Rachel J Harding, Yu-Feng Tong. Acta Pharmacol Sin 2018
Times Cited: 40
Times Cited: 40
Times Cited
Times Co-cited
Similarity
30
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M DiFiglia, E Sapp, K O Chase, S W Davies, G P Bates, J P Vonsattel, N Aronin. Science 1997
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Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease.
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Discovery of Small Molecules that Induce the Degradation of Huntingtin.
Shusuke Tomoshige, Sayaka Nomura, Kenji Ohgane, Yuichi Hashimoto, Minoru Ishikawa. Angew Chem Int Ed Engl 2017
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Huntingtin functions as a scaffold for selective macroautophagy.
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Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin.
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The cryo-electron microscopy structure of huntingtin.
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Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation.
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Mutant Huntingtin Disrupts the Nuclear Pore Complex.
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Design, Characterization, and Lead Selection of Therapeutic miRNAs Targeting Huntingtin for Development of Gene Therapy for Huntington's Disease.
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12
Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease.
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Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice.
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Reversal of Phenotypic Abnormalities by CRISPR/Cas9-Mediated Gene Correction in Huntington Disease Patient-Derived Induced Pluripotent Stem Cells.
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Mutant huntingtin reduction in astrocytes slows disease progression in the BACHD conditional Huntington's disease mouse model.
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Compartment-Dependent Degradation of Mutant Huntingtin Accounts for Its Preferential Accumulation in Neuronal Processes.
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The proteostasis network and its decline in ageing.
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Targeting the proteostasis network in Huntington's disease.
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Huntington disease: new insights into molecular pathogenesis and therapeutic opportunities.
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Early and progressive accumulation of reactive microglia in the Huntington disease brain.
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Trinucleotide repeat length instability and age of onset in Huntington's disease.
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Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules.
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10
Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease.
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Huntington's disease: underlying molecular mechanisms and emerging concepts.
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RAN Translation in Huntington Disease.
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10
AAV5-miHTT Gene Therapy Demonstrates Broad Distribution and Strong Human Mutant Huntingtin Lowering in a Huntington's Disease Minipig Model.
Melvin M Evers, Jana Miniarikova, Stefan Juhas, Astrid Vallès, Bozena Bohuslavova, Jana Juhasova, Helena Kupcova Skalnikova, Petr Vodicka, Ivona Valekova, Cynthia Brouwers,[...]. Mol Ther 2018
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10
Degradation of huntingtin mediated by a hybrid molecule composed of IAP antagonist linked to phenyldiazenyl benzothiazole derivative.
Shusuke Tomoshige, Sayaka Nomura, Kenji Ohgane, Yuichi Hashimoto, Minoru Ishikawa. Bioorg Med Chem Lett 2018
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CRISPR/Cas9-mediated gene editing ameliorates neurotoxicity in mouse model of Huntington's disease.
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Identification of genetic variants associated with Huntington's disease progression: a genome-wide association study.
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10
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.