HCMV modulation of cellular PI3K/AKT/mTOR signaling: New opportunities for therapeutic intervention?
Aaron M Altman, Jamil Mahmud, Zaneta Nikolovska-Coleska, Gary Chan. Antiviral Res 2019
Times Cited: 18
Times Cited: 18
Times Cited
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Platelet-derived growth factor-alpha receptor activation is required for human cytomegalovirus infection.
Liliana Soroceanu, Armin Akhavan, Charles S Cobbs. Nature 2008
Liliana Soroceanu, Armin Akhavan, Charles S Cobbs. Nature 2008
33
Human cytomegalovirus glycoprotein complex gH/gL/gO uses PDGFR-α as a key for entry.
Yiquan Wu, Adrian Prager, Simone Boos, Moritz Resch, Ilija Brizic, Michael Mach, Sabrina Wildner, Laura Scrivano, Barbara Adler. PLoS Pathog 2017
Yiquan Wu, Adrian Prager, Simone Boos, Moritz Resch, Ilija Brizic, Michael Mach, Sabrina Wildner, Laura Scrivano, Barbara Adler. PLoS Pathog 2017
33
THY-1 Cell Surface Antigen (CD90) Has an Important Role in the Initial Stage of Human Cytomegalovirus Infection.
Qingxue Li, Adrian R Wilkie, Melodie Weller, Xueqiao Liu, Jeffrey I Cohen. PLoS Pathog 2015
Qingxue Li, Adrian R Wilkie, Melodie Weller, Xueqiao Liu, Jeffrey I Cohen. PLoS Pathog 2015
27
Activation of EGFR on monocytes is required for human cytomegalovirus entry and mediates cellular motility.
Gary Chan, Maciej T Nogalski, Andrew D Yurochko. Proc Natl Acad Sci U S A 2009
Gary Chan, Maciej T Nogalski, Andrew D Yurochko. Proc Natl Acad Sci U S A 2009
27
Aberrant regulation of the Akt signaling network by human cytomegalovirus allows for targeting of infected monocytes.
Megan A Peppenelli, Michael J Miller, Aaron M Altman, Olesea Cojohari, Gary C Chan. Antiviral Res 2018
Megan A Peppenelli, Michael J Miller, Aaron M Altman, Olesea Cojohari, Gary C Chan. Antiviral Res 2018
33
Human Cytomegalovirus Requires Epidermal Growth Factor Receptor Signaling To Enter and Initiate the Early Steps in the Establishment of Latency in CD34+ Human Progenitor Cells.
Jung Heon Kim, Donna Collins-McMillen, Jason C Buehler, Felicia D Goodrum, Andrew D Yurochko. J Virol 2017
Jung Heon Kim, Donna Collins-McMillen, Jason C Buehler, Felicia D Goodrum, Andrew D Yurochko. J Virol 2017
22
Opposing Regulation of the EGF Receptor: A Molecular Switch Controlling Cytomegalovirus Latency and Replication.
Jason Buehler, Sebastian Zeltzer, Justin Reitsma, Alex Petrucelli, Mahadevaiah Umashankar, Mike Rak, Patricia Zagallo, Joyce Schroeder, Scott Terhune, Felicia Goodrum. PLoS Pathog 2016
Jason Buehler, Sebastian Zeltzer, Justin Reitsma, Alex Petrucelli, Mahadevaiah Umashankar, Mike Rak, Patricia Zagallo, Joyce Schroeder, Scott Terhune, Felicia Goodrum. PLoS Pathog 2016
22
The human cytomegalovirus UL55 (gB) and UL75 (gH) glycoprotein ligands initiate the rapid activation of Sp1 and NF-kappaB during infection.
A D Yurochko, E S Hwang, L Rasmussen, S Keay, L Pereira, E S Huang. J Virol 1997
A D Yurochko, E S Hwang, L Rasmussen, S Keay, L Pereira, E S Huang. J Virol 1997
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Epidermal growth factor receptor is a cellular receptor for human cytomegalovirus.
Xin Wang, Shu-Mei Huong, Marie L Chiu, Nancy Raab-Traub, Eng-Shang Huang. Nature 2003
Xin Wang, Shu-Mei Huong, Marie L Chiu, Nancy Raab-Traub, Eng-Shang Huang. Nature 2003
22
Alternative promoters drive human cytomegalovirus reactivation from latency.
