Simone M Haag, Muhammet F Gulen, Luc Reymond, Antoine Gibelin, Laurence Abrami, Alexiane Decout, Michael Heymann, F Gisou van der Goot, Gerardo Turcatti, Rayk Behrendt, Andrea Ablasser. Nature 2018
Times Cited: 265
Times Cited: 265
Times Cited
Times Co-cited
Similarity
Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway.
Lijun Sun, Jiaxi Wu, Fenghe Du, Xiang Chen, Zhijian J Chen. Science 2013
Lijun Sun, Jiaxi Wu, Fenghe Du, Xiang Chen, Zhijian J Chen. Science 2013
42
STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling.
Hiroki Ishikawa, Glen N Barber. Nature 2008
Hiroki Ishikawa, Glen N Barber. Nature 2008
39
STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity.
Hiroki Ishikawa, Zhe Ma, Glen N Barber. Nature 2009
Hiroki Ishikawa, Zhe Ma, Glen N Barber. Nature 2009
37
Activated STING in a vascular and pulmonary syndrome.
Y Liu, A A Jesus, B Marrero, D Yang, S E Ramsey, G A Montealegre Sanchez, K Tenbrock, H Wittkowski, O Y Jones, H S Kuehn,[...]. N Engl J Med 2014
Y Liu, A A Jesus, B Marrero, D Yang, S E Ramsey, G A Montealegre Sanchez, K Tenbrock, H Wittkowski, O Y Jones, H S Kuehn,[...]. N Engl J Med 2014
36
Activation of STING requires palmitoylation at the Golgi.
Kojiro Mukai, Hiroyasu Konno, Tatsuya Akiba, Takefumi Uemura, Satoshi Waguri, Toshihide Kobayashi, Glen N Barber, Hiroyuki Arai, Tomohiko Taguchi. Nat Commun 2016
Kojiro Mukai, Hiroyasu Konno, Tatsuya Akiba, Takefumi Uemura, Satoshi Waguri, Toshihide Kobayashi, Glen N Barber, Hiroyuki Arai, Tomohiko Taguchi. Nat Commun 2016
30
Autophagy induction via STING trafficking is a primordial function of the cGAS pathway.
Xiang Gui, Hui Yang, Tuo Li, Xiaojun Tan, Peiqing Shi, Minghao Li, Fenghe Du, Zhijian J Chen. Nature 2019
Xiang Gui, Hui Yang, Tuo Li, Xiaojun Tan, Peiqing Shi, Minghao Li, Fenghe Du, Zhijian J Chen. Nature 2019
29
Nitro-fatty acids are formed in response to virus infection and are potent inhibitors of STING palmitoylation and signaling.
Anne Louise Hansen, Gregory J Buchan, Michael Rühl, Kojiro Mukai, Sonia R Salvatore, Emari Ogawa, Sidsel D Andersen, Marie B Iversen, Anne L Thielke, Camilla Gunderstofte,[...]. Proc Natl Acad Sci U S A 2018
Anne Louise Hansen, Gregory J Buchan, Michael Rühl, Kojiro Mukai, Sonia R Salvatore, Emari Ogawa, Sidsel D Andersen, Marie B Iversen, Anne L Thielke, Camilla Gunderstofte,[...]. Proc Natl Acad Sci U S A 2018
31
Molecular mechanisms and cellular functions of cGAS-STING signalling.
Karl-Peter Hopfner, Veit Hornung. Nat Rev Mol Cell Biol 2020
Karl-Peter Hopfner, Veit Hornung. Nat Rev Mol Cell Biol 2020
25
Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA.
Jiaxi Wu, Lijun Sun, Xiang Chen, Fenghe Du, Heping Shi, Chuo Chen, Zhijian J Chen. Science 2013
Jiaxi Wu, Lijun Sun, Xiang Chen, Fenghe Du, Heping Shi, Chuo Chen, Zhijian J Chen. Science 2013
24
Cytosolic-DNA-mediated, STING-dependent proinflammatory gene induction necessitates canonical NF-κB activation through TBK1.
