Alban Ordureau, Joao A Paulo, Jiuchun Zhang, Heeseon An, Kirby N Swatek, Joe R Cannon, Qiaoqiao Wan, David Komander, J Wade Harper. Mol Cell 2020
Times Cited: 62
Times Cited: 62
Times Cited
Times Co-cited
Similarity
The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy.
Michael Lazarou, Danielle A Sliter, Lesley A Kane, Shireen A Sarraf, Chunxin Wang, Jonathon L Burman, Dionisia P Sideris, Adam I Fogel, Richard J Youle. Nature 2015
Michael Lazarou, Danielle A Sliter, Lesley A Kane, Shireen A Sarraf, Chunxin Wang, Jonathon L Burman, Dionisia P Sideris, Adam I Fogel, Richard J Youle. Nature 2015
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Dynamic Regulation of Mitochondrial Import by the Ubiquitin System.
Lilian Phu, Christopher M Rose, Joy S Tea, Christopher E Wall, Erik Verschueren, Tommy K Cheung, Donald S Kirkpatrick, Baris Bingol. Mol Cell 2020
Lilian Phu, Christopher M Rose, Joy S Tea, Christopher E Wall, Erik Verschueren, Tommy K Cheung, Donald S Kirkpatrick, Baris Bingol. Mol Cell 2020
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PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity.
Lesley A Kane, Michael Lazarou, Adam I Fogel, Yan Li, Koji Yamano, Shireen A Sarraf, Soojay Banerjee, Richard J Youle. J Cell Biol 2014
Lesley A Kane, Michael Lazarou, Adam I Fogel, Yan Li, Koji Yamano, Shireen A Sarraf, Soojay Banerjee, Richard J Youle. J Cell Biol 2014
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The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy.
Baris Bingol, Joy S Tea, Lilian Phu, Mike Reichelt, Corey E Bakalarski, Qinghua Song, Oded Foreman, Donald S Kirkpatrick, Morgan Sheng. Nature 2014
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Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
Shireen A Sarraf, Malavika Raman, Virginia Guarani-Pereira, Mathew E Sowa, Edward L Huttlin, Steven P Gygi, J Wade Harper. Nature 2013
Shireen A Sarraf, Malavika Raman, Virginia Guarani-Pereira, Mathew E Sowa, Edward L Huttlin, Steven P Gygi, J Wade Harper. Nature 2013
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Quantitative proteomics reveal a feedforward mechanism for mitochondrial PARKIN translocation and ubiquitin chain synthesis.
Alban Ordureau, Shireen A Sarraf, David M Duda, Jin-Mi Heo, Mark P Jedrychowski, Vladislav O Sviderskiy, Jennifer L Olszewski, James T Koerber, Tiao Xie, Sean A Beausoleil,[...]. Mol Cell 2014
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Mechanism of phospho-ubiquitin-induced PARKIN activation.
Tobias Wauer, Michal Simicek, Alexander Schubert, David Komander. Nature 2015
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Parkin is recruited selectively to impaired mitochondria and promotes their autophagy.
Derek Narendra, Atsushi Tanaka, Der-Fen Suen, Richard J Youle. J Cell Biol 2008
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Building and decoding ubiquitin chains for mitophagy.
J Wade Harper, Alban Ordureau, Jin-Mi Heo. Nat Rev Mol Cell Biol 2018
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Mitophagy and Quality Control Mechanisms in Mitochondrial Maintenance.
Sarah Pickles, Pierre Vigié, Richard J Youle. Curr Biol 2018
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Ubiquitin is phosphorylated by PINK1 to activate parkin.
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Dynamics of PARKIN-Dependent Mitochondrial Ubiquitylation in Induced Neurons and Model Systems Revealed by Digital Snapshot Proteomics.
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The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson's disease.
Alicia M Pickrell, Richard J Youle. Neuron 2015
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PINK1 is selectively stabilized on impaired mitochondria to activate Parkin.
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Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism.
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The PINK1-PARKIN Mitochondrial Ubiquitylation Pathway Drives a Program of OPTN/NDP52 Recruitment and TBK1 Activation to Promote Mitophagy.
