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Recapitulation of Human Retinal Development from Human Pluripotent Stem Cells Generates Transplantable Populations of Cone Photoreceptors.
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Transplanted hESC-Derived Retina Organoid Sheets Differentiate, Integrate, and Improve Visual Function in Retinal Degenerate Rats.
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Retinal transplantation of photoreceptors results in donor-host cytoplasmic exchange.
Tiago Santos-Ferreira, Sílvia Llonch, Oliver Borsch, Kai Postel, Jochen Haas, Marius Ader. Nat Commun 2016
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Donor and host photoreceptors engage in material transfer following transplantation of post-mitotic photoreceptor precursors.
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Transplanted photoreceptor precursors transfer proteins to host photoreceptors by a mechanism of cytoplasmic fusion.
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Optic vesicle-like structures derived from human pluripotent stem cells facilitate a customized approach to retinal disease treatment.
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Deepak A Lamba, Mike O Karl, Carol B Ware, Thomas A Reh. Proc Natl Acad Sci U S A 2006
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Photoreceptor precursors derived from three-dimensional embryonic stem cell cultures integrate and mature within adult degenerate retina.
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IGF-1 Signaling Plays an Important Role in the Formation of Three-Dimensional Laminated Neural Retina and Other Ocular Structures From Human Embryonic Stem Cells.
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Toward the generation of rod and cone photoreceptors from mouse, monkey and human embryonic stem cells.
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Identification and Correction of Mechanisms Underlying Inherited Blindness in Human iPSC-Derived Optic Cups.
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Transplantation of human embryonic stem cell-derived photoreceptors restores some visual function in Crx-deficient mice.
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Autologous Induced Stem-Cell-Derived Retinal Cells for Macular Degeneration.
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cGMP production of patient-specific iPSCs and photoreceptor precursor cells to treat retinal degenerative blindness.
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Reversal of end-stage retinal degeneration and restoration of visual function by photoreceptor transplantation.
Mandeep S Singh, Peter Charbel Issa, Rachel Butler, Chris Martin, Daniel M Lipinski, Sumathi Sekaran, Alun R Barnard, Robert E MacLaren. Proc Natl Acad Sci U S A 2013
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Use of bioreactors for culturing human retinal organoids improves photoreceptor yields.
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Three-Dimensional Retinal Organoids Facilitate the Investigation of Retinal Ganglion Cell Development, Organization and Neurite Outgrowth from Human Pluripotent Stem Cells.
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Merging organoid and organ-on-a-chip technology to generate complex multi-layer tissue models in a human retina-on-a-chip platform.
Kevin Achberger, Christopher Probst, Jasmin Haderspeck, Sylvia Bolz, Julia Rogal, Johanna Chuchuy, Marina Nikolova, Virginia Cora, Lena Antkowiak, Wadood Haq,[...]. Elife 2019
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Accelerated and Improved Differentiation of Retinal Organoids from Pluripotent Stem Cells in Rotating-Wall Vessel Bioreactors.
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Repair of the degenerate retina by photoreceptor transplantation.
Amanda C Barber, Claire Hippert, Yanai Duran, Emma L West, James W B Bainbridge, Katherine Warre-Cornish, Ulrich F O Luhmann, Jorn Lakowski, Jane C Sowden, Robin R Ali,[...]. Proc Natl Acad Sci U S A 2013
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Retinal Organoids from Pluripotent Stem Cells Efficiently Recapitulate Retinogenesis.
Manuela Völkner, Marlen Zschätzsch, Maria Rostovskaya, Rupert W Overall, Volker Busskamp, Konstantinos Anastassiadis, Mike O Karl. Stem Cell Reports 2016
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Transplantation of photoreceptors into the degenerative retina: Current state and future perspectives.
Sylvia J Gasparini, Sílvia Llonch, Oliver Borsch, Marius Ader. Prog Retin Eye Res 2019
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Medium- to long-term survival and functional examination of human iPSC-derived retinas in rat and primate models of retinal degeneration.
Hung-Ya Tu, Takehito Watanabe, Hiroshi Shirai, Suguru Yamasaki, Masaharu Kinoshita, Keizo Matsushita, Tomoyo Hashiguchi, Hirotaka Onoe, Take Matsuyama, Atsushi Kuwahara,[...]. EBioMedicine 2019
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Differentiation and Transplantation of Embryonic Stem Cell-Derived Cone Photoreceptors into a Mouse Model of End-Stage Retinal Degeneration.
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Increased integration of transplanted CD73-positive photoreceptor precursors into adult mouse retina.
Dominic Eberle, Sandra Schubert, Kai Postel, Denis Corbeil, Marius Ader. Invest Ophthalmol Vis Sci 2011
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Isolation and Comparative Transcriptome Analysis of Human Fetal and iPSC-Derived Cone Photoreceptor Cells.
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Human embryonic stem cell-derived retinal pigment epithelium in patients with age-related macular degeneration and Stargardt's macular dystrophy: follow-up of two open-label phase 1/2 studies.
Steven D Schwartz, Carl D Regillo, Byron L Lam, Dean Eliott, Philip J Rosenfeld, Ninel Z Gregori, Jean-Pierre Hubschman, Janet L Davis, Gad Heilwell, Marc Spirn,[...]. Lancet 2015
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Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.