Rik Derynck, Shannon J Turley, Rosemary J Akhurst. Nat Rev Clin Oncol 2021
Times Cited: 109
Times Cited: 109
Times Cited
Times Co-cited
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Transforming Growth Factor-β Signaling in Immunity and Cancer.
Eduard Batlle, Joan Massagué. Immunity 2019
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TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells.
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TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis.
Daniele V F Tauriello, Sergio Palomo-Ponce, Diana Stork, Antonio Berenguer-Llergo, Jordi Badia-Ramentol, Mar Iglesias, Marta Sevillano, Sales Ibiza, Adrià Cañellas, Xavier Hernando-Momblona,[...]. Nature 2018
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Enhanced preclinical antitumor activity of M7824, a bifunctional fusion protein simultaneously targeting PD-L1 and TGF-β.
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Specificity, versatility, and control of TGF-β family signaling.
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Contextual determinants of TGFβ action in development, immunity and cancer.
Charles J David, Joan Massagué. Nat Rev Mol Cell Biol 2018
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Bifunctional immune checkpoint-targeted antibody-ligand traps that simultaneously disable TGFβ enhance the efficacy of cancer immunotherapy.
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TGF-β and the TGF-β Family: Context-Dependent Roles in Cell and Tissue Physiology.
Masato Morikawa, Rik Derynck, Kohei Miyazono. Cold Spring Harb Perspect Biol 2016
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Signaling Receptors for TGF-β Family Members.
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α-PD-1 therapy elevates Treg/Th balance and increases tumor cell pSmad3 that are both targeted by α-TGFβ antibody to promote durable rejection and immunity in squamous cell carcinomas.
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A framework for advancing our understanding of cancer-associated fibroblasts.
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Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries.
Hyuna Sung, Jacques Ferlay, Rebecca L Siegel, Mathieu Laversanne, Isabelle Soerjomataram, Ahmedin Jemal, Freddie Bray. CA Cancer J Clin 2021
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TGF-β-associated extracellular matrix genes link cancer-associated fibroblasts to immune evasion and immunotherapy failure.
Ankur Chakravarthy, Lubaba Khan, Nathan Peter Bensler, Pinaki Bose, Daniel D De Carvalho. Nat Commun 2018
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Regulation of the Bioavailability of TGF-β and TGF-β-Related Proteins.
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Selective inhibition of TGFβ1 activation overcomes primary resistance to checkpoint blockade therapy by altering tumor immune landscape.
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TGF-β Signaling from Receptors to Smads.
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Phase I study of GC1008 (fresolimumab): a human anti-transforming growth factor-beta (TGFβ) monoclonal antibody in patients with advanced malignant melanoma or renal cell carcinoma.
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Stromal gene expression defines poor-prognosis subtypes in colorectal cancer.
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Immune-mediated eradication of tumors through the blockade of transforming growth factor-beta signaling in T cells.
L Gorelik, R A Flavell. Nat Med 2001
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TGF-beta directly targets cytotoxic T cell functions during tumor evasion of immune surveillance.
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TGF-β Family Signaling in the Control of Cell Proliferation and Survival.
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Integrin αvβ8-expressing tumor cells evade host immunity by regulating TGF-β activation in immune cells.
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Phase I Trial of M7824 (MSB0011359C), a Bifunctional Fusion Protein Targeting PD-L1 and TGFβ, in Advanced Solid Tumors.
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Approaches to treat immune hot, altered and cold tumours with combination immunotherapies.
Jérôme Galon, Daniela Bruni. Nat Rev Drug Discov 2019
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Dual targeting of TGF-β and PD-L1 via a bifunctional anti-PD-L1/TGF-βRII agent: status of preclinical and clinical advances.
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Targeting TGFβ signal transduction for cancer therapy.
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Primary, Adaptive, and Acquired Resistance to Cancer Immunotherapy.
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Cancer immunotherapy via targeted TGF-β signalling blockade in TH cells.
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TGF-β suppresses type 2 immunity to cancer.
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13
Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3.
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Focal Irradiation and Systemic TGFβ Blockade in Metastatic Breast Cancer.
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Polarization of tumor-associated neutrophil phenotype by TGF-beta: "N1" versus "N2" TAN.
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TGF-β inhibition via CRISPR promotes the long-term efficacy of CAR T cells against solid tumors.
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Induction of heart valve lesions by small-molecule ALK5 inhibitors.
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Molecular mechanisms of epithelial-mesenchymal transition.
Samy Lamouille, Jian Xu, Rik Derynck. Nat Rev Mol Cell Biol 2014
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Blocking immunosuppression by human Tregs in vivo with antibodies targeting integrin αVβ8.
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7
TGFβ Is a Master Regulator of Radiation Therapy-Induced Antitumor Immunity.
Claire Vanpouille-Box, Julie M Diamond, Karsten A Pilones, Jiri Zavadil, James S Babb, Silvia C Formenti, Mary Helen Barcellos-Hoff, Sandra Demaria. Cancer Res 2015
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Clinical development of therapies targeting TGFβ: current knowledge and future perspectives.
D Ciardiello, E Elez, J Tabernero, J Seoane. Ann Oncol 2020
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A Perspective on the Development of TGF-β Inhibitors for Cancer Treatment.
Linh Khanh Huynh, Christopher John Hipolito, Peter Ten Dijke. Biomolecules 2019
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A Potent Pan-TGFβ Neutralizing Monoclonal Antibody Elicits Cardiovascular Toxicity in Mice and Cynomolgus Monkeys.
Mayur S Mitra, Karla Lancaster, Adeyemi O Adedeji, Gopinath S Palanisamy, Rutwij A Dave, Fiona Zhong, Matthew S Holdren, Shannon J Turley, Wei-Ching Liang, Yan Wu,[...]. Toxicol Sci 2020
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22
Turning foes to friends: targeting cancer-associated fibroblasts.
Xueman Chen, Erwei Song. Nat Rev Drug Discov 2019
Xueman Chen, Erwei Song. Nat Rev Drug Discov 2019
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TGF-β: the master regulator of fibrosis.
Xiao-Ming Meng, David J Nikolic-Paterson, Hui Yao Lan. Nat Rev Nephrol 2016
Xiao-Ming Meng, David J Nikolic-Paterson, Hui Yao Lan. Nat Rev Nephrol 2016
6
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