Hermann Koepsell. Pharmacol Rev 2020
Times Cited: 96
Times Cited: 96
Times Cited
Times Co-cited
Similarity
Polyspecific organic cation transporters: structure, function, physiological roles, and biopharmaceutical implications.
Hermann Koepsell, Katrin Lips, Christopher Volk. Pharm Res 2007
Hermann Koepsell, Katrin Lips, Christopher Volk. Pharm Res 2007
27
Membrane transporters in drug development.
Kathleen M Giacomini, Shiew-Mei Huang, Donald J Tweedie, Leslie Z Benet, Kim L R Brouwer, Xiaoyan Chu, Amber Dahlin, Raymond Evers, Volker Fischer, Kathleen M Hillgren,[...]. Nat Rev Drug Discov 2010
Kathleen M Giacomini, Shiew-Mei Huang, Donald J Tweedie, Leslie Z Benet, Kim L R Brouwer, Xiaoyan Chu, Amber Dahlin, Raymond Evers, Volker Fischer, Kathleen M Hillgren,[...]. Nat Rev Drug Discov 2010
18
Cloning and characterization of two human polyspecific organic cation transporters.
V Gorboulev, J C Ulzheimer, A Akhoundova, I Ulzheimer-Teuber, U Karbach, S Quester, C Baumann, F Lang, A E Busch, H Koepsell. DNA Cell Biol 1997
V Gorboulev, J C Ulzheimer, A Akhoundova, I Ulzheimer-Teuber, U Karbach, S Quester, C Baumann, F Lang, A E Busch, H Koepsell. DNA Cell Biol 1997
18
Increased Systemic Exposure and Stronger Cardiovascular and Metabolic Adverse Reactions to Fenoterol in Individuals with Heritable OCT1 Deficiency.
Mladen V Tzvetkov, Johannes Matthaei, Sherin Pojar, Frank Faltraco, Sabrina Vogler, Thomas Prukop, Tina Seitz, Jürgen Brockmöller. Clin Pharmacol Ther 2018
Mladen V Tzvetkov, Johannes Matthaei, Sherin Pojar, Frank Faltraco, Sabrina Vogler, Thomas Prukop, Tina Seitz, Jürgen Brockmöller. Clin Pharmacol Ther 2018
45
Morphine is a substrate of the organic cation transporter OCT1 and polymorphisms in OCT1 gene affect morphine pharmacokinetics after codeine administration.
Mladen V Tzvetkov, Joao N dos Santos Pereira, Ingolf Meineke, Ali R Saadatmand, Julia C Stingl, Jürgen Brockmöller. Biochem Pharmacol 2013
Mladen V Tzvetkov, Joao N dos Santos Pereira, Ingolf Meineke, Ali R Saadatmand, Julia C Stingl, Jürgen Brockmöller. Biochem Pharmacol 2013
18
Organic cation transporters (OCTs, MATEs), in vitro and in vivo evidence for the importance in drug therapy.
Anne T Nies, Hermann Koepsell, Katja Damme, Matthias Schwab. Handb Exp Pharmacol 2011
Anne T Nies, Hermann Koepsell, Katja Damme, Matthias Schwab. Handb Exp Pharmacol 2011
17
Assessment of Substrate-Dependent Ligand Interactions at the Organic Cation Transporter OCT2 Using Six Model Substrates.
Philip J Sandoval, Kimberley M Zorn, Alex M Clark, Sean Ekins, Stephen H Wright. Mol Pharmacol 2018
Philip J Sandoval, Kimberley M Zorn, Alex M Clark, Sean Ekins, Stephen H Wright. Mol Pharmacol 2018
31
Multiple binding sites in organic cation transporters require sophisticated procedures to identify interactions of novel drugs.
Hermann Koepsell. Biol Chem 2019
Hermann Koepsell. Biol Chem 2019
53
Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver.
Anne T Nies, Hermann Koepsell, Stefan Winter, Oliver Burk, Kathrin Klein, Reinhold Kerb, Ulrich M Zanger, Dietrich Keppler, Matthias Schwab, Elke Schaeffeler. Hepatology 2009
Anne T Nies, Hermann Koepsell, Stefan Winter, Oliver Burk, Kathrin Klein, Reinhold Kerb, Ulrich M Zanger, Dietrich Keppler, Matthias Schwab, Elke Schaeffeler. Hepatology 2009
15
OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin.
