Magnus Ingelman-Sundberg, Volker M Lauschke. Pharmacogenomics 2018
Times Cited: 10
Times Cited: 10
Times Cited
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Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease.
Catherine C Bell, Delilah F G Hendriks, Sabrina M L Moro, Ewa Ellis, Joanne Walsh, Anna Renblom, Lisa Fredriksson Puigvert, Anita C A Dankers, Frank Jacobs, Jan Snoeys,[...]. Sci Rep 2016
Catherine C Bell, Delilah F G Hendriks, Sabrina M L Moro, Ewa Ellis, Joanne Walsh, Anna Renblom, Lisa Fredriksson Puigvert, Anita C A Dankers, Frank Jacobs, Jan Snoeys,[...]. Sci Rep 2016
70
Novel 3D Culture Systems for Studies of Human Liver Function and Assessments of the Hepatotoxicity of Drugs and Drug Candidates.
Volker M Lauschke, Delilah F G Hendriks, Catherine C Bell, Tommy B Andersson, Magnus Ingelman-Sundberg. Chem Res Toxicol 2016
Volker M Lauschke, Delilah F G Hendriks, Catherine C Bell, Tommy B Andersson, Magnus Ingelman-Sundberg. Chem Res Toxicol 2016
60
Microscale culture of human liver cells for drug development.
Salman R Khetani, Sangeeta N Bhatia. Nat Biotechnol 2008
Salman R Khetani, Sangeeta N Bhatia. Nat Biotechnol 2008
60
Massive rearrangements of cellular MicroRNA signatures are key drivers of hepatocyte dedifferentiation.
Volker M Lauschke, Sabine U Vorrink, Sabrina M L Moro, Fatemah Rezayee, Åsa Nordling, Delilah F G Hendriks, Catherine C Bell, Rowena Sison-Young, B Kevin Park, Christopher E Goldring,[...]. Hepatology 2016
Volker M Lauschke, Sabine U Vorrink, Sabrina M L Moro, Fatemah Rezayee, Åsa Nordling, Delilah F G Hendriks, Catherine C Bell, Rowena Sison-Young, B Kevin Park, Christopher E Goldring,[...]. Hepatology 2016
60
Endogenous and xenobiotic metabolic stability of primary human hepatocytes in long-term 3D spheroid cultures revealed by a combination of targeted and untargeted metabolomics.
Sabine U Vorrink, Shahid Ullah, Staffan Schmidt, Jatin Nandania, Vidya Velagapudi, Olof Beck, Magnus Ingelman-Sundberg, Volker M Lauschke. FASEB J 2017
Sabine U Vorrink, Shahid Ullah, Staffan Schmidt, Jatin Nandania, Vidya Velagapudi, Olof Beck, Magnus Ingelman-Sundberg, Volker M Lauschke. FASEB J 2017
60
Comparison of Hepatic 2D Sandwich Cultures and 3D Spheroids for Long-term Toxicity Applications: A Multicenter Study.
Catherine C Bell, Anita C A Dankers, Volker M Lauschke, Rowena Sison-Young, Roz Jenkins, Cliff Rowe, Chris E Goldring, Kevin Park, Sophie L Regan, Tracy Walker,[...]. Toxicol Sci 2018
Catherine C Bell, Anita C A Dankers, Volker M Lauschke, Rowena Sison-Young, Roz Jenkins, Cliff Rowe, Chris E Goldring, Kevin Park, Sophie L Regan, Tracy Walker,[...]. Toxicol Sci 2018
60
Transcriptional, Functional, and Mechanistic Comparisons of Stem Cell-Derived Hepatocytes, HepaRG Cells, and Three-Dimensional Human Hepatocyte Spheroids as Predictive In Vitro Systems for Drug-Induced Liver Injury.
Catherine C Bell, Volker M Lauschke, Sabine U Vorrink, Henrik Palmgren, Rodger Duffin, Tommy B Andersson, Magnus Ingelman-Sundberg. Drug Metab Dispos 2017
Catherine C Bell, Volker M Lauschke, Sabine U Vorrink, Henrik Palmgren, Rodger Duffin, Tommy B Andersson, Magnus Ingelman-Sundberg. Drug Metab Dispos 2017
60
Application of Microphysiological Systems to Enhance Safety Assessment in Drug Discovery.
