A citation-based method for searching scientific literature

Monika Bambouskova, Laurent Gorvel, Vicky Lampropoulou, Alexey Sergushichev, Ekaterina Loginicheva, Kendall Johnson, Daniel Korenfeld, Mary Elizabeth Mathyer, Hyeryun Kim, Li-Hao Huang, Dustin Duncan, Howard Bregman, Abdurrahman Keskin, Andrea Santeford, Rajendra S Apte, Raghav Sehgal, Britney Johnson, Gaya K Amarasinghe, Miguel P Soares, Takashi Satoh, Shizuo Akira, Tsonwin Hai, Cristina de Guzman Strong, Karine Auclair, Thomas P Roddy, Scott A Biller, Marko Jovanovic, Eynav Klechevsky, Kelly M Stewart, Gwendalyn J Randolph, Maxim N Artyomov. Nature 2018
Times Cited: 220







List of co-cited articles
851 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity


Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.
Evanna L Mills, Dylan G Ryan, Hiran A Prag, Dina Dikovskaya, Deepthi Menon, Zbigniew Zaslona, Mark P Jedrychowski, Ana S H Costa, Maureen Higgins, Emily Hams,[...]. Nature 2018
492
85

Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation.
Vicky Lampropoulou, Alexey Sergushichev, Monika Bambouskova, Sharmila Nair, Emma E Vincent, Ekaterina Loginicheva, Luisa Cervantes-Barragan, Xiucui Ma, Stanley Ching-Cheng Huang, Takla Griss,[...]. Cell Metab 2016
485
67

Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production.
Alessandro Michelucci, Thekla Cordes, Jenny Ghelfi, Arnaud Pailot, Norbert Reiling, Oliver Goldmann, Tina Binz, André Wegner, Aravind Tallam, Antonio Rausell,[...]. Proc Natl Acad Sci U S A 2013
442
52

Succinate is an inflammatory signal that induces IL-1β through HIF-1α.
G M Tannahill, A M Curtis, J Adamik, E M Palsson-McDermott, A F McGettrick, G Goel, C Frezza, N J Bernard, B Kelly, N H Foley,[...]. Nature 2013
44

Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels.
Thekla Cordes, Martina Wallace, Alessandro Michelucci, Ajit S Divakaruni, Sean C Sapcariu, Carole Sousa, Haruhiko Koseki, Pedro Cabrales, Anne N Murphy, Karsten Hiller,[...]. J Biol Chem 2016
197
40

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages.
Evanna L Mills, Beth Kelly, Angela Logan, Ana S H Costa, Mukund Varma, Clare E Bryant, Panagiotis Tourlomousis, J Henry M Däbritz, Eyal Gottlieb, Isabel Latorre,[...]. Cell 2016
743
36

Comparative evaluation of itaconate and its derivatives reveals divergent inflammasome and type I interferon regulation in macrophages.
Amanda Swain, Monika Bambouskova, Hyeryun Kim, Prabhakar Sairam Andhey, Dustin Duncan, Karine Auclair, Victor Chubukov, Donald M Simons, Thomas P Roddy, Kelly M Stewart,[...]. Nat Metab 2020
47
72

Network integration of parallel metabolic and transcriptional data reveals metabolic modules that regulate macrophage polarization.
Abhishek K Jha, Stanley Ching-Cheng Huang, Alexey Sergushichev, Vicky Lampropoulou, Yulia Ivanova, Ekaterina Loginicheva, Karina Chmielewski, Kelly M Stewart, Juliet Ashall, Bart Everts,[...]. Immunity 2015
802
29

Itaconic acid is a mammalian metabolite induced during macrophage activation.
Cheryl L Strelko, Wenyun Lu, Fay J Dufort, Thomas N Seyfried, Thomas C Chiles, Joshua D Rabinowitz, Mary F Roberts. J Am Chem Soc 2011
154
26

Itaconate: the poster child of metabolic reprogramming in macrophage function.
Luke A J O'Neill, Maxim N Artyomov. Nat Rev Immunol 2019
124
26