Takayuki Abe, Glen N Barber. J Virol 2014
Takayuki Abe, Glen N Barber. J Virol 2014
24
cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING.
Andrea Ablasser, Marion Goldeck, Taner Cavlar, Tobias Deimling, Gregor Witte, Ingo Röhl, Karl-Peter Hopfner, Janos Ludwig, Veit Hornung. Nature 2013
Andrea Ablasser, Marion Goldeck, Taner Cavlar, Tobias Deimling, Gregor Witte, Ingo Röhl, Karl-Peter Hopfner, Janos Ludwig, Veit Hornung. Nature 2013
21
STING Activation by Translocation from the ER Is Associated with Infection and Autoinflammatory Disease.
Nicole Dobbs, Nikolay Burnaevskiy, Didi Chen, Vijay K Gonugunta, Neal M Alto, Nan Yan. Cell Host Microbe 2015
Nicole Dobbs, Nikolay Burnaevskiy, Didi Chen, Vijay K Gonugunta, Neal M Alto, Nan Yan. Cell Host Microbe 2015
20
DNA sensing by the cGAS-STING pathway in health and disease.
Mona Motwani, Scott Pesiridis, Katherine A Fitzgerald. Nat Rev Genet 2019
Mona Motwani, Scott Pesiridis, Katherine A Fitzgerald. Nat Rev Genet 2019
19
Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING.
Xu Zhang, Heping Shi, Jiaxi Wu, Xuewu Zhang, Lijun Sun, Chuo Chen, Zhijian J Chen. Mol Cell 2013
Xu Zhang, Heping Shi, Jiaxi Wu, Xuewu Zhang, Lijun Sun, Chuo Chen, Zhijian J Chen. Mol Cell 2013
19
STING is a direct innate immune sensor of cyclic di-GMP.
Dara L Burdette, Kathryn M Monroe, Katia Sotelo-Troha, Jeff S Iwig, Barbara Eckert, Mamoru Hyodo, Yoshihiro Hayakawa, Russell E Vance. Nature 2011
Dara L Burdette, Kathryn M Monroe, Katia Sotelo-Troha, Jeff S Iwig, Barbara Eckert, Mamoru Hyodo, Yoshihiro Hayakawa, Russell E Vance. Nature 2011
19
Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP-AMP.
Guijun Shang, Conggang Zhang, Zhijian J Chen, Xiao-Chen Bai, Xuewu Zhang. Nature 2019
Guijun Shang, Conggang Zhang, Zhijian J Chen, Xiao-Chen Bai, Xuewu Zhang. Nature 2019
19
Cytoplasmic chromatin triggers inflammation in senescence and cancer.
Zhixun Dou, Kanad Ghosh, Maria Grazia Vizioli, Jiajun Zhu, Payel Sen, Kirk J Wangensteen, Johayra Simithy, Yemin Lan, Yanping Lin, Zhuo Zhou,[...]. Nature 2017
Zhixun Dou, Kanad Ghosh, Maria Grazia Vizioli, Jiajun Zhu, Payel Sen, Kirk J Wangensteen, Johayra Simithy, Yemin Lan, Yanping Lin, Zhuo Zhou,[...]. Nature 2017
19
Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence.
Selene Glück, Baptiste Guey, Muhammet Fatih Gulen, Katharina Wolter, Tae-Won Kang, Niklas Arndt Schmacke, Anne Bridgeman, Jan Rehwinkel, Lars Zender, Andrea Ablasser. Nat Cell Biol 2017
Selene Glück, Baptiste Guey, Muhammet Fatih Gulen, Katharina Wolter, Tae-Won Kang, Niklas Arndt Schmacke, Anne Bridgeman, Jan Rehwinkel, Lars Zender, Andrea Ablasser. Nat Cell Biol 2017
18
Signalling strength determines proapoptotic functions of STING.
