Chris Kay, Jennifer A Collins, Nicholas S Caron, Luciana de Andrade Agostinho, Hailey Findlay-Black, Lorenzo Casal, Dulika Sumathipala, Vajira H W Dissanayake, Mario Cornejo-Olivas, Fiona Baine, Amanda Krause, Jacquie L Greenberg, Carmen Lúcia Antão Paiva, Ferdinando Squitieri, Michael R Hayden. Am J Hum Genet 2019
Times Cited: 11
Times Cited: 11
Times Cited
Times Co-cited
Similarity
54
Targeting Huntingtin Expression in Patients with Huntington's Disease.
Sarah J Tabrizi, Blair R Leavitt, G Bernhard Landwehrmeyer, Edward J Wild, Carsten Saft, Roger A Barker, Nick F Blair, David Craufurd, Josef Priller, Hugh Rickards,[...]. N Engl J Med 2019
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45
Potent and selective antisense oligonucleotides targeting single-nucleotide polymorphisms in the Huntington disease gene / allele-specific silencing of mutant huntingtin.
Jeffrey B Carroll, Simon C Warby, Amber L Southwell, Crystal N Doty, Sarah Greenlee, Niels Skotte, Gene Hung, C Frank Bennett, Susan M Freier, Michael R Hayden. Mol Ther 2011
Jeffrey B Carroll, Simon C Warby, Amber L Southwell, Crystal N Doty, Sarah Greenlee, Niels Skotte, Gene Hung, C Frank Bennett, Susan M Freier, Michael R Hayden. Mol Ther 2011
45
Five siRNAs targeting three SNPs may provide therapy for three-quarters of Huntington's disease patients.
Edith L Pfister, Lori Kennington, Juerg Straubhaar, Sujata Wagh, Wanzhou Liu, Marian DiFiglia, Bernhard Landwehrmeyer, Jean-Paul Vonsattel, Phillip D Zamore, Neil Aronin. Curr Biol 2009
Edith L Pfister, Lori Kennington, Juerg Straubhaar, Sujata Wagh, Wanzhou Liu, Marian DiFiglia, Bernhard Landwehrmeyer, Jean-Paul Vonsattel, Phillip D Zamore, Neil Aronin. Curr Biol 2009
36
Preclinical safety of RNAi-mediated HTT suppression in the rhesus macaque as a potential therapy for Huntington's disease.
Jodi L McBride, Mark R Pitzer, Ryan L Boudreau, Brett Dufour, Theodore Hobbs, Sergio R Ojeda, Beverly L Davidson. Mol Ther 2011
Jodi L McBride, Mark R Pitzer, Ryan L Boudreau, Brett Dufour, Theodore Hobbs, Sergio R Ojeda, Beverly L Davidson. Mol Ther 2011
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Allele-selective transcriptional repression of mutant HTT for the treatment of Huntington's disease.
Bryan Zeitler, Steven Froelich, Kimberly Marlen, David A Shivak, Qi Yu, Davis Li, Jocelynn R Pearl, Jeffrey C Miller, Lei Zhang, David E Paschon,[...]. Nat Med 2019
Bryan Zeitler, Steven Froelich, Kimberly Marlen, David A Shivak, Qi Yu, Davis Li, Jocelynn R Pearl, Jeffrey C Miller, Lei Zhang, David E Paschon,[...]. Nat Med 2019
36
Sustained therapeutic reversal of Huntington's disease by transient repression of huntingtin synthesis.
Holly B Kordasiewicz, Lisa M Stanek, Edward V Wancewicz, Curt Mazur, Melissa M McAlonis, Kimberly A Pytel, Jonathan W Artates, Andreas Weiss, Seng H Cheng, Lamya S Shihabuddin,[...]. Neuron 2012
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Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease.
A Yamamoto, J J Lucas, R Hen. Cell 2000
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Huntingtin Haplotypes Provide Prioritized Target Panels for Allele-specific Silencing in Huntington Disease Patients of European Ancestry.
Chris Kay, Jennifer A Collins, Niels H Skotte, Amber L Southwell, Simon C Warby, Nicholas S Caron, Crystal N Doty, Betty Nguyen, Annamaria Griguoli, Colin J Ross,[...]. Mol Ther 2015
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36
Six-month partial suppression of Huntingtin is well tolerated in the adult rhesus striatum.
