Mona Motwani, Scott Pesiridis, Katherine A Fitzgerald. Nat Rev Genet 2019
Times Cited: 341
Times Cited: 341
Times Cited
Times Co-cited
Similarity
Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway.
Lijun Sun, Jiaxi Wu, Fenghe Du, Xiang Chen, Zhijian J Chen. Science 2013
Lijun Sun, Jiaxi Wu, Fenghe Du, Xiang Chen, Zhijian J Chen. Science 2013
32
STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling.
Hiroki Ishikawa, Glen N Barber. Nature 2008
Hiroki Ishikawa, Glen N Barber. Nature 2008
29
Molecular mechanisms and cellular functions of cGAS-STING signalling.
Karl-Peter Hopfner, Veit Hornung. Nat Rev Mol Cell Biol 2020
Karl-Peter Hopfner, Veit Hornung. Nat Rev Mol Cell Biol 2020
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Autophagy induction via STING trafficking is a primordial function of the cGAS pathway.
Xiang Gui, Hui Yang, Tuo Li, Xiaojun Tan, Peiqing Shi, Minghao Li, Fenghe Du, Zhijian J Chen. Nature 2019
Xiang Gui, Hui Yang, Tuo Li, Xiaojun Tan, Peiqing Shi, Minghao Li, Fenghe Du, Zhijian J Chen. Nature 2019
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Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA.
Jiaxi Wu, Lijun Sun, Xiang Chen, Fenghe Du, Heping Shi, Chuo Chen, Zhijian J Chen. Science 2013
Jiaxi Wu, Lijun Sun, Xiang Chen, Fenghe Du, Heping Shi, Chuo Chen, Zhijian J Chen. Science 2013
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Regulation and function of the cGAS-STING pathway of cytosolic DNA sensing.
Qi Chen, Lijun Sun, Zhijian J Chen. Nat Immunol 2016
Qi Chen, Lijun Sun, Zhijian J Chen. Nat Immunol 2016
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The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation.
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Targeting STING with covalent small-molecule inhibitors.
Simone M Haag, Muhammet F Gulen, Luc Reymond, Antoine Gibelin, Laurence Abrami, Alexiane Decout, Michael Heymann, F Gisou van der Goot, Gerardo Turcatti, Rayk Behrendt,[...]. Nature 2018
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15
STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity.
Hiroki Ishikawa, Zhe Ma, Glen N Barber. Nature 2009
Hiroki Ishikawa, Zhe Ma, Glen N Barber. Nature 2009
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The cGAS-STING pathway as a therapeutic target in inflammatory diseases.
Alexiane Decout, Jason D Katz, Shankar Venkatraman, Andrea Ablasser. Nat Rev Immunol 2021
Alexiane Decout, Jason D Katz, Shankar Venkatraman, Andrea Ablasser. Nat Rev Immunol 2021
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cGAS in action: Expanding roles in immunity and inflammation.
Andrea Ablasser, Zhijian J Chen. Science 2019
Andrea Ablasser, Zhijian J Chen. Science 2019
13
Mitochondrial DNA stress primes the antiviral innate immune response.
A Phillip West, William Khoury-Hanold, Matthew Staron, Michal C Tal, Cristiana M Pineda, Sabine M Lang, Megan Bestwick, Brett A Duguay, Nuno Raimundo, Donna A MacDuff,[...]. Nature 2015
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The Cytosolic DNA-Sensing cGAS-STING Pathway in Cancer.
John Kwon, Samuel F Bakhoum. Cancer Discov 2020
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cGAS surveillance of micronuclei links genome instability to innate immunity.
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Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation.
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Cytosolic-DNA-mediated, STING-dependent proinflammatory gene induction necessitates canonical NF-κB activation through TBK1.
Takayuki Abe, Glen N Barber. J Virol 2014
Takayuki Abe, Glen N Barber. J Virol 2014
13
cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING.
Andrea Ablasser, Marion Goldeck, Taner Cavlar, Tobias Deimling, Gregor Witte, Ingo Röhl, Karl-Peter Hopfner, Janos Ludwig, Veit Hornung. Nature 2013
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Nuclear cGAS suppresses DNA repair and promotes tumorigenesis.
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12
Activation of STING requires palmitoylation at the Golgi.
Kojiro Mukai, Hiroyasu Konno, Tatsuya Akiba, Takefumi Uemura, Satoshi Waguri, Toshihide Kobayashi, Glen N Barber, Hiroyuki Arai, Tomohiko Taguchi. Nat Commun 2016
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12
Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP-AMP.
