Michael D Shultz. J. Med. Chem. 2019
Times Cited: 43
Times Cited: 43
Times Cited
Times Co-cited
Similarity
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings.
C A Lipinski, F Lombardo, B W Dominy, P J Feeney. Adv. Drug Deliv. Rev. 2001
C A Lipinski, F Lombardo, B W Dominy, P J Feeney. Adv. Drug Deliv. Rev. 2001
23
Beyond the Rule of 5: Lessons Learned from AbbVie's Drugs and Compound Collection.
David A DeGoey, Hui-Ju Chen, Philip B Cox, Michael D Wendt. J. Med. Chem. 2018
David A DeGoey, Hui-Ju Chen, Philip B Cox, Michael D Wendt. J. Med. Chem. 2018
31
Oral druggable space beyond the rule of 5: insights from drugs and clinical candidates.
Bradley Croy Doak, Bjӧrn Over, Fabrizio Giordanetto, Jan Kihlberg. Chem. Biol. 2014
Bradley Croy Doak, Bjӧrn Over, Fabrizio Giordanetto, Jan Kihlberg. Chem. Biol. 2014
20
Molecular properties that influence the oral bioavailability of drug candidates.
Daniel F Veber, Stephen R Johnson, Hung-Yuan Cheng, Brian R Smith, Keith W Ward, Kenneth D Kopple. J. Med. Chem. 2002
Daniel F Veber, Stephen R Johnson, Hung-Yuan Cheng, Brian R Smith, Keith W Ward, Kenneth D Kopple. J. Med. Chem. 2002
16
Proteolysis targeting chimeras (PROTACs) in 'beyond rule-of-five' chemical space: Recent progress and future challenges.
Scott D Edmondson, Bin Yang, Charlene Fallan. Bioorg. Med. Chem. Lett. 2019
Scott D Edmondson, Bin Yang, Charlene Fallan. Bioorg. Med. Chem. Lett. 2019
25
New Modalities for Challenging Targets in Drug Discovery.
Eric Valeur, Stéphanie M Guéret, Hélène Adihou, Ranganath Gopalakrishnan, Malin Lemurell, Herbert Waldmann, Tom N Grossmann, Alleyn T Plowright. Angew. Chem. Int. Ed. Engl. 2017
Eric Valeur, Stéphanie M Guéret, Hélène Adihou, Ranganath Gopalakrishnan, Malin Lemurell, Herbert Waldmann, Tom N Grossmann, Alleyn T Plowright. Angew. Chem. Int. Ed. Engl. 2017
16
The role of ligand efficiency metrics in drug discovery.
Andrew L Hopkins, György M Keserü, Paul D Leeson, David C Rees, Charles H Reynolds. Nat Rev Drug Discov 2014
Andrew L Hopkins, György M Keserü, Paul D Leeson, David C Rees, Charles H Reynolds. Nat Rev Drug Discov 2014
11
How Beyond Rule of 5 Drugs and Clinical Candidates Bind to Their Targets.
Bradley C Doak, Jie Zheng, Doreen Dobritzsch, Jan Kihlberg. J. Med. Chem. 2016
Bradley C Doak, Jie Zheng, Doreen Dobritzsch, Jan Kihlberg. J. Med. Chem. 2016
11
Quantifying the chameleonic properties of macrocycles and other high-molecular-weight drugs.
Adrian Whitty, Mengqi Zhong, Lauren Viarengo, Dmitri Beglov, David R Hall, Sandor Vajda. Drug Discov. Today 2016
Adrian Whitty, Mengqi Zhong, Lauren Viarengo, Dmitri Beglov, David R Hall, Sandor Vajda. Drug Discov. Today 2016
11
How proteins bind macrocycles.
Elizabeth A Villar, Dmitri Beglov, Spandan Chennamadhavuni, John A Porco, Dima Kozakov, Sandor Vajda, Adrian Whitty. Nat. Chem. Biol. 2014
Elizabeth A Villar, Dmitri Beglov, Spandan Chennamadhavuni, John A Porco, Dima Kozakov, Sandor Vajda, Adrian Whitty. Nat. Chem. Biol. 2014
11
Lead- and drug-like compounds: the rule-of-five revolution.