Richard Grondin, Michael D Kaytor, Yi Ai, Peter T Nelson, Deepak R Thakker, Jennifer Heisel, Marcy R Weatherspoon, Janelle L Blum, Eric N Burright, Zhiming Zhang,[...]. Brain 2012
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Rational design of antisense oligonucleotides targeting single nucleotide polymorphisms for potent and allele selective suppression of mutant Huntingtin in the CNS.
Michael E Østergaard, Amber L Southwell, Holly Kordasiewicz, Andrew T Watt, Niels H Skotte, Crystal N Doty, Kuljeet Vaid, Erika B Villanueva, Eric E Swayze, C Frank Bennett,[...]. Nucleic Acids Res 2013
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Huntington's disease: from molecular pathogenesis to clinical treatment.
Christopher A Ross, Sarah J Tabrizi. Lancet Neurol 2011
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The Prevalence of Huntington's Disease.
Michael D Rawlins, Nancy S Wexler, Alice R Wexler, Sarah J Tabrizi, Ian Douglas, Stephen J W Evans, Liam Smeeth. Neuroepidemiology 2016
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RNA interference improves motor and neuropathological abnormalities in a Huntington's disease mouse model.
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Widespread suppression of huntingtin with convection-enhanced delivery of siRNA.
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Venezuelan kindreds reveal that genetic and environmental factors modulate Huntington's disease age of onset.
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27
CAG repeat expansion in Huntington disease determines age at onset in a fully dominant fashion.
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Quantification of mutant huntingtin protein in cerebrospinal fluid from Huntington's disease patients.
Edward J Wild, Roberto Boggio, Douglas Langbehn, Nicola Robertson, Salman Haider, James R C Miller, Henrik Zetterberg, Blair R Leavitt, Rainer Kuhn, Sarah J Tabrizi,[...]. J Clin Invest 2015
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27
CAG expansion in the Huntington disease gene is associated with a specific and targetable predisposing haplogroup.
Simon C Warby, Alexandre Montpetit, Anna R Hayden, Jeffrey B Carroll, Stefanie L Butland, Henk Visscher, Jennifer A Collins, Alicia Semaka, Thomas J Hudson, Michael R Hayden. Am J Hum Genet 2009
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27
Ultrasensitive measurement of huntingtin protein in cerebrospinal fluid demonstrates increase with Huntington disease stage and decrease following brain huntingtin suppression.
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Inactivation of Hdh in the brain and testis results in progressive neurodegeneration and sterility in mice.
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Ablation of huntingtin in adult neurons is nondeleterious but its depletion in young mice causes acute pancreatitis.
Guohao Wang, Xudong Liu, Marta A Gaertig, Shihua Li, Xiao-Jiang Li. Proc Natl Acad Sci U S A 2016
Guohao Wang, Xudong Liu, Marta A Gaertig, Shihua Li, Xiao-Jiang Li. Proc Natl Acad Sci U S A 2016
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27
The relationship between trinucleotide (CAG) repeat length and clinical features of Huntington's disease.
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Allele-specific suppression of mutant huntingtin using antisense oligonucleotides: providing a therapeutic option for all Huntington disease patients.
Niels H Skotte, Amber L Southwell, Michael E Østergaard, Jeffrey B Carroll, Simon C Warby, Crystal N Doty, Eugenia Petoukhov, Kuljeet Vaid, Holly Kordasiewicz, Andrew T Watt,[...]. PLoS One 2014
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27
Huntingtin suppression restores cognitive function in a mouse model of Huntington's disease.
Amber L Southwell, Holly B Kordasiewicz, Douglas Langbehn, Niels H Skotte, Matthew P Parsons, Erika B Villanueva, Nicholas S Caron, Michael E Østergaard, Lisa M Anderson, Yuanyun Xie,[...]. Sci Transl Med 2018
Amber L Southwell, Holly B Kordasiewicz, Douglas Langbehn, Niels H Skotte, Matthew P Parsons, Erika B Villanueva, Nicholas S Caron, Michael E Østergaard, Lisa M Anderson, Yuanyun Xie,[...]. Sci Transl Med 2018
27
A fully humanized transgenic mouse model of Huntington disease.
