Jang-Hyun Oh, Ju-Yeon Hyun, Shun-Jia Chen, Alexander Varshavsky. Proc Natl Acad Sci U S A 2020
Times Cited: 9
Times Cited: 9
Times Cited
Times Co-cited
Similarity
In vivo half-life of a protein is a function of its amino-terminal residue.
A Bachmair, D Finley, A Varshavsky. Science 1986
A Bachmair, D Finley, A Varshavsky. Science 1986
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N-terminal acetylation of cellular proteins creates specific degradation signals.
Cheol-Sang Hwang, Anna Shemorry, Alexander Varshavsky. Science 2010
Cheol-Sang Hwang, Anna Shemorry, Alexander Varshavsky. Science 2010
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An essential role of N-terminal arginylation in cardiovascular development.
Yong Tae Kwon, Anna S Kashina, Ilia V Davydov, Rong-Gui Hu, Jee Young An, Jai Wha Seo, Fangyong Du, Alexander Varshavsky. Science 2002
Yong Tae Kwon, Anna S Kashina, Ilia V Davydov, Rong-Gui Hu, Jee Young An, Jai Wha Seo, Fangyong Du, Alexander Varshavsky. Science 2002
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N-degron and C-degron pathways of protein degradation.
Alexander Varshavsky. Proc Natl Acad Sci U S A 2019
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The N-end rule pathway as a nitric oxide sensor controlling the levels of multiple regulators.
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Control of protein quality and stoichiometries by N-terminal acetylation and the N-end rule pathway.
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Jeong-Mok Kim, Ok-Hee Seok, Shinyeong Ju, Ji-Eun Heo, Jeonghun Yeom, Da-Som Kim, Joo-Yeon Yoo, Alexander Varshavsky, Cheolju Lee, Cheol-Sang Hwang. Science 2018
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An N-end rule pathway that recognizes proline and destroys gluconeogenic enzymes.
Shun-Jia Chen, Xia Wu, Brandon Wadas, Jang-Hyun Oh, Alexander Varshavsky. Science 2017
Shun-Jia Chen, Xia Wu, Brandon Wadas, Jang-Hyun Oh, Alexander Varshavsky. Science 2017
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The ubiquitin-proteasome system of Saccharomyces cerevisiae.
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Chang Hoon Ji, Yong Tae Kwon. Mol Cells 2017
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Conserved N-terminal cysteine dioxygenases transduce responses to hypoxia in animals and plants.
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Spotlight on protein N-terminal acetylation.
Rasmus Ree, Sylvia Varland, Thomas Arnesen. Exp Mol Med 2018
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A glycine-specific N-degron pathway mediates the quality control of protein N-myristoylation.
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Structural basis for dual specificity of yeast N-terminal amidase in the N-end rule pathway.
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Cellular quality control by the ubiquitin-proteasome system and autophagy.
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Alternative splicing results in differential expression, activity, and localization of the two forms of arginyl-tRNA-protein transferase, a component of the N-end rule pathway.
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The expanded specificity and physiological role of a widespread N-degron recognin.
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Structural basis for the recognition of N-end rule substrates by the UBR box of ubiquitin ligases.
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Interconversion between Anticipatory and Active GID E3 Ubiquitin Ligase Conformations via Metabolically Driven Substrate Receptor Assembly.
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Control of Hsp90 chaperone and its clients by N-terminal acetylation and the N-end rule pathway.
Jang-Hyun Oh, Ju-Yeon Hyun, Alexander Varshavsky. Proc Natl Acad Sci U S A 2017
Jang-Hyun Oh, Ju-Yeon Hyun, Alexander Varshavsky. Proc Natl Acad Sci U S A 2017
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Peptides accelerate their uptake by activating a ubiquitin-dependent proteolytic pathway.
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The plant N-degron pathways of ubiquitin-mediated proteolysis.
Michael John Holdsworth, Jorge Vicente, Gunjan Sharma, Mohamad Abbas, Agata Zubrycka. J Integr Plant Biol 2020
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The N-terminal methionine of cellular proteins as a degradation signal.
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Molecular basis of GID4-mediated recognition of degrons for the Pro/N-end rule pathway.
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Ablation of arginylation in the mouse N-end rule pathway: loss of fat, higher metabolic rate, damaged spermatogenesis, and neurological perturbations.
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Aminoacyl-transferases and the N-end rule pathway of prokaryotic/eukaryotic specificity in a human pathogen.
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Degradation of a cohesin subunit by the N-end rule pathway is essential for chromosome stability.
H Rao, F Uhlmann, K Nasmyth, A Varshavsky. Nature 2001
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'Spalog' and 'sequelog': neutral terms for spatial and sequence similarity.
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Altered activity, social behavior, and spatial memory in mice lacking the NTAN1p amidase and the asparagine branch of the N-end rule pathway.
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Deficiency of UBR1, a ubiquitin ligase of the N-end rule pathway, causes pancreatic dysfunction, malformations and mental retardation (Johanson-Blizzard syndrome).
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Yeast N-terminal amidase. A new enzyme and component of the N-end rule pathway.
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The N-end rule pathway is a sensor of heme.
Rong-Gui Hu, Haiqing Wang, Zanxian Xia, Alexander Varshavsky. Proc Natl Acad Sci U S A 2008
Rong-Gui Hu, Haiqing Wang, Zanxian Xia, Alexander Varshavsky. Proc Natl Acad Sci U S A 2008
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N-terminal arginylation generates a bimodal degron that modulates autophagic proteolysis.
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