A citation-based method for searching scientific literature

Denise Wootten, Arthur Christopoulos, Maria Marti-Solano, M Madan Babu, Patrick M Sexton. Nat Rev Mol Cell Biol 2018
Times Cited: 254







List of co-cited articles
950 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity


Trends in GPCR drug discovery: new agents, targets and indications.
Alexander S Hauser, Misty M Attwood, Mathias Rask-Andersen, Helgi B Schiöth, David E Gloriam. Nat Rev Drug Discov 2017
21

Biased signalling: from simple switches to allosteric microprocessors.
Jeffrey S Smith, Robert J Lefkowitz, Sudarshan Rajagopal. Nat Rev Drug Discov 2018
323
21

Signalling bias in new drug discovery: detection, quantification and therapeutic impact.
Terry Kenakin, Arthur Christopoulos. Nat Rev Drug Discov 2013
530
14

Angiotensin and biased analogs induce structurally distinct active conformations within a GPCR.
Laura M Wingler, Meredith A Skiba, Conor McMahon, Dean P Staus, Alissa L W Kleinhenz, Carl-Mikael Suomivuori, Naomi R Latorraca, Ron O Dror, Robert J Lefkowitz, Andrew C Kruse. Science 2020
82
17

The Molecular Basis of G Protein-Coupled Receptor Activation.
William I Weis, Brian K Kobilka. Annu Rev Biochem 2018
379
14


Structure-based discovery of opioid analgesics with reduced side effects.
Aashish Manglik, Henry Lin, Dipendra K Aryal, John D McCorvy, Daniela Dengler, Gregory Corder, Anat Levit, Ralf C Kling, Viachaslau Bernat, Harald Hübner,[...]. Nature 2016
520
11

Crystal structure of the β2 adrenergic receptor-Gs protein complex.
Søren G F Rasmussen, Brian T DeVree, Yaozhong Zou, Andrew C Kruse, Ka Young Chung, Tong Sun Kobilka, Foon Sun Thian, Pil Seok Chae, Els Pardon, Diane Calinski,[...]. Nature 2011
11

Molecular mechanism of biased signaling in a prototypical G protein-coupled receptor.
Carl-Mikael Suomivuori, Naomi R Latorraca, Laura M Wingler, Stephan Eismann, Matthew C King, Alissa L W Kleinhenz, Meredith A Skiba, Dean P Staus, Andrew C Kruse, Robert J Lefkowitz,[...]. Science 2020
86
12

Conformational Basis of G Protein-Coupled Receptor Signaling Versatility.
Laura M Wingler, Robert J Lefkowitz. Trends Cell Biol 2020
54
20

Structure and dynamics of GPCR signaling complexes.
Daniel Hilger, Matthieu Masureel, Brian K Kobilka. Nat Struct Mol Biol 2018
354
10

Molecular basis of β-arrestin coupling to formoterol-bound β1-adrenoceptor.
Yang Lee, Tony Warne, Rony Nehmé, Shubhi Pandey, Hemlata Dwivedi-Agnihotri, Madhu Chaturvedi, Patricia C Edwards, Javier García-Nafría, Andrew G W Leslie, Arun K Shukla,[...]. Nature 2020
81
12

Transduction of receptor signals by beta-arrestins.
Robert J Lefkowitz, Sudha K Shenoy. Science 2005
9

Biased agonism: An emerging paradigm in GPCR drug discovery.
Zoran Rankovic, Tarsis F Brust, Laura M Bohn. Bioorg Med Chem Lett 2016
166
9

Low intrinsic efficacy for G protein activation can explain the improved side effect profiles of new opioid agonists.
Alexander Gillis, Arisbel B Gondin, Andrea Kliewer, Julie Sanchez, Herman D Lim, Claudia Alamein, Preeti Manandhar, Marina Santiago, Sebastian Fritzwanker, Frank Schmiedel,[...]. Sci Signal 2020
115
9

Quantifying ligand bias at seven-transmembrane receptors.
Sudarshan Rajagopal, Seungkirl Ahn, David H Rominger, William Gowen-MacDonald, Christopher M Lam, Scott M Dewire, Jonathan D Violin, Robert J Lefkowitz. Mol Pharmacol 2011
267
9

Structure of the M2 muscarinic receptor-β-arrestin complex in a lipid nanodisc.
Dean P Staus, Hongli Hu, Michael J Robertson, Alissa L W Kleinhenz, Laura M Wingler, William D Capel, Naomi R Latorraca, Robert J Lefkowitz, Georgios Skiniotis. Nature 2020
124
9

