A citation-based method for searching scientific literature

Michael Ewers, Nicolai Franzmeier, Marc Suárez-Calvet, Estrella Morenas-Rodriguez, Miguel Angel Araque Caballero, Gernot Kleinberger, Laura Piccio, Carlos Cruchaga, Yuetiva Deming, Martin Dichgans, John Q Trojanowski, Leslie M Shaw, Michael W Weiner, Christian Haass. Sci Transl Med 2019
Times Cited: 118







List of co-cited articles
1096 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity


sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early-stage Alzheimer's disease and associate with neuronal injury markers.
Marc Suárez-Calvet, Gernot Kleinberger, Miguel Ángel Araque Caballero, Matthias Brendel, Axel Rominger, Daniel Alcolea, Juan Fortea, Alberto Lleó, Rafael Blesa, Juan Domingo Gispert,[...]. EMBO Mol Med 2016
264
35

A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease.
Hadas Keren-Shaul, Amit Spinrad, Assaf Weiner, Orit Matcovitch-Natan, Raz Dvir-Szternfeld, Tyler K Ulland, Eyal David, Kuti Baruch, David Lara-Astaiso, Beata Toth,[...]. Cell 2017
34

Variant of TREM2 associated with the risk of Alzheimer's disease.
Thorlakur Jonsson, Hreinn Stefansson, Stacy Steinberg, Ingileif Jonsdottir, Palmi V Jonsson, Jon Snaedal, Sigurbjorn Bjornsson, Johanna Huttenlocher, Allan I Levey, James J Lah,[...]. N Engl J Med 2013
34

TREM2 variants in Alzheimer's disease.
Rita Guerreiro, Aleksandra Wojtas, Jose Bras, Minerva Carrasquillo, Ekaterina Rogaeva, Elisa Majounie, Carlos Cruchaga, Celeste Sassi, John S K Kauwe, Steven Younkin,[...]. N Engl J Med 2013
32

Early increase of CSF sTREM2 in Alzheimer's disease is associated with tau related-neurodegeneration but not with amyloid-β pathology.
Marc Suárez-Calvet, Estrella Morenas-Rodríguez, Gernot Kleinberger, Kai Schlepckow, Miguel Ángel Araque Caballero, Nicolai Franzmeier, Anja Capell, Katrin Fellerer, Brigitte Nuscher, Erden Eren,[...]. Mol Neurodegener 2019
99
27

Increased cerebrospinal fluid soluble TREM2 concentration in Alzheimer's disease.
Amanda Heslegrave, Wendy Heywood, Ross Paterson, Nadia Magdalinou, Johan Svensson, Per Johansson, Annika Öhrfelt, Kaj Blennow, John Hardy, Jonathan Schott,[...]. Mol Neurodegener 2016
175
26

TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model.
Yaming Wang, Marina Cella, Kaitlin Mallinson, Jason D Ulrich, Katherine L Young, Michelle L Robinette, Susan Gilfillan, Gokul M Krishnan, Shwetha Sudhakar, Bernd H Zinselmeyer,[...]. Cell 2015
868
26

Early changes in CSF sTREM2 in dominantly inherited Alzheimer's disease occur after amyloid deposition and neuronal injury.
Marc Suárez-Calvet, Miguel Ángel Araque Caballero, Gernot Kleinberger, Randall J Bateman, Anne M Fagan, John C Morris, Johannes Levin, Adrian Danek, Michael Ewers, Christian Haass. Sci Transl Med 2016
154
25

Cerebrospinal fluid soluble TREM2 is higher in Alzheimer disease and associated with mutation status.
Laura Piccio, Yuetiva Deming, Jorge L Del-Águila, Laura Ghezzi, David M Holtzman, Anne M Fagan, Chiara Fenoglio, Daniela Galimberti, Barbara Borroni, Carlos Cruchaga. Acta Neuropathol 2016
197
25

Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE.
Samira Parhizkar, Thomas Arzberger, Matthias Brendel, Gernot Kleinberger, Maximilian Deussing, Carola Focke, Brigitte Nuscher, Monica Xiong, Alireza Ghasemigharagoz, Natalie Katzmarski,[...]. Nat Neurosci 2019
222
24

TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis.
Gernot Kleinberger, Yoshinori Yamanishi, Marc Suárez-Calvet, Eva Czirr, Ebba Lohmann, Elise Cuyvers, Hanne Struyfs, Nadine Pettkus, Andrea Wenninger-Weinzierl, Fargol Mazaheri,[...]. Sci Transl Med 2014
452
24

TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease.
Tyler K Ulland, Wilbur M Song, Stanley Ching-Cheng Huang, Jason D Ulrich, Alexey Sergushichev, Wandy L Beatty, Alexander A Loboda, Yingyue Zhou, Nigel J Cairns, Amal Kambal,[...]. Cell 2017
493
24

TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques.
Yaming Wang, Tyler K Ulland, Jason D Ulrich, Wilbur Song, John A Tzaferis, Justin T Hole, Peng Yuan, Thomas E Mahan, Yang Shi, Susan Gilfillan,[...]. J Exp Med 2016
394
23

NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease.
Clifford R Jack, David A Bennett, Kaj Blennow, Maria C Carrillo, Billy Dunn, Samantha Budd Haeberlein, David M Holtzman, William Jagust, Frank Jessen, Jason Karlawish,[...]. Alzheimers Dement 2018
22

Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer's disease model.
Li Zhong, Ying Xu, Rengong Zhuo, Tingting Wang, Kai Wang, Ruizhi Huang, Daxin Wang, Yue Gao, Yifei Zhu, Xuan Sheng,[...]. Nat Commun 2019
122
21

Soluble TREM2 induces inflammatory responses and enhances microglial survival.
Li Zhong, Xiao-Fen Chen, Tingting Wang, Zhe Wang, Chunyan Liao, Zongqi Wang, Ruizhi Huang, Daxin Wang, Xinxiu Li, Linbei Wu,[...]. J Exp Med 2017
164
20

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases.
Susanne Krasemann, Charlotte Madore, Ron Cialic, Caroline Baufeld, Narghes Calcagno, Rachid El Fatimy, Lien Beckers, Elaine O'Loughlin, Yang Xu, Zain Fanek,[...]. Immunity 2017
20

TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function.
Yingjun Zhao, Xilin Wu, Xiaoguang Li, Lu-Lin Jiang, Xun Gui, Yan Liu, Yu Sun, Bing Zhu, Juan C Piña-Crespo, Muxian Zhang,[...]. Neuron 2018
289
19

The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer's disease risk.
Yuetiva Deming, Fabia Filipello, Francesca Cignarella, Claudia Cantoni, Simon Hsu, Robert Mikesell, Zeran Li, Jorge L Del-Aguila, Umber Dube, Fabiana Geraldo Farias,[...]. Sci Transl Med 2019
87
21

Elevated TREM2 Gene Dosage Reprograms Microglia Responsivity and Ameliorates Pathological Phenotypes in Alzheimer's Disease Models.
C Y Daniel Lee, Anthony Daggett, Xiaofeng Gu, Lu-Lin Jiang, Peter Langfelder, Xiaoguang Li, Nan Wang, Yingjun Zhao, Chang Sin Park, Yonatan Cooper,[...]. Neuron 2018
169
19

Higher CSF sTREM2 and microglia activation are associated with slower rates of beta-amyloid accumulation.
Michael Ewers, Gloria Biechele, Marc Suárez-Calvet, Christian Sacher, Tanja Blume, Estrella Morenas-Rodriguez, Yuetiva Deming, Laura Piccio, Carlos Cruchaga, Gernot Kleinberger,[...]. EMBO Mol Med 2020
36
52

TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy.
Peng Yuan, Carlo Condello, C Dirk Keene, Yaming Wang, Thomas D Bird, Steven M Paul, Wenjie Luo, Marco Colonna, David Baddeley, Jaime Grutzendler. Neuron 2016
328
18

