A citation-based method for searching scientific literature


List of co-cited articles
197 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity



Beyond the Rule of 5: Lessons Learned from AbbVie's Drugs and Compound Collection.
David A DeGoey, Hui-Ju Chen, Philip B Cox, Michael D Wendt. J. Med. Chem. 2018
32
31

Oral druggable space beyond the rule of 5: insights from drugs and clinical candidates.
Bradley Croy Doak, Bjӧrn Over, Fabrizio Giordanetto, Jan Kihlberg. Chem. Biol. 2014
127
20

Molecular properties that influence the oral bioavailability of drug candidates.
Daniel F Veber, Stephen R Johnson, Hung-Yuan Cheng, Brian R Smith, Keith W Ward, Kenneth D Kopple. J. Med. Chem. 2002
16


New Modalities for Challenging Targets in Drug Discovery.
Eric Valeur, Stéphanie M Guéret, Hélène Adihou, Ranganath Gopalakrishnan, Malin Lemurell, Herbert Waldmann, Tom N Grossmann, Alleyn T Plowright. Angew. Chem. Int. Ed. Engl. 2017
81
16

The role of ligand efficiency metrics in drug discovery.
Andrew L Hopkins, György M Keserü, Paul D Leeson, David C Rees, Charles H Reynolds. Nat Rev Drug Discov 2014
347
11

How Beyond Rule of 5 Drugs and Clinical Candidates Bind to Their Targets.
Bradley C Doak, Jie Zheng, Doreen Dobritzsch, Jan Kihlberg. J. Med. Chem. 2016
80
11

Quantifying the chameleonic properties of macrocycles and other high-molecular-weight drugs.
Adrian Whitty, Mengqi Zhong, Lauren Viarengo, Dmitri Beglov, David R Hall, Sandor Vajda. Drug Discov. Today 2016
45
11

How proteins bind macrocycles.
Elizabeth A Villar, Dmitri Beglov, Spandan Chennamadhavuni, John A Porco, Dima Kozakov, Sandor Vajda, Adrian Whitty. Nat. Chem. Biol. 2014
157
11

Lead- and drug-like compounds: the rule-of-five revolution.
Christopher A Lipinski. Drug Discov Today Technol 2004
928
11

Catalytic in vivo protein knockdown by small-molecule PROTACs.
Daniel P Bondeson, Alina Mares, Ian E D Smith, Eunhwa Ko, Sebastien Campos, Afjal H Miah, Katie E Mulholland, Natasha Routly, Dennis L Buckley, Jeffrey L Gustafson,[...]. Nat. Chem. Biol. 2015
271
11

DRUG DEVELOPMENT. Phthalimide conjugation as a strategy for in vivo target protein degradation.
Georg E Winter, Dennis L Buckley, Joshiawa Paulk, Justin M Roberts, Amanda Souza, Sirano Dhe-Paganon, James E Bradner. Science 2015
428
11

SPR-Measured Dissociation Kinetics of PROTAC Ternary Complexes Influence Target Degradation Rate.
Michael J Roy, Sandra Winkler, Scott J Hughes, Claire Whitworth, Michael Galant, William Farnaby, Klaus Rumpel, Alessio Ciulli. ACS Chem. Biol. 2019
29
17

Small Molecule Inhibition of microRNA-210 Reprograms an Oncogenic Hypoxic Circuit.
Matthew G Costales, Christopher L Haga, Sai Pradeep Velagapudi, Jessica L Childs-Disney, Donald G Phinney, Matthew D Disney. J. Am. Chem. Soc. 2017
57
9

Precise small-molecule recognition of a toxic CUG RNA repeat expansion.
Suzanne G Rzuczek, Lesley A Colgan, Yoshio Nakai, Michael D Cameron, Denis Furling, Ryohei Yasuda, Matthew D Disney. Nat. Chem. Biol. 2017
82
9

Incorporating chemical modification constraints into a dynamic programming algorithm for prediction of RNA secondary structure.
David H Mathews, Matthew D Disney, Jessica L Childs, Susan J Schroeder, Michael Zuker, Douglas H Turner. Proc. Natl. Acad. Sci. U.S.A. 2004
790
9

Sequence-based design of bioactive small molecules that target precursor microRNAs.
Sai Pradeep Velagapudi, Steven M Gallo, Matthew D Disney. Nat. Chem. Biol. 2014
152
9

The druggable genome.
Andrew L Hopkins, Colin R Groom. Nat Rev Drug Discov 2002
9

Small Molecule Targeted Recruitment of a Nuclease to RNA.
Matthew G Costales, Yasumasa Matsumoto, Sai Pradeep Velagapudi, Matthew D Disney. J. Am. Chem. Soc. 2018
36
11

Drug discovery beyond the 'rule-of-five'.
Ming-Qiang Zhang, Barrie Wilkinson. Curr. Opin. Biotechnol. 2007
88
9

Quantifying the chemical beauty of drugs.
G Richard Bickerton, Gaia V Paolini, Jérémy Besnard, Sorel Muresan, Andrew L Hopkins. Nat Chem 2012
262
9

Molecular inflation, attrition and the rule of five.
Paul D Leeson. Adv. Drug Deliv. Rev. 2016
45
9

Impact of Dynamically Exposed Polarity on Permeability and Solubility of Chameleonic Drugs Beyond the Rule of 5.
Matteo Rossi Sebastiano, Bradley C Doak, Maria Backlund, Vasanthanathan Poongavanam, Björn Over, Giuseppe Ermondi, Giulia Caron, Pär Matsson, Jan Kihlberg. J. Med. Chem. 2018
21
19