Structure of the neurotensin receptor 1 in complex with β-arrestin 1.
Weijiao Huang, Matthieu Masureel, Qianhui Qu, John Janetzko, Asuka Inoue, Hideaki E Kato, Michael J Robertson, Khanh C Nguyen, Jeffrey S Glenn, Georgios Skiniotis,[...]. Nature 2020
125
9

Biased Receptor Signaling in Drug Discovery.
Terry Kenakin. Pharmacol Rev 2019
117
8

GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling.
Alex R B Thomsen, Bianca Plouffe, Thomas J Cahill, Arun K Shukla, Jeffrey T Tarrasch, Annie M Dosey, Alem W Kahsai, Ryan T Strachan, Biswaranjan Pani, Jacob P Mahoney,[...]. Cell 2016
303
8

Morphine side effects in beta-arrestin 2 knockout mice.
Kirsten M Raehal, Julia K L Walker, Laura M Bohn. J Pharmacol Exp Ther 2005
396
8

GPCR Signaling Regulation: The Role of GRKs and Arrestins.
Vsevolod V Gurevich, Eugenia V Gurevich. Front Pharmacol 2019
183
8

Distinct conformations of GPCR-β-arrestin complexes mediate desensitization, signaling, and endocytosis.
Thomas J Cahill, Alex R B Thomsen, Jeffrey T Tarrasch, Bianca Plouffe, Anthony H Nguyen, Fan Yang, Li-Yin Huang, Alem W Kahsai, Daniel L Bassoni, Bryant J Gavino,[...]. Proc Natl Acad Sci U S A 2017
189
8

Manifold roles of β-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9.
Louis M Luttrell, Jialu Wang, Bianca Plouffe, Jeffrey S Smith, Lama Yamani, Suneet Kaur, Pierre-Yves Jean-Charles, Christophe Gauthier, Mi-Hye Lee, Biswaranjan Pani,[...]. Sci Signal 2018
107
8

Illuminating G-Protein-Coupling Selectivity of GPCRs.
Asuka Inoue, Francesco Raimondi, Francois Marie Ngako Kadji, Gurdeep Singh, Takayuki Kishi, Akiharu Uwamizu, Yuki Ono, Yuji Shinjo, Satoru Ishida, Nadia Arang,[...]. Cell 2019
175
8

TRUPATH, an open-source biosensor platform for interrogating the GPCR transducerome.
Reid H J Olsen, Jeffrey F DiBerto, Justin G English, Alexis M Glaudin, Brian E Krumm, Samuel T Slocum, Tao Che, Ariana C Gavin, John D McCorvy, Bryan L Roth,[...]. Nat Chem Biol 2020
100
8

How Ligands Illuminate GPCR Molecular Pharmacology.
Daniel Wacker, Raymond C Stevens, Bryan L Roth. Cell 2017
275
7


Structural Insights into the Dynamic Process of β2-Adrenergic Receptor Signaling.
Aashish Manglik, Tae Hun Kim, Matthieu Masureel, Christian Altenbach, Zhongyu Yang, Daniel Hilger, Michael T Lerch, Tong Sun Kobilka, Foon Sun Thian, Wayne L Hubbell,[...]. Cell 2015
395
7

Enhanced morphine analgesia in mice lacking beta-arrestin 2.
L M Bohn, R J Lefkowitz, R R Gainetdinov, K Peppel, M G Caron, F T Lin. Science 1999
731
7

Fulfilling the Promise of "Biased" G Protein-Coupled Receptor Agonism.
Louis M Luttrell, Stuart Maudsley, Laura M Bohn. Mol Pharmacol 2015
140
7

Phase-plate cryo-EM structure of a class B GPCR-G-protein complex.
Yi-Lynn Liang, Maryam Khoshouei, Mazdak Radjainia, Yan Zhang, Alisa Glukhova, Jeffrey Tarrasch, David M Thal, Sebastian G B Furness, George Christopoulos, Thomas Coudrat,[...]. Nature 2017
306
7

Structural features for functional selectivity at serotonin receptors.
Daniel Wacker, Chong Wang, Vsevolod Katritch, Gye Won Han, Xi-Ping Huang, Eyal Vardy, John D McCorvy, Yi Jiang, Meihua Chu, Fai Yiu Siu,[...]. Science 2013
468
7

Morphine-induced respiratory depression is independent of β-arrestin2 signalling.
Andrea Kliewer, Alexander Gillis, Rob Hill, Frank Schmiedel, Chris Bailey, Eamonn Kelly, Graeme Henderson, Macdonald J Christie, Stefan Schulz. Br J Pharmacol 2020
100
7