Lorna Ewart, Eva-Maria Dehne, Kristin Fabre, Susan Gibbs, James Hickman, Ellinor Hornberg, Magnus Ingelman-Sundberg, Kyung-Jin Jang, David R Jones, Volker M Lauschke,[...]. Annu Rev Pharmacol Toxicol 2018
Lorna Ewart, Eva-Maria Dehne, Kristin Fabre, Susan Gibbs, James Hickman, Ellinor Hornberg, Magnus Ingelman-Sundberg, Kyung-Jin Jang, David R Jones, Volker M Lauschke,[...]. Annu Rev Pharmacol Toxicol 2018
50
Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework.
David Cook, Dearg Brown, Robert Alexander, Ruth March, Paul Morgan, Gemma Satterthwaite, Menelas N Pangalos. Nat Rev Drug Discov 2014
David Cook, Dearg Brown, Robert Alexander, Ruth March, Paul Morgan, Gemma Satterthwaite, Menelas N Pangalos. Nat Rev Drug Discov 2014
50
Cellular imaging predictions of clinical drug-induced liver injury.
Jinghai J Xu, Peter V Henstock, Margaret C Dunn, Arthur R Smith, Jeffrey R Chabot, David de Graaf. Toxicol Sci 2008
Jinghai J Xu, Peter V Henstock, Margaret C Dunn, Arthur R Smith, Jeffrey R Chabot, David de Graaf. Toxicol Sci 2008
50
Prediction of Drug-Induced Hepatotoxicity Using Long-Term Stable Primary Hepatic 3D Spheroid Cultures in Chemically Defined Conditions.
Sabine U Vorrink, Yitian Zhou, Magnus Ingelman-Sundberg, Volker M Lauschke. Toxicol Sci 2018
Sabine U Vorrink, Yitian Zhou, Magnus Ingelman-Sundberg, Volker M Lauschke. Toxicol Sci 2018
50
Multi-cell type human liver microtissues for hepatotoxicity testing.
S Messner, I Agarkova, W Moritz, J M Kelm. Arch Toxicol 2013
S Messner, I Agarkova, W Moritz, J M Kelm. Arch Toxicol 2013
50
Microengineered cultures containing human hepatic stellate cells and hepatocytes for drug development.
Matthew D Davidson, David A Kukla, Salman R Khetani. Integr Biol (Camb) 2017
Matthew D Davidson, David A Kukla, Salman R Khetani. Integr Biol (Camb) 2017
50
Utility of spherical human liver microtissues for prediction of clinical drug-induced liver injury.
William R Proctor, Alison J Foster, Jennifer Vogt, Claire Summers, Brian Middleton, Mark A Pilling, Daniel Shienson, Monika Kijanska, Simon Ströbel, Jens M Kelm,[...]. Arch Toxicol 2017
William R Proctor, Alison J Foster, Jennifer Vogt, Claire Summers, Brian Middleton, Mark A Pilling, Daniel Shienson, Monika Kijanska, Simon Ströbel, Jens M Kelm,[...]. Arch Toxicol 2017
50
Establishment of a hepatocyte-kupffer cell coculture model for assessment of proinflammatory cytokine effects on metabolizing enzymes and drug transporters.
Theresa V Nguyen, Okechukwu Ukairo, Salman R Khetani, Michael McVay, Chitra Kanchagar, Wolfgang Seghezzi, Gulesi Ayanoglu, Onyi Irrechukwu, Raymond Evers. Drug Metab Dispos 2015
Theresa V Nguyen, Okechukwu Ukairo, Salman R Khetani, Michael McVay, Chitra Kanchagar, Wolfgang Seghezzi, Gulesi Ayanoglu, Onyi Irrechukwu, Raymond Evers. Drug Metab Dispos 2015
50
Prediction of Drug-Induced Liver Injury in Micropatterned Co-cultures Containing iPSC-Derived Human Hepatocytes.
Brenton R Ware, Dustin R Berger, Salman R Khetani. Toxicol Sci 2015
Brenton R Ware, Dustin R Berger, Salman R Khetani. Toxicol Sci 2015
50
Assessment of a micropatterned hepatocyte coculture system to generate major human excretory and circulating drug metabolites.