Guijun Shang, Conggang Zhang, Zhijian J Chen, Xiao-Chen Bai, Xuewu Zhang. Nature 2019
Guijun Shang, Conggang Zhang, Zhijian J Chen, Xiao-Chen Bai, Xuewu Zhang. Nature 2019
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Cytoplasmic chromatin triggers inflammation in senescence and cancer.
Zhixun Dou, Kanad Ghosh, Maria Grazia Vizioli, Jiajun Zhu, Payel Sen, Kirk J Wangensteen, Johayra Simithy, Yemin Lan, Yanping Lin, Zhuo Zhou,[...]. Nature 2017
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11
STING is a direct innate immune sensor of cyclic di-GMP.
Dara L Burdette, Kathryn M Monroe, Katia Sotelo-Troha, Jeff S Iwig, Barbara Eckert, Mamoru Hyodo, Yoshihiro Hayakawa, Russell E Vance. Nature 2011
Dara L Burdette, Kathryn M Monroe, Katia Sotelo-Troha, Jeff S Iwig, Barbara Eckert, Mamoru Hyodo, Yoshihiro Hayakawa, Russell E Vance. Nature 2011
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STING Activation by Translocation from the ER Is Associated with Infection and Autoinflammatory Disease.
Nicole Dobbs, Nikolay Burnaevskiy, Didi Chen, Vijay K Gonugunta, Neal M Alto, Nan Yan. Cell Host Microbe 2015
Nicole Dobbs, Nikolay Burnaevskiy, Didi Chen, Vijay K Gonugunta, Neal M Alto, Nan Yan. Cell Host Microbe 2015
11
Cyclic GMP-AMP synthase is activated by double-stranded DNA-induced oligomerization.
Xin Li, Chang Shu, Guanghui Yi, Catherine T Chaton, Catherine L Shelton, Jiasheng Diao, Xiaobing Zuo, C Cheng Kao, Andrew B Herr, Pingwei Li. Immunity 2013
Xin Li, Chang Shu, Guanghui Yi, Catherine T Chaton, Catherine L Shelton, Jiasheng Diao, Xiaobing Zuo, C Cheng Kao, Andrew B Herr, Pingwei Li. Immunity 2013
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Activated STING in a vascular and pulmonary syndrome.
Y Liu, A A Jesus, B Marrero, D Yang, S E Ramsey, G A Montealegre Sanchez, K Tenbrock, H Wittkowski, O Y Jones, H S Kuehn,[...]. N Engl J Med 2014
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11
Design of amidobenzimidazole STING receptor agonists with systemic activity.
Joshi M Ramanjulu, G Scott Pesiridis, Jingsong Yang, Nestor Concha, Robert Singhaus, Shu-Yun Zhang, Jean-Luc Tran, Patrick Moore, Stephanie Lehmann, H Christian Eberl,[...]. Nature 2018
Joshi M Ramanjulu, G Scott Pesiridis, Jingsong Yang, Nestor Concha, Robert Singhaus, Shu-Yun Zhang, Jean-Luc Tran, Patrick Moore, Stephanie Lehmann, H Christian Eberl,[...]. Nature 2018
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Structural basis of STING binding with and phosphorylation by TBK1.
Conggang Zhang, Guijun Shang, Xiang Gui, Xuewu Zhang, Xiao-Chen Bai, Zhijian J Chen. Nature 2019
Conggang Zhang, Guijun Shang, Xiang Gui, Xuewu Zhang, Xiao-Chen Bai, Zhijian J Chen. Nature 2019
10
The cGAS-cGAMP-STING pathway connects DNA damage to inflammation, senescence, and cancer.
Tuo Li, Zhijian J Chen. J Exp Med 2018
Tuo Li, Zhijian J Chen. J Exp Med 2018
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STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors.
Seng-Ryong Woo, Mercedes B Fuertes, Leticia Corrales, Stefani Spranger, Michael J Furdyna, Michael Y K Leung, Ryan Duggan, Ying Wang, Glen N Barber, Katherine A Fitzgerald,[...]. Immunity 2014
Seng-Ryong Woo, Mercedes B Fuertes, Leticia Corrales, Stefani Spranger, Michael J Furdyna, Michael Y K Leung, Ryan Duggan, Ying Wang, Glen N Barber, Katherine A Fitzgerald,[...]. Immunity 2014
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The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors.
Taro Kawai, Shizuo Akira. Nat Immunol 2010
Taro Kawai, Shizuo Akira. Nat Immunol 2010
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Mitotic progression following DNA damage enables pattern recognition within micronuclei.
