Richard Gordon, Eduardo A Albornoz, Daniel C Christie, Monica R Langley, Vinod Kumar, Susanna Mantovani, Avril A B Robertson, Mark S Butler, Dominic B Rowe, Luke A O'Neill, Anumantha G Kanthasamy, Kate Schroder, Matthew A Cooper, Trent M Woodruff. Sci Transl Med 2018
Times Cited: 250
Times Cited: 250
Times Cited
Times Co-cited
Similarity
NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice.
Michael T Heneka, Markus P Kummer, Andrea Stutz, Andrea Delekate, Stephanie Schwartz, Ana Vieira-Saecker, Angelika Griep, Daisy Axt, Anita Remus, Te-Chen Tzeng,[...]. Nature 2013
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MPTP-driven NLRP3 inflammasome activation in microglia plays a central role in dopaminergic neurodegeneration.
Eunju Lee, Inhwa Hwang, Sangjun Park, Sujeong Hong, Boreum Hwang, Yoeseph Cho, Junghyun Son, Je-Wook Yu. Cell Death Differ 2019
Eunju Lee, Inhwa Hwang, Sangjun Park, Sujeong Hong, Boreum Hwang, Yoeseph Cho, Junghyun Son, Je-Wook Yu. Cell Death Differ 2019
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Triggering of inflammasome by aggregated α-synuclein, an inflammatory response in synucleinopathies.
Gaia Codolo, Nicoletta Plotegher, Tommaso Pozzobon, Marco Brucale, Isabella Tessari, Luigi Bubacco, Marina de Bernard. PLoS One 2013
Gaia Codolo, Nicoletta Plotegher, Tommaso Pozzobon, Marco Brucale, Isabella Tessari, Luigi Bubacco, Marina de Bernard. PLoS One 2013
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A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases.
Rebecca C Coll, Avril A B Robertson, Jae Jin Chae, Sarah C Higgins, Raúl Muñoz-Planillo, Marco C Inserra, Irina Vetter, Lara S Dungan, Brian G Monks, Andrea Stutz,[...]. Nat Med 2015
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Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-β and cognitive function in APP/PS1 mice.
C Dempsey, A Rubio Araiz, K J Bryson, O Finucane, C Larkin, E L Mills, A A B Robertson, M A Cooper, L A J O'Neill, M A Lynch. Brain Behav Immun 2017
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The NALP3 inflammasome is involved in the innate immune response to amyloid-beta.
Annett Halle, Veit Hornung, Gabor C Petzold, Cameron R Stewart, Brian G Monks, Thomas Reinheckel, Katherine A Fitzgerald, Eicke Latz, Kathryn J Moore, Douglas T Golenbock. Nat Immunol 2008
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Dopamine controls systemic inflammation through inhibition of NLRP3 inflammasome.
Yiqing Yan, Wei Jiang, Lei Liu, Xiaqiong Wang, Chen Ding, Zhigang Tian, Rongbin Zhou. Cell 2015
Yiqing Yan, Wei Jiang, Lei Liu, Xiaqiong Wang, Chen Ding, Zhigang Tian, Rongbin Zhou. Cell 2015
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Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia.
Changyoun Kim, Dong-Hwan Ho, Ji-Eun Suk, Sungyong You, Sarah Michael, Junghee Kang, Sung Joong Lee, Eliezer Masliah, Daehee Hwang, He-Jin Lee,[...]. Nat Commun 2013
Changyoun Kim, Dong-Hwan Ho, Ji-Eun Suk, Sungyong You, Sarah Michael, Junghee Kang, Sung Joong Lee, Eliezer Masliah, Daehee Hwang, He-Jin Lee,[...]. Nat Commun 2013
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Inflammasome signalling in brain function and neurodegenerative disease.
Michael T Heneka, Róisín M McManus, Eicke Latz. Nat Rev Neurosci 2018
Michael T Heneka, Róisín M McManus, Eicke Latz. Nat Rev Neurosci 2018
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Fyn kinase regulates misfolded α-synuclein uptake and NLRP3 inflammasome activation in microglia.
Nikhil Panicker, Souvarish Sarkar, Dilshan S Harischandra, Matthew Neal, Tae-In Kam, Huajun Jin, Hariharan Saminathan, Monica Langley, Adhithiya Charli, Manikandan Samidurai,[...]. J Exp Med 2019
Nikhil Panicker, Souvarish Sarkar, Dilshan S Harischandra, Matthew Neal, Tae-In Kam, Huajun Jin, Hariharan Saminathan, Monica Langley, Adhithiya Charli, Manikandan Samidurai,[...]. J Exp Med 2019
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Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer's disease.