Muhammet F Gulen, Ute Koch, Simone M Haag, Fabian Schuler, Lionel Apetoh, Andreas Villunger, Freddy Radtke, Andrea Ablasser. Nat Commun 2017
Muhammet F Gulen, Ute Koch, Simone M Haag, Fabian Schuler, Lionel Apetoh, Andreas Villunger, Freddy Radtke, Andrea Ablasser. Nat Commun 2017
18
Cyclic dinucleotides trigger ULK1 (ATG1) phosphorylation of STING to prevent sustained innate immune signaling.
Hiroyasu Konno, Keiko Konno, Glen N Barber. Cell 2013
Hiroyasu Konno, Keiko Konno, Glen N Barber. Cell 2013
18
Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation.
Siqi Liu, Xin Cai, Jiaxi Wu, Qian Cong, Xiang Chen, Tuo Li, Fenghe Du, Junyao Ren, You-Tong Wu, Nick V Grishin,[...]. Science 2015
Siqi Liu, Xin Cai, Jiaxi Wu, Qian Cong, Xiang Chen, Tuo Li, Fenghe Du, Junyao Ren, You-Tong Wu, Nick V Grishin,[...]. Science 2015
17
Structural basis of STING binding with and phosphorylation by TBK1.
Conggang Zhang, Guijun Shang, Xiang Gui, Xuewu Zhang, Xiao-Chen Bai, Zhijian J Chen. Nature 2019
Conggang Zhang, Guijun Shang, Xiang Gui, Xuewu Zhang, Xiao-Chen Bai, Zhijian J Chen. Nature 2019
17
The cGAS-STING pathway as a therapeutic target in inflammatory diseases.
Alexiane Decout, Jason D Katz, Shankar Venkatraman, Andrea Ablasser. Nat Rev Immunol 2021
Alexiane Decout, Jason D Katz, Shankar Venkatraman, Andrea Ablasser. Nat Rev Immunol 2021
18
cGAS in action: Expanding roles in immunity and inflammation.
Andrea Ablasser, Zhijian J Chen. Science 2019
Andrea Ablasser, Zhijian J Chen. Science 2019
16
Mitochondrial DNA stress primes the antiviral innate immune response.
A Phillip West, William Khoury-Hanold, Matthew Staron, Michal C Tal, Cristiana M Pineda, Sabine M Lang, Megan Bestwick, Brett A Duguay, Nuno Raimundo, Donna A MacDuff,[...]. Nature 2015
A Phillip West, William Khoury-Hanold, Matthew Staron, Michal C Tal, Cristiana M Pineda, Sabine M Lang, Megan Bestwick, Brett A Duguay, Nuno Raimundo, Donna A MacDuff,[...]. Nature 2015
16
Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase.
Pu Gao, Manuel Ascano, Yang Wu, Winfried Barchet, Barbara L Gaffney, Thomas Zillinger, Artem A Serganov, Yizhou Liu, Roger A Jones, Gunther Hartmann,[...]. Cell 2013
Pu Gao, Manuel Ascano, Yang Wu, Winfried Barchet, Barbara L Gaffney, Thomas Zillinger, Artem A Serganov, Yizhou Liu, Roger A Jones, Gunther Hartmann,[...]. Cell 2013
16
The Cyclopeptide Astin C Specifically Inhibits the Innate Immune CDN Sensor STING.
Senlin Li, Ze Hong, Zhe Wang, Fei Li, Jiahao Mei, Lulu Huang, Xiwen Lou, Simeng Zhao, Lihua Song, Wei Chen,[...]. Cell Rep 2018
Senlin Li, Ze Hong, Zhe Wang, Fei Li, Jiahao Mei, Lulu Huang, Xiwen Lou, Simeng Zhao, Lihua Song, Wei Chen,[...]. Cell Rep 2018
33
Discovery of a Novel cGAMP Competitive Ligand of the Inactive Form of STING.
