Wei Liu, Yonju Ha, Fan Xia, Shuang Zhu, Yi Li, Shuizhen Shi, Fang C Mei, Kevin Merkley, Gianmarco Vizzeri, Massoud Motamedi, Xiaodong Cheng, Hua Liu, Wenbo Zhang. J Exp Med 2020
Times Cited: 13
Times Cited: 13
Times Cited
Times Co-cited
Similarity
Intracellular cAMP Sensor EPAC: Physiology, Pathophysiology, and Therapeutics Development.
William G Robichaux, Xiaodong Cheng. Physiol Rev 2018
William G Robichaux, Xiaodong Cheng. Physiol Rev 2018
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Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP.
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Inhibition of Epac1 suppresses mitochondrial fission and reduces neointima formation induced by vascular injury.
Hui Wang, William G Robichaux, Ziqing Wang, Fang C Mei, Ming Cai, Guangwei Du, Ju Chen, Xiaodong Cheng. Sci Rep 2016
Hui Wang, William G Robichaux, Ziqing Wang, Fang C Mei, Ming Cai, Guangwei Du, Ju Chen, Xiaodong Cheng. Sci Rep 2016
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Epac and phospholipase Cepsilon regulate Ca2+ release in the heart by activation of protein kinase Cepsilon and calcium-calmodulin kinase II.
Emily A Oestreich, Sundeep Malik, Sanjeewa A Goonasekera, Burns C Blaxall, Grant G Kelley, Robert T Dirksen, Alan V Smrcka. J Biol Chem 2009
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Exchange protein directly activated by cAMP (epac): a multidomain cAMP mediator in the regulation of diverse biological functions.
Martina Schmidt, Frank J Dekker, Harm Maarsingh. Pharmacol Rev 2013
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The EPAC-Rap1 pathway prevents and reverses cytokine-induced retinal vascular permeability.
Carla J Ramos, Chengmao Lin, Xuwen Liu, David A Antonetti. J Biol Chem 2018
Carla J Ramos, Chengmao Lin, Xuwen Liu, David A Antonetti. J Biol Chem 2018
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Minocycline prevents retinal inflammation and vascular permeability following ischemia-reperfusion injury.
Steven F Abcouwer, Cheng-Mao Lin, Sumathi Shanmugam, Arivalagan Muthusamy, Alistair J Barber, David A Antonetti. J Neuroinflammation 2013
Steven F Abcouwer, Cheng-Mao Lin, Sumathi Shanmugam, Arivalagan Muthusamy, Alistair J Barber, David A Antonetti. J Neuroinflammation 2013
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Epac1 inhibition ameliorates pathological angiogenesis through coordinated activation of Notch and suppression of VEGF signaling.
Hua Liu, Fang C Mei, Wenli Yang, Hui Wang, Eitan Wong, Jingjing Cai, Emma Toth, Pei Luo, Yue-Ming Li, Wenbo Zhang,[...]. Sci Adv 2020
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Multifunctional Mitochondrial Epac1 Controls Myocardial Cell Death.
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A family of cAMP-binding proteins that directly activate Rap1.
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A novel EPAC-specific inhibitor suppresses pancreatic cancer cell migration and invasion.
Muayad Almahariq, Tamara Tsalkova, Fang C Mei, Haijun Chen, Jia Zhou, Sarita K Sastry, Frank Schwede, Xiaodong Cheng. Mol Pharmacol 2013
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HIF-1α binding to the Epac1 promoter recruits hematopoietic stem cells to the ischemic brain following stroke.
Ted Weita Lai, Shinn-Zong Lin, Hsu-Tung Lee, Jia-Rong Fan, Yung-Hsiang Hsu, Hsiao-Jung Wang, Yung-Luen Yu, Woei-Cherng Shyu. J Mol Cell Biol 2012
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Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B.
