Sisi Kang, Mei Yang, Zhongsi Hong, Liping Zhang, Zhaoxia Huang, Xiaoxue Chen, Suhua He, Ziliang Zhou, Zhechong Zhou, Qiuyue Chen, Yan Yan, Changsheng Zhang, Hong Shan, Shoudeng Chen. Acta Pharm Sin B 2020
Times Cited: 299
Times Cited: 299
Times Cited
Times Co-cited
Similarity
Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation.
Daniel Wrapp, Nianshuang Wang, Kizzmekia S Corbett, Jory A Goldsmith, Ching-Lin Hsieh, Olubukola Abiona, Barney S Graham, Jason S McLellan. Science 2020
Daniel Wrapp, Nianshuang Wang, Kizzmekia S Corbett, Jory A Goldsmith, Ching-Lin Hsieh, Olubukola Abiona, Barney S Graham, Jason S McLellan. Science 2020
34
A pneumonia outbreak associated with a new coronavirus of probable bat origin.
Peng Zhou, Xing-Lou Yang, Xian-Guang Wang, Ben Hu, Lei Zhang, Wei Zhang, Hao-Rui Si, Yan Zhu, Bei Li, Chao-Lin Huang,[...]. Nature 2020
Peng Zhou, Xing-Lou Yang, Xian-Guang Wang, Ben Hu, Lei Zhang, Wei Zhang, Hao-Rui Si, Yan Zhu, Bei Li, Chao-Lin Huang,[...]. Nature 2020
31
Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein.
Alexandra C Walls, Young-Jun Park, M Alejandra Tortorici, Abigail Wall, Andrew T McGuire, David Veesler. Cell 2020
Alexandra C Walls, Young-Jun Park, M Alejandra Tortorici, Abigail Wall, Andrew T McGuire, David Veesler. Cell 2020
29
The coronavirus nucleocapsid is a multifunctional protein.
Ruth McBride, Marjorie van Zyl, Burtram C Fielding. Viruses 2014
Ruth McBride, Marjorie van Zyl, Burtram C Fielding. Viruses 2014
28
SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor.
Markus Hoffmann, Hannah Kleine-Weber, Simon Schroeder, Nadine Krüger, Tanja Herrler, Sandra Erichsen, Tobias S Schiergens, Georg Herrler, Nai-Huei Wu, Andreas Nitsche,[...]. Cell 2020
Markus Hoffmann, Hannah Kleine-Weber, Simon Schroeder, Nadine Krüger, Tanja Herrler, Sandra Erichsen, Tobias S Schiergens, Georg Herrler, Nai-Huei Wu, Andreas Nitsche,[...]. Cell 2020
26
A Novel Coronavirus from Patients with Pneumonia in China, 2019.
Na Zhu, Dingyu Zhang, Wenling Wang, Xingwang Li, Bo Yang, Jingdong Song, Xiang Zhao, Baoying Huang, Weifeng Shi, Roujian Lu,[...]. N Engl J Med 2020
Na Zhu, Dingyu Zhang, Wenling Wang, Xingwang Li, Bo Yang, Jingdong Song, Xiang Zhao, Baoying Huang, Weifeng Shi, Roujian Lu,[...]. N Engl J Med 2020
25
A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.
David E Gordon, Gwendolyn M Jang, Mehdi Bouhaddou, Jiewei Xu, Kirsten Obernier, Kris M White, Matthew J O'Meara, Veronica V Rezelj, Jeffrey Z Guo, Danielle L Swaney,[...]. Nature 2020
David E Gordon, Gwendolyn M Jang, Mehdi Bouhaddou, Jiewei Xu, Kirsten Obernier, Kris M White, Matthew J O'Meara, Veronica V Rezelj, Jeffrey Z Guo, Danielle L Swaney,[...]. Nature 2020
24
A new coronavirus associated with human respiratory disease in China.