Donna Collins-McMillen, Mike Rak, Jason C Buehler, Suzu Igarashi-Hayes, Jeremy P Kamil, Nathaniel J Moorman, Felicia Goodrum. Proc Natl Acad Sci U S A 2019
Donna Collins-McMillen, Mike Rak, Jason C Buehler, Suzu Igarashi-Hayes, Jeremy P Kamil, Nathaniel J Moorman, Felicia Goodrum. Proc Natl Acad Sci U S A 2019
22
Human Cytomegalovirus Induces an Atypical Activation of Akt To Stimulate the Survival of Short-Lived Monocytes.
Olesea Cojohari, Megan A Peppenelli, Gary C Chan. J Virol 2016
Olesea Cojohari, Megan A Peppenelli, Gary C Chan. J Virol 2016
22
Activation of the NF-kappaB pathway in human cytomegalovirus-infected cells is necessary for efficient transactivation of the major immediate-early promoter.
Ian B DeMeritt, Liesl E Milford, Andrew D Yurochko. J Virol 2004
Ian B DeMeritt, Liesl E Milford, Andrew D Yurochko. J Virol 2004
16
Human cytomegalovirus IE1 protein disrupts interleukin-6 signaling by sequestering STAT3 in the nucleus.
Justin M Reitsma, Hiromi Sato, Michael Nevels, Scott S Terhune, Christina Paulus. J Virol 2013
Justin M Reitsma, Hiromi Sato, Michael Nevels, Scott S Terhune, Christina Paulus. J Virol 2013
16
Human cytomegalovirus infection alters the substrate specificities and rapamycin sensitivities of raptor- and rictor-containing complexes.
Sagar B Kudchodkar, Yongjun Yu, Tobi G Maguire, James C Alwine. Proc Natl Acad Sci U S A 2006
Sagar B Kudchodkar, Yongjun Yu, Tobi G Maguire, James C Alwine. Proc Natl Acad Sci U S A 2006
16
The HCMV gH/gL/UL128-131 complex triggers the specific cellular activation required for efficient viral internalization into target monocytes.
Maciej T Nogalski, Gary C T Chan, Emily V Stevenson, Donna K Collins-McMillen, Andrew D Yurochko. PLoS Pathog 2013
Maciej T Nogalski, Gary C T Chan, Emily V Stevenson, Donna K Collins-McMillen, Andrew D Yurochko. PLoS Pathog 2013
16
Release of human cytomegalovirus from latency by a KAP1/TRIM28 phosphorylation switch.
Benjamin Rauwel, Suk Min Jang, Marco Cassano, Adamandia Kapopoulou, Isabelle Barde, Didier Trono. Elife 2015
Benjamin Rauwel, Suk Min Jang, Marco Cassano, Adamandia Kapopoulou, Isabelle Barde, Didier Trono. Elife 2015
16
Suppression of immediate-early viral gene expression by herpesvirus-coded microRNAs: implications for latency.
Eain Murphy, Jirí Vanícek, Harlan Robins, Thomas Shenk, Arnold J Levine. Proc Natl Acad Sci U S A 2008
Eain Murphy, Jirí Vanícek, Harlan Robins, Thomas Shenk, Arnold J Levine. Proc Natl Acad Sci U S A 2008
16
Mitogen and stress activated kinases act co-operatively with CREB during the induction of human cytomegalovirus immediate-early gene expression from latency.
Verity G Kew, Jinxiang Yuan, Jeffery Meier, Matthew B Reeves. PLoS Pathog 2014
Verity G Kew, Jinxiang Yuan, Jeffery Meier, Matthew B Reeves. PLoS Pathog 2014
16
16
Modulation of oncogenic phenotype in human glioma cells by cytomegalovirus IE1-mediated mitogenicity.
Charles S Cobbs, Liliana Soroceanu, Scott Denham, Wenyue Zhang, Matthias H Kraus. Cancer Res 2008
Charles S Cobbs, Liliana Soroceanu, Scott Denham, Wenyue Zhang, Matthias H Kraus. Cancer Res 2008
16
PI3K-dependent upregulation of Mcl-1 by human cytomegalovirus is mediated by epidermal growth factor receptor and inhibits apoptosis in short-lived monocytes.
Gary Chan, Maciej T Nogalski, Gretchen L Bentz, M Shane Smith, Alexander Parmater, Andrew D Yurochko. J Immunol 2010
Gary Chan, Maciej T Nogalski, Gretchen L Bentz, M Shane Smith, Alexander Parmater, Andrew D Yurochko. J Immunol 2010
16
Human cytomegalovirus with IE-2 (UL122) deleted fails to express early lytic genes.