Christopher A Lipinski. Drug Discov Today Technol 2004
Christopher A Lipinski. Drug Discov Today Technol 2004
11
Catalytic in vivo protein knockdown by small-molecule PROTACs.
Daniel P Bondeson, Alina Mares, Ian E D Smith, Eunhwa Ko, Sebastien Campos, Afjal H Miah, Katie E Mulholland, Natasha Routly, Dennis L Buckley, Jeffrey L Gustafson,[...]. Nat. Chem. Biol. 2015
Daniel P Bondeson, Alina Mares, Ian E D Smith, Eunhwa Ko, Sebastien Campos, Afjal H Miah, Katie E Mulholland, Natasha Routly, Dennis L Buckley, Jeffrey L Gustafson,[...]. Nat. Chem. Biol. 2015
11
DRUG DEVELOPMENT. Phthalimide conjugation as a strategy for in vivo target protein degradation.
Georg E Winter, Dennis L Buckley, Joshiawa Paulk, Justin M Roberts, Amanda Souza, Sirano Dhe-Paganon, James E Bradner. Science 2015
Georg E Winter, Dennis L Buckley, Joshiawa Paulk, Justin M Roberts, Amanda Souza, Sirano Dhe-Paganon, James E Bradner. Science 2015
11
SPR-Measured Dissociation Kinetics of PROTAC Ternary Complexes Influence Target Degradation Rate.
Michael J Roy, Sandra Winkler, Scott J Hughes, Claire Whitworth, Michael Galant, William Farnaby, Klaus Rumpel, Alessio Ciulli. ACS Chem. Biol. 2019
Michael J Roy, Sandra Winkler, Scott J Hughes, Claire Whitworth, Michael Galant, William Farnaby, Klaus Rumpel, Alessio Ciulli. ACS Chem. Biol. 2019
17
Small Molecule Inhibition of microRNA-210 Reprograms an Oncogenic Hypoxic Circuit.
Matthew G Costales, Christopher L Haga, Sai Pradeep Velagapudi, Jessica L Childs-Disney, Donald G Phinney, Matthew D Disney. J. Am. Chem. Soc. 2017
Matthew G Costales, Christopher L Haga, Sai Pradeep Velagapudi, Jessica L Childs-Disney, Donald G Phinney, Matthew D Disney. J. Am. Chem. Soc. 2017
9
Precise small-molecule recognition of a toxic CUG RNA repeat expansion.
Suzanne G Rzuczek, Lesley A Colgan, Yoshio Nakai, Michael D Cameron, Denis Furling, Ryohei Yasuda, Matthew D Disney. Nat. Chem. Biol. 2017
Suzanne G Rzuczek, Lesley A Colgan, Yoshio Nakai, Michael D Cameron, Denis Furling, Ryohei Yasuda, Matthew D Disney. Nat. Chem. Biol. 2017
9
Incorporating chemical modification constraints into a dynamic programming algorithm for prediction of RNA secondary structure.
David H Mathews, Matthew D Disney, Jessica L Childs, Susan J Schroeder, Michael Zuker, Douglas H Turner. Proc. Natl. Acad. Sci. U.S.A. 2004
David H Mathews, Matthew D Disney, Jessica L Childs, Susan J Schroeder, Michael Zuker, Douglas H Turner. Proc. Natl. Acad. Sci. U.S.A. 2004
9
Sequence-based design of bioactive small molecules that target precursor microRNAs.
Sai Pradeep Velagapudi, Steven M Gallo, Matthew D Disney. Nat. Chem. Biol. 2014
Sai Pradeep Velagapudi, Steven M Gallo, Matthew D Disney. Nat. Chem. Biol. 2014
9
Small Molecule Targeted Recruitment of a Nuclease to RNA.