Fan Wu, Su Zhao, Bin Yu, Yan-Mei Chen, Wen Wang, Zhi-Gang Song, Yi Hu, Zhao-Wu Tao, Jun-Hua Tian, Yuan-Yuan Pei,[...]. Nature 2020
Fan Wu, Su Zhao, Bin Yu, Yan-Mei Chen, Wen Wang, Zhi-Gang Song, Yi Hu, Zhao-Wu Tao, Jun-Hua Tian, Yuan-Yuan Pei,[...]. Nature 2020
23
Structure of the RNA-dependent RNA polymerase from COVID-19 virus.
Yan Gao, Liming Yan, Yucen Huang, Fengjiang Liu, Yao Zhao, Lin Cao, Tao Wang, Qianqian Sun, Zhenhua Ming, Lianqi Zhang,[...]. Science 2020
Yan Gao, Liming Yan, Yucen Huang, Fengjiang Liu, Yao Zhao, Lin Cao, Tao Wang, Qianqian Sun, Zhenhua Ming, Lianqi Zhang,[...]. Science 2020
20
Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor.
Jun Lan, Jiwan Ge, Jinfang Yu, Sisi Shan, Huan Zhou, Shilong Fan, Qi Zhang, Xuanling Shi, Qisheng Wang, Linqi Zhang,[...]. Nature 2020
Jun Lan, Jiwan Ge, Jinfang Yu, Sisi Shan, Huan Zhou, Shilong Fan, Qi Zhang, Xuanling Shi, Qisheng Wang, Linqi Zhang,[...]. Nature 2020
19
Nucleocapsid Protein Recruitment to Replication-Transcription Complexes Plays a Crucial Role in Coronaviral Life Cycle.
Yingying Cong, Mustafa Ulasli, Hein Schepers, Mario Mauthe, Philip V'kovski, Franziska Kriegenburg, Volker Thiel, Cornelis A M de Haan, Fulvio Reggiori. J Virol 2020
Yingying Cong, Mustafa Ulasli, Hein Schepers, Mario Mauthe, Philip V'kovski, Franziska Kriegenburg, Volker Thiel, Cornelis A M de Haan, Fulvio Reggiori. J Virol 2020
18
Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors.
Linlin Zhang, Daizong Lin, Xinyuanyuan Sun, Ute Curth, Christian Drosten, Lucie Sauerhering, Stephan Becker, Katharina Rox, Rolf Hilgenfeld. Science 2020
Linlin Zhang, Daizong Lin, Xinyuanyuan Sun, Ute Curth, Christian Drosten, Lucie Sauerhering, Stephan Becker, Katharina Rox, Rolf Hilgenfeld. Science 2020
18
The SARS coronavirus nucleocapsid protein--forms and functions.
Chung-ke Chang, Ming-Hon Hou, Chi-Fon Chang, Chwan-Deng Hsiao, Tai-huang Huang. Antiviral Res 2014
Chung-ke Chang, Ming-Hon Hou, Chi-Fon Chang, Chwan-Deng Hsiao, Tai-huang Huang. Antiviral Res 2014
17
Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China.
Chaolin Huang, Yeming Wang, Xingwang Li, Lili Ren, Jianping Zhao, Yi Hu, Li Zhang, Guohui Fan, Jiuyang Xu, Xiaoying Gu,[...]. Lancet 2020
Chaolin Huang, Yeming Wang, Xingwang Li, Lili Ren, Jianping Zhao, Yi Hu, Li Zhang, Guohui Fan, Jiuyang Xu, Xiaoying Gu,[...]. Lancet 2020
16
Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2.
Renhong Yan, Yuanyuan Zhang, Yaning Li, Lu Xia, Yingying Guo, Qiang Zhou. Science 2020
Renhong Yan, Yuanyuan Zhang, Yaning Li, Lu Xia, Yingying Guo, Qiang Zhou. Science 2020
16
Structure of the SARS coronavirus nucleocapsid protein RNA-binding dimerization domain suggests a mechanism for helical packaging of viral RNA.
