A citation-based method for searching scientific literature

Alexander Varshavsky. Proc Natl Acad Sci U S A 2019
Times Cited: 221







List of co-cited articles
827 articles co-cited >1



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The N-end rule pathway and regulation by proteolysis.
Alexander Varshavsky. Protein Sci 2011
456
23

An N-end rule pathway that recognizes proline and destroys gluconeogenic enzymes.
Shun-Jia Chen, Xia Wu, Brandon Wadas, Jang-Hyun Oh, Alexander Varshavsky. Science 2017
112
20

N-terminal acetylation of cellular proteins creates specific degradation signals.
Cheol-Sang Hwang, Anna Shemorry, Alexander Varshavsky. Science 2010
442
18

The N-end rule pathway.
Takafumi Tasaki, Shashikanth M Sriram, Kyong Soo Park, Yong Tae Kwon. Annu Rev Biochem 2012
254
16

C-Terminal End-Directed Protein Elimination by CRL2 Ubiquitin Ligases.
Hsiu-Chuan Lin, Chi-Wei Yeh, Yen-Fu Chen, Ting-Ting Lee, Pei-Yun Hsieh, Domnita V Rusnac, Sung-Ya Lin, Stephen J Elledge, Ning Zheng, Hsueh-Chi S Yen. Mol Cell 2018
67
22

The Eukaryotic Proteome Is Shaped by E3 Ubiquitin Ligases Targeting C-Terminal Degrons.
Itay Koren, Richard T Timms, Tomasz Kula, Qikai Xu, Mamie Z Li, Stephen J Elledge. Cell 2018
102
14

A glycine-specific N-degron pathway mediates the quality control of protein N-myristoylation.
Richard T Timms, Zhiqian Zhang, David Y Rhee, J Wade Harper, Itay Koren, Stephen J Elledge. Science 2019
66
18

Molecular basis of GID4-mediated recognition of degrons for the Pro/N-end rule pathway.
Cheng Dong, Heng Zhang, Li Li, Wolfram Tempel, Peter Loppnau, Jinrong Min. Nat Chem Biol 2018
50
24

Ubiquitin Ligases: Structure, Function, and Regulation.
Ning Zheng, Nitzan Shabek. Annu Rev Biochem 2017
569
12

Formyl-methionine as an N-degron of a eukaryotic N-end rule pathway.
Jeong-Mok Kim, Ok-Hee Seok, Shinyeong Ju, Ji-Eun Heo, Jeonghun Yeom, Da-Som Kim, Joo-Yeon Yoo, Alexander Varshavsky, Cheolju Lee, Cheol-Sang Hwang. Science 2018
48
25

Homeostatic response to hypoxia is regulated by the N-end rule pathway in plants.
Daniel J Gibbs, Seung Cho Lee, Nurulhikma Md Isa, Silvia Gramuglia, Takeshi Fukao, George W Bassel, Cristina Sousa Correia, Françoise Corbineau, Frederica L Theodoulou, Julia Bailey-Serres,[...]. Nature 2011
384
11


Control of protein quality and stoichiometries by N-terminal acetylation and the N-end rule pathway.
Anna Shemorry, Cheol-Sang Hwang, Alexander Varshavsky. Mol Cell 2013
200
11

Structural basis for the recognition of N-end rule substrates by the UBR box of ubiquitin ligases.
Woo Suk Choi, Byung-Cheon Jeong, Yoo Jin Joo, Myeong-Ryeol Lee, Joon Kim, Michael J Eck, Hyun Kyu Song. Nat Struct Mol Biol 2010
101
10

A family of mammalian E3 ubiquitin ligases that contain the UBR box motif and recognize N-degrons.
Takafumi Tasaki, Lubbertus C F Mulder, Akihiro Iwamatsu, Min Jae Lee, Ilia V Davydov, Alexander Varshavsky, Mark Muesing, Yong Tae Kwon. Mol Cell Biol 2005
232
10

Recognition of the Diglycine C-End Degron by CRL2KLHDC2 Ubiquitin Ligase.
Domniţa-Valeria Rusnac, Hsiu-Chuan Lin, Daniele Canzani, Karena X Tien, Thomas R Hinds, Ashley F Tsue, Matthew F Bush, Hsueh-Chi S Yen, Ning Zheng. Mol Cell 2018
33
30