Soluble TREM2 and biomarkers of central and peripheral inflammation in neurodegenerative disease.
L M Bekris, M Khrestian, E Dyne, Y Shao, J A Pillai, S M Rao, S M Bemiller, B Lamb, H H Fernandez, J B Leverenz. J Neuroimmunol 2018
45
37

An Alzheimer-associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function.
Kai Schlepckow, Gernot Kleinberger, Akio Fukumori, Regina Feederle, Stefan F Lichtenthaler, Harald Steiner, Christian Haass. EMBO Mol Med 2017
107
17

Identification of soluble TREM-2 in the cerebrospinal fluid and its association with multiple sclerosis and CNS inflammation.
Laura Piccio, Cecilia Buonsanti, Marina Cella, Ilaria Tassi, Robert E Schmidt, Chiara Fenoglio, John Rinker, Robert T Naismith, Paola Panina-Bordignon, Nadia Passini,[...]. Brain 2008
180
16

Soluble TREM2 changes during the clinical course of Alzheimer's disease: A meta-analysis.
Dan Liu, Bing Cao, Yujia Zhao, Huanhuan Huang, Roger S McIntyre, Joshua D Rosenblat, Hui Zhou. Neurosci Lett 2018
48
33

Neuroinflammation in Alzheimer's disease.
Michael T Heneka, Monica J Carson, Joseph El Khoury, Gary E Landreth, Frederic Brosseron, Douglas L Feinstein, Andreas H Jacobs, Tony Wyss-Coray, Javier Vitorica, Richard M Ransohoff,[...]. Lancet Neurol 2015
16

Microglia in Alzheimer's disease.
David V Hansen, Jesse E Hanson, Morgan Sheng. J Cell Biol 2018
657
16


Cerebrospinal fluid soluble TREM2 in aging and Alzheimer's disease.
Kristi Henjum, Ina S Almdahl, Vibeke Årskog, Lennart Minthon, Oskar Hansson, Tormod Fladby, Lars N G Nilsson. Alzheimers Res Ther 2016
78
17

Humanized TREM2 mice reveal microglia-intrinsic and -extrinsic effects of R47H polymorphism.
Wilbur M Song, Satoru Joshita, Yingyue Zhou, Tyler K Ulland, Susan Gilfillan, Marco Colonna. J Exp Med 2018
122
14

TREM2 shedding by cleavage at the H157-S158 bond is accelerated for the Alzheimer's disease-associated H157Y variant.
Peter Thornton, Jean Sevalle, Michael J Deery, Graham Fraser, Ye Zhou, Sara Ståhl, Elske H Franssen, Roger B Dodd, Seema Qamar, Beatriz Gomez Perez-Nievas,[...]. EMBO Mol Med 2017
70
20

Dynamic changes of CSF sTREM2 in preclinical Alzheimer's disease: the CABLE study.
Ling-Zhi Ma, Lan Tan, Yan-Lin Bi, Xue-Ning Shen, Wei Xu, Ya-Hui Ma, Hong-Qi Li, Qiang Dong, Jin-Tai Yu. Mol Neurodegener 2020
25
56

Anti-human TREM2 induces microglia proliferation and reduces pathology in an Alzheimer's disease model.
Shoutang Wang, Meer Mustafa, Carla M Yuede, Santiago Viveros Salazar, Philip Kong, Hua Long, Michael Ward, Omer Siddiqui, Robert Paul, Susan Gilfillan,[...]. J Exp Med 2020
106
14

TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy.
Cheryl E G Leyns, Jason D Ulrich, Mary B Finn, Floy R Stewart, Lauren J Koscal, Javier Remolina Serrano, Grace O Robinson, Elise Anderson, Marco Colonna, David M Holtzman. Proc Natl Acad Sci U S A 2017
212
13

TREM2 - a key player in microglial biology and Alzheimer disease.
Tyler K Ulland, Marco Colonna. Nat Rev Neurol 2018
231
13

Alzheimer's disease risk gene CD33 inhibits microglial uptake of amyloid beta.
Ana Griciuc, Alberto Serrano-Pozo, Antonio R Parrado, Andrea N Lesinski, Caroline N Asselin, Kristina Mullin, Basavaraj Hooli, Se Hoon Choi, Bradley T Hyman, Rudolph E Tanzi. Neuron 2013
601
13

