RTEL1 suppresses G-quadruplex-associated R-loops at difficult-to-replicate loci in the human genome.
Wei Wu, Rahul Bhowmick, Ivan Vogel, Özgün Özer, Fiorella Ghisays, Roshan S Thakur, Esther Sanchez de Leon, Philipp H Richter, Liqun Ren, John H Petrini, Ian D Hickson, Ying Liu. Nat Struct Mol Biol 2020
Times Cited: 29
Times Cited: 29
Times Cited
Times Co-cited
Similarity
RTEL1 dismantles T loops and counteracts telomeric G4-DNA to maintain telomere integrity.
Jean-Baptiste Vannier, Visnja Pavicic-Kaltenbrunner, Mark I R Petalcorin, Hao Ding, Simon J Boulton. Cell 2012
Jean-Baptiste Vannier, Visnja Pavicic-Kaltenbrunner, Mark I R Petalcorin, Hao Ding, Simon J Boulton. Cell 2012
55
DNA damage and genome instability by G-quadruplex ligands are mediated by R loops in human cancer cells.
Alessio De Magis, Stefano G Manzo, Marco Russo, Jessica Marinello, Rita Morigi, Olivier Sordet, Giovanni Capranico. Proc Natl Acad Sci U S A 2019
Alessio De Magis, Stefano G Manzo, Marco Russo, Jessica Marinello, Rita Morigi, Olivier Sordet, Giovanni Capranico. Proc Natl Acad Sci U S A 2019
34
Replication stress activates DNA repair synthesis in mitosis.
Sheroy Minocherhomji, Songmin Ying, Victoria A Bjerregaard, Sara Bursomanno, Aiste Aleliunaite, Wei Wu, Hocine W Mankouri, Huahao Shen, Ying Liu, Ian D Hickson. Nature 2015
Sheroy Minocherhomji, Songmin Ying, Victoria A Bjerregaard, Sara Bursomanno, Aiste Aleliunaite, Wei Wu, Hocine W Mankouri, Huahao Shen, Ying Liu, Ian D Hickson. Nature 2015
34
RTEL1 is a replisome-associated helicase that promotes telomere and genome-wide replication.
Jean-Baptiste Vannier, Sumit Sandhu, Mark I R Petalcorin, Xiaoli Wu, Zinnatun Nabi, Hao Ding, Simon J Boulton. Science 2013
Jean-Baptiste Vannier, Sumit Sandhu, Mark I R Petalcorin, Xiaoli Wu, Zinnatun Nabi, Hao Ding, Simon J Boulton. Science 2013
31
Intracellular transcription of G-rich DNAs induces formation of G-loops, novel structures containing G4 DNA.
Michelle L Duquette, Priya Handa, Jack A Vincent, Andrew F Taylor, Nancy Maizels. Genes Dev 2004
Michelle L Duquette, Priya Handa, Jack A Vincent, Andrew F Taylor, Nancy Maizels. Genes Dev 2004
31
Transcription-Replication Conflict Orientation Modulates R-Loop Levels and Activates Distinct DNA Damage Responses.
Stephan Hamperl, Michael J Bocek, Joshua C Saldivar, Tomek Swigut, Karlene A Cimprich. Cell 2017
Stephan Hamperl, Michael J Bocek, Joshua C Saldivar, Tomek Swigut, Karlene A Cimprich. Cell 2017
31
R-Loops as Cellular Regulators and Genomic Threats.
Madzia P Crossley, Michael Bocek, Karlene A Cimprich. Mol Cell 2019
Madzia P Crossley, Michael Bocek, Karlene A Cimprich. Mol Cell 2019
27
Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication.
Agnel Sfeir, Settapong T Kosiyatrakul, Dirk Hockemeyer, Sheila L MacRae, Jan Karlseder, Carl L Schildkraut, Titia de Lange. Cell 2009
Agnel Sfeir, Settapong T Kosiyatrakul, Dirk Hockemeyer, Sheila L MacRae, Jan Karlseder, Carl L Schildkraut, Titia de Lange. Cell 2009
27
Telomere Length Determines TERRA and R-Loop Regulation through the Cell Cycle.
Marco Graf, Diego Bonetti, Arianna Lockhart, Kamar Serhal, Vanessa Kellner, André Maicher, Pascale Jolivet, Maria Teresa Teixeira, Brian Luke. Cell 2017
Marco Graf, Diego Bonetti, Arianna Lockhart, Kamar Serhal, Vanessa Kellner, André Maicher, Pascale Jolivet, Maria Teresa Teixeira, Brian Luke. Cell 2017
27
R-loop formation is a distinctive characteristic of unmethylated human CpG island promoters.
