Sarah H Shahmoradian, Amanda J Lewis, Christel Genoud, Jürgen Hench, Tim E Moors, Paula P Navarro, Daniel Castaño-Díez, Gabriel Schweighauser, Alexandra Graff-Meyer, Kenneth N Goldie, Rosmarie Sütterlin, Evelien Huisman, Angela Ingrassia, Yvonne de Gier, Annemieke J M Rozemuller, Jing Wang, Anne De Paepe, Johannes Erny, Andreas Staempfli, Joerg Hoernschemeyer, Frederik Großerüschkamp, Daniel Niedieker, Samir F El-Mashtoly, Marialuisa Quadri, Wilfred F J Van IJcken, Vincenzo Bonifati, Klaus Gerwert, Bernd Bohrmann, Stephan Frank, Markus Britschgi, Henning Stahlberg, Wilma D J Van de Berg, Matthias E Lauer. Nat Neurosci 2019
Times Cited: 369
Times Cited: 369
Times Cited
Times Co-cited
Similarity
Alpha-synuclein in Lewy bodies.
M G Spillantini, M L Schmidt, V M Lee, J Q Trojanowski, R Jakes, M Goedert. Nature 1997
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alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies.
M G Spillantini, R A Crowther, R Jakes, M Hasegawa, M Goedert. Proc Natl Acad Sci U S A 1998
M G Spillantini, R A Crowther, R Jakes, M Hasegawa, M Goedert. Proc Natl Acad Sci U S A 1998
23
The process of Lewy body formation, rather than simply α-synuclein fibrillization, is one of the major drivers of neurodegeneration.
Anne-Laure Mahul-Mellier, Johannes Burtscher, Niran Maharjan, Laura Weerens, Marie Croisier, Fabien Kuttler, Marion Leleu, Graham W Knott, Hilal A Lashuel. Proc Natl Acad Sci U S A 2020
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Staging of brain pathology related to sporadic Parkinson's disease.
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Structures of α-synuclein filaments from multiple system atrophy.
Manuel Schweighauser, Yang Shi, Airi Tarutani, Fuyuki Kametani, Alexey G Murzin, Bernardino Ghetti, Tomoyasu Matsubara, Taisuke Tomita, Takashi Ando, Kazuko Hasegawa,[...]. Nature 2020
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Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice.
Kelvin C Luk, Victoria Kehm, Jenna Carroll, Bin Zhang, Patrick O'Brien, John Q Trojanowski, Virginia M-Y Lee. Science 2012
Kelvin C Luk, Victoria Kehm, Jenna Carroll, Bin Zhang, Patrick O'Brien, John Q Trojanowski, Virginia M-Y Lee. Science 2012
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Exogenous α-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death.
Laura A Volpicelli-Daley, Kelvin C Luk, Tapan P Patel, Selcuk A Tanik, Dawn M Riddle, Anna Stieber, David F Meaney, John Q Trojanowski, Virginia M-Y Lee. Neuron 2011
Laura A Volpicelli-Daley, Kelvin C Luk, Tapan P Patel, Selcuk A Tanik, Dawn M Riddle, Anna Stieber, David F Meaney, John Q Trojanowski, Virginia M-Y Lee. Neuron 2011
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Mutation in the alpha-synuclein gene identified in families with Parkinson's disease.
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alpha-Synuclein is phosphorylated in synucleinopathy lesions.
Hideo Fujiwara, Masato Hasegawa, Naoshi Dohmae, Akiko Kawashima, Eliezer Masliah, Matthew S Goldberg, Jie Shen, Koji Takio, Takeshi Iwatsubo. Nat Cell Biol 2002
Hideo Fujiwara, Masato Hasegawa, Naoshi Dohmae, Akiko Kawashima, Eliezer Masliah, Matthew S Goldberg, Jie Shen, Koji Takio, Takeshi Iwatsubo. Nat Cell Biol 2002
16
Discriminating α-synuclein strains in Parkinson's disease and multiple system atrophy.
Mohammad Shahnawaz, Abhisek Mukherjee, Sandra Pritzkow, Nicolas Mendez, Prakruti Rabadia, Xiangan Liu, Bo Hu, Ann Schmeichel, Wolfgang Singer, Gang Wu,[...]. Nature 2020
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16
Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease.
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14
Cellular milieu imparts distinct pathological α-synuclein strains in α-synucleinopathies.
Chao Peng, Ronald J Gathagan, Dustin J Covell, Coraima Medellin, Anna Stieber, John L Robinson, Bin Zhang, Rose M Pitkin, Modupe F Olufemi, Kelvin C Luk,[...]. Nature 2018
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14
α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation.
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13
alpha-Synuclein locus triplication causes Parkinson's disease.
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13
Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro.
Jacqueline Burré, Manu Sharma, Theodoros Tsetsenis, Vladimir Buchman, Mark R Etherton, Thomas C Südhof. Science 2010
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The many faces of α-synuclein: from structure and toxicity to therapeutic target.