Ligong Chen, Yan Shu, Xiaomin Liang, Eugene C Chen, Sook Wah Yee, Arik A Zur, Shuanglian Li, Lu Xu, Kayvan R Keshari, Michael J Lin,[...]. Proc Natl Acad Sci U S A 2014
Ligong Chen, Yan Shu, Xiaomin Liang, Eugene C Chen, Sook Wah Yee, Arik A Zur, Shuanglian Li, Lu Xu, Kayvan R Keshari, Michael J Lin,[...]. Proc Natl Acad Sci U S A 2014
15
OCT1 mediates hepatic uptake of sumatriptan and loss-of-function OCT1 polymorphisms affect sumatriptan pharmacokinetics.
J Matthaei, D Kuron, F Faltraco, T Knoch, J N Dos Santos Pereira, M Abu Abed, T Prukop, J Brockmöller, M V Tzvetkov. Clin Pharmacol Ther 2016
J Matthaei, D Kuron, F Faltraco, T Knoch, J N Dos Santos Pereira, M Abu Abed, T Prukop, J Brockmöller, M V Tzvetkov. Clin Pharmacol Ther 2016
25
Human neurons express the polyspecific cation transporter hOCT2, which translocates monoamine neurotransmitters, amantadine, and memantine.
A E Busch, U Karbach, D Miska, V Gorboulev, A Akhoundova, C Volk, P Arndt, J C Ulzheimer, M S Sonders, C Baumann,[...]. Mol Pharmacol 1998
A E Busch, U Karbach, D Miska, V Gorboulev, A Akhoundova, C Volk, P Arndt, J C Ulzheimer, M S Sonders, C Baumann,[...]. Mol Pharmacol 1998
15
The SLC22 family with transporters of organic cations, anions and zwitterions.
Hermann Koepsell. Mol Aspects Med 2013
Hermann Koepsell. Mol Aspects Med 2013
14
An unsuspected role for organic cation transporter 3 in the actions of amphetamine.
Felix P Mayer, Diethart Schmid, W Anthony Owens, Georgianna G Gould, Mia Apuschkin, Oliver Kudlacek, Isabella Salzer, Stefan Boehm, Peter Chiba, Piper H Williams,[...]. Neuropsychopharmacology 2018
Felix P Mayer, Diethart Schmid, W Anthony Owens, Georgianna G Gould, Mia Apuschkin, Oliver Kudlacek, Isabella Salzer, Stefan Boehm, Peter Chiba, Piper H Williams,[...]. Neuropsychopharmacology 2018
43
Altered aminergic neurotransmission in the brain of organic cation transporter 3-deficient mice.
Vincent Vialou, Laure Balasse, Jacques Callebert, Jean-Marie Launay, Bruno Giros, Sophie Gautron. J Neurochem 2008
Vincent Vialou, Laure Balasse, Jacques Callebert, Jean-Marie Launay, Bruno Giros, Sophie Gautron. J Neurochem 2008
20
Selective transport of monoamine neurotransmitters by human plasma membrane monoamine transporter and organic cation transporter 3.
Haichuan Duan, Joanne Wang. J Pharmacol Exp Ther 2010
Haichuan Duan, Joanne Wang. J Pharmacol Exp Ther 2010
14
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Gustav Ahlin, Johan Karlsson, Jenny M Pedersen, Lena Gustavsson, Rolf Larsson, Pär Matsson, Ulf Norinder, Christel A S Bergström, Per Artursson. J Med Chem 2008
Gustav Ahlin, Johan Karlsson, Jenny M Pedersen, Lena Gustavsson, Rolf Larsson, Pär Matsson, Ulf Norinder, Christel A S Bergström, Per Artursson. J Med Chem 2008
14
Discovery of Competitive and Noncompetitive Ligands of the Organic Cation Transporter 1 (OCT1; SLC22A1).