Chun-Yuan Chen, Chung-Ke Chang, Yi-Wei Chang, Shih-Che Sue, Hsin-I Bai, Lilianty Riang, Chwan-Deng Hsiao, Tai-Huang Huang. J Mol Biol 2007
Chun-Yuan Chen, Chung-Ke Chang, Yi-Wei Chang, Shih-Che Sue, Hsin-I Bai, Lilianty Riang, Chwan-Deng Hsiao, Tai-Huang Huang. J Mol Biol 2007
16
Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors.
Zhenming Jin, Xiaoyu Du, Yechun Xu, Yongqiang Deng, Meiqin Liu, Yao Zhao, Bing Zhang, Xiaofeng Li, Leike Zhang, Chao Peng,[...]. Nature 2020
Zhenming Jin, Xiaoyu Du, Yechun Xu, Yongqiang Deng, Meiqin Liu, Yao Zhao, Bing Zhang, Xiaofeng Li, Leike Zhang, Chao Peng,[...]. Nature 2020
15
15
Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion.
Shuai Xia, Meiqin Liu, Chao Wang, Wei Xu, Qiaoshuai Lan, Siliang Feng, Feifei Qi, Linlin Bao, Lanying Du, Shuwen Liu,[...]. Cell Res 2020
Shuai Xia, Meiqin Liu, Chao Wang, Wei Xu, Qiaoshuai Lan, Siliang Feng, Feifei Qi, Linlin Bao, Lanying Du, Shuwen Liu,[...]. Cell Res 2020
14
Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding.
Roujian Lu, Xiang Zhao, Juan Li, Peihua Niu, Bo Yang, Honglong Wu, Wenling Wang, Hao Song, Baoying Huang, Na Zhu,[...]. Lancet 2020
Roujian Lu, Xiang Zhao, Juan Li, Peihua Niu, Bo Yang, Honglong Wu, Wenling Wang, Hao Song, Baoying Huang, Na Zhu,[...]. Lancet 2020
14
Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV.
Xiuyuan Ou, Yan Liu, Xiaobo Lei, Pei Li, Dan Mi, Lili Ren, Li Guo, Ruixuan Guo, Ting Chen, Jiaxin Hu,[...]. Nat Commun 2020
Xiuyuan Ou, Yan Liu, Xiaobo Lei, Pei Li, Dan Mi, Lili Ren, Li Guo, Ruixuan Guo, Ting Chen, Jiaxin Hu,[...]. Nat Commun 2020
14
Architecture and self-assembly of the SARS-CoV-2 nucleocapsid protein.
Qiaozhen Ye, Alan M V West, Steve Silletti, Kevin D Corbett. Protein Sci 2020
Qiaozhen Ye, Alan M V West, Steve Silletti, Kevin D Corbett. Protein Sci 2020
14
Crystal structure of Nsp15 endoribonuclease NendoU from SARS-CoV-2.
Youngchang Kim, Robert Jedrzejczak, Natalia I Maltseva, Mateusz Wilamowski, Michael Endres, Adam Godzik, Karolina Michalska, Andrzej Joachimiak. Protein Sci 2020
Youngchang Kim, Robert Jedrzejczak, Natalia I Maltseva, Mateusz Wilamowski, Michael Endres, Adam Godzik, Karolina Michalska, Andrzej Joachimiak. Protein Sci 2020
14
The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2.
. Nat Microbiol 2020
. Nat Microbiol 2020
14
Biochemical characterization of SARS-CoV-2 nucleocapsid protein.
Weihong Zeng, Guangfeng Liu, Huan Ma, Dan Zhao, Yunru Yang, Muziying Liu, Ahmed Mohammed, Changcheng Zhao, Yun Yang, Jiajia Xie,[...]. Biochem Biophys Res Commun 2020
Weihong Zeng, Guangfeng Liu, Huan Ma, Dan Zhao, Yunru Yang, Muziying Liu, Ahmed Mohammed, Changcheng Zhao, Yun Yang, Jiajia Xie,[...]. Biochem Biophys Res Commun 2020
13
The proximal origin of SARS-CoV-2.