Tony Siu, Michael D Altman, Gretchen A Baltus, Matthew Childers, J Michael Ellis, Hakan Gunaydin, Harold Hatch, Thu Ho, James Jewell, Brian M Lacey,[...]. ACS Med Chem Lett 2018
Tony Siu, Michael D Altman, Gretchen A Baltus, Matthew Childers, J Michael Ellis, Hakan Gunaydin, Harold Hatch, Thu Ho, James Jewell, Brian M Lacey,[...]. ACS Med Chem Lett 2018
41
STING Polymer Structure Reveals Mechanisms for Activation, Hyperactivation, and Inhibition.
Sabrina L Ergun, Daniel Fernandez, Thomas M Weiss, Lingyin Li. Cell 2019
Sabrina L Ergun, Daniel Fernandez, Thomas M Weiss, Lingyin Li. Cell 2019
18
The Ca2+ sensor STIM1 regulates the type I interferon response by retaining the signaling adaptor STING at the endoplasmic reticulum.
Sonal Srikanth, Jin Seok Woo, Beibei Wu, Yasser M El-Sherbiny, Jennifer Leung, Koollawat Chupradit, Laura Rice, Gil Ju Seo, Guillaume Calmettes, Chandran Ramakrishna,[...]. Nat Immunol 2019
Sonal Srikanth, Jin Seok Woo, Beibei Wu, Yasser M El-Sherbiny, Jennifer Leung, Koollawat Chupradit, Laura Rice, Gil Ju Seo, Guillaume Calmettes, Chandran Ramakrishna,[...]. Nat Immunol 2019
16
Inherited STING-activating mutation underlies a familial inflammatory syndrome with lupus-like manifestations.
Nadia Jeremiah, Bénédicte Neven, Matteo Gentili, Isabelle Callebaut, Sophia Maschalidi, Marie-Claude Stolzenberg, Nicolas Goudin, Marie-Louis Frémond, Patrick Nitschke, Thierry J Molina,[...]. J Clin Invest 2014
Nadia Jeremiah, Bénédicte Neven, Matteo Gentili, Isabelle Callebaut, Sophia Maschalidi, Marie-Claude Stolzenberg, Nicolas Goudin, Marie-Louis Frémond, Patrick Nitschke, Thierry J Molina,[...]. J Clin Invest 2014
15
Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases.
Daxing Gao, Tuo Li, Xiao-Dong Li, Xiang Chen, Quan-Zhen Li, Mary Wight-Carter, Zhijian J Chen. Proc Natl Acad Sci U S A 2015
Daxing Gao, Tuo Li, Xiao-Dong Li, Xiang Chen, Quan-Zhen Li, Mary Wight-Carter, Zhijian J Chen. Proc Natl Acad Sci U S A 2015
15
STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway.
Yasuo Tanaka, Zhijian J Chen. Sci Signal 2012
Yasuo Tanaka, Zhijian J Chen. Sci Signal 2012
15
Design of amidobenzimidazole STING receptor agonists with systemic activity.
Joshi M Ramanjulu, G Scott Pesiridis, Jingsong Yang, Nestor Concha, Robert Singhaus, Shu-Yun Zhang, Jean-Luc Tran, Patrick Moore, Stephanie Lehmann, H Christian Eberl,[...]. Nature 2018
Joshi M Ramanjulu, G Scott Pesiridis, Jingsong Yang, Nestor Concha, Robert Singhaus, Shu-Yun Zhang, Jean-Luc Tran, Patrick Moore, Stephanie Lehmann, H Christian Eberl,[...]. Nature 2018
15
Regulation and function of the cGAS-STING pathway of cytosolic DNA sensing.
Qi Chen, Lijun Sun, Zhijian J Chen. Nat Immunol 2016
Qi Chen, Lijun Sun, Zhijian J Chen. Nat Immunol 2016
15
cGAS surveillance of micronuclei links genome instability to innate immunity.