Eugene C Chen, Natalia Khuri, Xiaomin Liang, Adrian Stecula, Huan-Chieh Chien, Sook Wah Yee, Yong Huang, Andrej Sali, Kathleen M Giacomini. J Med Chem 2017
Eugene C Chen, Natalia Khuri, Xiaomin Liang, Adrian Stecula, Huan-Chieh Chien, Sook Wah Yee, Yong Huang, Andrej Sali, Kathleen M Giacomini. J Med Chem 2017
45
Identity of the organic cation transporter OCT3 as the extraneuronal monoamine transporter (uptake2) and evidence for the expression of the transporter in the brain.
X Wu, R Kekuda, W Huang, Y J Fei, F H Leibach, J Chen, S J Conway, V Ganapathy. J Biol Chem 1998
X Wu, R Kekuda, W Huang, Y J Fei, F H Leibach, J Chen, S J Conway, V Ganapathy. J Biol Chem 1998
13
Differential pharmacological in vitro properties of organic cation transporters and regional distribution in rat brain.
Anne Amphoux, Vincent Vialou, Eva Drescher, Michael Brüss, Clotilde Mannoury La Cour, Catherine Rochat, Mark J Millan, Bruno Giros, Heinz Bönisch, Sophie Gautron. Neuropharmacology 2006
Anne Amphoux, Vincent Vialou, Eva Drescher, Michael Brüss, Clotilde Mannoury La Cour, Catherine Rochat, Mark J Millan, Bruno Giros, Heinz Bönisch, Sophie Gautron. Neuropharmacology 2006
13
Drug excretion mediated by a new prototype of polyspecific transporter.
D Gründemann, V Gorboulev, S Gambaryan, M Veyhl, H Koepsell. Nature 1994
D Gründemann, V Gorboulev, S Gambaryan, M Veyhl, H Koepsell. Nature 1994
12
Interactions of tyrosine kinase inhibitors with organic cation transporters and multidrug and toxic compound extrusion proteins.
Tsuyoshi Minematsu, Kathleen M Giacomini. Mol Cancer Ther 2011
Tsuyoshi Minematsu, Kathleen M Giacomini. Mol Cancer Ther 2011
12
Substrate-dependent ligand inhibition of the human organic cation transporter OCT2.
Mathew Belzer, Mark Morales, Bhumasamudram Jagadish, Eugene A Mash, Stephen H Wright. J Pharmacol Exp Ther 2013
Mathew Belzer, Mark Morales, Bhumasamudram Jagadish, Eugene A Mash, Stephen H Wright. J Pharmacol Exp Ther 2013
17
Comparative analysis of novel decynium-22 analogs to inhibit transport by the low-affinity, high-capacity monoamine transporters, organic cation transporters 2 and 3, and plasma membrane monoamine transporter.
Rheaclare Fraser-Spears, Anwen M Krause-Heuer, Mohamed Basiouny, Felix P Mayer, Retrouvailles Manishimwe, Naomi A Wyatt, Jeremy C Dobrowolski, Maxine P Roberts, Ivan Greguric, Naresh Kumar,[...]. Eur J Pharmacol 2019
Rheaclare Fraser-Spears, Anwen M Krause-Heuer, Mohamed Basiouny, Felix P Mayer, Retrouvailles Manishimwe, Naomi A Wyatt, Jeremy C Dobrowolski, Maxine P Roberts, Ivan Greguric, Naresh Kumar,[...]. Eur J Pharmacol 2019
60
Global genetic analyses reveal strong inter-ethnic variability in the loss of activity of the organic cation transporter OCT1.
Tina Seitz, Robert Stalmann, Nawar Dalila, Jiayin Chen, Sherin Pojar, Joao N Dos Santos Pereira, Ralph Krätzner, Jürgen Brockmöller, Mladen V Tzvetkov. Genome Med 2015
Tina Seitz, Robert Stalmann, Nawar Dalila, Jiayin Chen, Sherin Pojar, Joao N Dos Santos Pereira, Ralph Krätzner, Jürgen Brockmöller, Mladen V Tzvetkov. Genome Med 2015
19
Organic cation transporter 2 controls brain norepinephrine and serotonin clearance and antidepressant response.
