Zonghui Ma, Ling Jiang, Guoxin Li, Dailin Liang, Luanfeng Li, Li Liu, Cheng Jiang. Bioorg Chem 2020
Times Cited: 4
Times Cited: 4
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Aldehyde dehydrogenase: its role as a cancer stem cell marker comes down to the specific isoform.
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Paola Marcato, Cheryl A Dean, Carman A Giacomantonio, Patrick W K Lee. Cell Cycle 2011
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Development of a high-throughput in vitro assay to identify selective inhibitors for human ALDH1A1.
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Cynthia A Morgan, Thomas D Hurley. Chem Biol Interact 2015
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Aldehyde dehydrogenase inhibitors: a comprehensive review of the pharmacology, mechanism of action, substrate specificity, and clinical application.
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Progress in the Field of Aldehyde Dehydrogenase Inhibitors: Novel Imidazo[1,2-a]pyridines against the 1A Family.
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N,N-diethylaminobenzaldehyde (DEAB) as a substrate and mechanism-based inhibitor for human ALDH isoenzymes.
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Discovery of Orally Bioavailable, Quinoline-Based Aldehyde Dehydrogenase 1A1 (ALDH1A1) Inhibitors with Potent Cellular Activity.
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The aldehyde dehydrogenase gene superfamily resource center.
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Reactions of formaldehyde plus acetaldehyde with deoxyguanosine and DNA: formation of cyclic deoxyguanosine adducts and formaldehyde cross-links.
Guang Cheng, Yongli Shi, Shana J Sturla, John R Jalas, Edward J McIntee, Peter W Villalta, Mingyao Wang, Stephen S Hecht. Chem Res Toxicol 2003
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Increased production of retinoic acid by intestinal macrophages contributes to their inflammatory phenotype in patients with Crohn's disease.
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The effects of alcohol and aldehyde dehydrogenases on disorders of hematopoiesis.
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Tissue distribution, ontogeny, and regulation of aldehyde dehydrogenase (Aldh) enzymes mRNA by prototypical microsomal enzyme inducers in mice.
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Design, synthesis characterization and biological evaluation of novel multi-isoform ALDH inhibitors as potential anticancer agents.
Saketh S Dinavahi, Raghavendra Gowda, Christopher G Bazewicz, Madhu Babu Battu, Jyh Ming Lin, Robert J Chitren, Manoj K Pandey, Shantu Amin, Gavin P Robertson, Krishne Gowda. Eur J Med Chem 2020
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Pharmacological inhibition of ALDH1A enzymes suppresses weight gain in a mouse model of diet-induced obesity.
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Discovery of coumarin-based selective aldehyde dehydrogenase 1A1 inhibitors with glucose metabolism improving activity.
Dailin Liang, Yazhou Fan, Zhou Yang, Zhenguo Zhang, Meiyang Liu, Li Liu, Cheng Jiang. Eur J Med Chem 2020
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Discovery of NCT-501, a Potent and Selective Theophylline-Based Inhibitor of Aldehyde Dehydrogenase 1A1 (ALDH1A1).
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Families of retinoid dehydrogenases regulating vitamin A function: production of visual pigment and retinoic acid.
G Duester. Eur J Biochem 2000
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ALDH1A isozymes are markers of human melanoma stem cells and potential therapeutic targets.
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Inhibitors of aldehyde dehydrogenases of the 1A subfamily as putative anticancer agents: Kinetic characterization and effect on human cancer cells.
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Sjögren-Larsson syndrome: diversity of mutations and polymorphisms in the fatty aldehyde dehydrogenase gene (ALDH3A2).
William B Rizzo, Gael Carney. Hum Mutat 2005
William B Rizzo, Gael Carney. Hum Mutat 2005
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Retinaldehyde dehydrogenase 1 coordinates hepatic gluconeogenesis and lipid metabolism.
Florian W Kiefer, Gabriela Orasanu, Shriram Nallamshetty, Jonathan D Brown, Hong Wang, Philip Luger, Nathan R Qi, Charles F Burant, Gregg Duester, Jorge Plutzky. Endocrinology 2012
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β-Catenin-regulated ALDH1A1 is a target in ovarian cancer spheroids.
S Condello, C A Morgan, S Nagdas, L Cao, J Turek, T D Hurley, D Matei. Oncogene 2015
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Aldehyde sources, metabolism, molecular toxicity mechanisms, and possible effects on human health.
Peter J O'Brien, Arno G Siraki, Nandita Shangari. Crit Rev Toxicol 2005
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Targeting ALDH1 to decrease tumorigenicity, growth and metastasis of human melanoma.
