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How Do Post-Translational Modifications Influence the Pathomechanistic Landscape of Huntington's Disease? A Comprehensive Review.
Beata Lontay, Andrea Kiss, László Virág, Krisztina Tar. Int J Mol Sci 2020
Times Cited: 9






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List of co-cited articles
47 articles co-cited >1



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  Times     Co-cited
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The Biology of Huntingtin.
Frédéric Saudou, Sandrine Humbert. Neuron 2016
405
5
55

Acetylation targets mutant huntingtin to autophagosomes for degradation.
Hyunkyung Jeong, Florian Then, Thomas J Melia, Joseph R Mazzulli, Libin Cui, Jeffrey N Savas, Cindy Voisine, Paolo Paganetti, Naoko Tanese, Anne C Hart,[...]. Cell 2009
275
3
33

IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome.
Leslie Michels Thompson, Charity T Aiken, Linda S Kaltenbach, Namita Agrawal, Katalin Illes, Ali Khoshnan, Marta Martinez-Vincente, Montserrat Arrasate, Jacqueline Gire O'Rourke, Hasan Khashwji,[...]. J Cell Biol 2009
258
3
33

Phosphorylation of threonine 3: implications for Huntingtin aggregation and neurotoxicity.
Charity T Aiken, Joan S Steffan, Cortnie M Guerrero, Hasan Khashwji, Tamas Lukacsovich, Danielle Simmons, Judy M Purcell, Kimia Menhaji, Ya-Zhen Zhu, Kim Green,[...]. J Biol Chem 2009
112
3
33

Serines 13 and 16 are critical determinants of full-length human mutant huntingtin induced disease pathogenesis in HD mice.
Xiaofeng Gu, Erin R Greiner, Rakesh Mishra, Ravindra Kodali, Alex Osmand, Steven Finkbeiner, Joan S Steffan, Leslie Michels Thompson, Ronald Wetzel, X William Yang. Neuron 2009
223
3
33

The IGF-1/Akt pathway is neuroprotective in Huntington's disease and involves Huntingtin phosphorylation by Akt.
Sandrine Humbert, Elzbieta A Bryson, Fabrice P Cordelières, Nathan C Connors, Sandeep R Datta, Steven Finkbeiner, Michael E Greenberg, Frédéric Saudou. Dev Cell 2002
362
3
33

Huntington's disease: from molecular pathogenesis to clinical treatment.
Christopher A Ross, Sarah J Tabrizi. Lancet Neurol 2011
945
2
22

The aggregation-enhancing huntingtin N-terminus is helical in amyloid fibrils.
V N Sivanandam, Murali Jayaraman, Cody L Hoop, Ravindra Kodali, Ronald Wetzel, Patrick C A van der Wel. J Am Chem Soc 2011
124
2
22

Proteostasis in Huntington's disease: disease mechanisms and therapeutic opportunities.
Rachel J Harding, Yu-Feng Tong. Acta Pharmacol Sin 2018
31
2
22

Secondary structure of Huntingtin amino-terminal region.
Mee Whi Kim, Yogarany Chelliah, Sang Woo Kim, Zbyszek Otwinowski, Ilya Bezprozvanny. Structure 2009
182
2
22

Effects of alpha-synuclein post-translational modifications on metal binding.
Nazareno González, Trinidad Arcos-López, Annekatrin König, Liliana Quintanar, Mauricio Menacho Márquez, Tiago F Outeiro, Claudio O Fernández. J Neurochem 2019
35
2
22

Elucidating the Role of Site-Specific Nitration of α-Synuclein in the Pathogenesis of Parkinson's Disease via Protein Semisynthesis and Mutagenesis.
Ritwik Burai, Nadine Ait-Bouziad, Anass Chiki, Hilal A Lashuel. J Am Chem Soc 2015
77
2
22

Polo-like kinase 2 regulates selective autophagic α-synuclein clearance and suppresses its toxicity in vivo.
Abid Oueslati, Bernard L Schneider, Patrick Aebischer, Hilal A Lashuel. Proc Natl Acad Sci U S A 2013
124
2
22

The Roles of Post-translational Modifications on α-Synuclein in the Pathogenesis of Parkinson's Diseases.
Jiaming Zhang, Xiaoping Li, Jia-Da Li. Front Neurosci 2019
76
2
22

Nitration of tyrosine 10 critically enhances amyloid β aggregation and plaque formation.
Markus P Kummer, Michael Hermes, Andrea Delekarte, Thea Hammerschmidt, Sathish Kumar, Dick Terwel, Jochen Walter, Hans-Christian Pape, Simone König, Sigrun Roeber,[...]. Neuron 2011
203
2
22

Palmitoylation of amyloid precursor protein regulates amyloidogenic processing in lipid rafts.
Raja Bhattacharyya, Cory Barren, Dora M Kovacs. J Neurosci 2013
90
2
22