Holger Rehmann, Ernesto Arias-Palomo, Michael A Hadders, Frank Schwede, Oscar Llorca, Johannes L Bos. Nature 2008
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Identification of a tetrahydroquinoline analog as a pharmacological inhibitor of the cAMP-binding protein Epac.
Delphine Courilleau, Malik Bisserier, Jean-Christophe Jullian, Alexandre Lucas, Pascal Bouyssou, Rodolphe Fischmeister, Jean-Paul Blondeau, Frank Lezoualc'h. J Biol Chem 2012
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Lithium and an EPAC-specific inhibitor ESI-09 synergistically suppress pancreatic cancer cell proliferation and survival.
Xinshuo Wang, Cheng Luo, Xiaodong Cheng, Meiling Lu. Acta Biochim Biophys Sin (Shanghai) 2017
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Phospholipase Cε hydrolyzes perinuclear phosphatidylinositol 4-phosphate to regulate cardiac hypertrophy.
Lianghui Zhang, Sundeep Malik, Jinjiang Pang, Huan Wang, Keigan M Park, David I Yule, Burns C Blaxall, Alan V Smrcka. Cell 2013
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The interaction of Epac1 and Ran promotes Rap1 activation at the nuclear envelope.
Chang Liu, Maho Takahashi, Yanping Li, Tara J Dillon, Stefanie Kaech, Philip J S Stork. Mol Cell Biol 2010
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A new phospholipase-C-calcium signalling pathway mediated by cyclic AMP and a Rap GTPase.
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A cardiac mitochondrial cAMP signaling pathway regulates calcium accumulation, permeability transition and cell death.
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Mitochondrial cAMP exerts positive feedback on mitochondrial Ca2+ uptake via the recruitment of Epac1.
Gergő Szanda, Éva Wisniewski, Anikó Rajki, András Spät. J Cell Sci 2018
Gergő Szanda, Éva Wisniewski, Anikó Rajki, András Spät. J Cell Sci 2018
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Epac-mediated activation of phospholipase C(epsilon) plays a critical role in beta-adrenergic receptor-dependent enhancement of Ca2+ mobilization in cardiac myocytes.
Emily A Oestreich, Huan Wang, Sundeep Malik, Katherine A Kaproth-Joslin, Burns C Blaxall, Grant G Kelley, Robert T Dirksen, Alan V Smrcka. J Biol Chem 2007
Emily A Oestreich, Huan Wang, Sundeep Malik, Katherine A Kaproth-Joslin, Burns C Blaxall, Grant G Kelley, Robert T Dirksen, Alan V Smrcka. J Biol Chem 2007
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Cell cycle-dependent subcellular localization of exchange factor directly activated by cAMP.
Jingbo Qiao, Fang C Mei, Vsevolod L Popov, Leoncio A Vergara, Xiaodong Cheng. J Biol Chem 2002
Jingbo Qiao, Fang C Mei, Vsevolod L Popov, Leoncio A Vergara, Xiaodong Cheng. J Biol Chem 2002
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Differential roles of Epac in regulating cell death in neuronal and myocardial cells.
Sayaka Suzuki, Utako Yokoyama, Takaya Abe, Hiroshi Kiyonari, Naoya Yamashita, Yuko Kato, Reiko Kurotani, Motohiko Sato, Satoshi Okumura, Yoshihiro Ishikawa. J Biol Chem 2010
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Caspase-8 promotes NLRP1/NLRP3 inflammasome activation and IL-1β production in acute glaucoma.
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Inhibition of Epac2 Attenuates Neural Cell Apoptosis and Improves Neurological Deficits in a Rat Model of Traumatic Brain Injury.
Ling Zhang, Li Zhang, Huixiang Liu, Feng Jiang, Huanjing Wang, Di Li, Rong Gao. Front Neurosci 2018
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BAX to basics: How the BCL2 gene family controls the death of retinal ganglion cells.
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PKA regulates HMGB1 through activation of IGFBP-3 and SIRT1 in human retinal endothelial cells cultured in high glucose.
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Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.