Shane M Harding, Joseph L Benci, Jerome Irianto, Dennis E Discher, Andy J Minn, Roger A Greenberg. Nature 2017
Shane M Harding, Joseph L Benci, Jerome Irianto, Dennis E Discher, Andy J Minn, Roger A Greenberg. Nature 2017
10
The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3.
Moritz M Gaidt, Thomas S Ebert, Dhruv Chauhan, Katharina Ramshorn, Francesca Pinci, Sarah Zuber, Fionan O'Duill, Jonathan L Schmid-Burgk, Florian Hoss, Raymund Buhmann,[...]. Cell 2017
Moritz M Gaidt, Thomas S Ebert, Dhruv Chauhan, Katharina Ramshorn, Francesca Pinci, Sarah Zuber, Fionan O'Duill, Jonathan L Schmid-Burgk, Florian Hoss, Raymund Buhmann,[...]. Cell 2017
10
Chromosomal instability drives metastasis through a cytosolic DNA response.
Samuel F Bakhoum, Bryan Ngo, Ashley M Laughney, Julie-Ann Cavallo, Charles J Murphy, Peter Ly, Pragya Shah, Roshan K Sriram, Thomas B K Watkins, Neil K Taunk,[...]. Nature 2018
Samuel F Bakhoum, Bryan Ngo, Ashley M Laughney, Julie-Ann Cavallo, Charles J Murphy, Peter Ly, Pragya Shah, Roshan K Sriram, Thomas B K Watkins, Neil K Taunk,[...]. Nature 2018
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Interferon-Independent Activities of Mammalian STING Mediate Antiviral Response and Tumor Immune Evasion.
Jianjun Wu, Nicole Dobbs, Kun Yang, Nan Yan. Immunity 2020
Jianjun Wu, Nicole Dobbs, Kun Yang, Nan Yan. Immunity 2020
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Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases.
Daxing Gao, Tuo Li, Xiao-Dong Li, Xiang Chen, Quan-Zhen Li, Mary Wight-Carter, Zhijian J Chen. Proc Natl Acad Sci U S A 2015
Daxing Gao, Tuo Li, Xiao-Dong Li, Xiang Chen, Quan-Zhen Li, Mary Wight-Carter, Zhijian J Chen. Proc Natl Acad Sci U S A 2015
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STING-mediated disruption of calcium homeostasis chronically activates ER stress and primes T cell death.
Jianjun Wu, Yu-Ju Chen, Nicole Dobbs, Tomomi Sakai, Jen Liou, Jonathan J Miner, Nan Yan. J Exp Med 2019
Jianjun Wu, Yu-Ju Chen, Nicole Dobbs, Tomomi Sakai, Jen Liou, Jonathan J Miner, Nan Yan. J Exp Med 2019
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TBK1 and IKKε Act Redundantly to Mediate STING-Induced NF-κB Responses in Myeloid Cells.
Katherine R Balka, Cynthia Louis, Tahnee L Saunders, Amber M Smith, Dale J Calleja, Damian B D'Silva, Fiona Moghaddas, Maximilien Tailler, Kate E Lawlor, Yifan Zhan,[...]. Cell Rep 2020
Katherine R Balka, Cynthia Louis, Tahnee L Saunders, Amber M Smith, Dale J Calleja, Damian B D'Silva, Fiona Moghaddas, Maximilien Tailler, Kate E Lawlor, Yifan Zhan,[...]. Cell Rep 2020
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cGAS drives noncanonical-inflammasome activation in age-related macular degeneration.
Nagaraj Kerur, Shinichi Fukuda, Daipayan Banerjee, Younghee Kim, Dongxu Fu, Ivana Apicella, Akhil Varshney, Reo Yasuma, Benjamin J Fowler, Elmira Baghdasaryan,[...]. Nat Med 2018
Nagaraj Kerur, Shinichi Fukuda, Daipayan Banerjee, Younghee Kim, Dongxu Fu, Ivana Apicella, Akhil Varshney, Reo Yasuma, Benjamin J Fowler, Elmira Baghdasaryan,[...]. Nat Med 2018
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Innate immune sensing and signaling of cytosolic nucleic acids.
Jiaxi Wu, Zhijian J Chen. Annu Rev Immunol 2014
Jiaxi Wu, Zhijian J Chen. Annu Rev Immunol 2014
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Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence.