Dual modification of Alzheimer's disease PHF-tau protein by lysine methylation and ubiquitylation: a mass spectrometry approach.
Stefani N Thomas, Kristen E Funk, Yunhu Wan, Zhongping Liao, Peter Davies, Jeff Kuret, Austin J Yang. Acta Neuropathol 2012
67
2
22

Higher Levels of Protein Palmitoylation in the Frontal Cortex across Aging Were Associated with Reference Memory and Executive Function Declines.
Daniel R Zamzow, Valerie Elias, Varinia A Acosta, Emily Escobedo, Kathy R Magnusson. eNeuro 2019
10
2
22

Palmitoylation in Alzheimer's disease and other neurodegenerative diseases.
Eunsil Cho, Mikyoung Park. Pharmacol Res 2016
62
2
22

Do Post-Translational Modifications Influence Protein Aggregation in Neurodegenerative Diseases: A Systematic Review.
Larissa-Nele Schaffert, Wayne G Carter. Brain Sci 2020
43
2
22

Palmitoylation of huntingtin by HIP14 is essential for its trafficking and function.
Anat Yanai, Kun Huang, Rujun Kang, Roshni R Singaraja, Pamela Arstikaitis, Lu Gan, Paul C Orban, Asher Mullard, Catherine M Cowan, Lynn A Raymond,[...]. Nat Neurosci 2006
209
2
22

The selective GSK3 inhibitor, SAR502250, displays neuroprotective activity and attenuates behavioral impairments in models of neuropsychiatric symptoms of Alzheimer's disease in rodents.
Guy Griebel, Jeanne Stemmelin, Mati Lopez-Grancha, Denis Boulay, Gerald Boquet, Franck Slowinski, Philippe Pichat, Sandra Beeské, Shinji Tanaka, Akiko Mori,[...]. Sci Rep 2019
33
2
22

Nitration of Y10 in Aβ1-40: is it a compensatory reaction against oxidative/nitrative stress and Aβ aggregation?
Jie Zhao, Peipei Wang, Hailing Li, Zhonghong Gao. Chem Res Toxicol 2015
18
2
22

Increased α-synuclein phosphorylation and nitration in the aging primate substantia nigra.
A L McCormack, S K Mak, D A Di Monte. Cell Death Dis 2012
42
2
22

Autophagy and Alzheimer's Disease.
Qian Li, Yi Liu, Miao Sun. Cell Mol Neurobiol 2017
153
2
22

Post-Translational Modifications (PTMs), Identified on Endogenous Huntingtin, Cluster within Proteolytic Domains between HEAT Repeats.
Tamara Ratovitski, Robert N O'Meally, Mali Jiang, Raghothama Chaerkady, Ekaterine Chighladze, Jacqueline C Stewart, Xiaofang Wang, Nicolas Arbez, Elaine Roby, Athanasios Alexandris,[...]. J Proteome Res 2017
27
2
22

Localization of active forms of C-jun kinase (JNK) and p38 kinase in Alzheimer's disease brains at different stages of neurofibrillary degeneration.
Jin-Jing Pei, Eva Braak, Heiko Braak, Inge Grundke-Iqbal, Khalid Iqbal, Bengt Winblad, Richard F. Cowburn. J Alzheimers Dis 2001
118
2
22

Acetylation within the First 17 Residues of Huntingtin Exon 1 Alters Aggregation and Lipid Binding.
Maxmore Chaibva, Sudi Jawahery, Albert W Pilkington, James R Arndt, Olivia Sarver, Stephen Valentine, Silvina Matysiak, Justin Legleiter. Biophys J 2016
36
2
22

Lysine methylation is an endogenous post-translational modification of tau protein in human brain and a modulator of aggregation propensity.
Kristen E Funk, Stefani N Thomas, Kelsey N Schafer, Grace L Cooper, Zhongping Liao, David J Clark, Austin J Yang, Jeff Kuret. Biochem J 2014
71
2
22

The acetylation of tau inhibits its function and promotes pathological tau aggregation.
Todd J Cohen, Jing L Guo, David E Hurtado, Linda K Kwong, Ian P Mills, John Q Trojanowski, Virginia M Y Lee. Nat Commun 2011
399
2
22

Alzheimer Disease: An Update on Pathobiology and Treatment Strategies.
Justin M Long, David M Holtzman. Cell 2019
695
2
22

Serine 421 regulates mutant huntingtin toxicity and clearance in mice.
Ian H Kratter, Hengameh Zahed, Alice Lau, Andrey S Tsvetkov, Aaron C Daub, Kurt F Weiberth, Xiaofeng Gu, Frédéric Saudou, Sandrine Humbert, X William Yang,[...]. J Clin Invest 2016
30
2
22

Alzheimer's disease is a synaptic failure.
Dennis J Selkoe. Science 2002
3023
2
22

