A citation-based method for searching scientific literature

Yunxiao Zhang, David P Bulkley, Yao Xin, Kelsey J Roberts, Daniel E Asarnow, Ashutosh Sharma, Benjamin R Myers, Wonhwa Cho, Yifan Cheng, Philip A Beachy. Cell 2018
Times Cited: 103







List of co-cited articles
1159 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity


Structural basis for the recognition of Sonic Hedgehog by human Patched1.
Xin Gong, Hongwu Qian, Pingping Cao, Xin Zhao, Qiang Zhou, Jianlin Lei, Nieng Yan. Science 2018
105
58

Structures of human Patched and its complex with native palmitoylated sonic hedgehog.
Xiaofeng Qi, Philip Schmiege, Elias Coutavas, Jiawei Wang, Xiaochun Li. Nature 2018
97
55

Two Patched molecules engage distinct sites on Hedgehog yielding a signaling-competent complex.
Xiaofeng Qi, Philip Schmiege, Elias Coutavas, Xiaochun Li. Science 2018
69
63

Cellular Cholesterol Directly Activates Smoothened in Hedgehog Signaling.
Pengxiang Huang, Daniel Nedelcu, Miyako Watanabe, Cindy Jao, Youngchang Kim, Jing Liu, Adrian Salic. Cell 2016
192
43

Structural basis of Smoothened regulation by its extracellular domains.
Eamon F X Byrne, Ria Sircar, Paul S Miller, George Hedger, Giovanni Luchetti, Sigrid Nachtergaele, Mark D Tully, Laurel Mydock-McGrane, Douglas F Covey, Robert P Rambo,[...]. Nature 2016
199
30

Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling.
Giovanni Luchetti, Ria Sircar, Jennifer H Kong, Sigrid Nachtergaele, Andreas Sagner, Eamon Fx Byrne, Douglas F Covey, Christian Siebold, Rajat Rohatgi. Elife 2016
130
29

Rapid, direct activity assays for Smoothened reveal Hedgehog pathway regulation by membrane cholesterol and extracellular sodium.
Benjamin R Myers, Lila Neahring, Yunxiao Zhang, Kelsey J Roberts, Philip A Beachy. Proc Natl Acad Sci U S A 2017
65
41

Inhibition of tetrameric Patched1 by Sonic Hedgehog through an asymmetric paradigm.
Hongwu Qian, Pingping Cao, Miaohui Hu, Shuai Gao, Nieng Yan, Xin Gong. Nat Commun 2019
40
67

The mechanisms of Hedgehog signalling and its roles in development and disease.
James Briscoe, Pascal P Thérond. Nat Rev Mol Cell Biol 2013
979
25


Smoothened stimulation by membrane sterols drives Hedgehog pathway activity.
Ishan Deshpande, Jiahao Liang, Danielle Hedeen, Kelsey J Roberts, Yunxiao Zhang, Betty Ha, Naomi R Latorraca, Bryan Faust, Ron O Dror, Philip A Beachy,[...]. Nature 2019
67
34

Structural basis of sterol recognition by human hedgehog receptor PTCH1.
Chao Qi, Giulio Di Minin, Irene Vercellino, Anton Wutz, Volodymyr M Korkhov. Sci Adv 2019
27
85

Structural Basis of Smoothened Activation in Hedgehog Signaling.
Pengxiang Huang, Sanduo Zheng, Bradley M Wierbowski, Youngchang Kim, Daniel Nedelcu, Laura Aravena, Jing Liu, Andrew C Kruse, Adrian Salic. Cell 2018
72
30

Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection.
Xin Gong, Hongwu Qian, Xinhui Zhou, Jianping Wu, Tao Wan, Pingping Cao, Weiyun Huang, Xin Zhao, Xudong Wang, Peiyi Wang,[...]. Cell 2016
170
22

Cilia-Associated Oxysterols Activate Smoothened.
David R Raleigh, Navdar Sever, Pervinder K Choksi, Monika Abedin Sigg, Kelly M Hines, Bonne M Thompson, Daniel Elnatan, Priyadarshini Jaishankar, Paola Bisignano, Francesc R Garcia-Gonzalo,[...]. Mol Cell 2018
56
39

Patched acts catalytically to suppress the activity of Smoothened.
J Taipale, M K Cooper, T Maiti, P A Beachy. Nature 2002
574
22