TREM2 Acts Downstream of CD33 in Modulating Microglial Pathology in Alzheimer's Disease.
Ana Griciuc, Shaun Patel, Anthony N Federico, Se Hoon Choi, Brendan J Innes, Mary K Oram, Gea Cereghetti, Danielle McGinty, Anthony Anselmo, Ruslan I Sadreyev,[...]. Neuron 2019
134
13

Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2).
Yuka Atagi, Chia-Chen Liu, Meghan M Painter, Xiao-Fen Chen, Christophe Verbeeck, Honghua Zheng, Xia Li, Rosa Rademakers, Silvia S Kang, Huaxi Xu,[...]. J Biol Chem 2015
276
13


Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk region.
Kai Schlepckow, Kathryn M Monroe, Gernot Kleinberger, Ludovico Cantuti-Castelvetri, Samira Parhizkar, Dan Xia, Michael Willem, Georg Werner, Nadine Pettkus, Bettina Brunner,[...]. EMBO Mol Med 2020
82
15

TREM2 function impedes tau seeding in neuritic plaques.
Cheryl E G Leyns, Maud Gratuze, Sneha Narasimhan, Nimansha Jain, Lauren J Koscal, Hong Jiang, Melissa Manis, Marco Colonna, Virginia M Y Lee, Jason D Ulrich,[...]. Nat Neurosci 2019
104
13


TREM2 ectodomain and its soluble form in Alzheimer's disease.
Jiaolong Yang, Zhihui Fu, Xingyu Zhang, Min Xiong, Lanxia Meng, Zhentao Zhang. J Neuroinflammation 2020
27
48

Glial activation and inflammation along the Alzheimer's disease continuum.
Kaja Nordengen, Bjørn-Eivind Kirsebom, Kristi Henjum, Per Selnes, Berglind Gísladóttir, Marianne Wettergreen, Silje Bøen Torsetnes, Gøril Rolfseng Grøntvedt, Knut K Waterloo, Dag Aarsland,[...]. J Neuroinflammation 2019
108
12

Disease Progression-Dependent Effects of TREM2 Deficiency in a Mouse Model of Alzheimer's Disease.
Taylor R Jay, Anna M Hirsch, Margaret L Broihier, Crystal M Miller, Lee E Neilson, Richard M Ransohoff, Bruce T Lamb, Gary E Landreth. J Neurosci 2017
236
12

Amyloid-beta modulates microglial responses by binding to the triggering receptor expressed on myeloid cells 2 (TREM2).
Li Zhong, Zongqi Wang, Daxin Wang, Zhe Wang, Yuka A Martens, Linbei Wu, Ying Xu, Kai Wang, Jianguo Li, Ruizhi Huang,[...]. Mol Neurodegener 2018
83
14

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease.
Rebecca Sims, Sven J van der Lee, Adam C Naj, Céline Bellenguez, Nandini Badarinarayan, Johanna Jakobsdottir, Brian W Kunkle, Anne Boland, Rachel Raybould, Joshua C Bis,[...]. Nat Genet 2017
498
12

TREM2 brain transcript-specific studies in AD and TREM2 mutation carriers.
Jorge L Del-Aguila, Bruno A Benitez, Zeran Li, Umber Dube, Kathie A Mihindukulasuriya, John P Budde, Fabiana H G Farias, Maria Victoria Fernández, Laura Ibanez, Shan Jiang,[...]. Mol Neurodegener 2019
33
36

Higher CSF sTREM2 attenuates ApoE4-related risk for cognitive decline and neurodegeneration.
Nicolai Franzmeier, M Suárez-Calvet, Lukas Frontzkowski, Annah Moore, Timothy J Hohman, Estrella Morenas-Rodriguez, Brigitte Nuscher, Leslie Shaw, John Q Trojanowski, Martin Dichgans,[...]. Mol Neurodegener 2020
20
60


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.