Paul A Ginno, Paul L Lott, Holly C Christensen, Ian Korf, Frédéric Chédin. Mol Cell 2012
Paul A Ginno, Paul L Lott, Holly C Christensen, Ian Korf, Frédéric Chédin. Mol Cell 2012
27
27
Regulation of murine telomere length by Rtel: an essential gene encoding a helicase-like protein.
Hao Ding, Mike Schertzer, Xiaoli Wu, Marina Gertsenstein, Sara Selig, Makoto Kammori, Reza Pourvali, Steven Poon, Irma Vulto, Elizabeth Chavez,[...]. Cell 2004
Hao Ding, Mike Schertzer, Xiaoli Wu, Marina Gertsenstein, Sara Selig, Makoto Kammori, Reza Pourvali, Steven Poon, Irma Vulto, Elizabeth Chavez,[...]. Cell 2004
24
Collisions between replication and transcription complexes cause common fragile site instability at the longest human genes.
Anne Helmrich, Monica Ballarino, Laszlo Tora. Mol Cell 2011
Anne Helmrich, Monica Ballarino, Laszlo Tora. Mol Cell 2011
24
TRF2 recruits RTEL1 to telomeres in S phase to promote t-loop unwinding.
Grzegorz Sarek, Jean-Baptiste Vannier, Stephanie Panier, John H J Petrini, Simon J Boulton. Mol Cell 2015
Grzegorz Sarek, Jean-Baptiste Vannier, Stephanie Panier, John H J Petrini, Simon J Boulton. Mol Cell 2015
24
SLX4 interacts with RTEL1 to prevent transcription-mediated DNA replication perturbations.
A Takedachi, E Despras, S Scaglione, R Guérois, J H Guervilly, M Blin, S Audebert, L Camoin, Z Hasanova, M Schertzer,[...]. Nat Struct Mol Biol 2020
A Takedachi, E Despras, S Scaglione, R Guérois, J H Guervilly, M Blin, S Audebert, L Camoin, Z Hasanova, M Schertzer,[...]. Nat Struct Mol Biol 2020
53
Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends.
Claus M Azzalin, Patrick Reichenbach, Lela Khoriauli, Elena Giulotto, Joachim Lingner. Science 2007
Claus M Azzalin, Patrick Reichenbach, Lela Khoriauli, Elena Giulotto, Joachim Lingner. Science 2007
24
RNaseH1 regulates TERRA-telomeric DNA hybrids and telomere maintenance in ALT tumour cells.
Rajika Arora, Yongwoo Lee, Harry Wischnewski, Catherine M Brun, Tobias Schwarz, Claus M Azzalin. Nat Commun 2014
Rajika Arora, Yongwoo Lee, Harry Wischnewski, Catherine M Brun, Tobias Schwarz, Claus M Azzalin. Nat Commun 2014
24
RTEL1 contributes to DNA replication and repair and telomere maintenance.
Evert-Jan Uringa, Kathleen Lisaingo, Hilda A Pickett, Julie Brind'Amour, Jan-Hendrik Rohde, Alex Zelensky, Jeroen Essers, Peter M Lansdorp. Mol Biol Cell 2012
Evert-Jan Uringa, Kathleen Lisaingo, Hilda A Pickett, Julie Brind'Amour, Jan-Hendrik Rohde, Alex Zelensky, Jeroen Essers, Peter M Lansdorp. Mol Biol Cell 2012
20
RTEL1 maintains genomic stability by suppressing homologous recombination.
Louise J Barber, Jillian L Youds, Jordan D Ward, Michael J McIlwraith, Nigel J O'Neil, Mark I R Petalcorin, Julie S Martin, Spencer J Collis, Sharon B Cantor, Melissa Auclair,[...]. Cell 2008
Louise J Barber, Jillian L Youds, Jordan D Ward, Michael J McIlwraith, Nigel J O'Neil, Mark I R Petalcorin, Julie S Martin, Spencer J Collis, Sharon B Cantor, Melissa Auclair,[...]. Cell 2008
20
Epigenetic instability due to defective replication of structured DNA.
Peter Sarkies, Charlie Reams, Laura J Simpson, Julian E Sale. Mol Cell 2010
Peter Sarkies, Charlie Reams, Laura J Simpson, Julian E Sale. Mol Cell 2010
20
G-quadruplex structures mark human regulatory chromatin.
