Joseph K Rathkey, Junjie Zhao, Zhonghua Liu, Yinghua Chen, Jie Yang, Hannah C Kondolf, Bryan L Benson, Steven M Chirieleison, Alex Y Huang, George R Dubyak, Tsan S Xiao, Xiaoxia Li, Derek W Abbott. Sci Immunol 2018
Times Cited: 179
Times Cited: 179
Times Cited
Times Co-cited
Similarity
Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores.
Xing Liu, Zhibin Zhang, Jianbin Ruan, Youdong Pan, Venkat Giri Magupalli, Hao Wu, Judy Lieberman. Nature 2016
Xing Liu, Zhibin Zhang, Jianbin Ruan, Youdong Pan, Venkat Giri Magupalli, Hao Wu, Judy Lieberman. Nature 2016
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Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death.
Jianjin Shi, Yue Zhao, Kun Wang, Xuyan Shi, Yue Wang, Huanwei Huang, Yinghua Zhuang, Tao Cai, Fengchao Wang, Feng Shao. Nature 2015
Jianjin Shi, Yue Zhao, Kun Wang, Xuyan Shi, Yue Wang, Huanwei Huang, Yinghua Zhuang, Tao Cai, Fengchao Wang, Feng Shao. Nature 2015
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FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation.
Jun Jacob Hu, Xing Liu, Shiyu Xia, Zhibin Zhang, Ying Zhang, Jingxia Zhao, Jianbin Ruan, Xuemei Luo, Xiwen Lou, Yang Bai,[...]. Nat Immunol 2020
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Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling.
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Pore-forming activity and structural autoinhibition of the gasdermin family.
Jingjin Ding, Kun Wang, Wang Liu, Yang She, Qi Sun, Jianjin Shi, Hanzi Sun, Da-Cheng Wang, Feng Shao. Nature 2016
Jingjin Ding, Kun Wang, Wang Liu, Yang She, Qi Sun, Jianjin Shi, Hanzi Sun, Da-Cheng Wang, Feng Shao. Nature 2016
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Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin.
Yupeng Wang, Wenqing Gao, Xuyan Shi, Jingjin Ding, Wang Liu, Huabin He, Kun Wang, Feng Shao. Nature 2017
Yupeng Wang, Wenqing Gao, Xuyan Shi, Jingjin Ding, Wang Liu, Huabin He, Kun Wang, Feng Shao. Nature 2017
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Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection.
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Succination inactivates gasdermin D and blocks pyroptosis.
Fiachra Humphries, Liraz Shmuel-Galia, Natalia Ketelut-Carneiro, Sheng Li, Bingwei Wang, Venkatesh V Nemmara, Ruth Wilson, Zhaozhao Jiang, Farnaz Khalighinejad, Khaja Muneeruddin,[...]. Science 2020
Fiachra Humphries, Liraz Shmuel-Galia, Natalia Ketelut-Carneiro, Sheng Li, Bingwei Wang, Venkatesh V Nemmara, Ruth Wilson, Zhaozhao Jiang, Farnaz Khalighinejad, Khaja Muneeruddin,[...]. Science 2020
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The gasdermins, a protein family executing cell death and inflammation.
Petr Broz, Pablo Pelegrín, Feng Shao. Nat Rev Immunol 2020
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Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death.
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Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death.
Jianjin Shi, Wenqing Gao, Feng Shao. Trends Biochem Sci 2017
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Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion.
Wan-ting He, Haoqiang Wan, Lichen Hu, Pengda Chen, Xin Wang, Zhe Huang, Zhang-Hua Yang, Chuan-Qi Zhong, Jiahuai Han. Cell Res 2015
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ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation.
Sebastian Rühl, Kateryna Shkarina, Benjamin Demarco, Rosalie Heilig, José Carlos Santos, Petr Broz. Science 2018
Sebastian Rühl, Kateryna Shkarina, Benjamin Demarco, Rosalie Heilig, José Carlos Santos, Petr Broz. Science 2018
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The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages.
Charles L Evavold, Jianbin Ruan, Yunhao Tan, Shiyu Xia, Hao Wu, Jonathan C Kagan. Immunity 2018
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Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells.
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GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death.
Lorenzo Sborgi, Sebastian Rühl, Estefania Mulvihill, Joka Pipercevic, Rosalie Heilig, Henning Stahlberg, Christopher J Farady, Daniel J Müller, Petr Broz, Sebastian Hiller. EMBO J 2016
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Gasdermin D plays a vital role in the generation of neutrophil extracellular traps.
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Non-canonical inflammasome activation targets caspase-11.
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A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases.
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Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation.
Corey Rogers, Dan A Erkes, Alexandria Nardone, Andrew E Aplin, Teresa Fernandes-Alnemri, Emad S Alnemri. Nat Commun 2019
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GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes.
Robin A Aglietti, Alberto Estevez, Aaron Gupta, Monica Gonzalez Ramirez, Peter S Liu, Nobuhiko Kayagaki, Claudio Ciferri, Vishva M Dixit, Erin C Dueber. Proc Natl Acad Sci U S A 2016
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Inflammatory caspases are innate immune receptors for intracellular LPS.
Jianjin Shi, Yue Zhao, Yupeng Wang, Wenqing Gao, Jingjin Ding, Peng Li, Liyan Hu, Feng Shao. Nature 2014
Jianjin Shi, Yue Zhao, Yupeng Wang, Wenqing Gao, Jingjin Ding, Peng Li, Liyan Hu, Feng Shao. Nature 2014
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Gasdermin E suppresses tumour growth by activating anti-tumour immunity.
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Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death.
Corey Rogers, Teresa Fernandes-Alnemri, Lindsey Mayes, Diana Alnemri, Gino Cingolani, Emad S Alnemri. Nat Commun 2017
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The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta.
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Gasdermin D Exerts Anti-inflammatory Effects by Promoting Neutrophil Death.
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Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.
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PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis.
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NINJ1 mediates plasma membrane rupture during lytic cell death.
Nobuhiko Kayagaki, Opher S Kornfeld, Bettina L Lee, Irma B Stowe, Karen O'Rourke, Qingling Li, Wendy Sandoval, Donghong Yan, Jing Kang, Min Xu,[...]. Nature 2021
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Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase.
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The NLRP3 inflammasome: molecular activation and regulation to therapeutics.
Karen V Swanson, Meng Deng, Jenny P-Y Ting. Nat Rev Immunol 2019
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Pyroptosis and Apoptosis Pathways Engage in Bidirectional Crosstalk in Monocytes and Macrophages.
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K⁺ efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter.
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Lipid Peroxidation Drives Gasdermin D-Mediated Pyroptosis in Lethal Polymicrobial Sepsis.
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40
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.