Structure of human Niemann-Pick C1 protein.
Xiaochun Li, Jiawei Wang, Elias Coutavas, Hang Shi, Qi Hao, Günter Blobel. Proc Natl Acad Sci U S A 2016
95
22

Hedgehog pathway modulation by multiple lipid binding sites on the smoothened effector of signal response.
Benjamin R Myers, Navdar Sever, Yong Chun Chong, James Kim, Jitendra D Belani, Scott Rychnovsky, J Fernando Bazan, Philip A Beachy. Dev Cell 2013
123
20

Identification of a palmitic acid-modified form of human Sonic hedgehog.
R B Pepinsky, C Zeng, D Wen, P Rayhorn, D P Baker, K P Williams, S A Bixler, C M Ambrose, E A Garber, K Miatkowski,[...]. J Biol Chem 1998
527
20

Cryo-EM structure of oxysterol-bound human Smoothened coupled to a heterotrimeric Gi.
Xiaofeng Qi, Heng Liu, Bonne Thompson, Jeffrey McDonald, Cheng Zhang, Xiaochun Li. Nature 2019
68
29

UCSF Chimera--a visualization system for exploratory research and analysis.
Eric F Pettersen, Thomas D Goddard, Conrad C Huang, Gregory S Couch, Daniel M Greenblatt, Elaine C Meng, Thomas E Ferrin. J Comput Chem 2004
19

The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism.
Amalie F Rudolf, Maia Kinnebrew, Christiane Kowatsch, T Bertie Ansell, Kamel El Omari, Benjamin Bishop, Els Pardon, Rebekka A Schwab, Tomas Malinauskas, Mingxing Qian,[...]. Nat Chem Biol 2019
27
70

Oxysterols are allosteric activators of the oncoprotein Smoothened.
Sigrid Nachtergaele, Laurel K Mydock, Kathiresan Krishnan, Jayan Rammohan, Paul H Schlesinger, Douglas F Covey, Rajat Rohatgi. Nat Chem Biol 2012
176
18

PHENIX: a comprehensive Python-based system for macromolecular structure solution.
Paul D Adams, Pavel V Afonine, Gábor Bunkóczi, Vincent B Chen, Ian W Davis, Nathaniel Echols, Jeffrey J Headd, Li-Wei Hung, Gary J Kapral, Ralf W Grosse-Kunstleve,[...]. Acta Crystallogr D Biol Crystallogr 2010
18

Patched1 regulates hedgehog signaling at the primary cilium.
Rajat Rohatgi, Ljiljana Milenkovic, Matthew P Scott. Science 2007
954
17


Dispatched and scube mediate the efficient secretion of the cholesterol-modified hedgehog ligand.
Hanna Tukachinsky, Ryan P Kuzmickas, Cindy Y Jao, Jing Liu, Adrian Salic. Cell Rep 2012
127
17

Biochemical mechanisms of vertebrate hedgehog signaling.
Jennifer H Kong, Christian Siebold, Rajat Rohatgi. Development 2019
83
20

The hedgehog receptor patched is involved in cholesterol transport.
Michel Bidet, Olivier Joubert, Benoit Lacombe, Marine Ciantar, Rony Nehmé, Patrick Mollat, Lionel Brétillon, Hélène Faure, Robert Bittman, Martial Ruat,[...]. PLoS One 2011
70
22

Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling.
Sigrid Nachtergaele, Daniel M Whalen, Laurel K Mydock, Zhonghua Zhao, Tomas Malinauskas, Kathiresan Krishnan, Philip W Ingham, Douglas F Covey, Christian Siebold, Rajat Rohatgi. Elife 2013
107
16

A defective response to Hedgehog signaling in disorders of cholesterol biosynthesis.
Michael K Cooper, Christopher A Wassif, Patrycja A Krakowiak, Jussi Taipale, Ruoyu Gong, Richard I Kelley, Forbes D Porter, Philip A Beachy. Nat Genet 2003
276
15

Structure of N-terminal domain of NPC1 reveals distinct subdomains for binding and transfer of cholesterol.
Hyock Joo Kwon, Lina Abi-Mosleh, Michael L Wang, Johann Deisenhofer, Joseph L Goldstein, Michael S Brown, Rodney E Infante. Cell 2009
422
15

