A citation-based method for searching scientific literature

Joan B Mannick, Melody Morris, Hans-Ulrich P Hockey, Guglielmo Roma, Martin Beibel, Kenneth Kulmatycki, Mollie Watkins, Tea Shavlakadze, Weihua Zhou, Dean Quinn, David J Glass, Lloyd B Klickstein. Sci Transl Med 2018
Times Cited: 156







List of co-cited articles
1399 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity


mTOR inhibition improves immune function in the elderly.
Joan B Mannick, Giuseppe Del Giudice, Maria Lattanzi, Nicholas M Valiante, Jens Praestgaard, Baisong Huang, Michael A Lonetto, Holden T Maecker, John Kovarik, Simon Carson,[...]. Sci Transl Med 2014
349
48

The hallmarks of aging.
Carlos López-Otín, Maria A Blasco, Linda Partridge, Manuel Serrano, Guido Kroemer. Cell 2013
31

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice.
David E Harrison, Randy Strong, Zelton Dave Sharp, James F Nelson, Clinton M Astle, Kevin Flurkey, Nancy L Nadon, J Erby Wilkinson, Krystyna Frenkel, Christy S Carter,[...]. Nature 2009
24

Metformin as a Tool to Target Aging.
Nir Barzilai, Jill P Crandall, Stephen B Kritchevsky, Mark A Espeland. Cell Metab 2016
405
20

Senolytics improve physical function and increase lifespan in old age.
Ming Xu, Tamar Pirtskhalava, Joshua N Farr, Bettina M Weigand, Allyson K Palmer, Megan M Weivoda, Christina L Inman, Mikolaj B Ogrodnik, Christine M Hachfeld, Daniel G Fraser,[...]. Nat Med 2018
554
18

mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells.
Chong Chen, Yu Liu, Yang Liu, Pan Zheng. Sci Signal 2009
401
16

mTOR regulates memory CD8 T-cell differentiation.
Koichi Araki, Alexandra P Turner, Virginia Oliva Shaffer, Shivaprakash Gangappa, Susanne A Keller, Martin F Bachmann, Christian P Larsen, Rafi Ahmed. Nature 2009
16

mTOR is a key modulator of ageing and age-related disease.
Simon C Johnson, Peter S Rabinovitch, Matt Kaeberlein. Nature 2013
924
16

Geroscience: linking aging to chronic disease.
Brian K Kennedy, Shelley L Berger, Anne Brunet, Judith Campisi, Ana Maria Cuervo, Elissa S Epel, Claudio Franceschi, Gordon J Lithgow, Richard I Morimoto, Jeffrey E Pessin,[...]. Cell 2014
801
13

The Achilles' heel of senescent cells: from transcriptome to senolytic drugs.
Yi Zhu, Tamara Tchkonia, Tamar Pirtskhalava, Adam C Gower, Husheng Ding, Nino Giorgadze, Allyson K Palmer, Yuji Ikeno, Gene B Hubbard, Marc Lenburg,[...]. Aging Cell 2015
733
13

Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease.
LaTonya J Hickson, Larissa G P Langhi Prata, Shane A Bobart, Tamara K Evans, Nino Giorgadze, Shahrukh K Hashmi, Sandra M Herrmann, Michael D Jensen, Qingyi Jia, Kyra L Jordan,[...]. EBioMedicine 2019
232
13

Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice.
Alessandro Bitto, Takashi K Ito, Victor V Pineda, Nicolas J LeTexier, Heather Z Huang, Elissa Sutlief, Herman Tung, Nicholas Vizzini, Belle Chen, Kaleb Smith,[...]. Elife 2016
145
12

Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study.
Jamie N Justice, Anoop M Nambiar, Tamar Tchkonia, Nathan K LeBrasseur, Rodolfo Pascual, Shahrukh K Hashmi, Larissa Prata, Michal M Masternak, Stephen B Kritchevsky, Nicolas Musi,[...]. EBioMedicine 2019
296
12

Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice.
Carolyn M Roos, Bin Zhang, Allyson K Palmer, Mikolaj B Ogrodnik, Tamar Pirtskhalava, Nassir M Thalji, Michael Hagler, Diana Jurk, Leslie A Smith, Grace Casaclang-Verzosa,[...]. Aging Cell 2016
295
12

Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor.
Jean-Philippe Coppé, Christopher K Patil, Francis Rodier, Yu Sun, Denise P Muñoz, Joshua Goldstein, Peter S Nelson, Pierre-Yves Desprez, Judith Campisi. PLoS Biol 2008
12

Fisetin is a senotherapeutic that extends health and lifespan.
Matthew J Yousefzadeh, Yi Zhu, Sara J McGowan, Luise Angelini, Heike Fuhrmann-Stroissnigg, Ming Xu, Yuan Yuan Ling, Kendra I Melos, Tamar Pirtskhalava, Christina L Inman,[...]. EBioMedicine 2018
179
12