The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation.
Alexander Hooftman, Stefano Angiari, Svenja Hester, Sarah E Corcoran, Marah C Runtsch, Chris Ling, Melanie C Ruzek, Peter F Slivka, Anne F McGettrick, Kathy Banahan,[...]. Cell Metab 2020
51
47

S-glycosylation-based cysteine profiling reveals regulation of glycolysis by itaconate.
Wei Qin, Ke Qin, Yanling Zhang, Wentong Jia, Ying Chen, Bo Cheng, Linghang Peng, Nan Chen, Yuan Liu, Wen Zhou,[...]. Nat Chem Biol 2019
58
37

Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity.
Rob J W Arts, Boris Novakovic, Rob Ter Horst, Agostinho Carvalho, Siroon Bekkering, Ekta Lachmandas, Fernando Rodrigues, Ricardo Silvestre, Shih-Chin Cheng, Shuang-Yin Wang,[...]. Cell Metab 2016
329
20

α-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming.
Pu-Ste Liu, Haiping Wang, Xiaoyun Li, Tung Chao, Tony Teav, Stefan Christen, Giusy Di Conza, Wan-Chen Cheng, Chih-Hung Chou, Magdalena Vavakova,[...]. Nat Immunol 2017
307
20

The Nucleotide Sensor ZBP1 and Kinase RIPK3 Induce the Enzyme IRG1 to Promote an Antiviral Metabolic State in Neurons.
Brian P Daniels, Sigal B Kofman, Julian R Smith, Geoffrey T Norris, Annelise G Snyder, Joseph P Kolb, Xia Gao, Jason W Locasale, Jennifer Martinez, Michael Gale,[...]. Immunity 2019
86
23

A guide to immunometabolism for immunologists.
Luke A J O'Neill, Rigel J Kishton, Jeff Rathmell. Nat Rev Immunol 2016
19

Irg1 expression in myeloid cells prevents immunopathology during M. tuberculosis infection.
Sharmila Nair, Jeremy P Huynh, Vicky Lampropoulou, Ekaterina Loginicheva, Ekaterina Esaulova, Anshu P Gounder, Adrianus C M Boon, Elizabeth A Schwarzkopf, Tara R Bradstreet, Brian T Edelson,[...]. J Exp Med 2018
79
24

4-Octyl itaconate inhibits aerobic glycolysis by targeting GAPDH to exert anti-inflammatory effects.
Shan-Ting Liao, Chao Han, Ding-Qiao Xu, Xiao-Wei Fu, Jun-Song Wang, Ling-Yi Kong. Nat Commun 2019
59
30

The Itaconate Pathway Is a Central Regulatory Node Linking Innate Immune Tolerance and Trained Immunity.
Jorge Domínguez-Andrés, Boris Novakovic, Yang Li, Brendon P Scicluna, Mark S Gresnigt, Rob J W Arts, Marije Oosting, Simone J C F M Moorlag, Laszlo A Groh, Jelle Zwaag,[...]. Cell Metab 2019
110
18

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS.
Edward T Chouchani, Victoria R Pell, Edoardo Gaude, Dunja Aksentijević, Stephanie Y Sundier, Ellen L Robb, Angela Logan, Sergiy M Nadtochiy, Emily N J Ord, Anthony C Smith,[...]. Nature 2014
17

Dimethyl fumarate targets GAPDH and aerobic glycolysis to modulate immunity.
Michael D Kornberg, Pavan Bhargava, Paul M Kim, Vasanta Putluri, Adele M Snowman, Nagireddy Putluri, Peter A Calabresi, Solomon H Snyder. Science 2018
227
17

The Human Knockout Gene CLYBL Connects Itaconate to Vitamin B12.
Hongying Shen, Gregory C Campanello, Daniel Flicker, Zenon Grabarek, Junchi Hu, Cheng Luo, Ruma Banerjee, Vamsi K Mootha. Cell 2017
56
26