Karen J Mackenzie, Paula Carroll, Carol-Anne Martin, Olga Murina, Adeline Fluteau, Daniel J Simpson, Nelly Olova, Hannah Sutcliffe, Jacqueline K Rainger, Andrea Leitch,[...]. Nature 2017
Karen J Mackenzie, Paula Carroll, Carol-Anne Martin, Olga Murina, Adeline Fluteau, Daniel J Simpson, Nelly Olova, Hannah Sutcliffe, Jacqueline K Rainger, Andrea Leitch,[...]. Nature 2017
14
STING-associated vasculopathy develops independently of IRF3 in mice.
James D Warner, Ricardo A Irizarry-Caro, Brock G Bennion, Teresa L Ai, Amber M Smith, Cathrine A Miner, Tomomi Sakai, Vijay K Gonugunta, Jianjun Wu, Derek J Platt,[...]. J Exp Med 2017
James D Warner, Ricardo A Irizarry-Caro, Brock G Bennion, Teresa L Ai, Amber M Smith, Cathrine A Miner, Tomomi Sakai, Vijay K Gonugunta, Jianjun Wu, Derek J Platt,[...]. J Exp Med 2017
16
The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation.
Bo Zhong, Yan Yang, Shu Li, Yan-Yi Wang, Ying Li, Feici Diao, Caoqi Lei, Xiao He, Lu Zhang, Po Tien,[...]. Immunity 2008
Bo Zhong, Yan Yang, Shu Li, Yan-Yi Wang, Ying Li, Feici Diao, Caoqi Lei, Xiao He, Lu Zhang, Po Tien,[...]. Immunity 2008
14
TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS.
Chien-Hsiung Yu, Sophia Davidson, Cassandra R Harapas, James B Hilton, Michael J Mlodzianoski, Pawat Laohamonthonkul, Cynthia Louis, Ronnie Ren Jie Low, Jonas Moecking, Dominic De Nardo,[...]. Cell 2020
Chien-Hsiung Yu, Sophia Davidson, Cassandra R Harapas, James B Hilton, Michael J Mlodzianoski, Pawat Laohamonthonkul, Cynthia Louis, Ronnie Ren Jie Low, Jonas Moecking, Dominic De Nardo,[...]. Cell 2020
14
cGAS is essential for cellular senescence.
Hui Yang, Hanze Wang, Junyao Ren, Qi Chen, Zhijian J Chen. Proc Natl Acad Sci U S A 2017
Hui Yang, Hanze Wang, Junyao Ren, Qi Chen, Zhijian J Chen. Proc Natl Acad Sci U S A 2017
14
Mutations in COPA lead to abnormal trafficking of STING to the Golgi and interferon signaling.
Alice Lepelley, Maria José Martin-Niclós, Melvin Le Bihan, Joseph A Marsh, Carolina Uggenti, Gillian I Rice, Vincent Bondet, Darragh Duffy, Jonny Hertzog, Jan Rehwinkel,[...]. J Exp Med 2020
Alice Lepelley, Maria José Martin-Niclós, Melvin Le Bihan, Joseph A Marsh, Carolina Uggenti, Gillian I Rice, Vincent Bondet, Darragh Duffy, Jonny Hertzog, Jan Rehwinkel,[...]. J Exp Med 2020
27
TBK1 and IKKε Act Redundantly to Mediate STING-Induced NF-κB Responses in Myeloid Cells.
Katherine R Balka, Cynthia Louis, Tahnee L Saunders, Amber M Smith, Dale J Calleja, Damian B D'Silva, Fiona Moghaddas, Maximilien Tailler, Kate E Lawlor, Yifan Zhan,[...]. Cell Rep 2020
Katherine R Balka, Cynthia Louis, Tahnee L Saunders, Amber M Smith, Dale J Calleja, Damian B D'Silva, Fiona Moghaddas, Maximilien Tailler, Kate E Lawlor, Yifan Zhan,[...]. Cell Rep 2020
18
The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3.