Kristian G Andersen, Andrew Rambaut, W Ian Lipkin, Edward C Holmes, Robert F Garry. Nat Med 2020
Kristian G Andersen, Andrew Rambaut, W Ian Lipkin, Edward C Holmes, Robert F Garry. Nat Med 2020
12
Delicate structural coordination of the Severe Acute Respiratory Syndrome coronavirus Nsp13 upon ATP hydrolysis.
Zhihui Jia, Liming Yan, Zhilin Ren, Lijie Wu, Jin Wang, Jing Guo, Litao Zheng, Zhenhua Ming, Lianqi Zhang, Zhiyong Lou,[...]. Nucleic Acids Res 2019
Zhihui Jia, Liming Yan, Zhilin Ren, Lijie Wu, Jin Wang, Jing Guo, Litao Zheng, Zhenhua Ming, Lianqi Zhang, Zhiyong Lou,[...]. Nucleic Acids Res 2019
12
Origin and evolution of pathogenic coronaviruses.
Jie Cui, Fang Li, Zheng-Li Shi. Nat Rev Microbiol 2019
Jie Cui, Fang Li, Zheng-Li Shi. Nat Rev Microbiol 2019
12
Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan.
Jasper Fuk-Woo Chan, Kin-Hang Kok, Zheng Zhu, Hin Chu, Kelvin Kai-Wang To, Shuofeng Yuan, Kwok-Yung Yuen. Emerg Microbes Infect 2020
Jasper Fuk-Woo Chan, Kin-Hang Kok, Zheng Zhu, Hin Chu, Kelvin Kai-Wang To, Shuofeng Yuan, Kwok-Yung Yuen. Emerg Microbes Infect 2020
12
Coronaviruses: an overview of their replication and pathogenesis.
Anthony R Fehr, Stanley Perlman. Methods Mol Biol 2015
Anthony R Fehr, Stanley Perlman. Methods Mol Biol 2015
11
The Architecture of SARS-CoV-2 Transcriptome.
Dongwan Kim, Joo-Yeon Lee, Jeong-Sun Yang, Jun Won Kim, V Narry Kim, Hyeshik Chang. Cell 2020
Dongwan Kim, Joo-Yeon Lee, Jeong-Sun Yang, Jun Won Kim, V Narry Kim, Hyeshik Chang. Cell 2020
11
The M, E, and N structural proteins of the severe acute respiratory syndrome coronavirus are required for efficient assembly, trafficking, and release of virus-like particles.
Y L Siu, K T Teoh, J Lo, C M Chan, F Kien, N Escriou, S W Tsao, J M Nicholls, R Altmeyer, J S M Peiris,[...]. J Virol 2008
Y L Siu, K T Teoh, J Lo, C M Chan, F Kien, N Escriou, S W Tsao, J M Nicholls, R Altmeyer, J S M Peiris,[...]. J Virol 2008
11
Structural basis of receptor recognition by SARS-CoV-2.
Jian Shang, Gang Ye, Ke Shi, Yushun Wan, Chuming Luo, Hideki Aihara, Qibin Geng, Ashley Auerbach, Fang Li. Nature 2020
Jian Shang, Gang Ye, Ke Shi, Yushun Wan, Chuming Luo, Hideki Aihara, Qibin Geng, Ashley Auerbach, Fang Li. Nature 2020
11
Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir.
Wanchao Yin, Chunyou Mao, Xiaodong Luan, Dan-Dan Shen, Qingya Shen, Haixia Su, Xiaoxi Wang, Fulai Zhou, Wenfeng Zhao, Minqi Gao,[...]. Science 2020
Wanchao Yin, Chunyou Mao, Xiaodong Luan, Dan-Dan Shen, Qingya Shen, Haixia Su, Xiaoxi Wang, Fulai Zhou, Wenfeng Zhao, Minqi Gao,[...]. Science 2020
11
Structural Basis for RNA Replication by the SARS-CoV-2 Polymerase.
Quan Wang, Jiqin Wu, Haofeng Wang, Yan Gao, Qiaojie Liu, An Mu, Wenxin Ji, Liming Yan, Yan Zhu, Chen Zhu,[...]. Cell 2020
Quan Wang, Jiqin Wu, Haofeng Wang, Yan Gao, Qiaojie Liu, An Mu, Wenxin Ji, Liming Yan, Yan Zhu, Chen Zhu,[...]. Cell 2020
11
Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease.
Wenhao Dai, Bing Zhang, Xia-Ming Jiang, Haixia Su, Jian Li, Yao Zhao, Xiong Xie, Zhenming Jin, Jingjing Peng, Fengjiang Liu,[...]. Science 2020
Wenhao Dai, Bing Zhang, Xia-Ming Jiang, Haixia Su, Jian Li, Yao Zhao, Xiong Xie, Zhenming Jin, Jingjing Peng, Fengjiang Liu,[...]. Science 2020
11
Oligomerization of the carboxyl terminal domain of the human coronavirus 229E nucleocapsid protein.
Yu-Sheng Lo, Shing-Yen Lin, Shiu-Mei Wang, Chin-Tien Wang, Ya-Li Chiu, Tai-Huang Huang, Ming-Hon Hou. FEBS Lett 2013
Yu-Sheng Lo, Shing-Yen Lin, Shiu-Mei Wang, Chin-Tien Wang, Ya-Li Chiu, Tai-Huang Huang, Ming-Hon Hou. FEBS Lett 2013
20
Transient oligomerization of the SARS-CoV N protein--implication for virus ribonucleoprotein packaging.
Chung-ke Chang, Chia-Min Michael Chen, Ming-hui Chiang, Yen-lan Hsu, Tai-huang Huang. PLoS One 2013
Chung-ke Chang, Chia-Min Michael Chen, Ming-hui Chiang, Yen-lan Hsu, Tai-huang Huang. PLoS One 2013
14
Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro.
Manli Wang, Ruiyuan Cao, Leike Zhang, Xinglou Yang, Jia Liu, Mingyue Xu, Zhengli Shi, Zhihong Hu, Wu Zhong, Gengfu Xiao. Cell Res 2020
Manli Wang, Ruiyuan Cao, Leike Zhang, Xinglou Yang, Jia Liu, Mingyue Xu, Zhengli Shi, Zhihong Hu, Wu Zhong, Gengfu Xiao. Cell Res 2020
10
Structural basis of RNA recognition by the SARS-CoV-2 nucleocapsid phosphoprotein.
Dhurvas Chandrasekaran Dinesh, Dominika Chalupska, Jan Silhan, Eliska Koutna, Radim Nencka, Vaclav Veverka, Evzen Boura. PLoS Pathog 2020
Dhurvas Chandrasekaran Dinesh, Dominika Chalupska, Jan Silhan, Eliska Koutna, Radim Nencka, Vaclav Veverka, Evzen Boura. PLoS Pathog 2020
13
Preliminary Identification of Potential Vaccine Targets for the COVID-19 Coronavirus (SARS-CoV-2) Based on SARS-CoV Immunological Studies.
Syed Faraz Ahmed, Ahmed A Quadeer, Matthew R McKay. Viruses 2020
Syed Faraz Ahmed, Ahmed A Quadeer, Matthew R McKay. Viruses 2020
10
Molecular Architecture of the SARS-CoV-2 Virus.
Hangping Yao, Yutong Song, Yong Chen, Nanping Wu, Jialu Xu, Chujie Sun, Jiaxing Zhang, Tianhao Weng, Zheyuan Zhang, Zhigang Wu,[...]. Cell 2020
Hangping Yao, Yutong Song, Yong Chen, Nanping Wu, Jialu Xu, Chujie Sun, Jiaxing Zhang, Tianhao Weng, Zheyuan Zhang, Zhigang Wu,[...]. Cell 2020
10
Structural and Functional Basis of SARS-CoV-2 Entry by Using Human ACE2.