A Bacq, L Balasse, G Biala, B Guiard, A M Gardier, A Schinkel, F Louis, V Vialou, M-P Martres, C Chevarin,[...]. Mol Psychiatry 2012
A Bacq, L Balasse, G Biala, B Guiard, A M Gardier, A Schinkel, F Louis, V Vialou, M-P Martres, C Chevarin,[...]. Mol Psychiatry 2012
14
The poorly membrane permeable antipsychotic drugs amisulpride and sulpiride are substrates of the organic cation transporters from the SLC22 family.
Joao N Dos Santos Pereira, Sina Tadjerpisheh, Manar Abu Abed, Ali R Saadatmand, Babette Weksler, Ignacio A Romero, Pierre-Olivier Couraud, Jürgen Brockmöller, Mladen V Tzvetkov. AAPS J 2014
Joao N Dos Santos Pereira, Sina Tadjerpisheh, Manar Abu Abed, Ali R Saadatmand, Babette Weksler, Ignacio A Romero, Pierre-Olivier Couraud, Jürgen Brockmöller, Mladen V Tzvetkov. AAPS J 2014
23
Discovery of the ergothioneine transporter.
Dirk Gründemann, Stephanie Harlfinger, Stefan Golz, Andreas Geerts, Andreas Lazar, Reinhard Berkels, Norma Jung, Andrea Rubbert, Edgar Schömig. Proc Natl Acad Sci U S A 2005
Dirk Gründemann, Stephanie Harlfinger, Stefan Golz, Andreas Geerts, Andreas Lazar, Reinhard Berkels, Norma Jung, Andrea Rubbert, Edgar Schömig. Proc Natl Acad Sci U S A 2005
11
Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action.
Yan Shu, Steven A Sheardown, Chaline Brown, Ryan P Owen, Shuzhong Zhang, Richard A Castro, Alexandra G Ianculescu, Lin Yue, Joan C Lo, Esteban G Burchard,[...]. J Clin Invest 2007
Yan Shu, Steven A Sheardown, Chaline Brown, Ryan P Owen, Shuzhong Zhang, Richard A Castro, Alexandra G Ianculescu, Lin Yue, Joan C Lo, Esteban G Burchard,[...]. J Clin Invest 2007
11
Expression and pharmacological profile of the human organic cation transporters hOCT1, hOCT2 and hOCT3.
Martina Hayer-Zillgen, Michael Brüss, Heinz Bönisch. Br J Pharmacol 2002
Martina Hayer-Zillgen, Michael Brüss, Heinz Bönisch. Br J Pharmacol 2002
11
Organic cation transporter 3: Keeping the brake on extracellular serotonin in serotonin-transporter-deficient mice.
Nicole L Baganz, Rebecca E Horton, Alfredo S Calderon, W Anthony Owens, Jaclyn L Munn, Lora T Watts, Nina Koldzic-Zivanovic, Nathaniel A Jeske, Wouter Koek, Glenn M Toney,[...]. Proc Natl Acad Sci U S A 2008
Nicole L Baganz, Rebecca E Horton, Alfredo S Calderon, W Anthony Owens, Jaclyn L Munn, Lora T Watts, Nina Koldzic-Zivanovic, Nathaniel A Jeske, Wouter Koek, Glenn M Toney,[...]. Proc Natl Acad Sci U S A 2008
11
Molecular and functional identification of sodium ion-dependent, high affinity human carnitine transporter OCTN2.
I Tamai, R Ohashi, J Nezu, H Yabuuchi, A Oku, M Shimane, Y Sai, A Tsuji. J Biol Chem 1998
I Tamai, R Ohashi, J Nezu, H Yabuuchi, A Oku, M Shimane, Y Sai, A Tsuji. J Biol Chem 1998
11
Identification of novel substrates and structure-activity relationship of cellular uptake mediated by human organic cation transporters 1 and 2.