Moritz M Gaidt, Thomas S Ebert, Dhruv Chauhan, Katharina Ramshorn, Francesca Pinci, Sarah Zuber, Fionan O'Duill, Jonathan L Schmid-Burgk, Florian Hoss, Raymund Buhmann,[...]. Cell 2017
Moritz M Gaidt, Thomas S Ebert, Dhruv Chauhan, Katharina Ramshorn, Francesca Pinci, Sarah Zuber, Fionan O'Duill, Jonathan L Schmid-Burgk, Florian Hoss, Raymund Buhmann,[...]. Cell 2017
14
Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage.
Gillian Dunphy, Sinéad M Flannery, Jessica F Almine, Dympna J Connolly, Christina Paulus, Kasper L Jønsson, Martin R Jakobsen, Michael M Nevels, Andrew G Bowie, Leonie Unterholzner. Mol Cell 2018
Gillian Dunphy, Sinéad M Flannery, Jessica F Almine, Dympna J Connolly, Christina Paulus, Kasper L Jønsson, Martin R Jakobsen, Michael M Nevels, Andrew G Bowie, Leonie Unterholzner. Mol Cell 2018
14
Parkin and PINK1 mitigate STING-induced inflammation.
Danielle A Sliter, Jennifer Martinez, Ling Hao, Xi Chen, Nuo Sun, Tara D Fischer, Jonathon L Burman, Yan Li, Zhe Zhang, Derek P Narendra,[...]. Nature 2018
Danielle A Sliter, Jennifer Martinez, Ling Hao, Xi Chen, Nuo Sun, Tara D Fischer, Jonathon L Burman, Yan Li, Zhe Zhang, Derek P Narendra,[...]. Nature 2018
13
Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice.
Jessica Vincent, Carolina Adura, Pu Gao, Antonio Luz, Lodoe Lama, Yasutomi Asano, Rei Okamoto, Toshihiro Imaeda, Jumpei Aida, Katherine Rothamel,[...]. Nat Commun 2017
Jessica Vincent, Carolina Adura, Pu Gao, Antonio Luz, Lodoe Lama, Yasutomi Asano, Rei Okamoto, Toshihiro Imaeda, Jumpei Aida, Katherine Rothamel,[...]. Nat Commun 2017
13
Intrinsic antiproliferative activity of the innate sensor STING in T lymphocytes.
Silvia Cerboni, Nadia Jeremiah, Matteo Gentili, Ulf Gehrmann, Cécile Conrad, Marie-Claude Stolzenberg, Capucine Picard, Bénédicte Neven, Alain Fischer, Sébastian Amigorena,[...]. J Exp Med 2017
Silvia Cerboni, Nadia Jeremiah, Matteo Gentili, Ulf Gehrmann, Cécile Conrad, Marie-Claude Stolzenberg, Capucine Picard, Bénédicte Neven, Alain Fischer, Sébastian Amigorena,[...]. J Exp Med 2017
13
ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization.
Wenxiang Sun, Yang Li, Lu Chen, Huihui Chen, Fuping You, Xiang Zhou, Yi Zhou, Zhonghe Zhai, Danying Chen, Zhengfan Jiang. Proc Natl Acad Sci U S A 2009
Wenxiang Sun, Yang Li, Lu Chen, Huihui Chen, Fuping You, Xiang Zhou, Yi Zhou, Zhonghe Zhai, Danying Chen, Zhengfan Jiang. Proc Natl Acad Sci U S A 2009
13
Agonist-Mediated Activation of STING Induces Apoptosis in Malignant B Cells.
Chih-Hang Anthony Tang, Joseph A Zundell, Sujeewa Ranatunga, Cindy Lin, Yulia Nefedova, Juan R Del Valle, Chih-Chi Andrew Hu. Cancer Res 2016
Chih-Hang Anthony Tang, Joseph A Zundell, Sujeewa Ranatunga, Cindy Lin, Yulia Nefedova, Juan R Del Valle, Chih-Chi Andrew Hu. Cancer Res 2016
13
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.