Jin-Mi Heo, Alban Ordureau, Joao A Paulo, Jesse Rinehart, J Wade Harper. Mol Cell 2015
Jin-Mi Heo, Alban Ordureau, Joao A Paulo, Jesse Rinehart, J Wade Harper. Mol Cell 2015
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Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65.
Agne Kazlauskaite, Chandana Kondapalli, Robert Gourlay, David G Campbell, Maria Stella Ritorto, Kay Hofmann, Dario R Alessi, Axel Knebel, Matthias Trost, Miratul M K Muqit. Biochem J 2014
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Mechanism and regulation of the Lys6-selective deubiquitinase USP30.
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Basal Mitophagy Occurs Independently of PINK1 in Mouse Tissues of High Metabolic Demand.
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Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin.
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Role of PINK1 binding to the TOM complex and alternate intracellular membranes in recruitment and activation of the E3 ligase Parkin.
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Mechanism of parkin activation by PINK1.
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PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65.
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Mechanism of parkin activation by phosphorylation.
Véronique Sauvé, George Sung, Naoto Soya, Guennadi Kozlov, Nina Blaimschein, Lis Schwartz Miotto, Jean-François Trempe, Gergely L Lukacs, Kalle Gehring. Nat Struct Mol Biol 2018
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Parkin and PINK1 mitigate STING-induced inflammation.
Danielle A Sliter, Jennifer Martinez, Ling Hao, Xi Chen, Nuo Sun, Tara D Fischer, Jonathon L Burman, Yan Li, Zhe Zhang, Derek P Narendra,[...]. Nature 2018
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PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1.
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PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria.
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Hereditary early-onset Parkinson's disease caused by mutations in PINK1.
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Broad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagy.
Nickie C Chan, Anna M Salazar, Anh H Pham, Michael J Sweredoski, Natalie J Kolawa, Robert L J Graham, Sonja Hess, David C Chan. Hum Mol Genet 2011
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USP30 and parkin homeostatically regulate atypical ubiquitin chains on mitochondria.
Christian N Cunningham, Joshua M Baughman, Lilian Phu, Joy S Tea, Christine Yu, Mary Coons, Donald S Kirkpatrick, Baris Bingol, Jacob E Corn. Nat Cell Biol 2015
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A Ubl/ubiquitin switch in the activation of Parkin.
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Véronique Sauvé, Asparouh Lilov, Marjan Seirafi, Marta Vranas, Shafqat Rasool, Guennadi Kozlov, Tara Sprules, Jimin Wang, Jean-François Trempe, Kalle Gehring. EMBO J 2015
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Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy.
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Spatiotemporal Control of ULK1 Activation by NDP52 and TBK1 during Selective Autophagy.
Jose Norberto S Vargas, Chunxin Wang, Eric Bunker, Ling Hao, Dragan Maric, Giampietro Schiavo, Felix Randow, Richard J Youle. Mol Cell 2019
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USP30 sets a trigger threshold for PINK1-PARKIN amplification of mitochondrial ubiquitylation.
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Emma V Rusilowicz-Jones, Jane Jardine, Andreas Kallinos, Adan Pinto-Fernandez, Franziska Guenther, Mariacarmela Giurrandino, Francesco G Barone, Katy McCarron, Christopher J Burke, Alejandro Murad,[...]. Life Sci Alliance 2020
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Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis.
Tobias Wauer, Kirby N Swatek, Jane L Wagstaff, Christina Gladkova, Jonathan N Pruneda, Martin A Michel, Malte Gersch, Christopher M Johnson, Stefan M V Freund, David Komander. EMBO J 2015
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Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL.
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USP8 regulates mitophagy by removing K6-linked ubiquitin conjugates from parkin.
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Dual role of USP30 in controlling basal pexophagy and mitophagy.
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Structure of the human Parkin ligase domain in an autoinhibited state.
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A dimeric PINK1-containing complex on depolarized mitochondria stimulates Parkin recruitment.
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Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation.
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PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy.
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Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells.
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PINK1 autophosphorylation is required for ubiquitin recognition.
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Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.