Ramon Hendrickx, Jenny G Johansson, Christina Lohmann, Rose-Marie Jenvert, Anders Blomgren, Lena Börjesson, Lena Gustavsson. J Med Chem 2013
Ramon Hendrickx, Jenny G Johansson, Christina Lohmann, Rose-Marie Jenvert, Anders Blomgren, Lena Börjesson, Lena Gustavsson. J Med Chem 2013
20
Profiling solute carrier transporters in the human blood-brain barrier.
E G Geier, E C Chen, A Webb, A C Papp, S W Yee, W Sadee, K M Giacomini. Clin Pharmacol Ther 2013
E G Geier, E C Chen, A Webb, A C Papp, S W Yee, W Sadee, K M Giacomini. Clin Pharmacol Ther 2013
13
The plasma membrane monoamine transporter (PMAT): Structure, function, and role in organic cation disposition.
J Wang. Clin Pharmacol Ther 2016
J Wang. Clin Pharmacol Ther 2016
32
Identification and characterization of a novel monoamine transporter in the human brain.
Karen Engel, Mingyan Zhou, Joanne Wang. J Biol Chem 2004
Karen Engel, Mingyan Zhou, Joanne Wang. J Biol Chem 2004
11
Cellular localization of the organic cation transporters, OCT1 and OCT2, in brain microvessel endothelial cells and its implication for MPTP transport across the blood-brain barrier and MPTP-induced dopaminergic toxicity in rodents.
Chun-Jung Lin, Ying Tai, Miao-Tzu Huang, Yuan-Feen Tsai, Hao-Jui Hsu, Kai-Yuan Tzen, Horng-Huei Liou. J Neurochem 2010
Chun-Jung Lin, Ying Tai, Miao-Tzu Huang, Yuan-Feen Tsai, Hao-Jui Hsu, Kai-Yuan Tzen, Horng-Huei Liou. J Neurochem 2010
12
Organic cation transporters are determinants of oxaliplatin cytotoxicity.
Shuzhong Zhang, Katherine S Lovejoy, James E Shima, Leah L Lagpacan, Yan Shu, Anna Lapuk, Ying Chen, Takafumi Komori, Joe W Gray, Xin Chen,[...]. Cancer Res 2006
Shuzhong Zhang, Katherine S Lovejoy, James E Shima, Leah L Lagpacan, Yan Shu, Anna Lapuk, Ying Chen, Takafumi Komori, Joe W Gray, Xin Chen,[...]. Cancer Res 2006
10
Pharmacokinetics of Organic Cation Transporter 1 (OCT1) Substrates in Oct1/2 Knockout Mice and Species Difference in Hepatic OCT1-Mediated Uptake.
Bridget L Morse, Anil Kolur, Loyd R Hudson, Andrew T Hogan, Lisa Hong Chen, Ryan M Brackman, Geri A Sawada, John K Fallon, Philip C Smith, Kathleen M Hillgren. Drug Metab Dispos 2020
Bridget L Morse, Anil Kolur, Loyd R Hudson, Andrew T Hogan, Lisa Hong Chen, Ryan M Brackman, Geri A Sawada, John K Fallon, Philip C Smith, Kathleen M Hillgren. Drug Metab Dispos 2020
66
Polyamine transport by the polyspecific organic cation transporters OCT1, OCT2, and OCT3.
Monica Sala-Rabanal, Dan C Li, Gregory R Dake, Harley T Kurata, Mikhail Inyushin, Serguei N Skatchkov, Colin G Nichols. Mol Pharm 2013
Monica Sala-Rabanal, Dan C Li, Gregory R Dake, Harley T Kurata, Mikhail Inyushin, Serguei N Skatchkov, Colin G Nichols. Mol Pharm 2013
18
Deficiency in the organic cation transporters 1 and 2 (Oct1/Oct2 [Slc22a1/Slc22a2]) in mice abolishes renal secretion of organic cations.
Johan W Jonker, Els Wagenaar, Sven Van Eijl, Alfred H Schinkel. Mol Cell Biol 2003
Johan W Jonker, Els Wagenaar, Sven Van Eijl, Alfred H Schinkel. Mol Cell Biol 2003
10
Rat Organic Cation Transporter 1 Contains Three Binding Sites for Substrate 1-Methyl-4-phenylpyridinium per Monomer.
