Junwei Hou, Rongce Zhao, Weiya Xia, Chiung-Wen Chang, Yun You, Jung-Mao Hsu, Lei Nie, Yeh Chen, Yu-Chuan Wang, Chunxiao Liu, Wei-Jan Wang, Yun Wu, Baozhen Ke, Jennifer L Hsu, Kebin Huang, Zu Ye, Yi Yang, Xianghou Xia, Yintao Li, Chia-Wei Li, Bin Shao, John A Tainer, Mien-Chie Hung. Nat Cell Biol 2020
Times Cited: 177
Times Cited: 177
Times Cited
Times Co-cited
Similarity
Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin.
Yupeng Wang, Wenqing Gao, Xuyan Shi, Jingjin Ding, Wang Liu, Huabin He, Kun Wang, Feng Shao. Nature 2017
Yupeng Wang, Wenqing Gao, Xuyan Shi, Jingjin Ding, Wang Liu, Huabin He, Kun Wang, Feng Shao. Nature 2017
45
Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells.
Zhiwei Zhou, Huabin He, Kun Wang, Xuyan Shi, Yupeng Wang, Ya Su, Yao Wang, Da Li, Wang Liu, Yongliang Zhang,[...]. Science 2020
Zhiwei Zhou, Huabin He, Kun Wang, Xuyan Shi, Yupeng Wang, Ya Su, Yao Wang, Da Li, Wang Liu, Yongliang Zhang,[...]. Science 2020
44
Gasdermin E suppresses tumour growth by activating anti-tumour immunity.
Zhibin Zhang, Ying Zhang, Shiyu Xia, Qing Kong, Shunying Li, Xing Liu, Caroline Junqueira, Karla F Meza-Sosa, Temy Mo Yin Mok, James Ansara,[...]. Nature 2020
Zhibin Zhang, Ying Zhang, Shiyu Xia, Qing Kong, Shunying Li, Xing Liu, Caroline Junqueira, Karla F Meza-Sosa, Temy Mo Yin Mok, James Ansara,[...]. Nature 2020
44
Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death.
Jianjin Shi, Yue Zhao, Kun Wang, Xuyan Shi, Yue Wang, Huanwei Huang, Yinghua Zhuang, Tao Cai, Fengchao Wang, Feng Shao. Nature 2015
Jianjin Shi, Yue Zhao, Kun Wang, Xuyan Shi, Yue Wang, Huanwei Huang, Yinghua Zhuang, Tao Cai, Fengchao Wang, Feng Shao. Nature 2015
42
Pore-forming activity and structural autoinhibition of the gasdermin family.
Jingjin Ding, Kun Wang, Wang Liu, Yang She, Qi Sun, Jianjin Shi, Hanzi Sun, Da-Cheng Wang, Feng Shao. Nature 2016
Jingjin Ding, Kun Wang, Wang Liu, Yang She, Qi Sun, Jianjin Shi, Hanzi Sun, Da-Cheng Wang, Feng Shao. Nature 2016
34
Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling.
Nobuhiko Kayagaki, Irma B Stowe, Bettina L Lee, Karen O'Rourke, Keith Anderson, Søren Warming, Trinna Cuellar, Benjamin Haley, Merone Roose-Girma, Qui T Phung,[...]. Nature 2015
Nobuhiko Kayagaki, Irma B Stowe, Bettina L Lee, Karen O'Rourke, Keith Anderson, Søren Warming, Trinna Cuellar, Benjamin Haley, Merone Roose-Girma, Qui T Phung,[...]. Nature 2015
34
Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death.
Corey Rogers, Teresa Fernandes-Alnemri, Lindsey Mayes, Diana Alnemri, Gino Cingolani, Emad S Alnemri. Nat Commun 2017
Corey Rogers, Teresa Fernandes-Alnemri, Lindsey Mayes, Diana Alnemri, Gino Cingolani, Emad S Alnemri. Nat Commun 2017
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Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death.
Jianjin Shi, Wenqing Gao, Feng Shao. Trends Biochem Sci 2017
Jianjin Shi, Wenqing Gao, Feng Shao. Trends Biochem Sci 2017
28
The gasdermins, a protein family executing cell death and inflammation.
Petr Broz, Pablo Pelegrín, Feng Shao. Nat Rev Immunol 2020
Petr Broz, Pablo Pelegrín, Feng Shao. Nat Rev Immunol 2020
26
Pyroptosis: A new frontier in cancer.
Yuan Fang, Shengwang Tian, Yutian Pan, Wei Li, Qiming Wang, Yu Tang, Tao Yu, Xi Wu, Yongkang Shi, Pei Ma,[...]. Biomed Pharmacother 2020
Yuan Fang, Shengwang Tian, Yutian Pan, Wei Li, Qiming Wang, Yu Tang, Tao Yu, Xi Wu, Yongkang Shi, Pei Ma,[...]. Biomed Pharmacother 2020
25
Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation.
Corey Rogers, Dan A Erkes, Alexandria Nardone, Andrew E Aplin, Teresa Fernandes-Alnemri, Emad S Alnemri. Nat Commun 2019
Corey Rogers, Dan A Erkes, Alexandria Nardone, Andrew E Aplin, Teresa Fernandes-Alnemri, Emad S Alnemri. Nat Commun 2019
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Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores.
Xing Liu, Zhibin Zhang, Jianbin Ruan, Youdong Pan, Venkat Giri Magupalli, Hao Wu, Judy Lieberman. Nature 2016
Xing Liu, Zhibin Zhang, Jianbin Ruan, Youdong Pan, Venkat Giri Magupalli, Hao Wu, Judy Lieberman. Nature 2016
23
23
Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death.
Pontus Orning, Dan Weng, Kristian Starheim, Dmitry Ratner, Zachary Best, Bettina Lee, Alexandria Brooks, Shiyu Xia, Hao Wu, Michelle A Kelliher,[...]. Science 2018
Pontus Orning, Dan Weng, Kristian Starheim, Dmitry Ratner, Zachary Best, Bettina Lee, Alexandria Brooks, Shiyu Xia, Hao Wu, Michelle A Kelliher,[...]. Science 2018
22
The role of pyroptosis in cancer: pro-cancer or pro-"host"?
Xiaojing Xia, Xin Wang, Zhe Cheng, Wanhai Qin, Liancheng Lei, Jinqing Jiang, Jianhe Hu. Cell Death Dis 2019
Xiaojing Xia, Xin Wang, Zhe Cheng, Wanhai Qin, Liancheng Lei, Jinqing Jiang, Jianhe Hu. Cell Death Dis 2019
21
Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection.
Joseph Sarhan, Beiyun C Liu, Hayley I Muendlein, Peng Li, Rachael Nilson, Amy Y Tang, Anthony Rongvaux, Stephen C Bunnell, Feng Shao, Douglas R Green,[...]. Proc Natl Acad Sci U S A 2018
Joseph Sarhan, Beiyun C Liu, Hayley I Muendlein, Peng Li, Rachael Nilson, Amy Y Tang, Anthony Rongvaux, Stephen C Bunnell, Feng Shao, Douglas R Green,[...]. Proc Natl Acad Sci U S A 2018
19
A bioorthogonal system reveals antitumour immune function of pyroptosis.
Qinyang Wang, Yupeng Wang, Jingjin Ding, Chunhong Wang, Xuehan Zhou, Wenqing Gao, Huanwei Huang, Feng Shao, Zhibo Liu. Nature 2020
Qinyang Wang, Yupeng Wang, Jingjin Ding, Chunhong Wang, Xuehan Zhou, Wenqing Gao, Huanwei Huang, Feng Shao, Zhibo Liu. Nature 2020
19
A novel defined pyroptosis-related gene signature for predicting the prognosis of ovarian cancer.
Ying Ye, Qinjin Dai, Hongbo Qi. Cell Death Discov 2021
Ying Ye, Qinjin Dai, Hongbo Qi. Cell Death Discov 2021
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Inflammatory caspases are innate immune receptors for intracellular LPS.
Jianjin Shi, Yue Zhao, Yupeng Wang, Wenqing Gao, Jingjin Ding, Peng Li, Liyan Hu, Feng Shao. Nature 2014
Jianjin Shi, Yue Zhao, Yupeng Wang, Wenqing Gao, Jingjin Ding, Peng Li, Liyan Hu, Feng Shao. Nature 2014
17
Shigella flexneri induces apoptosis in infected macrophages.
A Zychlinsky, M C Prevost, P J Sansonetti. Nature 1992
A Zychlinsky, M C Prevost, P J Sansonetti. Nature 1992
17
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.
Lorenzo Galluzzi, Ilio Vitale, Stuart A Aaronson, John M Abrams, Dieter Adam, Patrizia Agostinis, Emad S Alnemri, Lucia Altucci, Ivano Amelio, David W Andrews,[...]. Cell Death Differ 2018
Lorenzo Galluzzi, Ilio Vitale, Stuart A Aaronson, John M Abrams, Dieter Adam, Patrizia Agostinis, Emad S Alnemri, Lucia Altucci, Ivano Amelio, David W Andrews,[...]. Cell Death Differ 2018
17
Mutant BRAF and MEK Inhibitors Regulate the Tumor Immune Microenvironment via Pyroptosis.
Dan A Erkes, Weijia Cai, Ileine M Sanchez, Timothy J Purwin, Corey Rogers, Conroy O Field, Adam C Berger, Edward J Hartsough, Ulrich Rodeck, Emad S Alnemri,[...]. Cancer Discov 2020
Dan A Erkes, Weijia Cai, Ileine M Sanchez, Timothy J Purwin, Corey Rogers, Conroy O Field, Adam C Berger, Edward J Hartsough, Ulrich Rodeck, Emad S Alnemri,[...]. Cancer Discov 2020
16
Succination inactivates gasdermin D and blocks pyroptosis.
Fiachra Humphries, Liraz Shmuel-Galia, Natalia Ketelut-Carneiro, Sheng Li, Bingwei Wang, Venkatesh V Nemmara, Ruth Wilson, Zhaozhao Jiang, Farnaz Khalighinejad, Khaja Muneeruddin,[...]. Science 2020
Fiachra Humphries, Liraz Shmuel-Galia, Natalia Ketelut-Carneiro, Sheng Li, Bingwei Wang, Venkatesh V Nemmara, Ruth Wilson, Zhaozhao Jiang, Farnaz Khalighinejad, Khaja Muneeruddin,[...]. Science 2020
15
Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion.
Wan-ting He, Haoqiang Wan, Lichen Hu, Pengda Chen, Xin Wang, Zhe Huang, Zhang-Hua Yang, Chuan-Qi Zhong, Jiahuai Han. Cell Res 2015
Wan-ting He, Haoqiang Wan, Lichen Hu, Pengda Chen, Xin Wang, Zhe Huang, Zhang-Hua Yang, Chuan-Qi Zhong, Jiahuai Han. Cell Res 2015
15
Gasdermin C Is Upregulated by Inactivation of Transforming Growth Factor β Receptor Type II in the Presence of Mutated Apc, Promoting Colorectal Cancer Proliferation.
Masashi Miguchi, Takao Hinoi, Manabu Shimomura, Tomohiro Adachi, Yasufumi Saito, Hiroaki Niitsu, Masatoshi Kochi, Haruki Sada, Yusuke Sotomaru, Tsuneo Ikenoue,[...]. PLoS One 2016
Masashi Miguchi, Takao Hinoi, Manabu Shimomura, Tomohiro Adachi, Yasufumi Saito, Hiroaki Niitsu, Masatoshi Kochi, Haruki Sada, Yusuke Sotomaru, Tsuneo Ikenoue,[...]. PLoS One 2016
18
Gasdermin E-mediated target cell pyroptosis by CAR T cells triggers cytokine release syndrome.
Yuying Liu, Yiliang Fang, Xinfeng Chen, Zhenfeng Wang, Xiaoyu Liang, Tianzhen Zhang, Mengyu Liu, Nannan Zhou, Jiadi Lv, Ke Tang,[...]. Sci Immunol 2020
Yuying Liu, Yiliang Fang, Xinfeng Chen, Zhenfeng Wang, Xiaoyu Liang, Tianzhen Zhang, Mengyu Liu, Nannan Zhou, Jiadi Lv, Ke Tang,[...]. Sci Immunol 2020
15
FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation.
Jun Jacob Hu, Xing Liu, Shiyu Xia, Zhibin Zhang, Ying Zhang, Jingxia Zhao, Jianbin Ruan, Xuemei Luo, Xiwen Lou, Yang Bai,[...]. Nat Immunol 2020
Jun Jacob Hu, Xing Liu, Shiyu Xia, Zhibin Zhang, Ying Zhang, Jingxia Zhao, Jianbin Ruan, Xuemei Luo, Xiwen Lou, Yang Bai,[...]. Nat Immunol 2020
14
Gasdermin D plays a vital role in the generation of neutrophil extracellular traps.
Gabriel Sollberger, Axel Choidas, Garth Lawrence Burn, Peter Habenberger, Raffaella Di Lucrezia, Susanne Kordes, Sascha Menninger, Jan Eickhoff, Peter Nussbaumer, Bert Klebl,[...]. Sci Immunol 2018
Gabriel Sollberger, Axel Choidas, Garth Lawrence Burn, Peter Habenberger, Raffaella Di Lucrezia, Susanne Kordes, Sascha Menninger, Jan Eickhoff, Peter Nussbaumer, Bert Klebl,[...]. Sci Immunol 2018
14
Ferroptosis, necroptosis, and pyroptosis in anticancer immunity.
Rong Tang, Jin Xu, Bo Zhang, Jiang Liu, Chen Liang, Jie Hua, Qingcai Meng, Xianjun Yu, Si Shi. J Hematol Oncol 2020
Rong Tang, Jin Xu, Bo Zhang, Jiang Liu, Chen Liang, Jie Hua, Qingcai Meng, Xianjun Yu, Si Shi. J Hematol Oncol 2020
14
Gene polymorphism linked to increased asthma and IBD risk alters gasdermin-B structure, a sulfatide and phosphoinositide binding protein.
Kinlin L Chao, Liudmila Kulakova, Osnat Herzberg. Proc Natl Acad Sci U S A 2017
Kinlin L Chao, Liudmila Kulakova, Osnat Herzberg. Proc Natl Acad Sci U S A 2017
19
Non-canonical inflammasome activation targets caspase-11.
Nobuhiko Kayagaki, Søren Warming, Mohamed Lamkanfi, Lieselotte Vande Walle, Salina Louie, Jennifer Dong, Kim Newton, Yan Qu, Jinfeng Liu, Sherry Heldens,[...]. Nature 2011
Nobuhiko Kayagaki, Søren Warming, Mohamed Lamkanfi, Lieselotte Vande Walle, Salina Louie, Jennifer Dong, Kim Newton, Yan Qu, Jinfeng Liu, Sherry Heldens,[...]. Nature 2011
13
Extrinsic and intrinsic apoptosis activate pannexin-1 to drive NLRP3 inflammasome assembly.
Kaiwen W Chen, Benjamin Demarco, Rosalie Heilig, Kateryna Shkarina, Andreas Boettcher, Christopher J Farady, Pawel Pelczar, Petr Broz. EMBO J 2019
Kaiwen W Chen, Benjamin Demarco, Rosalie Heilig, Kateryna Shkarina, Andreas Boettcher, Christopher J Farady, Pawel Pelczar, Petr Broz. EMBO J 2019
13
Chemical disruption of the pyroptotic pore-forming protein gasdermin D inhibits inflammatory cell death and sepsis.
Joseph K Rathkey, Junjie Zhao, Zhonghua Liu, Yinghua Chen, Jie Yang, Hannah C Kondolf, Bryan L Benson, Steven M Chirieleison, Alex Y Huang, George R Dubyak,[...]. Sci Immunol 2018
Joseph K Rathkey, Junjie Zhao, Zhonghua Liu, Yinghua Chen, Jie Yang, Hannah C Kondolf, Bryan L Benson, Steven M Chirieleison, Alex Y Huang, George R Dubyak,[...]. Sci Immunol 2018
13
Pyroptosis and Apoptosis Pathways Engage in Bidirectional Crosstalk in Monocytes and Macrophages.
Cornelius Y Taabazuing, Marian C Okondo, Daniel A Bachovchin. Cell Chem Biol 2017
Cornelius Y Taabazuing, Marian C Okondo, Daniel A Bachovchin. Cell Chem Biol 2017
13
Mechanism and regulation of pyroptosis-mediated in cancer cell death.
Jianwei Ruan, