A citation-based method for searching scientific literature

A Bachmair, D Finley, A Varshavsky. Science 1986
Times Cited: 1519







List of co-cited articles
695 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity


N-degron and C-degron pathways of protein degradation.
Alexander Varshavsky. Proc Natl Acad Sci U S A 2019
204
36

The N-end rule pathway and regulation by proteolysis.
Alexander Varshavsky. Protein Sci 2011
436
30

The N-end rule pathway.
Takafumi Tasaki, Shashikanth M Sriram, Kyong Soo Park, Yong Tae Kwon. Annu Rev Biochem 2012
245
21

N-terminal acetylation of cellular proteins creates specific degradation signals.
Cheol-Sang Hwang, Anna Shemorry, Alexander Varshavsky. Science 2010
431
19

A glycine-specific N-degron pathway mediates the quality control of protein N-myristoylation.
Richard T Timms, Zhiqian Zhang, David Y Rhee, J Wade Harper, Itay Koren, Stephen J Elledge. Science 2019
64
28

An N-end rule pathway that recognizes proline and destroys gluconeogenic enzymes.
Shun-Jia Chen, Xia Wu, Brandon Wadas, Jang-Hyun Oh, Alexander Varshavsky. Science 2017
105
18

The Eukaryotic Proteome Is Shaped by E3 Ubiquitin Ligases Targeting C-Terminal Degrons.
Itay Koren, Richard T Timms, Tomasz Kula, Qikai Xu, Mamie Z Li, Stephen J Elledge. Cell 2018
96
17

C-Terminal End-Directed Protein Elimination by CRL2 Ubiquitin Ligases.
Hsiu-Chuan Lin, Chi-Wei Yeh, Yen-Fu Chen, Ting-Ting Lee, Pei-Yun Hsieh, Domnita V Rusnac, Sung-Ya Lin, Stephen J Elledge, Ning Zheng, Hsueh-Chi S Yen. Mol Cell 2018
61
26

The N-end rule pathway counteracts cell death by destroying proapoptotic protein fragments.
Konstantin I Piatkov, Christopher S Brower, Alexander Varshavsky. Proc Natl Acad Sci U S A 2012
98
13

Control of protein quality and stoichiometries by N-terminal acetylation and the N-end rule pathway.
Anna Shemorry, Cheol-Sang Hwang, Alexander Varshavsky. Mol Cell 2013
194
13

Structural basis for the recognition of N-end rule substrates by the UBR box of ubiquitin ligases.
Woo Suk Choi, Byung-Cheon Jeong, Yoo Jin Joo, Myeong-Ryeol Lee, Joon Kim, Michael J Eck, Hyun Kyu Song. Nat Struct Mol Biol 2010
97
13

The degradation signal in a short-lived protein.
A Bachmair, A Varshavsky. Cell 1989
355
13

Ubiquitin Ligases: Structure, Function, and Regulation.
Ning Zheng, Nitzan Shabek. Annu Rev Biochem 2017
533
13

An essential role of N-terminal arginylation in cardiovascular development.
Yong Tae Kwon, Anna S Kashina, Ilia V Davydov, Rong-Gui Hu, Jee Young An, Jai Wha Seo, Fangyong Du, Alexander Varshavsky. Science 2002
243
12

A family of mammalian E3 ubiquitin ligases that contain the UBR box motif and recognize N-degrons.
Takafumi Tasaki, Lubbertus C F Mulder, Akihiro Iwamatsu, Min Jae Lee, Ilia V Davydov, Alexander Varshavsky, Mark Muesing, Yong Tae Kwon. Mol Cell Biol 2005
229
12


The N-end rule pathway as a nitric oxide sensor controlling the levels of multiple regulators.
Rong-Gui Hu, Jun Sheng, Xin Qi, Zhenming Xu, Terry T Takahashi, Alexander Varshavsky. Nature 2005
222
11

Neurodegeneration-associated protein fragments as short-lived substrates of the N-end rule pathway.
Christopher S Brower, Konstantin I Piatkov, Alexander Varshavsky. Mol Cell 2013
78
14

The N-end rule in bacteria.
J W Tobias, T E Shrader, G Rocap, A Varshavsky. Science 1991
420
11

Molecular basis of GID4-mediated recognition of degrons for the Pro/N-end rule pathway.
Cheng Dong, Heng Zhang, Li Li, Wolfram Tempel, Peter Loppnau, Jinrong Min. Nat Chem Biol 2018
44
25

In vivo aspects of protein folding and quality control.
David Balchin, Manajit Hayer-Hartl, F Ulrich Hartl. Science 2016
677
11



RGS4 and RGS5 are in vivo substrates of the N-end rule pathway.
Min Jae Lee, Takafumi Tasaki, Kayoko Moroi, Jee Young An, Sadao Kimura, Ilia V Davydov, Yong Tae Kwon. Proc Natl Acad Sci U S A 2005
181
9

Conserved N-terminal cysteine dioxygenases transduce responses to hypoxia in animals and plants.
Norma Masson, Thomas P Keeley, Beatrice Giuntoli, Mark D White, Mikel Lavilla Puerta, Pierdomenico Perata, Richard J Hopkinson, Emily Flashman, Francesco Licausi, Peter J Ratcliffe. Science 2019
78
11

The N-terminal methionine of cellular proteins as a degradation signal.
Heon-Ki Kim, Ryu-Ryun Kim, Jang-Hyun Oh, Hanna Cho, Alexander Varshavsky, Cheol-Sang Hwang. Cell 2014
115
9