Wendy WeiWei Wang, Salman R Khetani, Stacy Krzyzewski, David B Duignan, R Scott Obach. Drug Metab Dispos 2010
Wendy WeiWei Wang, Salman R Khetani, Stacy Krzyzewski, David B Duignan, R Scott Obach. Drug Metab Dispos 2010
50
Use of micropatterned cocultures to detect compounds that cause drug-induced liver injury in humans.
Salman R Khetani, Chitra Kanchagar, Okechukwu Ukairo, Stacy Krzyzewski, Amanda Moore, Julianne Shi, Simon Aoyama, Michael Aleo, Yvonne Will. Toxicol Sci 2013
Salman R Khetani, Chitra Kanchagar, Okechukwu Ukairo, Stacy Krzyzewski, Amanda Moore, Julianne Shi, Simon Aoyama, Michael Aleo, Yvonne Will. Toxicol Sci 2013
50
Human hepatic 3D spheroids as a model for steatosis and insulin resistance.
Mikael Kozyra, Inger Johansson, Åsa Nordling, Shahid Ullah, Volker M Lauschke, Magnus Ingelman-Sundberg. Sci Rep 2018
Mikael Kozyra, Inger Johansson, Åsa Nordling, Shahid Ullah, Volker M Lauschke, Magnus Ingelman-Sundberg. Sci Rep 2018
50
3D Primary Hepatocyte Culture Systems for Analyses of Liver Diseases, Drug Metabolism, and Toxicity: Emerging Culture Paradigms and Applications.
Volker M Lauschke, Reza Z Shafagh, Delilah F G Hendriks, Magnus Ingelman-Sundberg. Biotechnol J 2019
Volker M Lauschke, Reza Z Shafagh, Delilah F G Hendriks, Magnus Ingelman-Sundberg. Biotechnol J 2019
50
Hepatic 3D spheroid models for the detection and study of compounds with cholestatic liability.
Delilah F G Hendriks, Lisa Fredriksson Puigvert, Simon Messner, Wolfgang Mortiz, Magnus Ingelman-Sundberg. Sci Rep 2016
Delilah F G Hendriks, Lisa Fredriksson Puigvert, Simon Messner, Wolfgang Mortiz, Magnus Ingelman-Sundberg. Sci Rep 2016
40
Predicting circulating human metabolites: how good are we?
Shelby Anderson, Debra Luffer-Atlas, Mary Pat Knadler. Chem Res Toxicol 2009
Shelby Anderson, Debra Luffer-Atlas, Mary Pat Knadler. Chem Res Toxicol 2009
40
Assessment of three human in vitro systems in the generation of major human excretory and circulating metabolites.
Deepak Dalvie, R Scott Obach, Ping Kang, Chandra Prakash, Cho-Ming Loi, Susan Hurst, Angus Nedderman, Lance Goulet, Evan Smith, Hai-Zhi Bu,[...]. Chem Res Toxicol 2009
Deepak Dalvie, R Scott Obach, Ping Kang, Chandra Prakash, Cho-Ming Loi, Susan Hurst, Angus Nedderman, Lance Goulet, Evan Smith, Hai-Zhi Bu,[...]. Chem Res Toxicol 2009
40
Transcriptomic, Proteomic, and Functional Long-Term Characterization of Multicellular Three-Dimensional Human Liver Microtissues.
Simon Messner, Lisa Fredriksson, Volker M Lauschke, Katrin Roessger, Claudia Escher, Magdalena Bober, Jens M Kelm, Magnus Ingelman-Sundberg, Wolfgang Moritz. Appl In Vitro Toxicol 2018
Simon Messner, Lisa Fredriksson, Volker M Lauschke, Katrin Roessger, Claudia Escher, Magdalena Bober, Jens M Kelm, Magnus Ingelman-Sundberg, Wolfgang Moritz. Appl In Vitro Toxicol 2018
40
A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity.