Qihui Wang, Yanfang Zhang, Lili Wu, Sheng Niu, Chunli Song, Zengyuan Zhang, Guangwen Lu, Chengpeng Qiao, Yu Hu, Kwok-Yung Yuen,[...]. Cell 2020
Qihui Wang, Yanfang Zhang, Lili Wu, Sheng Niu, Chunli Song, Zengyuan Zhang, Guangwen Lu, Chengpeng Qiao, Yu Hu, Kwok-Yung Yuen,[...]. Cell 2020
10
Crystal Structure of the SARS-CoV-2 Non-structural Protein 9, Nsp9.
Dene R Littler, Benjamin S Gully, Rhys N Colson, Jamie Rossjohn. iScience 2020
Dene R Littler, Benjamin S Gully, Rhys N Colson, Jamie Rossjohn. iScience 2020
12
Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2.
Matthias Thoms, Robert Buschauer, Michael Ameismeier, Lennart Koepke, Timo Denk, Maximilian Hirschenberger, Hanna Kratzat, Manuel Hayn, Timur Mackens-Kiani, Jingdong Cheng,[...]. Science 2020
Matthias Thoms, Robert Buschauer, Michael Ameismeier, Lennart Koepke, Timo Denk, Maximilian Hirschenberger, Hanna Kratzat, Manuel Hayn, Timur Mackens-Kiani, Jingdong Cheng,[...]. Science 2020
10
Structure of replicating SARS-CoV-2 polymerase.
Hauke S Hillen, Goran Kokic, Lucas Farnung, Christian Dienemann, Dimitry Tegunov, Patrick Cramer. Nature 2020
Hauke S Hillen, Goran Kokic, Lucas Farnung, Christian Dienemann, Dimitry Tegunov, Patrick Cramer. Nature 2020
10
Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus.
Bette Korber, Will M Fischer, Sandrasegaram Gnanakaran, Hyejin Yoon, James Theiler, Werner Abfalterer, Nick Hengartner, Elena E Giorgi, Tanmoy Bhattacharya, Brian Foley,[...]. Cell 2020
Bette Korber, Will M Fischer, Sandrasegaram Gnanakaran, Hyejin Yoon, James Theiler, Werner Abfalterer, Nick Hengartner, Elena E Giorgi, Tanmoy Bhattacharya, Brian Foley,[...]. Cell 2020
10
The nucleocapsid protein of severe acute respiratory syndrome-coronavirus inhibits the activity of cyclin-cyclin-dependent kinase complex and blocks S phase progression in mammalian cells.
Milan Surjit, Boping Liu, Vincent T K Chow, Sunil K Lal. J Biol Chem 2006
Milan Surjit, Boping Liu, Vincent T K Chow, Sunil K Lal. J Biol Chem 2006
9
Structural basis for the identification of the N-terminal domain of coronavirus nucleocapsid protein as an antiviral target.
Shing-Yen Lin, Chia-Ling Liu, Yu-Ming Chang, Jincun Zhao, Stanley Perlman, Ming-Hon Hou. J Med Chem 2014
Shing-Yen Lin, Chia-Ling Liu, Yu-Ming Chang, Jincun Zhao, Stanley Perlman, Ming-Hon Hou. J Med Chem 2014
13
A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV.
Meng Yuan, Nicholas C Wu, Xueyong Zhu, Chang-Chun D Lee, Ray T Y So, Huibin Lv, Chris K P Mok, Ian A Wilson. Science 2020
Meng Yuan, Nicholas C Wu, Xueyong Zhu, Chang-Chun D Lee, Ray T Y So, Huibin Lv, Chris K P Mok, Ian A Wilson. Science 2020
9
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.