Hilal A Lashuel, Cassia R Overk, Abid Oueslati, Eliezer Masliah. Nat Rev Neurosci 2013
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12
Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation.
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12
In vivo demonstration that alpha-synuclein oligomers are toxic.
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11
Cryo-EM structure of alpha-synuclein fibrils.
Ricardo Guerrero-Ferreira, Nicholas Mi Taylor, Daniel Mona, Philippe Ringler, Matthias E Lauer, Roland Riek, Markus Britschgi, Henning Stahlberg. Elife 2018
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11
Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation.
Céline Galvagnion, Alexander K Buell, Georg Meisl, Thomas C T Michaels, Michele Vendruscolo, Tuomas P J Knowles, Christopher M Dobson. Nat Chem Biol 2015
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11
Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease.
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11
Mutations associated with familial Parkinson's disease alter the initiation and amplification steps of α-synuclein aggregation.
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11
Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism.
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11
Exogenous alpha-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells.
Kelvin C Luk, Cheng Song, Patrick O'Brien, Anna Stieber, Jonathan R Branch, Kurt R Brunden, John Q Trojanowski, Virginia M-Y Lee. Proc Natl Acad Sci U S A 2009
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11
α-Synuclein strains cause distinct synucleinopathies after local and systemic administration.
W Peelaerts, L Bousset, A Van der Perren, A Moskalyuk, R Pulizzi, M Giugliano, C Van den Haute, R Melki, V Baekelandt. Nature 2015
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11
Structural and functional characterization of two alpha-synuclein strains.
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11
Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies.
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10
Do Lewy bodies contain alpha-synuclein fibrils? and Does it matter? A brief history and critical analysis of recent reports.
Hilal A Lashuel. Neurobiol Dis 2020
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Filamentous alpha-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies.
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10
α-synuclein oligomers and fibrils: a spectrum of species, a spectrum of toxicities.
Parvez Alam, Luc Bousset, Ronald Melki, Daniel E Otzen. J Neurochem 2019
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10
Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers.
Giuliana Fusco, Serene W Chen, Philip T F Williamson, Roberta Cascella, Michele Perni, James A Jarvis, Cristina Cecchi, Michele Vendruscolo, Fabrizio Chiti, Nunilo Cremades,[...]. Science 2017
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9
Structural disorder of monomeric α-synuclein persists in mammalian cells.
Francois-Xavier Theillet, Andres Binolfi, Beata Bekei, Andrea Martorana, Honor May Rose, Marchel Stuiver, Silvia Verzini, Dorothea Lorenz, Marleen van Rossum, Daniella Goldfarb,[...]. Nature 2016
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9
Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis.
Venu M Nemani, Wei Lu, Victoria Berge, Ken Nakamura, Bibiana Onoa, Michael K Lee, Farrukh A Chaudhry, Roger A Nicoll, Robert H Edwards. Neuron 2010
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9
A Stearoyl-Coenzyme A Desaturase Inhibitor Prevents Multiple Parkinson Disease Phenotypes in α-Synuclein Mice.
Silke Nuber, Alice Y Nam, Molly M Rajsombath, Haley Cirka, Xiaoping Hronowski, Junmin Wang, Kevin Hodgetts, Liubov S Kalinichenko, Christian P Müller, Vera Lambrecht,[...]. Ann Neurol 2021
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36
Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment.
Saranna Fanning, Aftabul Haque, Thibaut Imberdis, Valeriya Baru, M Inmaculada Barrasa, Silke Nuber, Daniel Termine, Nagendran Ramalingam, Gary P H Ho, Tallie Noble,[...]. Mol Cell 2019
Saranna Fanning, Aftabul Haque, Thibaut Imberdis, Valeriya Baru, M Inmaculada Barrasa, Silke Nuber, Daniel Termine, Nagendran Ramalingam, Gary P H Ho, Tallie Noble,[...]. Mol Cell 2019
9
α-Synuclein strains target distinct brain regions and cell types.
Angus Lau, Raphaella W L So, Heather H C Lau, Jason C Sang, Alejandro Ruiz-Riquelme, Shelaine C Fleck, Erica Stuart, Sindhu Menon, Naomi P Visanji, Georg Meisl,[...]. Nat Neurosci 2020
Angus Lau, Raphaella W L So, Heather H C Lau, Jason C Sang, Alejandro Ruiz-Riquelme, Shelaine C Fleck, Erica Stuart, Sindhu Menon, Naomi P Visanji, Georg Meisl,[...]. Nat Neurosci 2020
9
NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded.
P H Weinreb, W Zhen, A W Poon, K A Conway, P T Lansbury. Biochemistry 1996
P H Weinreb, W Zhen, A W Poon, K A Conway, P T Lansbury. Biochemistry 1996
9
Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds.