Rowena L Sison-Young, Volker M Lauschke, Esther Johann, Eliane Alexandre, Sébastien Antherieu, Hélène Aerts, Helga H J Gerets, Gilles Labbe, Delphine Hoët, Martina Dorau,[...]. Arch Toxicol 2017
Rowena L Sison-Young, Volker M Lauschke, Esther Johann, Eliane Alexandre, Sébastien Antherieu, Hélène Aerts, Helga H J Gerets, Gilles Labbe, Delphine Hoët, Martina Dorau,[...]. Arch Toxicol 2017
40
Human liver cell spheroids in extended perfusion bioreactor culture for repeated-dose drug testing.
Rui M Tostões, Sofia B Leite, Margarida Serra, Janne Jensen, Petter Björquist, Manuel J T Carrondo, Catarina Brito, Paula M Alves. Hepatology 2012
Rui M Tostões, Sofia B Leite, Margarida Serra, Janne Jensen, Petter Björquist, Manuel J T Carrondo, Catarina Brito, Paula M Alves. Hepatology 2012
40
A comparison of whole genome gene expression profiles of HepaRG cells and HepG2 cells to primary human hepatocytes and human liver tissues.
Steven N Hart, Ye Li, Kaori Nakamoto, Eva-anne Subileau, David Steen, Xiao-bo Zhong. Drug Metab Dispos 2010
Steven N Hart, Ye Li, Kaori Nakamoto, Eva-anne Subileau, David Steen, Xiao-bo Zhong. Drug Metab Dispos 2010
40
Perfused multiwell plate for 3D liver tissue engineering.
Karel Domansky, Walker Inman, James Serdy, Ajit Dash, Matthew H M Lim, Linda G Griffith. Lab Chip 2010
Karel Domansky, Walker Inman, James Serdy, Ajit Dash, Matthew H M Lim, Linda G Griffith. Lab Chip 2010
40
3D spheroid culture of hESC/hiPSC-derived hepatocyte-like cells for drug toxicity testing.
Kazuo Takayama, Kenji Kawabata, Yasuhito Nagamoto, Keisuke Kishimoto, Katsuhisa Tashiro, Fuminori Sakurai, Masashi Tachibana, Katsuhiro Kanda, Takao Hayakawa, Miho Kusuda Furue,[...]. Biomaterials 2013
Kazuo Takayama, Kenji Kawabata, Yasuhito Nagamoto, Keisuke Kishimoto, Katsuhisa Tashiro, Fuminori Sakurai, Masashi Tachibana, Katsuhiro Kanda, Takao Hayakawa, Miho Kusuda Furue,[...]. Biomaterials 2013
40
Bioprinted 3D Primary Liver Tissues Allow Assessment of Organ-Level Response to Clinical Drug Induced Toxicity In Vitro.
Deborah G Nguyen, Juergen Funk, Justin B Robbins, Candace Crogan-Grundy, Sharon C Presnell, Thomas Singer, Adrian B Roth. PLoS One 2016
Deborah G Nguyen, Juergen Funk, Justin B Robbins, Candace Crogan-Grundy, Sharon C Presnell, Thomas Singer, Adrian B Roth. PLoS One 2016
40
Control of oxygen tension recapitulates zone-specific functions in human liver microphysiology systems.
Felipe T Lee-Montiel, Subin M George, Albert H Gough, Anup D Sharma, Juanfang Wu, Richard DeBiasio, Lawrence A Vernetti, D Lansing Taylor. Exp Biol Med (Maywood) 2017
Felipe T Lee-Montiel, Subin M George, Albert H Gough, Anup D Sharma, Juanfang Wu, Richard DeBiasio, Lawrence A Vernetti, D Lansing Taylor. Exp Biol Med (Maywood) 2017
40
Prediction of Drug Clearance and Drug-Drug Interactions in Microscale Cultures of Human Hepatocytes.
Christine Lin, Julianne Shi, Amanda Moore, Salman R Khetani. Drug Metab Dispos 2016
Christine Lin, Julianne Shi, Amanda Moore, Salman R Khetani. Drug Metab Dispos 2016
40
Species differences between mouse, rat, dog, monkey and human CYP-mediated drug metabolism, inhibition and induction.
Marcella Martignoni, Geny M M Groothuis, Ruben de Kanter. Expert Opin Drug Metab Toxicol 2006
Marcella Martignoni, Geny M M Groothuis, Ruben de Kanter. Expert Opin Drug Metab Toxicol 2006
40
Evaluation of human hepatocytes cultured by three-dimensional spheroid systems for drug metabolism.