Carmen Venegas, Sathish Kumar, Bernardo S Franklin, Tobias Dierkes, Rebecca Brinkschulte, Dario Tejera, Ana Vieira-Saecker, Stephanie Schwartz, Francesco Santarelli, Markus P Kummer,[...]. Nature 2017
Carmen Venegas, Sathish Kumar, Bernardo S Franklin, Tobias Dierkes, Rebecca Brinkschulte, Dario Tejera, Ana Vieira-Saecker, Stephanie Schwartz, Francesco Santarelli, Markus P Kummer,[...]. Nature 2017
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NLRP3 inflammasome activation drives tau pathology.
Christina Ising, Carmen Venegas, Shuangshuang Zhang, Hannah Scheiblich, Susanne V Schmidt, Ana Vieira-Saecker, Stephanie Schwartz, Shadi Albasset, Róisín M McManus, Dario Tejera,[...]. Nature 2019
Christina Ising, Carmen Venegas, Shuangshuang Zhang, Hannah Scheiblich, Susanne V Schmidt, Ana Vieira-Saecker, Stephanie Schwartz, Shadi Albasset, Róisín M McManus, Dario Tejera,[...]. Nature 2019
15
The NLRP3 inflammasome: molecular activation and regulation to therapeutics.
Karen V Swanson, Meng Deng, Jenny P-Y Ting. Nat Rev Immunol 2019
Karen V Swanson, Meng Deng, Jenny P-Y Ting. Nat Rev Immunol 2019
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Neurotoxic reactive astrocytes are induced by activated microglia.
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Caspase-1 causes truncation and aggregation of the Parkinson's disease-associated protein α-synuclein.
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15
MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition.
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A role for mitochondria in NLRP3 inflammasome activation.
Rongbin Zhou, Amir S Yazdi, Philippe Menu, Jürg Tschopp. Nature 2011
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14
MicroRNA-7 targets Nod-like receptor protein 3 inflammasome to modulate neuroinflammation in the pathogenesis of Parkinson's disease.
Yan Zhou, Ming Lu, Ren-Hong Du, Chen Qiao, Chun-Yi Jiang, Ke-Zhong Zhang, Jian-Hua Ding, Gang Hu. Mol Neurodegener 2016
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Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease.
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The NLRP3 Inflammasome is Involved in the Pathogenesis of Parkinson's Disease in Rats.
Zhijuan Mao, Chanchan Liu, Suqiong Ji, Qingmei Yang, Hongxiang Ye, Haiyan Han, Zheng Xue. Neurochem Res 2017
Zhijuan Mao, Chanchan Liu, Suqiong Ji, Qingmei Yang, Hongxiang Ye, Haiyan Han, Zheng Xue. Neurochem Res 2017
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Mitochondrial impairment in microglia amplifies NLRP3 inflammasome proinflammatory signaling in cell culture and animal models of Parkinson's disease.
Souvarish Sarkar, Emir Malovic, Dilshan S Harishchandra, Shivani Ghaisas, Nikhil Panicker, Adhithiya Charli, Bharathi N Palanisamy, Dharmin Rokad, Huajun Jin, Vellareddy Anantharam,[...]. NPJ Parkinsons Dis 2017
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13
In vivo imaging of microglial activation with [11C](R)-PK11195 PET in idiopathic Parkinson's disease.
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K⁺ efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter.
Raúl Muñoz-Planillo, Peter Kuffa, Giovanny Martínez-Colón, Brenna L Smith, Thekkelnaycke M Rajendiran, Gabriel Núñez. Immunity 2013
Raúl Muñoz-Planillo, Peter Kuffa, Giovanny Martínez-Colón, Brenna L Smith, Thekkelnaycke M Rajendiran, Gabriel Núñez. Immunity 2013
13
Systemic activation of NLRP3 inflammasome and plasma α-synuclein levels are correlated with motor severity and progression in Parkinson's disease.
Zheng Fan, Yu-Ting Pan, Zhi-Yuan Zhang, Hui Yang, Shu-Yue Yu, Yan Zheng, Jing-Hong Ma, Xiao-Min Wang. J Neuroinflammation 2020
Zheng Fan, Yu-Ting Pan, Zhi-Yuan Zhang, Hui Yang, Shu-Yue Yu, Yan Zheng, Jing-Hong Ma, Xiao-Min Wang. J Neuroinflammation 2020
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NLRP3 expression in mesencephalic neurons and characterization of a rare NLRP3 polymorphism associated with decreased risk of Parkinson's disease.
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Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains.
