A citation-based method for searching scientific literature

Petr Ježek. Antioxid Redox Signal 2020
Times Cited: 25







List of co-cited articles
185 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity


Cancer-associated IDH1 mutations produce 2-hydroxyglutarate.
Lenny Dang, David W White, Stefan Gross, Bryson D Bennett, Mark A Bittinger, Edward M Driggers, Valeria R Fantin, Hyun Gyung Jang, Shengfang Jin, Marie C Keenan,[...]. Nature 2009
44

Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases.
Wei Xu, Hui Yang, Ying Liu, Ying Yang, Ping Wang, Se-Hee Kim, Shinsuke Ito, Chen Yang, Pu Wang, Meng-Tao Xiao,[...]. Cancer Cell 2011
32

L-2-Hydroxyglutarate production arises from noncanonical enzyme function at acidic pH.
Andrew M Intlekofer, Bo Wang, Hui Liu, Hardik Shah, Carlos Carmona-Fontaine, Ariën S Rustenburg, Salah Salah, M R Gunner, John D Chodera, Justin R Cross,[...]. Nat Chem Biol 2017
120
28

Hypoxia Induces Production of L-2-Hydroxyglutarate.
Andrew M Intlekofer, Raymond G Dematteo, Sriram Venneti, Lydia W S Finley, Chao Lu, Alexander R Judkins, Ariën S Rustenburg, Patrick B Grinaway, John D Chodera, Justin R Cross,[...]. Cell Metab 2015
249
28

Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation.
Peppi Koivunen, Sungwoo Lee, Christopher G Duncan, Giselle Lopez, Gang Lu, Shakti Ramkissoon, Julie A Losman, Päivi Joensuu, Ulrich Bergmann, Stefan Gross,[...]. Nature 2012
499
24

Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation.
Maria E Figueroa, Omar Abdel-Wahab, Chao Lu, Patrick S Ward, Jay Patel, Alan Shih, Yushan Li, Neha Bhagwat, Aparna Vasanthakumar, Hugo F Fernandez,[...]. Cancer Cell 2010
20

The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases.
Rasheduzzaman Chowdhury, Kar Kheng Yeoh, Ya-Min Tian, Lars Hillringhaus, Eleanor A Bagg, Nathan R Rose, Ivanhoe K H Leung, Xuan S Li, Esther C Y Woon, Ming Yang,[...]. EMBO Rep 2011
636
20

IDH mutation impairs histone demethylation and results in a block to cell differentiation.
Chao Lu, Patrick S Ward, Gurpreet S Kapoor, Dan Rohle, Sevin Turcan, Omar Abdel-Wahab, Christopher R Edwards, Raya Khanin, Maria E Figueroa, Ari Melnick,[...]. Nature 2012
20

L-2-hydroxyglutaric aciduria, a defect of metabolite repair.
R Rzem, M-F Vincent, E Van Schaftingen, M Veiga-da-Cunha. J Inherit Metab Dis 2007
101
20

Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase.
Mary A Selak, Sean M Armour, Elaine D MacKenzie, Houda Boulahbel, David G Watson, Kyle D Mansfield, Yi Pan, M Celeste Simon, Craig B Thompson, Eyal Gottlieb. Cancer Cell 2005
16


HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing.
M Ivan, K Kondo, H Yang, W Kim, J Valiando, M Ohh, A Salic, J M Asara, W S Lane, W G Kaelin. Science 2001
16

Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability.
David R Wise, Patrick S Ward, Jessica E S Shay, Justin R Cross, Joshua J Gruber, Uma M Sachdeva, Jesse M Platt, Raymond G DeMatteo, M Celeste Simon, Craig B Thompson. Proc Natl Acad Sci U S A 2011
642
16

MYC-driven accumulation of 2-hydroxyglutarate is associated with breast cancer prognosis.
Atsushi Terunuma, Nagireddy Putluri, Prachi Mishra, Ewy A Mathé, Tiffany H Dorsey, Ming Yi, Tiffany A Wallace, Haleem J Issaq, Ming Zhou, J Keith Killian,[...]. J Clin Invest 2014
257
16

L-2-Hydroxyglutarate: an epigenetic modifier and putative oncometabolite in renal cancer.
Eun-Hee Shim, Carolina B Livi, Dinesh Rakheja, Jubilee Tan, Daniel Benson, Vishwas Parekh, Eun-Young Kho, Arindam P Ghosh, Richard Kirkman, Sadanan Velu,[...]. Cancer Discov 2014
160
16