Lili Yue, Zhi-Ming Huang, Stephen Fong, Stanley Leong, James G Jakowatz, Alex Charruyer-Reinwald, Maria Wei, Ruby Ghadially. Melanoma Res 2015
Lili Yue, Zhi-Ming Huang, Stephen Fong, Stanley Leong, James G Jakowatz, Alex Charruyer-Reinwald, Maria Wei, Ruby Ghadially. Melanoma Res 2015
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The role of human aldehyde dehydrogenase in normal and cancer stem cells.
Irene Ma, Alison L Allan. Stem Cell Rev Rep 2011
Irene Ma, Alison L Allan. Stem Cell Rev Rep 2011
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Retinaldehyde dehydrogenase 1 regulates a thermogenic program in white adipose tissue.
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Neurotoxicity and metabolism of the catecholamine-derived 3,4-dihydroxyphenylacetaldehyde and 3,4-dihydroxyphenylglycolaldehyde: the role of aldehyde dehydrogenase.
Satori A Marchitti, Richard A Deitrich, Vasilis Vasiliou. Pharmacol Rev 2007
Satori A Marchitti, Richard A Deitrich, Vasilis Vasiliou. Pharmacol Rev 2007
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Structure-Based Optimization of a Novel Class of Aldehyde Dehydrogenase 1A (ALDH1A) Subfamily-Selective Inhibitors as Potential Adjuncts to Ovarian Cancer Chemotherapy.
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A High-Content Assay Enables the Automated Screening and Identification of Small Molecules with Specific ALDH1A1-Inhibitory Activity.
Adam Yasgar, Steven A Titus, Yuhong Wang, Carina Danchik, Shyh-Ming Yang, Vasilis Vasiliou, Ajit Jadhav, David J Maloney, Anton Simeonov, Natalia J Martinez. PLoS One 2017
Adam Yasgar, Steven A Titus, Yuhong Wang, Carina Danchik, Shyh-Ming Yang, Vasilis Vasiliou, Ajit Jadhav, David J Maloney, Anton Simeonov, Natalia J Martinez. PLoS One 2017
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Characterization of two distinct structural classes of selective aldehyde dehydrogenase 1A1 inhibitors.
Cynthia A Morgan, Thomas D Hurley. J Med Chem 2015
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Structural, Biochemical, and Computational Studies Reveal the Mechanism of Selective Aldehyde Dehydrogenase 1A1 Inhibition by Cytotoxic Duocarmycin Analogues.
Maximilian F Koch, Sabrina Harteis, Iris D Blank, Galina Pestel, Lutz F Tietze, Christian Ochsenfeld, Sabine Schneider, Stephan A Sieber. Angew Chem Int Ed Engl 2015
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Novel quinazolinone-based 2,4-thiazolidinedione-3-acetic acid derivatives as potent aldose reductase inhibitors.
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Discovery of a series of aromatic lactones as ALDH1/2-directed inhibitors.
Cameron D Buchman, Krishna K Mahalingan, Thomas D Hurley. Chem Biol Interact 2015
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Inhibition of the Aldehyde Dehydrogenase 1/2 Family by Psoralen and Coumarin Derivatives.
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Development of selective inhibitors for aldehyde dehydrogenases based on substituted indole-2,3-diones.
Ann C Kimble-Hill, Bibek Parajuli, Che-Hong Chen, Daria Mochly-Rosen, Thomas D Hurley. J Med Chem 2014
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Karen Niederreither, Valérie Fraulob, Jean-Marie Garnier, Pierre Chambon, Pascal Dollé. Mech Dev 2002
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Eukaryotic aldehyde dehydrogenase (ALDH) genes: human polymorphisms, and recommended nomenclature based on divergent evolution and chromosomal mapping.
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Alcohol and aldehyde dehydrogenases: retinoid metabolic effects in mouse knockout models.
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The enzymatic activity of human aldehyde dehydrogenases 1A2 and 2 (ALDH1A2 and ALDH2) is detected by Aldefluor, inhibited by diethylaminobenzaldehyde and has significant effects on cell proliferation and drug resistance.
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Surveillance of Cancer Stem Cell Plasticity Using an Isoform-Selective Fluorescent Probe for Aldehyde Dehydrogenase 1A1.
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Improving small molecule virtual screening strategies for the next generation of therapeutics.
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Tracking cancer drugs in living cells by thermal profiling of the proteome.
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HSP90 regulates DNA repair via the interaction between XRCC1 and DNA polymerase β.
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Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.