Brandon B Holmes, Sarah L DeVos, Najla Kfoury, Mei Li, Rachel Jacks, Kiran Yanamandra, Mohand O Ouidja, Frances M Brodsky, Jayne Marasa, Devika P Bagchi,[...]. Proc Natl Acad Sci U S A 2013
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9
Cryo-EM of full-length α-synuclein reveals fibril polymorphs with a common structural kernel.
Binsen Li, Peng Ge, Kevin A Murray, Phorum Sheth, Meng Zhang, Gayatri Nair, Michael R Sawaya, Woo Shik Shin, David R Boyer, Shulin Ye,[...]. Nat Commun 2018
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9
Amyloid fibril structure of α-synuclein determined by cryo-electron microscopy.
Yaowang Li, Chunyu Zhao, Feng Luo, Zhenying Liu, Xinrui Gui, Zhipu Luo, Xiang Zhang, Dan Li, Cong Liu, Xueming Li. Cell Res 2018
Yaowang Li, Chunyu Zhao, Feng Luo, Zhenying Liu, Xinrui Gui, Zhipu Luo, Xiang Zhang, Dan Li, Cong Liu, Xueming Li. Cell Res 2018
9
G51D α-synuclein mutation causes a novel parkinsonian-pyramidal syndrome.
Suzanne Lesage, Mathieu Anheim, Franck Letournel, Luc Bousset, Aurélie Honoré, Nelly Rozas, Laura Pieri, Karine Madiona, Alexandra Dürr, Ronald Melki,[...]. Ann Neurol 2013
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8
The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia.
Juan J Zarranz, Javier Alegre, Juan C Gómez-Esteban, Elena Lezcano, Raquel Ros, Israel Ampuero, Lídice Vidal, Janet Hoenicka, Olga Rodriguez, Begoña Atarés,[...]. Ann Neurol 2004
Juan J Zarranz, Javier Alegre, Juan C Gómez-Esteban, Elena Lezcano, Raquel Ros, Israel Ampuero, Lídice Vidal, Janet Hoenicka, Olga Rodriguez, Begoña Atarés,[...]. Ann Neurol 2004
8
Cell Biology and Pathophysiology of α-Synuclein.
Jacqueline Burré, Manu Sharma, Thomas C Südhof. Cold Spring Harb Perspect Med 2018
Jacqueline Burré, Manu Sharma, Thomas C Südhof. Cold Spring Harb Perspect Med 2018
8
Implication of Alpha-Synuclein Phosphorylation at S129 in Synucleinopathies: What Have We Learned in the Last Decade?
Abid Oueslati. J Parkinsons Dis 2016
Abid Oueslati. J Parkinsons Dis 2016
8
Direct observation of the three regions in α-synuclein that determine its membrane-bound behaviour.
Giuliana Fusco, Alfonso De Simone, Tata Gopinath, Vitaly Vostrikov, Michele Vendruscolo, Christopher M Dobson, Gianluigi Veglia. Nat Commun 2014
Giuliana Fusco, Alfonso De Simone, Tata Gopinath, Vitaly Vostrikov, Michele Vendruscolo, Christopher M Dobson, Gianluigi Veglia. Nat Commun 2014
8
α-Synuclein aggregation nucleates through liquid-liquid phase separation.
Soumik Ray, Nitu Singh, Rakesh Kumar, Komal Patel, Satyaprakash Pandey, Debalina Datta, Jaladhar Mahato, Rajlaxmi Panigrahi, Ambuja Navalkar, Surabhi Mehra,[...]. Nat Chem 2020
Soumik Ray, Nitu Singh, Rakesh Kumar, Komal Patel, Satyaprakash Pandey, Debalina Datta, Jaladhar Mahato, Rajlaxmi Panigrahi, Ambuja Navalkar, Surabhi Mehra,[...]. Nat Chem 2020
8
Gaucher disease glucocerebrosidase and α-synuclein form a bidirectional pathogenic loop in synucleinopathies.
Joseph R Mazzulli, You-Hai Xu, Ying Sun, Adam L Knight, Pamela J McLean, Guy A Caldwell, Ellen Sidransky, Gregory A Grabowski, Dimitri Krainc. Cell 2011
Joseph R Mazzulli, You-Hai Xu, Ying Sun, Adam L Knight, Pamela J McLean, Guy A Caldwell, Ellen Sidransky, Gregory A Grabowski, Dimitri Krainc. Cell 2011
8
The Lewy body in Parkinson's disease: molecules implicated in the formation and degradation of alpha-synuclein aggregates.
Koichi Wakabayashi, Kunikazu Tanji, Fumiaki Mori, Hitoshi Takahashi. Neuropathology 2007
Koichi Wakabayashi, Kunikazu Tanji, Fumiaki Mori, Hitoshi Takahashi. Neuropathology 2007
8
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.