Takako Ohkura, Kunihiro Ohta, Takuya Nagao, Kumiko Kusumoto, Akiko Koeda, Tadayoshi Ueda, Tomoko Jomura, Takeshi Ikeya, Emiko Ozeki, Kazuki Wada,[...]. Drug Metab Pharmacokinet 2014
Takako Ohkura, Kunihiro Ohta, Takuya Nagao, Kumiko Kusumoto, Akiko Koeda, Tadayoshi Ueda, Tomoko Jomura, Takeshi Ikeya, Emiko Ozeki, Kazuki Wada,[...]. Drug Metab Pharmacokinet 2014
40
Bioprinted liver provides early insight into the role of Kupffer cells in TGF-β1 and methotrexate-induced fibrogenesis.
Leah M Norona, Deborah G Nguyen, David A Gerber, Sharon C Presnell, Merrie Mosedale, Paul B Watkins. PLoS One 2019
Leah M Norona, Deborah G Nguyen, David A Gerber, Sharon C Presnell, Merrie Mosedale, Paul B Watkins. PLoS One 2019
40
Exploring Chronic Drug Effects on Microengineered Human Liver Cultures Using Global Gene Expression Profiling.
Brenton R Ware, Michael McVay, Wendy Y Sunada, Salman R Khetani. Toxicol Sci 2017
Brenton R Ware, Michael McVay, Wendy Y Sunada, Salman R Khetani. Toxicol Sci 2017
40
Integrated in vitro models for hepatic safety and metabolism: evaluation of a human Liver-Chip and liver spheroid.
Alison J Foster, Bhavik Chouhan, Sophie L Regan, Helen Rollison, Sara Amberntsson, Linda C Andersson, Abhishek Srivastava, Malin Darnell, Jonathan Cairns, Stanley E Lazic,[...]. Arch Toxicol 2019
Alison J Foster, Bhavik Chouhan, Sophie L Regan, Helen Rollison, Sara Amberntsson, Linda C Andersson, Abhishek Srivastava, Malin Darnell, Jonathan Cairns, Stanley E Lazic,[...]. Arch Toxicol 2019
40
A microfluidic hepatic coculture platform for cell-based drug metabolism studies.
Eric Novik, Timothy J Maguire, Piyun Chao, K C Cheng, Martin L Yarmush. Biochem Pharmacol 2010
Eric Novik, Timothy J Maguire, Piyun Chao, K C Cheng, Martin L Yarmush. Biochem Pharmacol 2010
40
Enhancing the functional maturity of induced pluripotent stem cell-derived human hepatocytes by controlled presentation of cell-cell interactions in vitro.
Dustin R Berger, Brenton R Ware, Matthew D Davidson, Samuel R Allsup, Salman R Khetani. Hepatology 2015
Dustin R Berger, Brenton R Ware, Matthew D Davidson, Samuel R Allsup, Salman R Khetani. Hepatology 2015
40
Comprehensive Evaluation of Organotypic and Microphysiological Liver Models for Prediction of Drug-Induced Liver Injury.
Yitian Zhou, Joanne X Shen, Volker M Lauschke. Front Pharmacol 2019
Yitian Zhou, Joanne X Shen, Volker M Lauschke. Front Pharmacol 2019
40
Functionally Enhanced Human Stem Cell Derived Hepatocytes in Galactosylated Cellulosic Sponges for Hepatotoxicity Testing.
Farah Tasnim, Yi-Chin Toh, Yinghua Qu, Huan Li, Derek Phan, Balakrishnan C Narmada, Abhishek Ananthanarayanan, Nikhil Mittal, Ryan Q Meng, Hanry Yu. Mol Pharm 2016
Farah Tasnim, Yi-Chin Toh, Yinghua Qu, Huan Li, Derek Phan, Balakrishnan C Narmada, Abhishek Ananthanarayanan, Nikhil Mittal, Ryan Q Meng, Hanry Yu. Mol Pharm 2016
40
Advances in Engineered Liver Models for Investigating Drug-Induced Liver Injury.
Christine Lin, Salman R Khetani. Biomed Res Int 2016
Christine Lin, Salman R Khetani. Biomed Res Int 2016
40
Organs-on-a-Chip: A Fast Track for Engineered Human Tissues in Drug Development.