Hedgehog-mediated patterning of the mammalian embryo requires transporter-like function of dispatched.
Yong Ma, Alfrun Erkner, Ruoyu Gong, Shenqin Yao, Jussi Taipale, Konrad Basler, Philip A Beachy. Cell 2002
219
15

Scube/You activity mediates release of dually lipid-modified Hedgehog signal in soluble form.
Adrian Creanga, Thomas D Glenn, Randall K Mann, Adam M Saunders, William S Talbot, Philip A Beachy. Genes Dev 2012
88
17

Oxysterol binding to the extracellular domain of Smoothened in Hedgehog signaling.
Daniel Nedelcu, Jing Liu, Yangqing Xu, Cindy Jao, Adrian Salic. Nat Chem Biol 2013
130
15

Cholesterol Modification of Smoothened Is Required for Hedgehog Signaling.
Xu Xiao, Jing-Jie Tang, Chao Peng, Yan Wang, Lin Fu, Zhi-Ping Qiu, Yue Xiong, Lian-Fang Yang, Hai-Wei Cui, Xiao-Long He,[...]. Mol Cell 2017
95
15

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy.
Shawn Q Zheng, Eugene Palovcak, Jean-Paul Armache, Kliment A Verba, Yifan Cheng, David A Agard. Nat Methods 2017
15

Structural Insight into Eukaryotic Sterol Transport through Niemann-Pick Type C Proteins.
Mikael B L Winkler, Rune T Kidmose, Maria Szomek, Katja Thaysen, Shaun Rawson, Stephen P Muench, Daniel Wüstner, Bjørn Panyella Pedersen. Cell 2019
47
31

The sterol-sensing domain: multiple families, a unique role?
Patricia E Kuwabara, Michel Labouesse. Trends Genet 2002
209
14


Niemann-Pick C1 disease gene: homology to mediators of cholesterol homeostasis.
E D Carstea, J A Morris, K G Coleman, S K Loftus, D Zhang, C Cummings, J Gu, M A Rosenfeld, W J Pavan, D B Krizman,[...]. Science 1997
14

Vertebrate Smoothened functions at the primary cilium.
Kevin C Corbit, Pia Aanstad, Veena Singla, Andrew R Norman, Didier Y R Stainier, Jeremy F Reiter. Nature 2005
13

Skinny hedgehog, an acyltransferase required for palmitoylation and activity of the hedgehog signal.
Z Chamoun, R K Mann, D Nellen, D P von Kessler, M Bellotto, P A Beachy, K Basler. Science 2001
304
13

Mechanism of inhibition of the tumor suppressor Patched by Sonic Hedgehog.
Hanna Tukachinsky, Kostadin Petrov, Miyako Watanabe, Adrian Salic. Proc Natl Acad Sci U S A 2016
49
26

Features and development of Coot.
P Emsley, B Lohkamp, W G Scott, K Cowtan. Acta Crystallogr D Biol Crystallogr 2010
13

New tools for automated high-resolution cryo-EM structure determination in RELION-3.
Jasenko Zivanov, Takanori Nakane, Björn O Forsberg, Dari Kimanius, Wim Jh Hagen, Erik Lindahl, Sjors Hw Scheres. Elife 2018
13

Cholesterol accessibility at the ciliary membrane controls hedgehog signaling.
Maia Kinnebrew, Ellen J Iverson, Bhaven B Patel, Ganesh V Pusapati, Jennifer H Kong, Kristen A Johnson, Giovanni Luchetti, Kaitlyn M Eckert, Jeffrey G McDonald, Douglas F Covey,[...]. Elife 2019
41
31

Structural basis for itraconazole-mediated NPC1 inhibition.
Tao Long, Xiaofeng Qi, Abdirahman Hassan, Qiren Liang, Jef K De Brabander, Xiaochun Li. Nat Commun 2020
25
52

Cryo-EM structure of the Hedgehog release protein Dispatched.
Fabien Cannac, Chao Qi, Julia Falschlunger, George Hausmann, Konrad Basler, Volodymyr M Korkhov. Sci Adv 2020
19
68

Structural Basis of Low-pH-Dependent Lysosomal Cholesterol Egress by NPC1 and NPC2.
Hongwu Qian, Xuelan Wu, Ximing Du, Xia Yao, Xin Zhao, Joyce Lee, Hongyuan Yang, Nieng Yan. Cell 2020
28
46


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.