A citation-based method for searching scientific literature

Tamara Tchkonia, James L Kirkland. JAMA 2018
Times Cited: 122







List of co-cited articles
917 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity


Senolytics improve physical function and increase lifespan in old age.
Ming Xu, Tamar Pirtskhalava, Joshua N Farr, Bettina M Weigand, Allyson K Palmer, Megan M Weivoda, Christina L Inman, Mikolaj B Ogrodnik, Christine M Hachfeld, Daniel G Fraser,[...]. Nat Med 2018
750
42

The Achilles' heel of senescent cells: from transcriptome to senolytic drugs.
Yi Zhu, Tamara Tchkonia, Tamar Pirtskhalava, Adam C Gower, Husheng Ding, Nino Giorgadze, Allyson K Palmer, Yuji Ikeno, Gene B Hubbard, Marc Lenburg,[...]. Aging Cell 2015
929
27

Cellular Senescence: A Translational Perspective.
James L Kirkland, Tamara Tchkonia. EBioMedicine 2017
432
25

Targeting senescent cells enhances adipogenesis and metabolic function in old age.
Ming Xu, Allyson K Palmer, Husheng Ding, Megan M Weivoda, Tamar Pirtskhalava, Thomas A White, Anna Sepe, Kurt O Johnson, Michael B Stout, Nino Giorgadze,[...]. Elife 2015
288
25

Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor.
Jean-Philippe Coppé, Christopher K Patil, Francis Rodier, Yu Sun, Denise P Muñoz, Joshua Goldstein, Peter S Nelson, Pierre-Yves Desprez, Judith Campisi. PLoS Biol 2008
23

Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice.
Carolyn M Roos, Bin Zhang, Allyson K Palmer, Mikolaj B Ogrodnik, Tamar Pirtskhalava, Nassir M Thalji, Michael Hagler, Diana Jurk, Leslie A Smith, Grace Casaclang-Verzosa,[...]. Aging Cell 2016
349
22

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders.
Darren J Baker, Tobias Wijshake, Tamar Tchkonia, Nathan K LeBrasseur, Bennett G Childs, Bart van de Sluis, James L Kirkland, Jan M van Deursen. Nature 2011
21

Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease.
LaTonya J Hickson, Larissa G P Langhi Prata, Shane A Bobart, Tamara K Evans, Nino Giorgadze, Shahrukh K Hashmi, Sandra M Herrmann, Michael D Jensen, Qingyi Jia, Kyra L Jordan,[...]. EBioMedicine 2019
351
21

The hallmarks of aging.
Carlos López-Otín, Maria A Blasco, Linda Partridge, Manuel Serrano, Guido Kroemer. Cell 2013
20

Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan.
Darren J Baker, Bennett G Childs, Matej Durik, Melinde E Wijers, Cynthia J Sieben, Jian Zhong, Rachel A Saltness, Karthik B Jeganathan, Grace Casaclang Verzosa, Abdulmohammad Pezeshki,[...]. Nature 2016
20

Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study.
Jamie N Justice, Anoop M Nambiar, Tamar Tchkonia, Nathan K LeBrasseur, Rodolfo Pascual, Shahrukh K Hashmi, Larissa Prata, Michal M Masternak, Stephen B Kritchevsky, Nicolas Musi,[...]. EBioMedicine 2019
403
20

Cellular senescence and the senescent secretory phenotype: therapeutic opportunities.
Tamara Tchkonia, Yi Zhu, Jan van Deursen, Judith Campisi, James L Kirkland. J Clin Invest 2013
919
20

Targeting cellular senescence prevents age-related bone loss in mice.
Joshua N Farr, Ming Xu, Megan M Weivoda, David G Monroe, Daniel G Fraser, Jennifer L Onken, Brittany A Negley, Jad G Sfeir, Mikolaj B Ogrodnik, Christine M Hachfeld,[...]. Nat Med 2017
441
20

Fisetin is a senotherapeutic that extends health and lifespan.
Matthew J Yousefzadeh, Yi Zhu, Sara J McGowan, Luise Angelini, Heike Fuhrmann-Stroissnigg, Ming Xu, Yuan Yuan Ling, Kendra I Melos, Tamar Pirtskhalava, Christina L Inman,[...]. EBioMedicine 2018
273
19

Cellular senescence mediates fibrotic pulmonary disease.
Marissa J Schafer, Thomas A White, Koji Iijima, Andrew J Haak, Giovanni Ligresti, Elizabeth J Atkinson, Ann L Oberg, Jodie Birch, Hanna Salmonowicz, Yi Zhu,[...]. Nat Commun 2017
621
19

The serial cultivation of human diploid cell strains.
L HAYFLICK, P S MOORHEAD. Exp Cell Res 1961
17