Matthew G Costales, Yasumasa Matsumoto, Sai Pradeep Velagapudi, Matthew D Disney. J. Am. Chem. Soc. 2018
Matthew G Costales, Yasumasa Matsumoto, Sai Pradeep Velagapudi, Matthew D Disney. J. Am. Chem. Soc. 2018
11
Drug discovery beyond the 'rule-of-five'.
Ming-Qiang Zhang, Barrie Wilkinson. Curr. Opin. Biotechnol. 2007
Ming-Qiang Zhang, Barrie Wilkinson. Curr. Opin. Biotechnol. 2007
9
Quantifying the chemical beauty of drugs.
G Richard Bickerton, Gaia V Paolini, Jérémy Besnard, Sorel Muresan, Andrew L Hopkins. Nat Chem 2012
G Richard Bickerton, Gaia V Paolini, Jérémy Besnard, Sorel Muresan, Andrew L Hopkins. Nat Chem 2012
9
9
Impact of Dynamically Exposed Polarity on Permeability and Solubility of Chameleonic Drugs Beyond the Rule of 5.
Matteo Rossi Sebastiano, Bradley C Doak, Maria Backlund, Vasanthanathan Poongavanam, Björn Over, Giuseppe Ermondi, Giulia Caron, Pär Matsson, Jan Kihlberg. J. Med. Chem. 2018
Matteo Rossi Sebastiano, Bradley C Doak, Maria Backlund, Vasanthanathan Poongavanam, Björn Over, Giuseppe Ermondi, Giulia Caron, Pär Matsson, Jan Kihlberg. J. Med. Chem. 2018
19
Structural and conformational determinants of macrocycle cell permeability.
Björn Over, Pär Matsson, Christian Tyrchan, Per Artursson, Bradley C Doak, Michael A Foley, Constanze Hilgendorf, Stephen E Johnston, Maurice D Lee, Richard J Lewis,[...]. Nat. Chem. Biol. 2016
Björn Over, Pär Matsson, Christian Tyrchan, Per Artursson, Bradley C Doak, Michael A Foley, Constanze Hilgendorf, Stephen E Johnston, Maurice D Lee, Richard J Lewis,[...]. Nat. Chem. Biol. 2016
9
Lessons in PROTAC Design from Selective Degradation with a Promiscuous Warhead.
Daniel P Bondeson, Blake E Smith, George M Burslem, Alexandru D Buhimschi, John Hines, Saul Jaime-Figueroa, Jing Wang, Brian D Hamman, Alexey Ishchenko, Craig M Crews. Cell Chem Biol 2018
Daniel P Bondeson, Blake E Smith, George M Burslem, Alexandru D Buhimschi, John Hines, Saul Jaime-Figueroa, Jing Wang, Brian D Hamman, Alexey Ishchenko, Craig M Crews. Cell Chem Biol 2018
9
Structural basis of PROTAC cooperative recognition for selective protein degradation.
Morgan S Gadd, Andrea Testa, Xavier Lucas, Kwok-Ho Chan, Wenzhang Chen, Douglas J Lamont, Michael Zengerle, Alessio Ciulli. Nat. Chem. Biol. 2017
Morgan S Gadd, Andrea Testa, Xavier Lucas, Kwok-Ho Chan, Wenzhang Chen, Douglas J Lamont, Michael Zengerle, Alessio Ciulli. Nat. Chem. Biol. 2017
9
SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules.
Antoine Daina, Olivier Michielin, Vincent Zoete. Sci Rep 2017
Antoine Daina, Olivier Michielin, Vincent Zoete. Sci Rep 2017
9
Mechanistic studies of a small-molecule modulator of SMN2 splicing.
Jingxin Wang, Peter G Schultz, Kristen A Johnson. Proc. Natl. Acad. Sci. U.S.A. 2018
Jingxin Wang, Peter G Schultz, Kristen A Johnson. Proc. Natl. Acad. Sci. U.S.A. 2018
9
Design of a small molecule against an oncogenic noncoding RNA.
