A citation-based method for searching scientific literature

Federica Sarno, Angela Nebbioso, Lucia Altucci. Epigenetics 2020
Times Cited: 13







List of co-cited articles
68 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity


The diverse functions of Dot1 and H3K79 methylation.
Anh Tram Nguyen, Yi Zhang. Genes Dev 2011
351
46

The DOT1L inhibitor pinometostat reduces H3K79 methylation and has modest clinical activity in adult acute leukemia.
Eytan M Stein, Guillermo Garcia-Manero, David A Rizzieri, Raoul Tibes, Jesus G Berdeja, Michael R Savona, Mojca Jongen-Lavrenic, Jessica K Altman, Blythe Thomson, Stephen J Blakemore,[...]. Blood 2018
159
46

Potent inhibition of DOT1L as treatment of MLL-fusion leukemia.
Scott R Daigle, Edward J Olhava, Carly A Therkelsen, Aravind Basavapathruni, Lei Jin, P Ann Boriack-Sjodin, Christina J Allain, Christine R Klaus, Alejandra Raimondi, Margaret Porter Scott,[...]. Blood 2013
434
46

MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L.
Kathrin M Bernt, Nan Zhu, Amit U Sinha, Sridhar Vempati, Joerg Faber, Andrei V Krivtsov, Zhaohui Feng, Natalie Punt, Amanda Daigle, Lars Bullinger,[...]. Cancer Cell 2011
569
38

DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells.
David J Steger, Martina I Lefterova, Lei Ying, Aaron J Stonestrom, Michael Schupp, David Zhuo, Adam L Vakoc, Ja-Eun Kim, Junjie Chen, Mitchell A Lazar,[...]. Mol Cell Biol 2008
307
30

Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia.
Mark A Dawson, Rab K Prinjha, Antje Dittmann, George Giotopoulos, Marcus Bantscheff, Wai-In Chan, Samuel C Robson, Chun-wa Chung, Carsten Hopf, Mikhail M Savitski,[...]. Nature 2011
23

DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia.
Chun-Wei Chen, Richard P Koche, Amit U Sinha, Aniruddha J Deshpande, Nan Zhu, Rowena Eng, John G Doench, Haiming Xu, Scott H Chu, Jun Qi,[...]. Nat Med 2015
132
23

The histone H3K79 methyltransferase Dot1L is essential for mammalian development and heterochromatin structure.
Brendan Jones, Hui Su, Audesh Bhat, Hong Lei, Jeffrey Bajko, Sarah Hevi, Gretchen A Baltus, Shilpa Kadam, Huili Zhai, Reginald Valdez,[...]. PLoS Genet 2008
228
23

Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor.
Scott R Daigle, Edward J Olhava, Carly A Therkelsen, Christina R Majer, Christopher J Sneeringer, Jeffrey Song, L Danielle Johnston, Margaret Porter Scott, Jesse J Smith, Yonghong Xiao,[...]. Cancer Cell 2011
626
23

hDOT1L links histone methylation to leukemogenesis.
Yuki Okada, Qin Feng, Yihui Lin, Qi Jiang, Yaqiang Li, Vernon M Coffield, Lishan Su, Guoliang Xu, Yi Zhang. Cell 2005
564
23

MLL translocations, histone modifications and leukaemia stem-cell development.
Andrei V Krivtsov, Scott A Armstrong. Nat Rev Cancer 2007
769
23

New Potent DOT1L Inhibitors for in Vivo Evaluation in Mouse.
Frédéric Stauffer, Andreas Weiss, Clemens Scheufler, Henrik Möbitz, Christian Ragot, Kim S Beyer, Keith Calkins, Daniel Guthy, Michael Kiffe, Bernard Van Eerdenbrugh,[...]. ACS Med Chem Lett 2019
10
30

The emerging roles of DOT1L in leukemia and normal development.
C M McLean, I D Karemaker, F van Leeuwen. Leukemia 2014
72
23

DOT1L cooperates with the c-Myc-p300 complex to epigenetically derepress CDH1 transcription factors in breast cancer progression.
Min-Hyung Cho, Ji-Hye Park, Hee-Joo Choi, Mi-Kyung Park, Hee-Young Won, Yeon-Ji Park, Chang Hoon Lee, Seung-Hyun Oh, Young-Soo Song, Hyun Sung Kim,[...]. Nat Commun 2015
103
23

Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours.
Loren M Lasko, Clarissa G Jakob, Rohinton P Edalji, Wei Qiu, Debra Montgomery, Enrico L Digiammarino, T Matt Hansen, Roberto M Risi, Robin Frey, Vlasios Manaves,[...]. Nature 2017
240
23

Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials.
Yuan Cheng, Cai He, Manni Wang, Xuelei Ma, Fei Mo, Shengyong Yang, Junhong Han, Xiawei Wei. Signal Transduct Target Ther 2019
131
23

ORY-1001, a Potent and Selective Covalent KDM1A Inhibitor, for the Treatment of Acute Leukemia.
Tamara Maes, Cristina Mascaró, Iñigo Tirapu, Angels Estiarte, Filippo Ciceri, Serena Lunardi, Nathalie Guibourt, Alvaro Perdones, Michele M P Lufino, Tim C P Somervaille,[...]. Cancer Cell 2018
110
23

The timeline of epigenetic drug discovery: from reality to dreams.
A Ganesan, Paola B Arimondo, Marianne G Rots, Carmen Jeronimo, María Berdasco. Clin Epigenetics 2019
94
23

Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials.
Yuan Cheng, Cai He, Manni Wang, Xuelei Ma, Fei Mo, Shengyong Yang, Junhong Han, Xiawei Wei. Signal Transduct Target Ther 2019
120
23

A trithorax-like gene is interrupted by chromosome 11q23 translocations in acute leukaemias.
M Djabali, L Selleri, P Parry, M Bower, B D Young, G A Evans. Nat Genet 1992
468
15



The diverse functions of histone lysine methylation.
Cyrus Martin, Yi Zhang. Nat Rev Mol Cell Biol 2005
15

Methylation of H3-lysine 79 is mediated by a new family of HMTases without a SET domain.
Qin Feng, Hengbin Wang, Huck Hui Ng, Hediye Erdjument-Bromage, Paul Tempst, Kevin Struhl, Yi Zhang. Curr Biol 2002
545
15

DOT1L, the H3K79 methyltransferase, is required for MLL-AF9-mediated leukemogenesis.
Anh Tram Nguyen, Olena Taranova, Jin He, Yi Zhang. Blood 2011
172
15

Lysine methylation within the globular domain of histone H3 by Dot1 is important for telomeric silencing and Sir protein association.
Huck Hui Ng, Qin Feng, Hengbin Wang, Hediye Erdjument-Bromage, Paul Tempst, Yi Zhang, Kevin Struhl. Genes Dev 2002
385
15

The role of chromatin during transcription.
Bing Li, Michael Carey, Jerry L Workman. Cell 2007
15

Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias.
S Ziemin-van der Poel, N R McCabe, H J Gill, R Espinosa, Y Patel, A Harden, P Rubinelli, S D Smith, M M LeBeau, J D Rowley. Proc Natl Acad Sci U S A 1991
503
15


DOT1L inhibitor EPZ-5676 displays synergistic antiproliferative activity in combination with standard of care drugs and hypomethylating agents in MLL-rearranged leukemia cells.
Christine R Klaus, Dorothy Iwanowicz, Danielle Johnston, Carly A Campbell, Jesse J Smith, Mikel P Moyer, Robert A Copeland, Edward J Olhava, Margaret Porter Scott, Roy M Pollock,[...]. J Pharmacol Exp Ther 2014
74
15

Gene silencing: trans-histone regulatory pathway in chromatin.
Scott D Briggs, Tiaojiang Xiao, Zu-Wen Sun, Jennifer A Caldwell, Jeffrey Shabanowitz, Donald F Hunt, C David Allis, Brian D Strahl. Nature 2002
357
15

The MLL recombinome of acute leukemias in 2017.
C Meyer, T Burmeister, D Gröger, G Tsaur, L Fechina, A Renneville, R Sutton, N C Venn, M Emerenciano, M S Pombo-de-Oliveira,[...]. Leukemia 2018
265
15

Novel inhibitors of the histone methyltransferase DOT1L show potent antileukemic activity in patient-derived xenografts.
Florian Perner, Jayant Y Gadrey, Yijun Xiong, Charles Hatton, Benjamin K Eschle, Andreas Weiss, Frédéric Stauffer, Christoph Gaul, Ralph Tiedt, Jennifer A Perry,[...]. Blood 2020
11
18

Requirement for Dot1l in murine postnatal hematopoiesis and leukemogenesis by MLL translocation.
Stephanie Y Jo, Eric M Granowicz, Ivan Maillard, Dafydd Thomas, Jay L Hess. Blood 2011
144
15