IFNs Modify the Proteome of Legionella-Containing Vacuoles and Restrict Infection Via IRG1-Derived Itaconic Acid.
Jan Naujoks, Christoph Tabeling, Brian D Dill, Christine Hoffmann, Andrew S Brown, Mareike Kunze, Stefan Kempa, Andrea Peter, Hans-Joachim Mollenkopf, Anca Dorhoi,[...]. PLoS Pathog 2016
124
15

Itaconate modulates tricarboxylic acid and redox metabolism to mitigate reperfusion injury.
Thekla Cordes, Alfredo Lucas, Ajit S Divakaruni, Anne N Murphy, Pedro Cabrales, Christian M Metallo. Mol Metab 2020
28
53

GPR91 senses extracellular succinate released from inflammatory macrophages and exacerbates rheumatoid arthritis.
Amanda Littlewood-Evans, Sophie Sarret, Verena Apfel, Perrine Loesle, Janet Dawson, Juan Zhang, Alban Muller, Bruno Tigani, Rainer Kneuer, Saijel Patel,[...]. J Exp Med 2016
193
14

Bacterial itaconate degradation promotes pathogenicity.
Jahminy Sasikaran, Michał Ziemski, Piotr K Zadora, Angela Fleig, Ivan A Berg. Nat Chem Biol 2014
91
14


Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase.
Mary A Selak, Sean M Armour, Elaine D MacKenzie, Houda Boulahbel, David G Watson, Kyle D Mansfield, Yi Pan, M Celeste Simon, Craig B Thompson, Eyal Gottlieb. Cancer Cell 2005
13

ATP-citrate lyase links cellular metabolism to histone acetylation.
Kathryn E Wellen, Georgia Hatzivassiliou, Uma M Sachdeva, Thi V Bui, Justin R Cross, Craig B Thompson. Science 2009
13

mTOR- and HIF-1α-mediated aerobic glycolysis as metabolic basis for trained immunity.
Shih-Chin Cheng, Jessica Quintin, Robert A Cramer, Kelly M Shepardson, Sadia Saeed, Vinod Kumar, Evangelos J Giamarellos-Bourboulis, Joost H A Martens, Nagesha Appukudige Rao, Ali Aghajanirefah,[...]. Science 2014
877
13

Abolition of mitochondrial substrate-level phosphorylation by itaconic acid produced by LPS-induced Irg1 expression in cells of murine macrophage lineage.
Beáta Németh, Judit Doczi, Dániel Csete, Gergely Kacso, Dora Ravasz, Daniel Adams, Gergely Kiss, Adam M Nagy, Gergo Horvath, Laszlo Tretter,[...]. FASEB J 2016
69
18

Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription.
Eri H Kobayashi, Takafumi Suzuki, Ryo Funayama, Takeshi Nagashima, Makiko Hayashi, Hiroki Sekine, Nobuyuki Tanaka, Takashi Moriguchi, Hozumi Motohashi, Keiko Nakayama,[...]. Nat Commun 2016
620
12

Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors.
Mengtao Xiao, Hui Yang, Wei Xu, Shenghong Ma, Huaipeng Lin, Honguang Zhu, Lixia Liu, Ying Liu, Chen Yang, Yanhui Xu,[...]. Genes Dev 2012
569
12

Dimethyl Itaconate Is Not Metabolized into Itaconate Intracellularly.
Mahmoud ElAzzouny, Christopher T M B Tom, Charles R Evans, Lori L Olson, Mary J Tanga, Katherine A Gallagher, Brent R Martin, Charles F Burant. J Biol Chem 2017
37
32

Itaconic acid mediates crosstalk between macrophage metabolism and peritoneal tumors.
Jonathan M Weiss, Luke C Davies, Megan Karwan, Lilia Ileva, Michelle K Ozaki, Robert Ys Cheng, Lisa A Ridnour, Christina M Annunziata, David A Wink, Daniel W McVicar. J Clin Invest 2018
77
15