Aged-senescent cells contribute to impaired heart regeneration.
Fiona C Lewis-McDougall, Prashant J Ruchaya, Eva Domenjo-Vila, Tze Shin Teoh, Larissa Prata, Beverley J Cottle, James E Clark, Prakash P Punjabi, Wael Awad, Daniele Torella,[...]. Aging Cell 2019
112
17

Targeting senescent cells alleviates obesity-induced metabolic dysfunction.
Allyson K Palmer, Ming Xu, Yi Zhu, Tamar Pirtskhalava, Megan M Weivoda, Christine M Hachfeld, Larissa G Prata, Theo H van Dijk, Esther Verkade, Grace Casaclang-Verzosa,[...]. Aging Cell 2019
219
17

The senescence-associated secretory phenotype: the dark side of tumor suppression.
Jean-Philippe Coppé, Pierre-Yves Desprez, Ana Krtolica, Judith Campisi. Annu Rev Pathol 2010
17

Cellular Senescence Biomarker p16INK4a+ Cell Burden in Thigh Adipose is Associated With Poor Physical Function in Older Women.
Jamie N Justice, Heather Gregory, Tamar Tchkonia, Nathan K LeBrasseur, James L Kirkland, Stephen B Kritchevsky, Barbara J Nicklas. J Gerontol A Biol Sci Med Sci 2018
64
25

Cellular Senescence: Defining a Path Forward.
Vassilis Gorgoulis, Peter D Adams, Andrea Alimonti, Dorothy C Bennett, Oliver Bischof, Cleo Bishop, Judith Campisi, Manuel Collado, Konstantinos Evangelou, Gerardo Ferbeyre,[...]. Cell 2019
674
16

The Clinical Potential of Senolytic Drugs.
James L Kirkland, Tamara Tchkonia, Yi Zhu, Laura J Niedernhofer, Paul D Robbins. J Am Geriatr Soc 2017
276
15

Cellular senescence drives age-dependent hepatic steatosis.
Mikolaj Ogrodnik, Satomi Miwa, Tamar Tchkonia, Dina Tiniakos, Caroline L Wilson, Albert Lahat, Christoper P Day, Alastair Burt, Allyson Palmer, Quentin M Anstee,[...]. Nat Commun 2017
403
15

Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging.
Marjolein P Baar, Renata M C Brandt, Diana A Putavet, Julian D D Klein, Kasper W J Derks, Benjamin R M Bourgeois, Sarah Stryeck, Yvonne Rijksen, Hester van Willigenburg, Danny A Feijtel,[...]. Cell 2017
635
14

An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA.
Marco Demaria, Naoko Ohtani, Sameh A Youssef, Francis Rodier, Wendy Toussaint, James R Mitchell, Remi-Martin Laberge, Jan Vijg, Harry Van Steeg, Martijn E T Dollé,[...]. Dev Cell 2014
873
14

Geroscience: linking aging to chronic disease.
Brian K Kennedy, Shelley L Berger, Anne Brunet, Judith Campisi, Ana Maria Cuervo, Elissa S Epel, Claudio Franceschi, Gordon J Lithgow, Richard I Morimoto, Jeffrey E Pessin,[...]. Cell 2014
981
13

Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer's disease model.
Peisu Zhang, Yuki Kishimoto, Ioannis Grammatikakis, Kamalvishnu Gottimukkala, Roy G Cutler, Shiliang Zhang, Kotb Abdelmohsen, Vilhelm A Bohr, Jyoti Misra Sen, Myriam Gorospe,[...]. Nat Neurosci 2019
303
13

Fat tissue, aging, and cellular senescence.
Tamara Tchkonia, Dean E Morbeck, Thomas Von Zglinicki, Jan Van Deursen, Joseph Lustgarten, Heidi Scrable, Sundeep Khosla, Michael D Jensen, James L Kirkland. Aging Cell 2010
611
13

Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors.
Yi Zhu, Tamara Tchkonia, Heike Fuhrmann-Stroissnigg, Haiming M Dai, Yuanyuan Y Ling, Michael B Stout, Tamar Pirtskhalava, Nino Giorgadze, Kurt O Johnson, Cory B Giles,[...]. Aging Cell 2016
433
13

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice.
Jianhui Chang, Yingying Wang, Lijian Shao, Remi-Martin Laberge, Marco Demaria, Judith Campisi, Krishnamurthy Janakiraman, Norman E Sharpless, Sheng Ding, Wei Feng,[...]. Nat Med 2016
823
13

Cellular senescence: when bad things happen to good cells.
Judith Campisi, Fabrizio d'Adda di Fagagna. Nat Rev Mol Cell Biol 2007
13