A Marchini, H Liu, H Zhu. J Virol 2001
A Marchini, H Liu, H Zhu. J Virol 2001
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High-resolution human cytomegalovirus transcriptome.
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Latency, chromatin remodeling, and reactivation of human cytomegalovirus in the dendritic cells of healthy carriers.
M B Reeves, P A MacAry, P J Lehner, J G P Sissons, J H Sinclair. Proc Natl Acad Sci U S A 2005
M B Reeves, P A MacAry, P J Lehner, J G P Sissons, J H Sinclair. Proc Natl Acad Sci U S A 2005
16
Host signaling and EGR1 transcriptional control of human cytomegalovirus replication and latency.
Jason Buehler, Ethan Carpenter, Sebastian Zeltzer, Suzu Igarashi, Michael Rak, Iliyana Mikell, Jay A Nelson, Felicia Goodrum. PLoS Pathog 2019
Jason Buehler, Ethan Carpenter, Sebastian Zeltzer, Suzu Igarashi, Michael Rak, Iliyana Mikell, Jay A Nelson, Felicia Goodrum. PLoS Pathog 2019
16
Human cytomegalovirus gene expression is silenced by Daxx-mediated intrinsic immune defense in model latent infections established in vitro.
Ryan T Saffert, Robert F Kalejta. J Virol 2007
Ryan T Saffert, Robert F Kalejta. J Virol 2007
16
Human cytomegalovirus miR-UL112-1 promotes the down-regulation of viral immediate early-gene expression during latency to prevent T-cell recognition of latently infected cells.
Betty Lau, Emma Poole, Ellen Van Damme, Lieve Bunkens, Madeleine Sowash, Harry King, Eain Murphy, Mark Wills, Marnix Van Loock, John Sinclair. J Gen Virol 2016
Betty Lau, Emma Poole, Ellen Van Damme, Lieve Bunkens, Madeleine Sowash, Harry King, Eain Murphy, Mark Wills, Marnix Van Loock, John Sinclair. J Gen Virol 2016
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Control of cytomegalovirus lytic gene expression by histone acetylation.
Jane C Murphy, Wolfgang Fischle, Eric Verdin, John H Sinclair. EMBO J 2002
Jane C Murphy, Wolfgang Fischle, Eric Verdin, John H Sinclair. EMBO J 2002
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An in vitro model for the regulation of human cytomegalovirus latency and reactivation in dendritic cells by chromatin remodelling.
M B Reeves, P J Lehner, J G P Sissons, J H Sinclair. J Gen Virol 2005
M B Reeves, P J Lehner, J G P Sissons, J H Sinclair. J Gen Virol 2005
16
HCMV miR-US22 down-regulation of EGR-1 regulates CD34+ hematopoietic progenitor cell proliferation and viral reactivation.
Iliyana Mikell, Lindsey B Crawford, Meaghan H Hancock, Jennifer Mitchell, Jason Buehler, Felicia Goodrum, Jay A Nelson. PLoS Pathog 2019
Iliyana Mikell, Lindsey B Crawford, Meaghan H Hancock, Jennifer Mitchell, Jason Buehler, Felicia Goodrum, Jay A Nelson. PLoS Pathog 2019
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Reversal of human cytomegalovirus major immediate-early enhancer/promoter silencing in quiescently infected cells via the cyclic AMP signaling pathway.
Michael J Keller, Allen W Wu, Janet I Andrews, Patrick W McGonagill, Eric E Tibesar, Jeffery L Meier. J Virol 2007
Michael J Keller, Allen W Wu, Janet I Andrews, Patrick W McGonagill, Eric E Tibesar, Jeffery L Meier. J Virol 2007
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Transcriptome-wide characterization of human cytomegalovirus in natural infection and experimental latency.
Shu Cheng, Katie Caviness, Jason Buehler, Megan Smithey, Janko Nikolich-Žugich, Felicia Goodrum. Proc Natl Acad Sci U S A 2017
Shu Cheng, Katie Caviness, Jason Buehler, Megan Smithey, Janko Nikolich-Žugich, Felicia Goodrum. Proc Natl Acad Sci U S A 2017
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Initiation of human cytomegalovirus infection requires initial interaction with cell surface heparan sulfate.
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Latent and persistent infections of monocytes and macrophages.
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An Unbiased Screen for Human Cytomegalovirus Identifies Neuropilin-2 as a Central Viral Receptor.