Amber L Southwell, Simon C Warby, Jeffrey B Carroll, Crystal N Doty, Niels H Skotte, Weining Zhang, Erika B Villanueva, Vlad Kovalik, Yuanyun Xie, Mahmoud A Pouladi,[...]. Hum Mol Genet 2013
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27
Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes.
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Elimination of huntingtin in the adult mouse leads to progressive behavioral deficits, bilateral thalamic calcification, and altered brain iron homeostasis.
Paula Dietrich, Irudayam Maria Johnson, Shanta Alli, Ioannis Dragatsis. PLoS Genet 2017
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In vivo evaluation of candidate allele-specific mutant huntingtin gene silencing antisense oligonucleotides.
Amber L Southwell, Niels H Skotte, Holly B Kordasiewicz, Michael E Østergaard, Andrew T Watt, Jeffrey B Carroll, Crystal N Doty, Erika B Villanueva, Eugenia Petoukhov, Kuljeet Vaid,[...]. Mol Ther 2014
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Synthetic zinc finger repressors reduce mutant huntingtin expression in the brain of R6/2 mice.
Mireia Garriga-Canut, Carmen Agustín-Pavón, Frank Herrmann, Aurora Sánchez, Mara Dierssen, Cristina Fillat, Mark Isalan. Proc Natl Acad Sci U S A 2012
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18
Intrastriatal rAAV-mediated delivery of anti-huntingtin shRNAs induces partial reversal of disease progression in R6/1 Huntington's disease transgenic mice.
Edgardo Rodriguez-Lebron, Eileen M Denovan-Wright, Kevin Nash, Alfred S Lewin, Ronald J Mandel. Mol Ther 2005
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Normal huntingtin function: an alternative approach to Huntington's disease.
Elena Cattaneo, Chiara Zuccato, Marzia Tartari. Nat Rev Neurosci 2005
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Antisense oligonucleotides: the next frontier for treatment of neurological disorders.
Carlo Rinaldi, Matthew J A Wood. Nat Rev Neurol 2018
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Permanent inactivation of Huntington's disease mutation by personalized allele-specific CRISPR/Cas9.
Jun Wan Shin, Kyung-Hee Kim, Michael J Chao, Ranjit S Atwal, Tammy Gillis, Marcy E MacDonald, James F Gusella, Jong-Min Lee. Hum Mol Genet 2016
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Pharmacokinetics, biodistribution and cell uptake of antisense oligonucleotides.
Richard S Geary, Daniel Norris, Rosie Yu, C Frank Bennett. Adv Drug Deliv Rev 2015
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Design, Characterization, and Lead Selection of Therapeutic miRNAs Targeting Huntingtin for Development of Gene Therapy for Huntington's Disease.
Jana Miniarikova, Ilaria Zanella, Angelina Huseinovic, Tom van der Zon, Evelyn Hanemaaijer, Raygene Martier, Annemart Koornneef, Amber L Southwell, Michael R Hayden, Sander J van Deventer,[...]. Mol Ther Nucleic Acids 2016
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18
Nonallele-specific silencing of mutant and wild-type huntingtin demonstrates therapeutic efficacy in Huntington's disease mice.
Ryan L Boudreau, Jodi L McBride, Inês Martins, Shihao Shen, Yi Xing, Barrie J Carter, Beverly L Davidson. Mol Ther 2009
Ryan L Boudreau, Jodi L McBride, Inês Martins, Shihao Shen, Yi Xing, Barrie J Carter, Beverly L Davidson. Mol Ther 2009
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A majority of Huntington's disease patients may be treatable by individualized allele-specific RNA interference.
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Preclinical Huntington's disease: compensatory brain responses during learning.
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Therapies targeting DNA and RNA in Huntington's disease.
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A divalent siRNA chemical scaffold for potent and sustained modulation of gene expression throughout the central nervous system.
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Wild-type huntingtin reduces the cellular toxicity of mutant huntingtin in vivo.
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Silencing mutant huntingtin by adeno-associated virus-mediated RNA interference ameliorates disease manifestations in the YAC128 mouse model of Huntington's disease.
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HTT haplotypes contribute to differences in Huntington disease prevalence between Europe and East Asia.
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A Study of a Geographical Cluster of Huntington's Disease in a Brazilian Town of Zona da Mata, Minas Gerais State.
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Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.