg Jahnke, Beate Englich, Mathilde Girard, Andrea A Robitzki. Analyst 2017
30
Effect of prolonged differentiation on functional maturation of human pluripotent stem cell-derived neuronal cultures.
Tanja Paavilainen, Anssi Pelkonen, Meeri E-L Mäkinen, Marja Peltola, Heini Huhtala, Dmitriy Fayuk, Susanna Narkilahti. Stem Cell Res 2018
Tanja Paavilainen, Anssi Pelkonen, Meeri E-L Mäkinen, Marja Peltola, Heini Huhtala, Dmitriy Fayuk, Susanna Narkilahti. Stem Cell Res 2018
14
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