Selene Glück, Baptiste Guey, Muhammet Fatih Gulen, Katharina Wolter, Tae-Won Kang, Niklas Arndt Schmacke, Anne Bridgeman, Jan Rehwinkel, Lars Zender, Andrea Ablasser. Nat Cell Biol 2017
Selene Glück, Baptiste Guey, Muhammet Fatih Gulen, Katharina Wolter, Tae-Won Kang, Niklas Arndt Schmacke, Anne Bridgeman, Jan Rehwinkel, Lars Zender, Andrea Ablasser. Nat Cell Biol 2017
9
Signalling strength determines proapoptotic functions of STING.
Muhammet F Gulen, Ute Koch, Simone M Haag, Fabian Schuler, Lionel Apetoh, Andreas Villunger, Freddy Radtke, Andrea Ablasser. Nat Commun 2017
Muhammet F Gulen, Ute Koch, Simone M Haag, Fabian Schuler, Lionel Apetoh, Andreas Villunger, Freddy Radtke, Andrea Ablasser. Nat Commun 2017
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cGAS is essential for cellular senescence.
Hui Yang, Hanze Wang, Junyao Ren, Qi Chen, Zhijian J Chen. Proc Natl Acad Sci U S A 2017
Hui Yang, Hanze Wang, Junyao Ren, Qi Chen, Zhijian J Chen. Proc Natl Acad Sci U S A 2017
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Parkin and PINK1 mitigate STING-induced inflammation.
Danielle A Sliter, Jennifer Martinez, Ling Hao, Xi Chen, Nuo Sun, Tara D Fischer, Jonathon L Burman, Yan Li, Zhe Zhang, Derek P Narendra,[...]. Nature 2018
Danielle A Sliter, Jennifer Martinez, Ling Hao, Xi Chen, Nuo Sun, Tara D Fischer, Jonathon L Burman, Yan Li, Zhe Zhang, Derek P Narendra,[...]. Nature 2018
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Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING.
Xu Zhang, Heping Shi, Jiaxi Wu, Xuewu Zhang, Lijun Sun, Chuo Chen, Zhijian J Chen. Mol Cell 2013
Xu Zhang, Heping Shi, Jiaxi Wu, Xuewu Zhang, Lijun Sun, Chuo Chen, Zhijian J Chen. Mol Cell 2013
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The Cytosolic Sensor cGAS Detects Mycobacterium tuberculosis DNA to Induce Type I Interferons and Activate Autophagy.
Robert O Watson, Samantha L Bell, Donna A MacDuff, Jacqueline M Kimmey, Elie J Diner, Joanna Olivas, Russell E Vance, Christina L Stallings, Herbert W Virgin, Jeffery S Cox. Cell Host Microbe 2015
Robert O Watson, Samantha L Bell, Donna A MacDuff, Jacqueline M Kimmey, Elie J Diner, Joanna Olivas, Russell E Vance, Christina L Stallings, Herbert W Virgin, Jeffery S Cox. Cell Host Microbe 2015
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Structural mechanism of cytosolic DNA sensing by cGAS.
Filiz Civril, Tobias Deimling, Carina C de Oliveira Mann, Andrea Ablasser, Manuela Moldt, Gregor Witte, Veit Hornung, Karl-Peter Hopfner. Nature 2013
Filiz Civril, Tobias Deimling, Carina C de Oliveira Mann, Andrea Ablasser, Manuela Moldt, Gregor Witte, Veit Hornung, Karl-Peter Hopfner. Nature 2013
9
C9orf72 in myeloid cells suppresses STING-induced inflammation.
Madelyn E McCauley, Jacqueline Gire O'Rourke, Alberto Yáñez, Janet L Markman, Ritchie Ho, Xinchen Wang, Shuang Chen, Deepti Lall, Mengyao Jin, A K M G Muhammad,[...]. Nature 2020
Madelyn E McCauley, Jacqueline Gire O'Rourke, Alberto Yáñez, Janet L Markman, Ritchie Ho, Xinchen Wang, Shuang Chen, Deepti Lall, Mengyao Jin, A K M G Muhammad,[...]. Nature 2020
12
TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS.
Chien-Hsiung Yu, Sophia Davidson, Cassandra R Harapas, James B Hilton, Michael J Mlodzianoski, Pawat Laohamonthonkul, Cynthia Louis, Ronnie Ren Jie Low, Jonas Moecking, Dominic De Nardo,[...]. Cell 2020
Chien-Hsiung Yu, Sophia Davidson, Cassandra R Harapas, James B Hilton, Michael J Mlodzianoski, Pawat Laohamonthonkul, Cynthia Louis, Ronnie Ren Jie Low, Jonas Moecking, Dominic De Nardo,[...]. Cell 2020
8
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.