Formyl-methionine as an N-degron of a eukaryotic N-end rule pathway.
Jeong-Mok Kim, Ok-Hee Seok, Shinyeong Ju, Ji-Eun Heo, Jeonghun Yeom, Da-Som Kim, Joo-Yeon Yoo, Alexander Varshavsky, Cheolju Lee, Cheol-Sang Hwang. Science 2018
44
20

The ubiquitin-proteasome system of Saccharomyces cerevisiae.
Daniel Finley, Helle D Ulrich, Thomas Sommer, Peter Kaiser. Genetics 2012
256
9

The N-end rule pathway is mediated by a complex of the RING-type Ubr1 and HECT-type Ufd4 ubiquitin ligases.
Cheol-Sang Hwang, Anna Shemorry, Daniel Auerbach, Alexander Varshavsky. Nat Cell Biol 2010
101
9


Homeostatic response to hypoxia is regulated by the N-end rule pathway in plants.
Daniel J Gibbs, Seung Cho Lee, Nurulhikma Md Isa, Silvia Gramuglia, Takeshi Fukao, George W Bassel, Cristina Sousa Correia, Françoise Corbineau, Frederica L Theodoulou, Julia Bailey-Serres,[...]. Nature 2011
372
8

The eukaryotic N-end rule pathway: conserved mechanisms and diverse functions.
Daniel J Gibbs, Jaume Bacardit, Andreas Bachmair, Michael J Holdsworth. Trends Cell Biol 2014
132
8

Recognition of the Diglycine C-End Degron by CRL2KLHDC2 Ubiquitin Ligase.
Domniţa-Valeria Rusnac, Hsiu-Chuan Lin, Daniele Canzani, Karena X Tien, Thomas R Hinds, Ashley F Tsue, Matthew F Bush, Hsueh-Chi S Yen, Ning Zheng. Mol Cell 2018
32
25


Calpain-generated natural protein fragments as short-lived substrates of the N-end rule pathway.
Konstantin I Piatkov, Jang-Hyun Oh, Yuan Liu, Alexander Varshavsky. Proc Natl Acad Sci U S A 2014
58
13

Gid10 as an alternative N-recognin of the Pro/N-degron pathway.
Artem Melnykov, Shun-Jia Chen, Alexander Varshavsky. Proc Natl Acad Sci U S A 2019
21
38

Control of Hsp90 chaperone and its clients by N-terminal acetylation and the N-end rule pathway.
Jang-Hyun Oh, Ju-Yeon Hyun, Alexander Varshavsky. Proc Natl Acad Sci U S A 2017
34
23


The plant N-degron pathways of ubiquitin-mediated proteolysis.
Michael John Holdsworth, Jorge Vicente, Gunjan Sharma, Mohamad Abbas, Agata Zubrycka. J Integr Plant Biol 2020
27
29

Discovery of cellular regulation by protein degradation.
Alexander Varshavsky. J Biol Chem 2008
73
10

PINK1 is degraded through the N-end rule pathway.
Koji Yamano, Richard J Youle. Autophagy 2013
365
8

Structural basis of substrate recognition and specificity in the N-end rule pathway.
Edna Matta-Camacho, Guennadi Kozlov, Flora F Li, Kalle Gehring. Nat Struct Mol Biol 2010
74
10

Diversity of degradation signals in the ubiquitin-proteasome system.
Tommer Ravid, Mark Hochstrasser. Nat Rev Mol Cell Biol 2008
557
7

Plant cysteine oxidases control the oxygen-dependent branch of the N-end-rule pathway.
Daan A Weits, Beatrice Giuntoli, Monika Kosmacz, Sandro Parlanti, Hans-Michael Hubberten, Heike Riegler, Rainer Hoefgen, Pierdomenico Perata, Joost T van Dongen, Francesco Licausi. Nat Commun 2014
183
7

Oxygen sensing in plants is mediated by an N-end rule pathway for protein destabilization.
Francesco Licausi, Monika Kosmacz, Daan A Weits, Beatrice Giuntoli, Federico M Giorgi, Laurentius A C J Voesenek, Pierdomenico Perata, Joost T van Dongen. Nature 2011
389
7

Plant cysteine oxidases are dioxygenases that directly enable arginyl transferase-catalysed arginylation of N-end rule targets.
Mark D White, Maria Klecker, Richard J Hopkinson, Daan A Weits, Carolin Mueller, Christin Naumann, Rebecca O'Neill, James Wickens, Jiayu Yang, Jonathan C Brooks-Bartlett,[...]. Nat Commun 2017
100
7

The auto-generated fragment of the Usp1 deubiquitylase is a physiological substrate of the N-end rule pathway.
Konstantin I Piatkov, Luca Colnaghi, Miklos Békés, Alexander Varshavsky, Tony T Huang. Mol Cell 2012
50
14

First Things First: Vital Protein Marks by N-Terminal Acetyltransferases.
Henriette Aksnes, Adrian Drazic, Michaël Marie, Thomas Arnesen. Trends Biochem Sci 2016
136
7

The substrate recognition domains of the N-end rule pathway.
Takafumi Tasaki, Adriana Zakrzewska, Drew D Dudgeon, Yonghua Jiang, John S Lazo, Yong Tae Kwon. J Biol Chem 2009
89
7

Basic Medical Research Award. The ubiquitin system.
A Hershko, A Ciechanover, A Varshavsky. Nat Med 2000
528
7


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.