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Human primary liver cancer-derived organoid cultures for disease modeling and drug screening.
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Prospective derivation of a living organoid biobank of colorectal cancer patients.
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A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity.
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Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche.
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Patient-derived organoids model treatment response of metastatic gastrointestinal cancers.
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A Comprehensive Human Gastric Cancer Organoid Biobank Captures Tumor Subtype Heterogeneity and Enables Therapeutic Screening.
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Generation of Tumor-Reactive T Cells by Co-culture of Peripheral Blood Lymphocytes and Tumor Organoids.
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Organoid Modeling of the Tumor Immune Microenvironment.
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Organoid cultures derived from patients with advanced prostate cancer.
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Organoid models of human and mouse ductal pancreatic cancer.
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Human primary liver cancer organoids reveal intratumor and interpatient drug response heterogeneity.
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Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium.
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Human Pancreatic Tumor Organoids Reveal Loss of Stem Cell Niche Factor Dependence during Disease Progression.
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Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer.
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A Colorectal Tumor Organoid Library Demonstrates Progressive Loss of Niche Factor Requirements during Tumorigenesis.
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In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration.
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Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids.
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Patient-derived lung cancer organoids as in vitro cancer models for therapeutic screening.
Minsuh Kim, Hyemin Mun, Chang Oak Sung, Eun Jeong Cho, Hye-Joon Jeon, Sung-Min Chun, Da Jung Jung, Tae Hoon Shin, Gi Seok Jeong, Dong Kwan Kim,[...]. Nat Commun 2019
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An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity.
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Oded Kopper, Chris J de Witte, Kadi Lõhmussaar, Jose Espejo Valle-Inclan, Nizar Hami, Lennart Kester, Anjali Vanita Balgobind, Jeroen Korving, Natalie Proost, Harry Begthel,[...]. Nat Med 2019
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Patient-Derived Organoids Predict Chemoradiation Responses of Locally Advanced Rectal Cancer.
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Ye Yao, Xiaoya Xu, Lifeng Yang, Ji Zhu, Juefeng Wan, Lijun Shen, Fan Xia, Guoxiang Fu, Yun Deng, Mengxue Pan,[...]. Cell Stem Cell 2020
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Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.
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Vascularized and functional human liver from an iPSC-derived organ bud transplant.
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Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell- and patient-derived tumor organoids.
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Establishment of Patient-Derived Organoids and Drug Screening for Biliary Tract Carcinoma.
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Development of primary human pancreatic cancer organoids, matched stromal and immune cells and 3D tumor microenvironment models.
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Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation.
Laura Broutier, Amanda Andersson-Rolf, Christopher J Hindley, Sylvia F Boj, Hans Clevers, Bon-Kyoung Koo, Meritxell Huch. Nat Protoc 2016
Laura Broutier, Amanda Andersson-Rolf, Christopher J Hindley, Sylvia F Boj, Hans Clevers, Bon-Kyoung Koo, Meritxell Huch. Nat Protoc 2016
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An organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneity.
Camilla Calandrini, Frans Schutgens, Rurika Oka, Thanasis Margaritis, Tito Candelli, Luka Mathijsen, Carola Ammerlaan, Ravian L van Ineveld, Sepide Derakhshan, Sanne de Haan,[...]. Nat Commun 2020
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Pancreatic cancer organoids recapitulate disease and allow personalized drug screening.
Else Driehuis, Arne van Hoeck, Kat Moore, Sigrid Kolders, Hayley E Francies, M Can Gulersonmez, Edwin C A Stigter, Boudewijn Burgering, Veerle Geurts, Ana Gracanin,[...]. Proc Natl Acad Sci U S A 2019
Else Driehuis, Arne van Hoeck, Kat Moore, Sigrid Kolders, Hayley E Francies, M Can Gulersonmez, Edwin C A Stigter, Boudewijn Burgering, Veerle Geurts, Ana Gracanin,[...]. Proc Natl Acad Sci U S A 2019
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Human gastric cancer modelling using organoids.
Therese Seidlitz, Sebastian R Merker, Alexander Rothe, Falk Zakrzewski, Cläre von Neubeck, Konrad Grützmann, Ulrich Sommer, Christine Schweitzer, Sebastian Schölch, Heike Uhlemann,[...]. Gut 2019
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Modeling colorectal cancer using CRISPR-Cas9-mediated engineering of human intestinal organoids.
Mami Matano, Shoichi Date, Mariko Shimokawa, Ai Takano, Masayuki Fujii, Yuki Ohta, Toshiaki Watanabe, Takanori Kanai, Toshiro Sato. Nat Med 2015
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Sequential cancer mutations in cultured human intestinal stem cells.
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Organoid cultures recapitulate esophageal adenocarcinoma heterogeneity providing a model for clonality studies and precision therapeutics.
Xiaodun Li, Hayley E Francies, Maria Secrier, Juliane Perner, Ahmad Miremadi, Núria Galeano-Dalmau, William J Barendt, Laura Letchford, Genevieve M Leyden, Emma K Goffin,[...]. Nat Commun 2018
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Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer.
Daniel Öhlund, Abram Handly-Santana, Giulia Biffi, Ela Elyada, Ana S Almeida, Mariano Ponz-Sarvise, Vincenzo Corbo, Tobiloba E Oni, Stephen A Hearn, Eun Jung Lee,[...]. J Exp Med 2017
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A rectal cancer organoid platform to study individual responses to chemoradiation.
Karuna Ganesh, Chao Wu, Kevin P O'Rourke, Bryan C Szeglin, Youyun Zheng, Charles-Etienne Gabriel Sauvé, Mohammad Adileh, Isaac Wasserman, Michael R Marco, Amanda S Kim,[...]. Nat Med 2019
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A Patient-Derived Glioblastoma Organoid Model and Biobank Recapitulates Inter- and Intra-tumoral Heterogeneity.
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Divergent Routes toward Wnt and R-spondin Niche Independency during Human Gastric Carcinogenesis.
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Sorafenib in advanced hepatocellular carcinoma.
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Modeling Steatohepatitis in Humans with Pluripotent Stem Cell-Derived Organoids.
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Human ESC-derived expandable hepatic organoids enable therapeutic liver repopulation and pathophysiological modeling of alcoholic liver injury.
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In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection.
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Organogenesis in a dish: modeling development and disease using organoid technologies.
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Patient-derived organoids can predict response to chemotherapy in metastatic colorectal cancer patients.
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Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.