The N-end rule in bacteria.
J W Tobias, T E Shrader, G Rocap, A Varshavsky. Science 1991
422
10

Oxygen sensing in plants is mediated by an N-end rule pathway for protein destabilization.
Francesco Licausi, Monika Kosmacz, Daan A Weits, Beatrice Giuntoli, Federico M Giorgi, Laurentius A C J Voesenek, Pierdomenico Perata, Joost T van Dongen. Nature 2011
404
10

Control of mammalian G protein signaling by N-terminal acetylation and the N-end rule pathway.
Sang-Eun Park, Jeong-Mok Kim, Ok-Hee Seok, Hanna Cho, Brandon Wadas, Seon-Young Kim, Alexander Varshavsky, Cheol-Sang Hwang. Science 2015
95
10

The N-end rule pathway as a nitric oxide sensor controlling the levels of multiple regulators.
Rong-Gui Hu, Jun Sheng, Xin Qi, Zhenming Xu, Terry T Takahashi, Alexander Varshavsky. Nature 2005
226
9

The substrate recognition domains of the N-end rule pathway.
Takafumi Tasaki, Adriana Zakrzewska, Drew D Dudgeon, Yonghua Jiang, John S Lazo, Yong Tae Kwon. J Biol Chem 2009
93
9

Plant cysteine oxidases control the oxygen-dependent branch of the N-end-rule pathway.
Daan A Weits, Beatrice Giuntoli, Monika Kosmacz, Sandro Parlanti, Hans-Michael Hubberten, Heike Riegler, Rainer Hoefgen, Pierdomenico Perata, Joost T van Dongen, Francesco Licausi. Nat Commun 2014
190
9


The N-terminal methionine of cellular proteins as a degradation signal.
Heon-Ki Kim, Ryu-Ryun Kim, Jang-Hyun Oh, Hanna Cho, Alexander Varshavsky, Cheol-Sang Hwang. Cell 2014
121
9

Gid10 as an alternative N-recognin of the Pro/N-degron pathway.
Artem Melnykov, Shun-Jia Chen, Alexander Varshavsky. Proc Natl Acad Sci U S A 2019
24
37

The N-end rule pathway counteracts cell death by destroying proapoptotic protein fragments.
Konstantin I Piatkov, Christopher S Brower, Alexander Varshavsky. Proc Natl Acad Sci U S A 2012
102
8

An apical hypoxic niche sets the pace of shoot meristem activity.
Daan A Weits, Alicja B Kunkowska, Nicholas C W Kamps, Katharina M S Portz, Niko K Packbier, Zoe Nemec Venza, Christophe Gaillochet, Jan U Lohmann, Ole Pedersen, Joost T van Dongen,[...]. Nature 2019
75
10

Plant cysteine oxidases are dioxygenases that directly enable arginyl transferase-catalysed arginylation of N-end rule targets.
Mark D White, Maria Klecker, Richard J Hopkinson, Daan A Weits, Carolin Mueller, Christin Naumann, Rebecca O'Neill, James Wickens, Jiayu Yang, Jonathan C Brooks-Bartlett,[...]. Nat Commun 2017
107
8

Conserved N-terminal cysteine dioxygenases transduce responses to hypoxia in animals and plants.
Norma Masson, Thomas P Keeley, Beatrice Giuntoli, Mark D White, Mikel Lavilla Puerta, Pierdomenico Perata, Richard J Hopkinson, Emily Flashman, Francesco Licausi, Peter J Ratcliffe. Science 2019
86
9

The ubiquitin code.
David Komander, Michael Rape. Annu Rev Biochem 2012
8

An essential role of N-terminal arginylation in cardiovascular development.
Yong Tae Kwon, Anna S Kashina, Ilia V Davydov, Rong-Gui Hu, Jee Young An, Jai Wha Seo, Fangyong Du, Alexander Varshavsky. Science 2002
248
8

First Things First: Vital Protein Marks by N-Terminal Acetyltransferases.
Henriette Aksnes, Adrian Drazic, Michaël Marie, Thomas Arnesen. Trends Biochem Sci 2016
142
7