Kacey Ronaldson-Bouchard, Gordana Vunjak-Novakovic. Cell Stem Cell 2018
Kacey Ronaldson-Bouchard, Gordana Vunjak-Novakovic. Cell Stem Cell 2018
30
Mimicking liver sinusoidal structures and functions using a 3D-configured microfluidic chip.
Yu Du, Ning Li, Hao Yang, Chunhua Luo, Yixin Gong, Chunfang Tong, Yuxin Gao, Shouqin Lü, Mian Long. Lab Chip 2017
Yu Du, Ning Li, Hao Yang, Chunhua Luo, Yixin Gong, Chunfang Tong, Yuxin Gao, Shouqin Lü, Mian Long. Lab Chip 2017
30
Three-dimensional co-culture of human hepatocytes and mesenchymal stem cells: improved functionality in long-term bioreactor cultures.
Sofia P Rebelo, Rita Costa, Marta M Silva, Paulo Marcelino, Catarina Brito, Paula M Alves. J Tissue Eng Regen Med 2017
Sofia P Rebelo, Rita Costa, Marta M Silva, Paulo Marcelino, Catarina Brito, Paula M Alves. J Tissue Eng Regen Med 2017
30
Perfused human hepatocyte microtissues identify reactive metabolite-forming and mitochondria-perturbing hepatotoxins.
Cliff Rowe, Mohsen Shaeri, Emma Large, Terri Cornforth, Angela Robinson, Tomasz Kostrzewski, Rowena Sison-Young, Christopher Goldring, Kevin Park, David Hughes. Toxicol In Vitro 2018
Cliff Rowe, Mohsen Shaeri, Emma Large, Terri Cornforth, Angela Robinson, Tomasz Kostrzewski, Rowena Sison-Young, Christopher Goldring, Kevin Park, David Hughes. Toxicol In Vitro 2018
30
Development of an in vitro human liver system for interrogating nonalcoholic steatohepatitis.
Ryan E Feaver, Banumathi K Cole, Mark J Lawson, Stephen A Hoang, Svetlana Marukian, Brett R Blackman, Robert A Figler, Arun J Sanyal, Brian R Wamhoff, Ajit Dash. JCI Insight 2016
Ryan E Feaver, Banumathi K Cole, Mark J Lawson, Stephen A Hoang, Svetlana Marukian, Brett R Blackman, Robert A Figler, Arun J Sanyal, Brian R Wamhoff, Ajit Dash. JCI Insight 2016
30
Meeting the challenge of predicting hepatic clearance of compounds slowly metabolized by cytochrome P450 using a novel hepatocyte model, HepatoPac.
Tom S Chan, Hongbin Yu, Amanda Moore, Salman R Khetani, Donald Tweedie. Drug Metab Dispos 2013
Tom S Chan, Hongbin Yu, Amanda Moore, Salman R Khetani, Donald Tweedie. Drug Metab Dispos 2013
30
A human liver microphysiology platform for investigating physiology, drug safety, and disease models.
Lawrence A Vernetti, Nina Senutovitch, Robert Boltz, Richard DeBiasio, Tong Ying Shun, Albert Gough, D Lansing Taylor. Exp Biol Med (Maywood) 2016
Lawrence A Vernetti, Nina Senutovitch, Robert Boltz, Richard DeBiasio, Tong Ying Shun, Albert Gough, D Lansing Taylor. Exp Biol Med (Maywood) 2016
30
Phenotypic and functional analyses show stem cell-derived hepatocyte-like cells better mimic fetal rather than adult hepatocytes.
Melissa Baxter, Sarah Withey, Sean Harrison, Charis-Patricia Segeritz, Fang Zhang, Rebecca Atkinson-Dell, Cliff Rowe, Dave T Gerrard, Rowena Sison-Young, Roz Jenkins,[...]. J Hepatol 2015
Melissa Baxter, Sarah Withey, Sean Harrison, Charis-Patricia Segeritz, Fang Zhang, Rebecca Atkinson-Dell, Cliff Rowe, Dave T Gerrard, Rowena Sison-Young, Roz Jenkins,[...]. J Hepatol 2015
30
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.