Robert Hänsel-Hertsch, Dario Beraldi, Stefanie V Lensing, Giovanni Marsico, Katherine Zyner, Aled Parry, Marco Di Antonio, Jeremy Pike, Hiroshi Kimura, Masashi Narita,[...]. Nat Genet 2016
Robert Hänsel-Hertsch, Dario Beraldi, Stefanie V Lensing, Giovanni Marsico, Katherine Zyner, Aled Parry, Marco Di Antonio, Jeremy Pike, Hiroshi Kimura, Masashi Narita,[...]. Nat Genet 2016
20
Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds.
Jutta Zimmer, Eliana M C Tacconi, Cecilia Folio, Sophie Badie, Manuela Porru, Kerstin Klare, Manuela Tumiati, Enni Markkanen, Swagata Halder, Anderson Ryan,[...]. Mol Cell 2016
Jutta Zimmer, Eliana M C Tacconi, Cecilia Folio, Sophie Badie, Manuela Porru, Kerstin Klare, Manuela Tumiati, Enni Markkanen, Swagata Halder, Anderson Ryan,[...]. Mol Cell 2016
20
High-throughput sequencing of DNA G-quadruplex structures in the human genome.
Vicki S Chambers, Giovanni Marsico, Jonathan M Boutell, Marco Di Antonio, Geoffrey P Smith, Shankar Balasubramanian. Nat Biotechnol 2015
Vicki S Chambers, Giovanni Marsico, Jonathan M Boutell, Marco Di Antonio, Geoffrey P Smith, Shankar Balasubramanian. Nat Biotechnol 2015
20
FANCJ coordinates two pathways that maintain epigenetic stability at G-quadruplex DNA.
Peter Sarkies, Pierre Murat, Lara G Phillips, K J Patel, Shankar Balasubramanian, Julian E Sale. Nucleic Acids Res 2012
Peter Sarkies, Pierre Murat, Lara G Phillips, K J Patel, Shankar Balasubramanian, Julian E Sale. Nucleic Acids Res 2012
20
Pif1 family helicases suppress genome instability at G-quadruplex motifs.
Katrin Paeschke, Matthew L Bochman, P Daniela Garcia, Petr Cejka, Katherine L Friedman, Stephen C Kowalczykowski, Virginia A Zakian. Nature 2013
Katrin Paeschke, Matthew L Bochman, P Daniela Garcia, Petr Cejka, Katherine L Friedman, Stephen C Kowalczykowski, Virginia A Zakian. Nature 2013
20
DNA replication through G-quadruplex motifs is promoted by the Saccharomyces cerevisiae Pif1 DNA helicase.
Katrin Paeschke, John A Capra, Virginia A Zakian. Cell 2011
Katrin Paeschke, John A Capra, Virginia A Zakian. Cell 2011
20
DNA Topoisomerase I differentially modulates R-loops across the human genome.
Stefano G Manzo, Stella R Hartono, Lionel A Sanz, Jessica Marinello, Sara De Biasi, Andrea Cossarizza, Giovanni Capranico, Frederic Chedin. Genome Biol 2018
Stefano G Manzo, Stella R Hartono, Lionel A Sanz, Jessica Marinello, Sara De Biasi, Andrea Cossarizza, Giovanni Capranico, Frederic Chedin. Genome Biol 2018
20
High-resolution mapping of mitotic DNA synthesis regions and common fragile sites in the human genome through direct sequencing.
Morgane Macheret, Rahul Bhowmick, Katarzyna Sobkowiak, Laura Padayachy, Jonathan Mailler, Ian D Hickson, Thanos D Halazonetis. Cell Res 2020
Morgane Macheret, Rahul Bhowmick, Katarzyna Sobkowiak, Laura Padayachy, Jonathan Mailler, Ian D Hickson, Thanos D Halazonetis. Cell Res 2020
20
Causes and consequences of replication stress.
Michelle K Zeman, Karlene A Cimprich. Nat Cell Biol 2014
Michelle K Zeman, Karlene A Cimprich. Nat Cell Biol 2014
20
RAD52 Facilitates Mitotic DNA Synthesis Following Replication Stress.
Rahul Bhowmick, Sheroy Minocherhomji, Ian D Hickson. Mol Cell 2016
Rahul Bhowmick, Sheroy Minocherhomji, Ian D Hickson. Mol Cell 2016
20
Prevalent, Dynamic, and Conserved R-Loop Structures Associate with Specific Epigenomic Signatures in Mammals.
Lionel A Sanz, Stella R Hartono, Yoong Wearn Lim, Sandra Steyaert, Aparna Rajpurkar, Paul A Ginno, Xiaoqin Xu, Frédéric Chédin. Mol Cell 2016
Lionel A Sanz, Stella R Hartono, Yoong Wearn Lim, Sandra Steyaert, Aparna Rajpurkar, Paul A Ginno, Xiaoqin Xu, Frédéric Chédin. Mol Cell 2016
20
FANCM limits ALT activity by restricting telomeric replication stress induced by deregulated BLM and R-loops.