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P L McGeer, S Itagaki, B E Boyes, E G McGeer. Neurology 1988
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Aggregated Tau activates NLRP3-ASC inflammasome exacerbating exogenously seeded and non-exogenously seeded Tau pathology in vivo.
Ilie-Cosmin Stancu, Niels Cremers, Hannah Vanrusselt, Julien Couturier, Alexandre Vanoosthuyse, Sofie Kessels, Chritica Lodder, Bert Brône, François Huaux, Jean-Noël Octave,[...]. Acta Neuropathol 2019
Ilie-Cosmin Stancu, Niels Cremers, Hannah Vanrusselt, Julien Couturier, Alexandre Vanoosthuyse, Sofie Kessels, Chritica Lodder, Bert Brône, François Huaux, Jean-Noël Octave,[...]. Acta Neuropathol 2019
12
Targeting the NLRP3 inflammasome in inflammatory diseases.
Matthew S J Mangan, Edward J Olhava, William R Roush, H Martin Seidel, Gary D Glick, Eicke Latz. Nat Rev Drug Discov 2018
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Toll-like receptor 4 is required for α-synuclein dependent activation of microglia and astroglia.
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Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death.
Jianjin Shi, Yue Zhao, Kun Wang, Xuyan Shi, Yue Wang, Huanwei Huang, Yinghua Zhuang, Tao Cai, Fengchao Wang, Feng Shao. Nature 2015
Jianjin Shi, Yue Zhao, Kun Wang, Xuyan Shi, Yue Wang, Huanwei Huang, Yinghua Zhuang, Tao Cai, Fengchao Wang, Feng Shao. Nature 2015
11
Activation and regulation of the inflammasomes.
Eicke Latz, T Sam Xiao, Andrea Stutz. Nat Rev Immunol 2013
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Parkinson disease.
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Editor's Highlight: Nlrp3 Is Required for Inflammatory Changes and Nigral Cell Loss Resulting From Chronic Intragastric Rotenone Exposure in Mice.
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Interleukin-1 beta and interleukin-6 are elevated in the cerebrospinal fluid of Alzheimer's and de novo Parkinson's disease patients.
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11
NLRP3 inflammasome is expressed by astrocytes in the SOD1 mouse model of ALS and in human sporadic ALS patients.
Sonja Johann, Marius Heitzer, Mithila Kanagaratnam, Anand Goswami, Tania Rizo, Joachim Weis, Dirk Troost, Cordian Beyer. Glia 2015
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Inflammasomes in neuroinflammatory and neurodegenerative diseases.
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Neuroinflammation in Parkinson's disease: a target for neuroprotection?
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The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta.
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Innate immune activation in neurodegenerative disease.
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Anti-inflammatory compounds parthenolide and Bay 11-7082 are direct inhibitors of the inflammasome.
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10
Inflammasome and α-synuclein in Parkinson's disease: A cross-sectional study.
Koustav Chatterjee, Akash Roy, Rebecca Banerjee, Supriyo Choudhury, Banashree Mondal, Saptak Halder, Purba Basu, Shantanu Shubham, Sanjit Dey, Hrishikesh Kumar. J Neuroimmunol 2020
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Targeting the microglial NLRP3 inflammasome and its role in Parkinson's disease.
Md Ezazul Haque, Mahbuba Akther, Md Jakaria, In-Su Kim, Shofiul Azam, Dong-Kug Choi. Mov Disord 2020
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NLR members NLRC4 and NLRP3 mediate sterile inflammasome activation in microglia and astrocytes.
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The microglial NLRP3 inflammasome is activated by amyotrophic lateral sclerosis proteins.
Vandana Deora, John D Lee, Eduardo A Albornoz, Luke McAlary, Cyril J Jagaraj, Avril A B Robertson, Julie D Atkin, Matthew A Cooper, Kate Schroder, Justin J Yerbury,[...]. Glia 2020
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The mechanisms of NLRP3 inflammasome/pyroptosis activation and their role in Parkinson's disease.
Shuo Wang, Yu-He Yuan, Nai-Hong Chen, Hong-Bo Wang. Int Immunopharmacol 2019
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Small molecule-driven NLRP3 inflammation inhibition via interplay between ubiquitination and autophagy: implications for Parkinson disease.
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Microglia clear neuron-released α-synuclein via selective autophagy and prevent neurodegeneration.
Insup Choi, Yuanxi Zhang, Steven P Seegobin, Mathilde Pruvost, Qian Wang, Kerry Purtell, Bin Zhang, Zhenyu Yue. Nat Commun 2020
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Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease.
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9
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.