Sai Pradeep Velagapudi, Michael D Cameron, Christopher L Haga, Laura H Rosenberg, Marie Lafitte, Derek R Duckett, Donald G Phinney, Matthew D Disney. Proc. Natl. Acad. Sci. U.S.A. 2016
Sai Pradeep Velagapudi, Michael D Cameron, Christopher L Haga, Laura H Rosenberg, Marie Lafitte, Derek R Duckett, Donald G Phinney, Matthew D Disney. Proc. Natl. Acad. Sci. U.S.A. 2016
6
Defining RNA-Small Molecule Affinity Landscapes Enables Design of a Small Molecule Inhibitor of an Oncogenic Noncoding RNA.
Sai Pradeep Velagapudi, Yiling Luo, Tuan Tran, Hafeez S Haniff, Yoshio Nakai, Mohammad Fallahi, Gustavo J Martinez, Jessica L Childs-Disney, Matthew D Disney. 2017
Sai Pradeep Velagapudi, Yiling Luo, Tuan Tran, Hafeez S Haniff, Yoshio Nakai, Mohammad Fallahi, Gustavo J Martinez, Jessica L Childs-Disney, Matthew D Disney. 2017
8
Improving drug candidates by design: a focus on physicochemical properties as a means of improving compound disposition and safety.
Nicholas A Meanwell. Chem. Res. Toxicol. 2011
Nicholas A Meanwell. Chem. Res. Toxicol. 2011
6
Inforna 2.0: A Platform for the Sequence-Based Design of Small Molecules Targeting Structured RNAs.
Matthew D Disney, Audrey M Winkelsas, Sai Pradeep Velagapudi, Mark Southern, Mohammad Fallahi, Jessica L Childs-Disney. ACS Chem. Biol. 2016
Matthew D Disney, Audrey M Winkelsas, Sai Pradeep Velagapudi, Mark Southern, Mohammad Fallahi, Jessica L Childs-Disney. ACS Chem. Biol. 2016
6
Approved Anti-cancer Drugs Target Oncogenic Non-coding RNAs.
Sai Pradeep Velagapudi, Matthew G Costales, Balayeshwanth R Vummidi, Yoshio Nakai, Alicia J Angelbello, Tuan Tran, Hafeez S Haniff, Yasumasa Matsumoto, Zi Fu Wang, Arnab K Chatterjee,[...]. Cell Chem Biol 2018
Sai Pradeep Velagapudi, Matthew G Costales, Balayeshwanth R Vummidi, Yoshio Nakai, Alicia J Angelbello, Tuan Tran, Hafeez S Haniff, Yasumasa Matsumoto, Zi Fu Wang, Arnab K Chatterjee,[...]. Cell Chem Biol 2018
13
Selective small-molecule inhibition of an RNA structural element.
John A Howe, Hao Wang, Thierry O Fischmann, Carl J Balibar, Li Xiao, Andrew M Galgoci, Juliana C Malinverni, Todd Mayhood, Artjohn Villafania, Ali Nahvi,[...]. Nature 2015
John A Howe, Hao Wang, Thierry O Fischmann, Carl J Balibar, Li Xiao, Andrew M Galgoci, Juliana C Malinverni, Todd Mayhood, Artjohn Villafania, Ali Nahvi,[...]. Nature 2015
6
Probing the links between in vitro potency, ADMET and physicochemical parameters.
M Paul Gleeson, Anne Hersey, Dino Montanari, John Overington. Nat Rev Drug Discov 2011
M Paul Gleeson, Anne Hersey, Dino Montanari, John Overington. Nat Rev Drug Discov 2011
6
Practical application of ligand efficiency metrics in lead optimisation.
James S Scott, Michael J Waring. Bioorg. Med. Chem. 2018
James S Scott, Michael J Waring. Bioorg. Med. Chem. 2018
42
Rule of five in 2015 and beyond: Target and ligand structural limitations, ligand chemistry structure and drug discovery project decisions.
Christopher A Lipinski. Adv. Drug Deliv. Rev. 2016
Christopher A Lipinski. Adv. Drug Deliv. Rev. 2016
6
Getting across the cell membrane: an overview for small molecules, peptides, and proteins.