The molecular basis of N-end rule recognition.
Kevin H Wang, Giselle Roman-Hernandez, Robert A Grant, Robert T Sauer, Tania A Baker. Mol Cell 2008
73
9

ClpS is an essential component of the N-end rule pathway in Escherichia coli.
A Erbse, R Schmidt, T Bornemann, J Schneider-Mergener, A Mogk, R Zahn, D A Dougan, B Bukau. Nature 2006
171
7

Oxygen-dependent proteolysis regulates the stability of angiosperm polycomb repressive complex 2 subunit VERNALIZATION 2.
Daniel J Gibbs, Hannah M Tedds, Anne-Marie Labandera, Mark Bailey, Mark D White, Sjon Hartman, Colleen Sprigg, Sophie L Mogg, Rory Osborne, Charlene Dambire,[...]. Nat Commun 2018
56
12

p62/SQSTM1/Sequestosome-1 is an N-recognin of the N-end rule pathway which modulates autophagosome biogenesis.
Hyunjoo Cha-Molstad, Ji Eun Yu, Zhiwei Feng, Su Hyun Lee, Jung Gi Kim, Peng Yang, Bitnara Han, Ki Woon Sung, Young Dong Yoo, Joonsung Hwang,[...]. Nat Commun 2017
130
7

Amino-terminal arginylation targets endoplasmic reticulum chaperone BiP for autophagy through p62 binding.
Hyunjoo Cha-Molstad, Ki Sa Sung, Joonsung Hwang, Kyoung A Kim, Ji Eun Yu, Young Dong Yoo, Jun Min Jang, Dong Hoon Han, Michael Molstad, Jung Gi Kim,[...]. Nat Cell Biol 2015
143
7

Interconversion between Anticipatory and Active GID E3 Ubiquitin Ligase Conformations via Metabolically Driven Substrate Receptor Assembly.
Shuai Qiao, Christine R Langlois, Jakub Chrustowicz, Dawafuti Sherpa, Ozge Karayel, Fynn M Hansen, Viola Beier, Susanne von Gronau, Daniel Bollschweiler, Tillman Schäfer,[...]. Mol Cell 2020
29
24

The degradation signal in a short-lived protein.
A Bachmair, A Varshavsky. Cell 1989
358
7

Calpain-generated natural protein fragments as short-lived substrates of the N-end rule pathway.
Konstantin I Piatkov, Jang-Hyun Oh, Yuan Liu, Alexander Varshavsky. Proc Natl Acad Sci U S A 2014
61
11

Highly accurate protein structure prediction with AlphaFold.
John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko,[...]. Nature 2021
7

AAA+ proteases: ATP-fueled machines of protein destruction.
Robert T Sauer, Tania A Baker. Annu Rev Biochem 2011
495
6

Discovery of cellular regulation by protein degradation.
Alexander Varshavsky. J Biol Chem 2008
74
8

The eukaryotic N-end rule pathway: conserved mechanisms and diverse functions.
Daniel J Gibbs, Jaume Bacardit, Andreas Bachmair, Michael J Holdsworth. Trends Cell Biol 2014
134
6

The N-Degron Pathway Mediates ER-phagy.
Chang Hoon Ji, Hee Yeon Kim, Ah Jung Heo, Su Hyun Lee, Min Ju Lee, Su Bin Kim, Ganipisetti Srinivasrao, Su Ran Mun, Hyunjoo Cha-Molstad, Aaron Ciechanover,[...]. Mol Cell 2019
55
10

Features and development of Coot.
P Emsley, B Lohkamp, W G Scott, K Cowtan. Acta Crystallogr D Biol Crystallogr 2010
6

Spotlight on protein N-terminal acetylation.
Rasmus Ree, Sylvia Varland, Thomas Arnesen. Exp Mol Med 2018
155
6

Structural basis of substrate recognition and specificity in the N-end rule pathway.
Edna Matta-Camacho, Guennadi Kozlov, Flora F Li, Kalle Gehring. Nat Struct Mol Biol 2010
75
8

Recognition of nonproline N-terminal residues by the Pro/N-degron pathway.
Cheng Dong, Shun-Jia Chen, Artem Melnykov, Sara Weirich, Kelly Sun, Albert Jeltsch, Alexander Varshavsky, Jinrong Min. Proc Natl Acad Sci U S A 2020
15
40


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.