Thorsten Keller, Valentin Gorboulev, Thomas D Mueller, Volker Dötsch, Frank Bernhard, Hermann Koepsell. Mol Pharmacol 2019
Thorsten Keller, Valentin Gorboulev, Thomas D Mueller, Volker Dötsch, Frank Bernhard, Hermann Koepsell. Mol Pharmacol 2019
50
Role of organic cation transporters in drug-drug interaction.
Hermann Koepsell. Expert Opin Drug Metab Toxicol 2015
Hermann Koepsell. Expert Opin Drug Metab Toxicol 2015
17
Effects of OCT1 polymorphisms on the cellular uptake, plasma concentrations and efficacy of the 5-HT(3) antagonists tropisetron and ondansetron.
M V Tzvetkov, A R Saadatmand, K Bokelmann, I Meineke, R Kaiser, J Brockmöller. Pharmacogenomics J 2012
M V Tzvetkov, A R Saadatmand, K Bokelmann, I Meineke, R Kaiser, J Brockmöller. Pharmacogenomics J 2012
10
OCTN: A Small Transporter Subfamily with Great Relevance to Human Pathophysiology, Drug Discovery, and Diagnostics.
Lorena Pochini, Michele Galluccio, Mariafrancesca Scalise, Lara Console, Cesare Indiveri. SLAS Discov 2019
Lorena Pochini, Michele Galluccio, Mariafrancesca Scalise, Lara Console, Cesare Indiveri. SLAS Discov 2019
28
Contribution of organic cation transporter 2 (OCT2) to cisplatin-induced nephrotoxicity.
K K Filipski, R H Mathijssen, T S Mikkelsen, A H Schinkel, A Sparreboom. Clin Pharmacol Ther 2009
K K Filipski, R H Mathijssen, T S Mikkelsen, A H Schinkel, A Sparreboom. Clin Pharmacol Ther 2009
9
Oxaliplatin-induced neurotoxicity is dependent on the organic cation transporter OCT2.
Jason A Sprowl, Giuliano Ciarimboli, Cynthia S Lancaster, Hugh Giovinazzo, Alice A Gibson, Guoqing Du, Laura J Janke, Guido Cavaletti, Anthony F Shields, Alex Sparreboom. Proc Natl Acad Sci U S A 2013
Jason A Sprowl, Giuliano Ciarimboli, Cynthia S Lancaster, Hugh Giovinazzo, Alice A Gibson, Guoqing Du, Laura J Janke, Guido Cavaletti, Anthony F Shields, Alex Sparreboom. Proc Natl Acad Sci U S A 2013
9
Corticosterone-sensitive monoamine transport in the rat dorsomedial hypothalamus: potential role for organic cation transporter 3 in stress-induced modulation of monoaminergic neurotransmission.
Paul J Gasser, Christopher A Lowry, Miles Orchinik. J Neurosci 2006
Paul J Gasser, Christopher A Lowry, Miles Orchinik. J Neurosci 2006
9
Effects of genetic polymorphisms on the OCT1 and OCT2-mediated uptake of ranitidine.
Marleen Julia Meyer, Tina Seitz, Jürgen Brockmöller, Mladen Vassilev Tzvetkov. PLoS One 2017
Marleen Julia Meyer, Tina Seitz, Jürgen Brockmöller, Mladen Vassilev Tzvetkov. PLoS One 2017
42
The organic cation transporter-3 is a pivotal modulator of neurodegeneration in the nigrostriatal dopaminergic pathway.
Mei Cui, Radha Aras, Whitney V Christian, Phillip M Rappold, Mamata Hatwar, Joseph Panza, Vernice Jackson-Lewis, Jonathan A Javitch, Nazzareno Ballatori, Serge Przedborski,[...]. Proc Natl Acad Sci U S A 2009
Mei Cui, Radha Aras, Whitney V Christian, Phillip M Rappold, Mamata Hatwar, Joseph Panza, Vernice Jackson-Lewis, Jonathan A Javitch, Nazzareno Ballatori, Serge Przedborski,[...]. Proc Natl Acad Sci U S A 2009
9
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.