Cdk5 phosphorylation of huntingtin reduces its cleavage by caspases: implications for mutant huntingtin toxicity.
Shouqing Luo, Coralie Vacher, Janet E Davies, David C Rubinsztein. J Cell Biol 2005
132
2
22

Huntington disease.
Gillian P Bates, Ray Dorsey, James F Gusella, Michael R Hayden, Chris Kay, Blair R Leavitt, Martha Nance, Christopher A Ross, Rachael I Scahill, Ronald Wetzel,[...]. Nat Rev Dis Primers 2015
629
2
22

Mechanisms of neurodegeneration in Huntington's disease.
Joana M Gil, Ana Cristina Rego. Eur J Neurosci 2008
308
2
22

Kinase inhibitors modulate huntingtin cell localization and toxicity.
Randy Singh Atwal, Carly R Desmond, Nicholas Caron, Tamara Maiuri, Jianrun Xia, Simonetta Sipione, Ray Truant. Nat Chem Biol 2011
121
2
22

Phosphorylation of mutant huntingtin at serine 116 modulates neuronal toxicity.
Erin E Watkin, Nicolas Arbez, Elaine Waldron-Roby, Robert O'Meally, Tamara Ratovitski, Robert N Cole, Christopher A Ross. PLoS One 2014
32
2
22

Huntingtin phosphorylation sites mapped by mass spectrometry. Modulation of cleavage and toxicity.
Birgit Schilling, Juliette Gafni, Cameron Torcassi, Xin Cong, Richard H Row, Michelle A LaFevre-Bernt, Michael P Cusack, Tamara Ratovitski, Ricky Hirschhorn, Christopher A Ross,[...]. J Biol Chem 2006
91
2
22

Kinetically competing huntingtin aggregation pathways control amyloid polymorphism and properties.
Murali Jayaraman, Rakesh Mishra, Ravindra Kodali, Ashwani K Thakur, Leonardus M I Koharudin, Angela M Gronenborn, Ronald Wetzel. Biochemistry 2012
52
2
22

Polyglutamine disruption of the huntingtin exon 1 N terminus triggers a complex aggregation mechanism.
Ashwani K Thakur, Murali Jayaraman, Rakesh Mishra, Monika Thakur, Veronique M Chellgren, In-Ja L Byeon, Dalaver H Anjum, Ravindra Kodali, Trevor P Creamer, James F Conway,[...]. Nat Struct Mol Biol 2009
312
2
22

Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions.
Katerina E Paleologou, Abid Oueslati, Gideon Shakked, Carla C Rospigliosi, Hai-Young Kim, Gonzalo R Lamberto, Claudio O Fernandez, Adrian Schmid, Fariba Chegini, Wei Ping Gai,[...]. J Neurosci 2010
200
2
22

Small changes, big impact: posttranslational modifications and function of huntingtin in Huntington disease.
Dagmar E Ehrnhoefer, Liza Sutton, Michael R Hayden. Neuroscientist 2011
113
2
22

The emerging role of the first 17 amino acids of huntingtin in Huntington's disease.
James R Arndt, Maxmore Chaibva, Justin Legleiter. Biomol Concepts 2015
39
2
22

Potential function for the Huntingtin protein as a scaffold for selective autophagy.
Joseph Ochaba, Tamás Lukacsovich, George Csikos, Shuqiu Zheng, Julia Margulis, Lisa Salazar, Kai Mao, Alice L Lau, Sylvia Y Yeung, Sandrine Humbert,[...]. Proc Natl Acad Sci U S A 2014
170
2
22

Huntington's disease genetics.
Richard H Myers. NeuroRx 2004
171
2
22

SUMO modification of Huntingtin and Huntington's disease pathology.
Joan S Steffan, Namita Agrawal, Judit Pallos, Erica Rockabrand, Lloyd C Trotman, Natalia Slepko, Katalin Illes, Tamas Lukacsovich, Ya-Zhen Zhu, Elena Cattaneo,[...]. Science 2004
504
2
22

A molecular investigation of true dominance in Huntington's disease.
Y Narain, A Wyttenbach, J Rankin, R A Furlong, D C Rubinsztein. J Med Genet 1999
120
1
11

Elevated proteasome capacity extends replicative lifespan in Saccharomyces cerevisiae.
Undine Kruegel, Brett Robison, Thomas Dange, Günther Kahlert, Joe R Delaney, Soumya Kotireddy, Mitsuhiro Tsuchiya, Scott Tsuchiyama, Christopher J Murakami, Jennifer Schleit,[...]. PLoS Genet 2011
159
1
11

Degradation of mutant huntingtin via the ubiquitin/proteasome system is modulated by FE65.
Wan Ning Vanessa Chow, Hon Wing Luk, Ho Yin Edwin Chan, Kwok-Fai Lau. Biochem J 2012
20
1
11


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.

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