Bruno Silva, Richard Pentz, Ana Margarida Figueira, Rajika Arora, Yong Woo Lee, Charlotte Hodson, Harry Wischnewski, Andrew J Deans, Claus M Azzalin. Nat Commun 2019
Bruno Silva, Richard Pentz, Ana Margarida Figueira, Rajika Arora, Yong Woo Lee, Charlotte Hodson, Harry Wischnewski, Andrew J Deans, Claus M Azzalin. Nat Commun 2019
20
Cotranscriptionally formed DNA:RNA hybrids mediate transcription elongation impairment and transcription-associated recombination.
Pablo Huertas, Andrés Aguilera. Mol Cell 2003
Pablo Huertas, Andrés Aguilera. Mol Cell 2003
20
RTEL1 Regulates G4/R-Loops to Avert Replication-Transcription Collisions.
Panagiotis Kotsantis, Sandra Segura-Bayona, Pol Margalef, Paulina Marzec, Phil Ruis, Graeme Hewitt, Roberto Bellelli, Harshil Patel, Robert Goldstone, Anna R Poetsch,[...]. Cell Rep 2020
Panagiotis Kotsantis, Sandra Segura-Bayona, Pol Margalef, Paulina Marzec, Phil Ruis, Graeme Hewitt, Roberto Bellelli, Harshil Patel, Robert Goldstone, Anna R Poetsch,[...]. Cell Rep 2020
54
Identification of early replicating fragile sites that contribute to genome instability.
Jacqueline H Barlow, Robert B Faryabi, Elsa Callén, Nancy Wong, Amy Malhowski, Hua Tang Chen, Gustavo Gutierrez-Cruz, Hong-Wei Sun, Peter McKinnon, George Wright,[...]. Cell 2013
Jacqueline H Barlow, Robert B Faryabi, Elsa Callén, Nancy Wong, Amy Malhowski, Hua Tang Chen, Gustavo Gutierrez-Cruz, Hong-Wei Sun, Peter McKinnon, George Wright,[...]. Cell 2013
17
A Mechanism for Controlled Breakage of Under-replicated Chromosomes during Mitosis.
Heike Duda, Meret Arter, Jiradet Gloggnitzer, Federico Teloni, Philipp Wild, Miguel G Blanco, Matthias Altmeyer, Joao Matos. Dev Cell 2016
Heike Duda, Meret Arter, Jiradet Gloggnitzer, Federico Teloni, Philipp Wild, Miguel G Blanco, Matthias Altmeyer, Joao Matos. Dev Cell 2016
17
Human RTEL1 deficiency causes Hoyeraal-Hreidarsson syndrome with short telomeres and genome instability.
Tangui Le Guen, Laurent Jullien, Fabien Touzot, Michael Schertzer, Laetitia Gaillard, Mylène Perderiset, Wassila Carpentier, Patrick Nitschke, Capucine Picard, Gérard Couillault,[...]. Hum Mol Genet 2013
Tangui Le Guen, Laurent Jullien, Fabien Touzot, Michael Schertzer, Laetitia Gaillard, Mylène Perderiset, Wassila Carpentier, Patrick Nitschke, Capucine Picard, Gérard Couillault,[...]. Hum Mol Genet 2013
17
Germline mutations of regulator of telomere elongation helicase 1, RTEL1, in Dyskeratosis congenita.
Bari J Ballew, Meredith Yeager, Kevin Jacobs, Neelam Giri, Joseph Boland, Laurie Burdett, Blanche P Alter, Sharon A Savage. Hum Genet 2013
Bari J Ballew, Meredith Yeager, Kevin Jacobs, Neelam Giri, Joseph Boland, Laurie Burdett, Blanche P Alter, Sharon A Savage. Hum Genet 2013
17
Alternative Lengthening of Telomeres Mediated by Mitotic DNA Synthesis Engages Break-Induced Replication Processes.
Jaewon Min, Woodring E Wright, Jerry W Shay. Mol Cell Biol 2017
Jaewon Min, Woodring E Wright, Jerry W Shay. Mol Cell Biol 2017
17
Small-molecule-induced DNA damage identifies alternative DNA structures in human genes.