Structural and conformational determinants of macrocycle cell permeability.
Björn Over, Pär Matsson, Christian Tyrchan, Per Artursson, Bradley C Doak, Michael A Foley, Constanze Hilgendorf, Stephen E Johnston, Maurice D Lee, Richard J Lewis,[...]. Nat. Chem. Biol. 2016
42
9

Lessons in PROTAC Design from Selective Degradation with a Promiscuous Warhead.
Daniel P Bondeson, Blake E Smith, George M Burslem, Alexandru D Buhimschi, John Hines, Saul Jaime-Figueroa, Jing Wang, Brian D Hamman, Alexey Ishchenko, Craig M Crews. Cell Chem Biol 2018
108
9

Structural basis of PROTAC cooperative recognition for selective protein degradation.
Morgan S Gadd, Andrea Testa, Xavier Lucas, Kwok-Ho Chan, Wenzhang Chen, Douglas J Lamont, Michael Zengerle, Alessio Ciulli. Nat. Chem. Biol. 2017
166
9


Mechanistic studies of a small-molecule modulator of SMN2 splicing.
Jingxin Wang, Peter G Schultz, Kristen A Johnson. Proc. Natl. Acad. Sci. U.S.A. 2018
32
9

Design of a small molecule against an oncogenic noncoding RNA.
Sai Pradeep Velagapudi, Michael D Cameron, Christopher L Haga, Laura H Rosenberg, Marie Lafitte, Derek R Duckett, Donald G Phinney, Matthew D Disney. Proc. Natl. Acad. Sci. U.S.A. 2016
79
6

Defining RNA-Small Molecule Affinity Landscapes Enables Design of a Small Molecule Inhibitor of an Oncogenic Noncoding RNA.
Sai Pradeep Velagapudi, Yiling Luo, Tuan Tran, Hafeez S Haniff, Yoshio Nakai, Mohammad Fallahi, Gustavo J Martinez, Jessica L Childs-Disney, Matthew D Disney.  2017
34
8


Inforna 2.0: A Platform for the Sequence-Based Design of Small Molecules Targeting Structured RNAs.
Matthew D Disney, Audrey M Winkelsas, Sai Pradeep Velagapudi, Mark Southern, Mohammad Fallahi, Jessica L Childs-Disney. ACS Chem. Biol. 2016
56
6

Approved Anti-cancer Drugs Target Oncogenic Non-coding RNAs.
Sai Pradeep Velagapudi, Matthew G Costales, Balayeshwanth R Vummidi, Yoshio Nakai, Alicia J Angelbello, Tuan Tran, Hafeez S Haniff, Yasumasa Matsumoto, Zi Fu Wang, Arnab K Chatterjee,[...]. Cell Chem Biol 2018
23
13

Selective small-molecule inhibition of an RNA structural element.
John A Howe, Hao Wang, Thierry O Fischmann, Carl J Balibar, Li Xiao, Andrew M Galgoci, Juliana C Malinverni, Todd Mayhood, Artjohn Villafania, Ali Nahvi,[...]. Nature 2015
146
6

Probing the links between in vitro potency, ADMET and physicochemical parameters.
M Paul Gleeson, Anne Hersey, Dino Montanari, John Overington. Nat Rev Drug Discov 2011
213
6

Practical application of ligand efficiency metrics in lead optimisation.
James S Scott, Michael J Waring. Bioorg. Med. Chem. 2018
7
42



Use of 3D properties to characterize beyond rule-of-5 property space for passive permeation.
Cristiano R W Guimarães, Alan M Mathiowetz, Marina Shalaeva, Gilles Goetz, Spiros Liras. J Chem Inf Model 2012
36
8

Lipophilic Permeability Efficiency Reconciles the Opposing Roles of Lipophilicity in Membrane Permeability and Aqueous Solubility.
Matthew R Naylor, Andrew M Ly, Mason J Handford, Daniel P Ramos, Cameron R Pye, Akihiro Furukawa, Victoria G Klein, Ryan P Noland, Quinn Edmondson, Alexandra C Turmon,[...]. J. Med. Chem. 2018
12
25


Targeted Protein Degradation: from Chemical Biology to Drug Discovery.
Philipp M Cromm, Craig M Crews. Cell Chem Biol 2017
77
6

Opportunities and guidelines for discovery of orally absorbed drugs in beyond rule of 5 space.
Vasanthanathan Poongavanam, Bradley C Doak, Jan Kihlberg. Curr Opin Chem Biol 2018
8
37

Ligand efficiency: a useful metric for lead selection.
Andrew L Hopkins, Colin R Groom, Alexander Alex. Drug Discov. Today 2004
959
6

Coexistence of passive and carrier-mediated processes in drug transport.
Kiyohiko Sugano, Manfred Kansy, Per Artursson, Alex Avdeef, Stefanie Bendels, Li Di, Gerhard F Ecker, Bernard Faller, Holger Fischer, Grégori Gerebtzoff,[...]. Nat Rev Drug Discov 2010
265
6

Escape from flatland: increasing saturation as an approach to improving clinical success.
Frank Lovering, Jack Bikker, Christine Humblet. J Med Chem 2009
885
6


Getting physical in drug discovery II: the impact of chromatographic hydrophobicity measurements and aromaticity.
Robert J Young, Darren V S Green, Christopher N Luscombe, Alan P Hill. Drug Discov. Today 2011
113
6



Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.