Inflamm-aging. An evolutionary perspective on immunosenescence.
C Franceschi, M Bonafè, S Valensin, F Olivieri, M De Luca, E Ottaviani, G De Benedictis. Ann N Y Acad Sci 2000
12

Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity.
Dudley W Lamming, Lan Ye, Pekka Katajisto, Marcus D Goncalves, Maki Saitoh, Deanna M Stevens, James G Davis, Adam B Salmon, Arlan Richardson, Rexford S Ahima,[...]. Science 2012
713
11

Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.
Colin Selman, Jennifer M A Tullet, Daniela Wieser, Elaine Irvine, Steven J Lingard, Agharul I Choudhury, Marc Claret, Hind Al-Qassab, Danielle Carmignac, Faruk Ramadani,[...]. Science 2009
756
11

A randomized control trial to establish the feasibility and safety of rapamycin treatment in an older human cohort: Immunological, physical performance, and cognitive effects.
Ellen Kraig, Leslie A Linehan, Hanyu Liang, Terry Q Romo, Qianqian Liu, Yubo Wu, Adriana D Benavides, Tyler J Curiel, Martin A Javors, Nicolas Musi,[...]. Exp Gerontol 2018
52
21

mTOR Signaling in Growth, Metabolism, and Disease.
Robert A Saxton, David M Sabatini. Cell 2017
11

Rapamycin slows aging in mice.
John E Wilkinson, Lisa Burmeister, Susan V Brooks, Chi-Chao Chan, Sabrina Friedline, David E Harrison, James F Hejtmancik, Nancy Nadon, Randy Strong, Lauren K Wood,[...]. Aging Cell 2012
391
11

A randomized controlled trial to establish effects of short-term rapamycin treatment in 24 middle-aged companion dogs.
Silvan R Urfer, Tammi L Kaeberlein, Susan Mailheau, Philip J Bergman, Kate E Creevy, Daniel E L Promislow, Matt Kaeberlein. Geroscience 2017
77
12

Late-life rapamycin treatment reverses age-related heart dysfunction.
James M Flynn, Monique N O'Leary, Christopher A Zambataro, Emmeline C Academia, Michael P Presley, Brittany J Garrett, Artem Zykovich, Sean D Mooney, Randy Strong, Clifford J Rosen,[...]. Aging Cell 2013
176
10

Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction.
Richard A Miller, David E Harrison, Clinton M Astle, Elizabeth Fernandez, Kevin Flurkey, Melissa Han, Martin A Javors, Xinna Li, Nancy L Nadon, James F Nelson,[...]. Aging Cell 2014
290
10

Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway.
Pankaj Kapahi, Brian M Zid, Tony Harper, Daniel Koslover, Viveca Sapin, Seymour Benzer. Curr Biol 2004
876
10

Extending healthy life span--from yeast to humans.
Luigi Fontana, Linda Partridge, Valter D Longo. Science 2010
10

Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster.
Ivana Bjedov, Janne M Toivonen, Fiona Kerr, Cathy Slack, Jake Jacobson, Andrea Foley, Linda Partridge. Cell Metab 2010
603
10

Rapamycin extends life and health in C57BL/6 mice.
Yiqiang Zhang, Alex Bokov, John Gelfond, Vanessa Soto, Yuji Ikeno, Gene Hubbard, Vivian Diaz, Lauren Sloane, Keith Maslin, Stephen Treaster,[...]. J Gerontol A Biol Sci Med Sci 2014
179
10

An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA.
Marco Demaria, Naoko Ohtani, Sameh A Youssef, Francis Rodier, Wendy Toussaint, James R Mitchell, Remi-Martin Laberge, Jan Vijg, Harry Van Steeg, Martijn E T Dollé,[...]. Dev Cell 2014
739
10

Senescent cells evade immune clearance via HLA-E-mediated NK and CD8+ T cell inhibition.
Branca I Pereira, Oliver P Devine, Milica Vukmanovic-Stejic, Emma S Chambers, Priya Subramanian, Neil Patel, Alex Virasami, Neil J Sebire, Veronica Kinsler, Alexis Valdovinos,[...]. Nat Commun 2019
100
10

Enhancement of cutaneous immunity during aging by blocking p38 mitogen-activated protein (MAP) kinase-induced inflammation.
Milica Vukmanovic-Stejic, Emma S Chambers, Mayte Suárez-Fariñas, Daisy Sandhu, Judilyn Fuentes-Duculan, Neil Patel, Elaine Agius, Katie E Lacy, Carolin T Turner, Anis Larbi,[...]. J Allergy Clin Immunol 2018
36
27

Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice.
Richard A Miller, David E Harrison, C M Astle, Joseph A Baur, Angela Rodriguez Boyd, Rafael de Cabo, Elizabeth Fernandez, Kevin Flurkey, Martin A Javors, James F Nelson,[...]. J Gerontol A Biol Sci Med Sci 2011
572
9

Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan.
Darren J Baker, Bennett G Childs, Matej Durik, Melinde E Wijers, Cynthia J Sieben, Jian Zhong, Rachel A Saltness, Karthik B Jeganathan, Grace Casaclang Verzosa, Abdulmohammad Pezeshki,[...]. Nature 2016
9

MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation.
Remi-Martin Laberge, Yu Sun, Arturo V Orjalo, Christopher K Patil, Adam Freund, Lili Zhou, Samuel C Curran, Albert R Davalos, Kathleen A Wilson-Edell, Su Liu,[...]. Nat Cell Biol 2015
478
9

Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging.
Marjolein P Baar, Renata M C Brandt, Diana A Putavet, Julian D D Klein, Kasper W J Derks, Benjamin R M Bourgeois, Sarah Stryeck, Yvonne Rijksen, Hester van Willigenburg, Danny A Feijtel,[...]. Cell 2017
518
9

Cellular Senescence: A Translational Perspective.
James L Kirkland, Tamara Tchkonia. EBioMedicine 2017
333
9

Cellular senescence mediates fibrotic pulmonary disease.
Marissa J Schafer, Thomas A White, Koji Iijima, Andrew J Haak, Giovanni Ligresti, Elizabeth J Atkinson, Ann L Oberg, Jodie Birch, Hanna Salmonowicz, Yi Zhu,[...]. Nat Commun 2017
499
9

Topical rapamycin reduces markers of senescence and aging in human skin: an exploratory, prospective, randomized trial.
Christina Lee Chung, Ibiyonu Lawrence, Melissa Hoffman, Dareen Elgindi, Kumar Nadhan, Manali Potnis, Annie Jin, Catlin Sershon, Rhonda Binnebose, Antonello Lorenzini,[...]. Geroscience 2019
39
23

Cellular Senescence: Defining a Path Forward.
Vassilis Gorgoulis, Peter D Adams, Andrea Alimonti, Dorothy C Bennett, Oliver Bischof, Cleo Bishop, Judith Campisi, Manuel Collado, Konstantinos Evangelou, Gerardo Ferbeyre,[...]. Cell 2019
392
9

Immunosenescence and Inflamm-Aging As Two Sides of the Same Coin: Friends or Foes?
Tamas Fulop, Anis Larbi, Gilles Dupuis, Aurélie Le Page, Eric H Frost, Alan A Cohen, Jacek M Witkowski, Claudio Franceschi. Front Immunol 2018
370
9

Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation.
Leena P Bharath, Madhur Agrawal, Grace McCambridge, Dequina A Nicholas, Hatice Hasturk, Jing Liu, Kai Jiang, Rui Liu, Zhenheng Guo, Jude Deeney,[...]. Cell Metab 2020
79
11

Regulation of immune responses by mTOR.
Jonathan D Powell, Kristen N Pollizzi, Emily B Heikamp, Maureen R Horton. Annu Rev Immunol 2012
489
8

Altered proteome turnover and remodeling by short-term caloric restriction or rapamycin rejuvenate the aging heart.
Dao-Fu Dai, Pabalu P Karunadharma, Ying A Chiao, Nathan Basisty, David Crispin, Edward J Hsieh, Tony Chen, Haiwei Gu, Danijel Djukovic, Daniel Raftery,[...]. Aging Cell 2014
172
8

mTOR signaling in growth control and disease.
Mathieu Laplante, David M Sabatini. Cell 2012
8

The Clinical Potential of Senolytic Drugs.
James L Kirkland, Tamara Tchkonia, Yi Zhu, Laura J Niedernhofer, Paul D Robbins. J Am Geriatr Soc 2017
227
8


Cellular senescence drives age-dependent hepatic steatosis.
Mikolaj Ogrodnik, Satomi Miwa, Tamar Tchkonia, Dina Tiniakos, Caroline L Wilson, Albert Lahat, Christoper P Day, Alastair Burt, Allyson Palmer, Quentin M Anstee,[...]. Nat Commun 2017
316
8

Identification of HSP90 inhibitors as a novel class of senolytics.
Heike Fuhrmann-Stroissnigg, Yuan Yuan Ling, Jing Zhao, Sara J McGowan, Yi Zhu, Robert W Brooks, Diego Grassi, Siobhan Q Gregg, Jennifer L Stripay, Akaitz Dorronsoro,[...]. Nat Commun 2017
222
8

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders.
Darren J Baker, Tobias Wijshake, Tamar Tchkonia, Nathan K LeBrasseur, Bennett G Childs, Bart van de Sluis, James L Kirkland, Jan M van Deursen. Nature 2011
8


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.