Senescent cell clearance by the immune system: Emerging therapeutic opportunities.
Larissa G P Langhi Prata, Inna G Ovsyannikova, Tamara Tchkonia, James L Kirkland. Semin Immunol 2018
136
13

Length-independent telomere damage drives post-mitotic cardiomyocyte senescence.
Rhys Anderson, Anthony Lagnado, Damien Maggiorani, Anna Walaszczyk, Emily Dookun, James Chapman, Jodie Birch, Hanna Salmonowicz, Mikolaj Ogrodnik, Diana Jurk,[...]. EMBO J 2019
174
13

Senolytic drugs: from discovery to translation.
J L Kirkland, T Tchkonia. J Intern Med 2020
188
13

Cellular senescence in aging and age-related disease: from mechanisms to therapy.
Bennett G Childs, Matej Durik, Darren J Baker, Jan M van Deursen. Nat Med 2015
963
12

JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age.
Ming Xu, Tamara Tchkonia, Husheng Ding, Mikolaj Ogrodnik, Ellen R Lubbers, Tamar Pirtskhalava, Thomas A White, Kurt O Johnson, Michael B Stout, Vojtech Mezera,[...]. Proc Natl Acad Sci U S A 2015
344
12

Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline.
Tyler J Bussian, Asef Aziz, Charlton F Meyer, Barbara L Swenson, Jan M van Deursen, Darren J Baker. Nature 2018
452
12

Aging, cellular senescence, and cancer.
Judith Campisi. Annu Rev Physiol 2013
12

Inflammatory networks during cellular senescence: causes and consequences.
Adam Freund, Arturo V Orjalo, Pierre-Yves Desprez, Judith Campisi. Trends Mol Med 2010
782
12

Senescent intimal foam cells are deleterious at all stages of atherosclerosis.
Bennett G Childs, Darren J Baker, Tobias Wijshake, Cheryl A Conover, Judith Campisi, Jan M van Deursen. Science 2016
523
12

The role of cellular senescence in ageing and endocrine disease.
Sundeep Khosla, Joshua N Farr, Tamara Tchkonia, James L Kirkland. Nat Rev Endocrinol 2020
131
12

New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463.
Yi Zhu, Ewald J Doornebal, Tamar Pirtskhalava, Nino Giorgadze, Mark Wentworth, Heike Fuhrmann-Stroissnigg, Laura J Niedernhofer, Paul D Robbins, Tamara Tchkonia, James L Kirkland. Aging (Albany NY) 2017
270
11

Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment.
Ok Hee Jeon, Chaekyu Kim, Remi-Martin Laberge, Marco Demaria, Sona Rathod, Alain P Vasserot, Jae Wook Chung, Do Hun Kim, Yan Poon, Nathaniel David,[...]. Nat Med 2017
622
11

Senescence in Health and Disease.
Shenghui He, Norman E Sharpless. Cell 2017
613
11

Transplanted Senescent Cells Induce an Osteoarthritis-Like Condition in Mice.
Ming Xu, Elizabeth W Bradley, Megan M Weivoda, Soyun M Hwang, Tamar Pirtskhalava, Teresa Decklever, Geoffry L Curran, Mikolaj Ogrodnik, Diana Jurk, Kurt O Johnson,[...]. J Gerontol A Biol Sci Med Sci 2017
159
11

Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis.
Mikolaj Ogrodnik, Yi Zhu, Larissa G P Langhi, Tamar Tchkonia, Patrick Krüger, Edward Fielder, Stella Victorelli, Rifqha A Ruswhandi, Nino Giorgadze, Tamar Pirtskhalava,[...]. Cell Metab 2019
160
11

Cellular senescence and the senescent secretory phenotype in age-related chronic diseases.
Yi Zhu, Jacqueline L Armstrong, Tamara Tchkonia, James L Kirkland. Curr Opin Clin Nutr Metab Care 2014
166
11

A complex secretory program orchestrated by the inflammasome controls paracrine senescence.
Juan Carlos Acosta, Ana Banito, Torsten Wuestefeld, Athena Georgilis, Peggy Janich, Jennifer P Morton, Dimitris Athineos, Tae-Won Kang, Felix Lasitschka, Mindaugas Andrulis,[...]. Nat Cell Biol 2013
11

The role of senescent cells in ageing.
Jan M van Deursen. Nature 2014
11

Systemic clearance of p16INK4a -positive senescent cells mitigates age-associated intervertebral disc degeneration.
Prashanti Patil, Qing Dong, Dong Wang, Jianhui Chang, Christopher Wiley, Marco Demaria, Joon Lee, James Kang, Laura J Niedernhofer, Paul D Robbins,[...]. Aging Cell 2019
64
15


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.