Nadia Martinez-Martin, Jessica Marcandalli, Christine S Huang, Christopher P Arthur, Michela Perotti, Mathilde Foglierini, Hoangdung Ho, Annie M Dosey, Stephanie Shriver, Jian Payandeh,[...]. Cell 2018
Nadia Martinez-Martin, Jessica Marcandalli, Christine S Huang, Christopher P Arthur, Michela Perotti, Mathilde Foglierini, Hoangdung Ho, Annie M Dosey, Stephanie Shriver, Jian Payandeh,[...]. Cell 2018
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Protein pUL128 of human cytomegalovirus is necessary for monocyte infection and blocking of migration.
Sarah Straschewski, Marco Patrone, Paul Walther, Andrea Gallina, Thomas Mertens, Giada Frascaroli. J Virol 2011
Sarah Straschewski, Marco Patrone, Paul Walther, Andrea Gallina, Thomas Mertens, Giada Frascaroli. J Virol 2011
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Role of human cytomegalovirus UL131A in cell type-specific virus entry and release.
Barbara Adler, Laura Scrivano, Zsolt Ruzcics, Brigitte Rupp, Christian Sinzger, Ulrich Koszinowski. J Gen Virol 2006
Barbara Adler, Laura Scrivano, Zsolt Ruzcics, Brigitte Rupp, Christian Sinzger, Ulrich Koszinowski. J Gen Virol 2006
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Human cytomegalovirus-regulated paxillin in monocytes links cellular pathogenic motility to the process of viral entry.
Maciej T Nogalski, Gary Chan, Emily V Stevenson, Scarlet Gray, Andrew D Yurochko. J Virol 2011
Maciej T Nogalski, Gary Chan, Emily V Stevenson, Scarlet Gray, Andrew D Yurochko. J Virol 2011
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Human cytomegalovirus stimulates monocyte-to-macrophage differentiation via the temporal regulation of caspase 3.
Gary Chan, Maciej T Nogalski, Andrew D Yurochko. J Virol 2012
Gary Chan, Maciej T Nogalski, Andrew D Yurochko. J Virol 2012
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Induction of endogenous human cytomegalovirus gene expression after differentiation of monocytes from healthy carriers.
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Platelet-derived growth factor-α receptor is the cellular receptor for human cytomegalovirus gHgLgO trimer.
Anna Kabanova, Jessica Marcandalli, Tongqing Zhou, Siro Bianchi, Ulrich Baxa, Yaroslav Tsybovsky, Daniele Lilleri, Chiara Silacci-Fregni, Mathilde Foglierini, Blanca Maria Fernandez-Rodriguez,[...]. Nat Microbiol 2016
Anna Kabanova, Jessica Marcandalli, Tongqing Zhou, Siro Bianchi, Ulrich Baxa, Yaroslav Tsybovsky, Daniele Lilleri, Chiara Silacci-Fregni, Mathilde Foglierini, Blanca Maria Fernandez-Rodriguez,[...]. Nat Microbiol 2016
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The human cytomegalovirus UL74 gene encodes the third component of the glycoprotein H-glycoprotein L-containing envelope complex.
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Cellular integrins function as entry receptors for human cytomegalovirus via a highly conserved disintegrin-like domain.
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CD147 Promotes Entry of Pentamer-Expressing Human Cytomegalovirus into Epithelial and Endothelial Cells.
Adam L Vanarsdall, Sarah R Pritchard, Todd W Wisner, Jing Liu, Ted S Jardetzky, David C Johnson. mBio 2018
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Monocytes are a major site of persistence of human cytomegalovirus in peripheral blood mononuclear cells.
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Integrin alphavbeta3 is a coreceptor for human cytomegalovirus.
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Human cytomegalovirus induces monocyte differentiation and migration as a strategy for dissemination and persistence.
M Shane Smith, Gretchen L Bentz, J Steven Alexander, Andrew D Yurochko. J Virol 2004
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Intracellular formation and processing of the heterotrimeric gH-gL-gO (gCIII) glycoprotein envelope complex of human cytomegalovirus.
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Human cytomegalovirus chemokine receptor gene US28 is transcribed in latently infected THP-1 monocytes.
P S Beisser, L Laurent, J L Virelizier, S Michelson. J Virol 2001
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HCMV activates PI(3)K in monocytes and promotes monocyte motility and transendothelial migration in a PI(3)K-dependent manner.
M Shane Smith, Gretchen L Bentz, Patrick M Smith, Elizabeth R Bivins, Andrew D Yurochko. J Leukoc Biol 2004
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16
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