(1)H NMR-based metabolomic profiling in mice infected with Mycobacterium tuberculosis.
Ji-Hyun Shin, Ji-Young Yang, Bo-Young Jeon, Yoo Jeong Yoon, Sang-Nae Cho, Yeon-Ho Kang, Do Hyun Ryu, Geum-Sook Hwang. J Proteome Res 2011
142
12

Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation.
Anthony J Covarrubias, Halil Ibrahim Aksoylar, Jiujiu Yu, Nathaniel W Snyder, Andrew J Worth, Shankar S Iyer, Jiawei Wang, Issam Ben-Sahra, Vanessa Byles, Tiffany Polynne-Stapornkul,[...]. Elife 2016
216
12


Itaconic Acid: The Surprising Role of an Industrial Compound as a Mammalian Antimicrobial Metabolite.
Thekla Cordes, Alessandro Michelucci, Karsten Hiller. Annu Rev Nutr 2015
88
13

Oxidative metabolism and PGC-1beta attenuate macrophage-mediated inflammation.
Divya Vats, Lata Mukundan, Justin I Odegaard, Lina Zhang, Kristi L Smith, Christine R Morel, Roger A Wagner, David R Greaves, Peter J Murray, Ajay Chawla. Cell Metab 2006
809
12

The Immunomodulatory Potential of the Metabolite Itaconate.
Alexander Hooftman, Luke A J O'Neill. Trends Immunol 2019
47
25

Immune-Responsive Gene 1/Itaconate Activates Nuclear Factor Erythroid 2-Related Factor 2 in Hepatocytes to Protect Against Liver Ischemia-Reperfusion Injury.
Zhongjie Yi, Meihong Deng, Melanie J Scott, Guang Fu, Patricia A Loughran, Zhao Lei, Shilai Li, Ping Sun, Chenxuan Yang, Wenbo Li,[...]. Hepatology 2020
37
32

Coupling Krebs cycle metabolites to signalling in immunity and cancer.
Dylan G Ryan, Michael P Murphy, Christian Frezza, Hiran A Prag, Edward T Chouchani, Luke A O'Neill, Evanna L Mills. Nat Metab 2019
112
11

Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages.
Stanley Ching-Cheng Huang, Bart Everts, Yulia Ivanova, David O'Sullivan, Marcia Nascimento, Amber M Smith, Wandy Beatty, Latisha Love-Gregory, Wing Y Lam, Christina M O'Neill,[...]. Nat Immunol 2014
573
11

Triggering the succinate receptor GPR91 on dendritic cells enhances immunity.
Tina Rubic, Günther Lametschwandtner, Sandra Jost, Sonja Hinteregger, Julia Kund, Nicole Carballido-Perrig, Christoph Schwärzler, Tobias Junt, Hans Voshol, Josef G Meingassner,[...]. Nat Immunol 2008
250
10

ATP-citrate lyase is essential for macrophage inflammatory response.
Vittoria Infantino, Vito Iacobazzi, Ferdinando Palmieri, Alessio Menga. Biochem Biophys Res Commun 2013
135
10

Pyruvate kinase M2 regulates Hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in LPS-activated macrophages.
Eva M Palsson-McDermott, Anne M Curtis, Gautam Goel, Mario A R Lauterbach, Frederick J Sheedy, Laura E Gleeson, Mirjam W M van den Bosch, Susan R Quinn, Raquel Domingo-Fernandez, Daniel G W Johnston,[...]. Cell Metab 2015
497
10

Glycolytic Stimulation Is Not a Requirement for M2 Macrophage Differentiation.
Feilong Wang, Song Zhang, Ivan Vuckovic, Ryounghoon Jeon, Amir Lerman, Clifford D Folmes, Petras P Dzeja, Joerg Herrmann. Cell Metab 2018
101
10

Immunometabolism governs dendritic cell and macrophage function.
Luke A J O'Neill, Edward J Pearce. J Exp Med 2016
718
10


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.