Methyltransferase Dot1l preferentially promotes innate IL-6 and IFN-β production by mediating H3K79me2/3 methylation in macrophages.
Xiang Chen, Xingguang Liu, Yunkai Zhang, Wanwan Huai, Qingqing Zhou, Sheng Xu, Xi Chen, Nan Li, Xuetao Cao. Cell Mol Immunol 2020
21
15

DOT1L inhibition reveals a distinct subset of enhancers dependent on H3K79 methylation.
Laura Godfrey, Nicholas T Crump, Ross Thorne, I-Jun Lau, Emmanouela Repapi, Dimitra Dimou, Alastair L Smith, Joe R Harman, Jelena M Telenius, A Marieke Oudelaar,[...]. Nat Commun 2019
35
15

DOT1L inhibition attenuates graft-versus-host disease by allogeneic T cells in adoptive immunotherapy models.
Yuki Kagoya, Munehide Nakatsugawa, Kayoko Saso, Tingxi Guo, Mark Anczurowski, Chung-Hsi Wang, Marcus O Butler, Cheryl H Arrowsmith, Naoto Hirano. Nat Commun 2018
13
15

Combinatorial patterns of histone acetylations and methylations in the human genome.
Zhibin Wang, Chongzhi Zang, Jeffrey A Rosenfeld, Dustin E Schones, Artem Barski, Suresh Cuddapah, Kairong Cui, Tae-Young Roh, Weiqun Peng, Michael Q Zhang,[...]. Nat Genet 2008
15

Phase I Study of the Novel Enhancer of Zeste Homolog 2 (EZH2) Inhibitor GSK2816126 in Patients with Advanced Hematologic and Solid Tumors.
Timothy A Yap, Jane N Winter, Lisa Giulino-Roth, Jemma Longley, Juanita Lopez, Jean-Marie Michot, John P Leonard, Vincent Ribrag, Michael T McCabe, Caretha L Creasy,[...]. Clin Cancer Res 2019
33
15

A higher-order configuration of the heterodimeric DOT1L-AF10 coiled-coil domains potentiates their leukemogenenic activity.
Xiaosheng Song, Liuliu Yang, Mingzhu Wang, Yue Gu, Buqing Ye, Zusen Fan, Rui-Ming Xu, Na Yang. Proc Natl Acad Sci U S A 2019
9
22

The polycomb group protein EZH2 is involved in progression of prostate cancer.
Sooryanarayana Varambally, Saravana M Dhanasekaran, Ming Zhou, Terrence R Barrette, Chandan Kumar-Sinha, Martin G Sanda, Debashis Ghosh, Kenneth J Pienta, Richard G A B Sewalt, Arie P Otte,[...]. Nature 2002
15


Targeting Epigenetics in Cancer.
Richard L Bennett, Jonathan D Licht. Annu Rev Pharmacol Toxicol 2018
89
15


Bromodomain inhibitor OTX015 in patients with lymphoma or multiple myeloma: a dose-escalation, open-label, pharmacokinetic, phase 1 study.
Sandy Amorim, Anastasios Stathis, Mary Gleeson, Sunil Iyengar, Valeria Magarotto, Xavier Leleu, Franck Morschhauser, Lionel Karlin, Florence Broussais, Keyvan Rezai,[...]. Lancet Haematol 2016
235
15

Histone demethylation mediated by the nuclear amine oxidase homolog LSD1.
Yujiang Shi, Fei Lan, Caitlin Matson, Peter Mulligan, Johnathan R Whetstine, Philip A Cole, Robert A Casero, Yang Shi. Cell 2004
15

Histone recognition and large-scale structural analysis of the human bromodomain family.
Panagis Filippakopoulos, Sarah Picaud, Maria Mangos, Tracy Keates, Jean-Philippe Lambert, Dalia Barsyte-Lovejoy, Ildiko Felletar, Rudolf Volkmer, Susanne Müller, Tony Pawson,[...]. Cell 2012
866
15


Degree of recruitment of DOT1L to MLL-AF9 defines level of H3K79 Di- and tri-methylation on target genes and transformation potential.
Aravinda Kuntimaddi, Nicholas J Achille, Jeremy Thorpe, Alyson A Lokken, Ritambhara Singh, Charles S Hemenway, Mazhar Adli, Nancy J Zeleznik-Le, John H Bushweller. Cell Rep 2015
62
15


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.