Raphaël Rodriguez, Kyle M Miller, Josep V Forment, Charles R Bradshaw, Mehran Nikan, Sébastien Britton, Tobias Oelschlaegel, Blerta Xhemalce, Shankar Balasubramanian, Stephen P Jackson. Nat Chem Biol 2012
Raphaël Rodriguez, Kyle M Miller, Josep V Forment, Charles R Bradshaw, Mehran Nikan, Sébastien Britton, Tobias Oelschlaegel, Blerta Xhemalce, Shankar Balasubramanian, Stephen P Jackson. Nat Chem Biol 2012
17
Pot1, the putative telomere end-binding protein in fission yeast and humans.
P Baumann, T R Cech. Science 2001
P Baumann, T R Cech. Science 2001
17
Super-resolution fluorescence imaging of telomeres reveals TRF2-dependent T-loop formation.
Ylli Doksani, John Y Wu, Titia de Lange, Xiaowei Zhuang. Cell 2013
Ylli Doksani, John Y Wu, Titia de Lange, Xiaowei Zhuang. Cell 2013
17
BLM helicase facilitates telomere replication during leading strand synthesis of telomeres.
William C Drosopoulos, Settapong T Kosiyatrakul, Carl L Schildkraut. J Cell Biol 2015
William C Drosopoulos, Settapong T Kosiyatrakul, Carl L Schildkraut. J Cell Biol 2015
17
The chromatin remodelling factor ATRX suppresses R-loops in transcribed telomeric repeats.
Diu Tt Nguyen, Hsiao Phin J Voon, Barbara Xella, Caroline Scott, David Clynes, Christian Babbs, Helena Ayyub, Jon Kerry, Jacqueline A Sharpe, Jackie A Sloane-Stanley,[...]. EMBO Rep 2017
Diu Tt Nguyen, Hsiao Phin J Voon, Barbara Xella, Caroline Scott, David Clynes, Christian Babbs, Helena Ayyub, Jon Kerry, Jacqueline A Sharpe, Jackie A Sloane-Stanley,[...]. EMBO Rep 2017
17
CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours.
Hong Xu, Marco Di Antonio, Steven McKinney, Veena Mathew, Brandon Ho, Nigel J O'Neil, Nancy Dos Santos, Jennifer Silvester, Vivien Wei, Jessica Garcia,[...]. Nat Commun 2017
Hong Xu, Marco Di Antonio, Steven McKinney, Veena Mathew, Brandon Ho, Nigel J O'Neil, Nancy Dos Santos, Jennifer Silvester, Vivien Wei, Jessica Garcia,[...]. Nat Commun 2017
17
Increased global transcription activity as a mechanism of replication stress in cancer.
Panagiotis Kotsantis, Lara Marques Silva, Sarah Irmscher, Rebecca M Jones, Lisa Folkes, Natalia Gromak, Eva Petermann. Nat Commun 2016
Panagiotis Kotsantis, Lara Marques Silva, Sarah Irmscher, Rebecca M Jones, Lisa Folkes, Natalia Gromak, Eva Petermann. Nat Commun 2016
17
The regulation and functions of DNA and RNA G-quadruplexes.
Dhaval Varshney, Jochen Spiegel, Katherine Zyner, David Tannahill, Shankar Balasubramanian. Nat Rev Mol Cell Biol 2020
Dhaval Varshney, Jochen Spiegel, Katherine Zyner, David Tannahill, Shankar Balasubramanian. Nat Rev Mol Cell Biol 2020
17
Fork Cleavage-Religation Cycle and Active Transcription Mediate Replication Restart after Fork Stalling at Co-transcriptional R-Loops.
Nagaraja Chappidi, Zuzana Nascakova, Barbora Boleslavska, Ralph Zellweger, Esin Isik, Martin Andrs, Shruti Menon, Jana Dobrovolna, Chiara Balbo Pogliano, Joao Matos,[...]. Mol Cell 2020
Nagaraja Chappidi, Zuzana Nascakova, Barbora Boleslavska, Ralph Zellweger, Esin Isik, Martin Andrs, Shruti Menon, Jana Dobrovolna, Chiara Balbo Pogliano, Joao Matos,[...]. Mol Cell 2020
17
Genome-wide high-resolution mapping of mitotic DNA synthesis sites and common fragile sites by direct sequencing.
Fang Ji, Hongwei Liao, Sheng Pan, Liujian Ouyang, Fang Jia, Zaiyang Fu, Fengjiao Zhang, Xinwei Geng, Xinming Wang, Tingting Li,[...]. Cell Res 2020
Fang Ji, Hongwei Liao, Sheng Pan, Liujian Ouyang, Fang Jia, Zaiyang Fu, Fengjiao Zhang, Xinwei Geng, Xinming Wang, Tingting Li,[...]. Cell Res 2020
33
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.