Nicole J Yang, Marlon J Hinner. Methods Mol. Biol. 2015
Nicole J Yang, Marlon J Hinner. Methods Mol. Biol. 2015
6
Use of 3D properties to characterize beyond rule-of-5 property space for passive permeation.
Cristiano R W Guimarães, Alan M Mathiowetz, Marina Shalaeva, Gilles Goetz, Spiros Liras. J Chem Inf Model 2012
Cristiano R W Guimarães, Alan M Mathiowetz, Marina Shalaeva, Gilles Goetz, Spiros Liras. J Chem Inf Model 2012
8
Lipophilic Permeability Efficiency Reconciles the Opposing Roles of Lipophilicity in Membrane Permeability and Aqueous Solubility.
Matthew R Naylor, Andrew M Ly, Mason J Handford, Daniel P Ramos, Cameron R Pye, Akihiro Furukawa, Victoria G Klein, Ryan P Noland, Quinn Edmondson, Alexandra C Turmon,[...]. J. Med. Chem. 2018
Matthew R Naylor, Andrew M Ly, Mason J Handford, Daniel P Ramos, Cameron R Pye, Akihiro Furukawa, Victoria G Klein, Ryan P Noland, Quinn Edmondson, Alexandra C Turmon,[...]. J. Med. Chem. 2018
25
New Modalities, Technologies, and Partnerships in Probe and Lead Generation: Enabling a Mode-of-Action Centric Paradigm.
Eric Valeur, Patrick Jimonet. J. Med. Chem. 2018
Eric Valeur, Patrick Jimonet. J. Med. Chem. 2018
33
Targeted Protein Degradation: from Chemical Biology to Drug Discovery.
Philipp M Cromm, Craig M Crews. Cell Chem Biol 2017
Philipp M Cromm, Craig M Crews. Cell Chem Biol 2017
6
Opportunities and guidelines for discovery of orally absorbed drugs in beyond rule of 5 space.
Vasanthanathan Poongavanam, Bradley C Doak, Jan Kihlberg. Curr Opin Chem Biol 2018
Vasanthanathan Poongavanam, Bradley C Doak, Jan Kihlberg. Curr Opin Chem Biol 2018
37
Ligand efficiency: a useful metric for lead selection.
Andrew L Hopkins, Colin R Groom, Alexander Alex. Drug Discov. Today 2004
Andrew L Hopkins, Colin R Groom, Alexander Alex. Drug Discov. Today 2004
6
Coexistence of passive and carrier-mediated processes in drug transport.
Kiyohiko Sugano, Manfred Kansy, Per Artursson, Alex Avdeef, Stefanie Bendels, Li Di, Gerhard F Ecker, Bernard Faller, Holger Fischer, Grégori Gerebtzoff,[...]. Nat Rev Drug Discov 2010
Kiyohiko Sugano, Manfred Kansy, Per Artursson, Alex Avdeef, Stefanie Bendels, Li Di, Gerhard F Ecker, Bernard Faller, Holger Fischer, Grégori Gerebtzoff,[...]. Nat Rev Drug Discov 2010
6
Escape from flatland: increasing saturation as an approach to improving clinical success.
Frank Lovering, Jack Bikker, Christine Humblet. J Med Chem 2009
Frank Lovering, Jack Bikker, Christine Humblet. J Med Chem 2009
6
Drug-like properties and the causes of poor solubility and poor permeability.
C A Lipinski. J Pharmacol Toxicol Methods 2000
C A Lipinski. J Pharmacol Toxicol Methods 2000
6
Getting physical in drug discovery II: the impact of chromatographic hydrophobicity measurements and aromaticity.
Robert J Young, Darren V S Green, Christopher N Luscombe, Alan P Hill. Drug Discov. Today 2011
Robert J Young, Darren V S Green, Christopher N Luscombe, Alan P Hill. Drug Discov. Today 2011
6
The impact of aromatic ring count on compound developability--are too many aromatic rings a liability in drug design?
Timothy J Ritchie, Simon J F Macdonald. Drug Discov Today 2009
Timothy J Ritchie, Simon J F Macdonald. Drug Discov Today 2009
6
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