Hypoxia-Mediated Increases in L-2-hydroxyglutarate Coordinate the Metabolic Response to Reductive Stress.
William M Oldham, Clary B Clish, Yi Yang, Joseph Loscalzo. Cell Metab 2015
182
16

Tumour hypoxia causes DNA hypermethylation by reducing TET activity.
Bernard Thienpont, Jessica Steinbacher, Hui Zhao, Flora D'Anna, Anna Kuchnio, Athanasios Ploumakis, Bart Ghesquière, Laurien Van Dyck, Bram Boeckx, Luc Schoonjans,[...]. Nature 2016
290
16

Hallmarks of cancer: the next generation.
Douglas Hanahan, Robert A Weinberg. Cell 2011
16

Human phosphoglycerate dehydrogenase produces the oncometabolite D-2-hydroxyglutarate.
Jing Fan, Xin Teng, Ling Liu, Katherine R Mattaini, Ryan E Looper, Matthew G Vander Heiden, Joshua D Rabinowitz. ACS Chem Biol 2015
117
16

An integrated genomic analysis of human glioblastoma multiforme.
D Williams Parsons, Siân Jones, Xiaosong Zhang, Jimmy Cheng-Ho Lin, Rebecca J Leary, Philipp Angenendt, Parminder Mankoo, Hannah Carter, I-Mei Siu, Gary L Gallia,[...]. Science 2008
16

The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary.
David N Louis, Arie Perry, Guido Reifenberger, Andreas von Deimling, Dominique Figarella-Branger, Webster K Cavenee, Hiroko Ohgaki, Otmar D Wiestler, Paul Kleihues, David W Ellison. Acta Neuropathol 2016
16

IDH1 and IDH2 mutations in gliomas.
Hai Yan, D Williams Parsons, Genglin Jin, Roger McLendon, B Ahmed Rasheed, Weishi Yuan, Ivan Kos, Ines Batinic-Haberle, Siân Jones, Gregory J Riggins,[...]. N Engl J Med 2009
16

Acidic pH Is a Metabolic Switch for 2-Hydroxyglutarate Generation and Signaling.
Sergiy M Nadtochiy, Xenia Schafer, Dragony Fu, Keith Nehrke, Joshua Munger, Paul S Brookes. J Biol Chem 2016
82
16

Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation.
Vicky Lampropoulou, Alexey Sergushichev, Monika Bambouskova, Sharmila Nair, Emma E Vincent, Ekaterina Loginicheva, Luisa Cervantes-Barragan, Xiucui Ma, Stanley Ching-Cheng Huang, Takla Griss,[...]. Cell Metab 2016
485
12

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation.
P Jaakkola, D R Mole, Y M Tian, M I Wilson, J Gielbert, S J Gaskell, A von Kriegsheim, H F Hebestreit, M Mukherji, C J Schofield,[...]. Science 2001
12

Fundamentals of cancer metabolism.
Ralph J DeBerardinis, Navdeep S Chandel. Sci Adv 2016
12

Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: possible links between cell metabolism and stabilization of HIF.
Peppi Koivunen, Maija Hirsilä, Anne M Remes, Ilmo E Hassinen, Kari I Kivirikko, Johanna Myllyharju. J Biol Chem 2007
351
12

Reductive carboxylation and 2-hydroxyglutarate formation by wild-type IDH2 in breast carcinoma cells.
Katarína Smolková, Aleš Dvořák, Jaroslav Zelenka, Libor Vítek, Petr Ježek. Int J Biochem Cell Biol 2015
28
12

The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway.
Mélissa Carbonneau, Laurence M Gagné, Marie-Eve Lalonde, Marie-Anne Germain, Alena Motorina, Marie-Christine Guiot, Blandine Secco, Emma E Vincent, Anthony Tumber, Laura Hulea,[...]. Nat Commun 2016
86
12

Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA.
Yu-Fei He, Bin-Zhong Li, Zheng Li, Peng Liu, Yang Wang, Qingyu Tang, Jianping Ding, Yingying Jia, Zhangcheng Chen, Lin Li,[...]. Science 2011
12

Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor.
Maija Hirsilä, Peppi Koivunen, Volkmar Günzler, Kari I Kivirikko, Johanna Myllyharju. J Biol Chem 2003
587
12

IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype.
Sevin Turcan, Daniel Rohle, Anuj Goenka, Logan A Walsh, Fang Fang, Emrullah Yilmaz, Carl Campos, Armida W M Fabius, Chao Lu, Patrick S Ward,[...]. Nature 2012
12

Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma.
Samuel K McBrayer, Jared R Mayers, Gabriel J DiNatale, Diana D Shi, Januka Khanal, Abhishek A Chakraborty, Kristopher A Sarosiek, Kimberly J Briggs, Alissa K Robbins, Tomasz Sewastianik,[...]. Cell 2018
120
12

Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors.
Mengtao Xiao, Hui Yang, Wei Xu, Shenghong Ma, Huaipeng Lin, Honguang Zhu, Lixia Liu, Ying Liu, Chen Yang, Yanhui Xu,[...]. Genes Dev 2012
569
12

(R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible.
Julie-Aurore Losman, Ryan E Looper, Peppi Koivunen, Sungwoo Lee, Rebekka K Schneider, Christine McMahon, Glenn S Cowley, David E Root, Benjamin L Ebert, William G Kaelin. Science 2013
469
12

Fumarate hydratase in cancer: A multifaceted tumour suppressor.
Christina Schmidt, Marco Sciacovelli, Christian Frezza. Semin Cell Dev Biol 2020
29
12

Fumarate and Succinate Regulate Expression of Hypoxia-inducible Genes via TET Enzymes.
Tuomas Laukka, Christopher J Mariani, Tuukka Ihantola, John Z Cao, Juho Hokkanen, William G Kaelin, Lucy A Godley, Peppi Koivunen. J Biol Chem 2016
146
12

Kinetic characterization of human hydroxyacid-oxoacid transhydrogenase: relevance to D-2-hydroxyglutaric and gamma-hydroxybutyric acidurias.
E A Struys, N M Verhoeven, H J Ten Brink, W V Wickenhagen, K M Gibson, C Jakobs. J Inherit Metab Dis 2005
47
12

S-2-hydroxyglutarate regulates CD8+ T-lymphocyte fate.
Petros A Tyrakis, Asis Palazon, David Macias, Kian L Lee, Anthony T Phan, Pedro Veliça, Jia You, Grace S Chia, Jingwei Sim, Andrew Doedens,[...]. Nature 2016
197
12


Advances in Hypoxia-Inducible Factor Biology.
Hani Choudhry, Adrian L Harris. Cell Metab 2018
248
12

Biological Role and Therapeutic Potential of IDH Mutations in Cancer.
Matthew S Waitkus, Bill H Diplas, Hai Yan. Cancer Cell 2018
122
12

Metabolism, Activity, and Targeting of D- and L-2-Hydroxyglutarates.
Dan Ye, Kun-Liang Guan, Yue Xiong. Trends Cancer 2018
85
12

Progress in understanding 2-hydroxyglutaric acidurias.
Martijn Kranendijk, Eduard A Struys, Gajja S Salomons, Marjo S Van der Knaap, Cornelis Jakobs. J Inherit Metab Dis 2012
158
12

The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate.
Patrick S Ward, Jay Patel, David R Wise, Omar Abdel-Wahab, Bryson D Bennett, Hilary A Coller, Justin R Cross, Valeria R Fantin, Cyrus V Hedvat, Alexander E Perl,[...]. Cancer Cell 2010
12

Mutant Isocitrate Dehydrogenase Inhibitors as Targeted Cancer Therapeutics.
Danielle Golub, Nishanth Iyengar, Siddhant Dogra, Taylor Wong, Devin Bready, Karen Tang, Aram S Modrek, Dimitris G Placantonakis. Front Oncol 2019
102
12

Lactate in the Regulation of Tumor Microenvironment and Therapeutic Approaches.
Karen G de la Cruz-López, Leonardo Josué Castro-Muñoz, Diego O Reyes-Hernández, Alejandro García-Carrancá, Joaquín Manzo-Merino. Front Oncol 2019
158
12

IDH mutation in glioma: molecular mechanisms and potential therapeutic targets.
Sue Han, Yang Liu, Sabrina J Cai, Mingyu Qian, Jianyi Ding, Mioara Larion, Mark R Gilbert, Chunzhang Yang. Br J Cancer 2020
60
12

IDH1 and IDH2 mutations in gliomas.
Adam L Cohen, Sheri L Holmen, Howard Colman. Curr Neurol Neurosci Rep 2013
304
12

Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer.
Ian P M Tomlinson, N Afrina Alam, Andrew J Rowan, Ella Barclay, Emma E M Jaeger, David Kelsell, Irene Leigh, Patricia Gorman, Hanan Lamlum, Shamima Rahman,[...]. Nat Genet 2002
12


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.