The role of kinetic context in apparent biased agonism at GPCRs.
Carmen Klein Herenbrink, David A Sykes, Prashant Donthamsetti, Meritxell Canals, Thomas Coudrat, Jeremy Shonberg, Peter J Scammells, Ben Capuano, Patrick M Sexton, Steven J Charlton,[...]. Nat Commun 2016
210
7

Generic GPCR residue numbers - aligning topology maps while minding the gaps.
Vignir Isberg, Chris de Graaf, Andrea Bortolato, Vadim Cherezov, Vsevolod Katritch, Fiona H Marshall, Stefan Mordalski, Jean-Philippe Pin, Raymond C Stevens, Gerrit Vriend,[...]. Trends Pharmacol Sci 2015
246
7

Structure of the µ-opioid receptor-Gi protein complex.
Antoine Koehl, Hongli Hu, Shoji Maeda, Yan Zhang, Qianhui Qu, Joseph M Paggi, Naomi R Latorraca, Daniel Hilger, Roger Dawson, Hugues Matile,[...]. Nature 2018
315
7

Structural determinants of 5-HT2B receptor activation and biased agonism.
John D McCorvy, Daniel Wacker, Sheng Wang, Bemnat Agegnehu, Jing Liu, Katherine Lansu, Alexandra R Tribo, Reid H J Olsen, Tao Che, Jian Jin,[...]. Nat Struct Mol Biol 2018
62
9

Functional selectivity and classical concepts of quantitative pharmacology.
Jonathan D Urban, William P Clarke, Mark von Zastrow, David E Nichols, Brian Kobilka, Harel Weinstein, Jonathan A Javitch, Bryan L Roth, Arthur Christopoulos, Patrick M Sexton,[...]. J Pharmacol Exp Ther 2007
821
6

Formyl-Peptide Receptors in Infection, Inflammation, and Cancer.
Elisabeth Weiß, Dorothee Kretschmer. Trends Immunol 2018
77
7

A comprehensive map of molecular drug targets.
Rita Santos, Oleg Ursu, Anna Gaulton, A Patrícia Bento, Ramesh S Donadi, Cristian G Bologa, Anneli Karlsson, Bissan Al-Lazikani, Anne Hersey, Tudor I Oprea,[...]. Nat Rev Drug Discov 2017
929
6

Biased ligands at G-protein-coupled receptors: promise and progress.
Jonathan D Violin, Aimee L Crombie, David G Soergel, Michael W Lark. Trends Pharmacol Sci 2014
247
6

A simple method for quantifying functional selectivity and agonist bias.
Terry Kenakin, Christian Watson, Vanessa Muniz-Medina, Arthur Christopoulos, Steven Novick. ACS Chem Neurosci 2012
317
6

Bias Factor and Therapeutic Window Correlate to Predict Safer Opioid Analgesics.
Cullen L Schmid, Nicole M Kennedy, Nicolette C Ross, Kimberly M Lovell, Zhizhou Yue, Jenny Morgenweck, Michael D Cameron, Thomas D Bannister, Laura M Bohn. Cell 2017
276
6

Diverse activation pathways in class A GPCRs converge near the G-protein-coupling region.
A J Venkatakrishnan, Xavier Deupi, Guillaume Lebon, Franziska M Heydenreich, Tilman Flock, Tamara Miljus, Santhanam Balaji, Michel Bouvier, Dmitry B Veprintsev, Christopher G Tate,[...]. Nature 2016
169
6

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein-coupled receptors.
Stephen P H Alexander, Arthur Christopoulos, Anthony P Davenport, Eamonn Kelly, Alistair Mathie, John A Peters, Emma L Veale, Jane F Armstrong, Elena Faccenda, Simon D Harding,[...]. Br J Pharmacol 2019
498
6

Biased signaling pathways in β2-adrenergic receptor characterized by 19F-NMR.
Jeffrey J Liu, Reto Horst, Vsevolod Katritch, Raymond C Stevens, Kurt Wüthrich. Science 2012
485
6

Functional selectivity profiling of the angiotensin II type 1 receptor using pathway-wide BRET signaling sensors.
Yoon Namkung, Christian LeGouill, Sahil Kumar, Yubo Cao, Larissa B Teixeira, Viktoriya Lukasheva, Jenna Giubilaro, Sarah C Simões, Jean-Michel Longpré, Dominic Devost,[...]. Sci Signal 2018
56
10

Biased Agonism in Drug Discovery-Is It Too Soon to Choose a Path?
Martin C Michel, Steven J Charlton. Mol Pharmacol 2018
54
11

GPCR Dynamics: Structures in Motion.
Naomi R Latorraca, A J Venkatakrishnan, Ron O Dror. Chem Rev 2017
333
6


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.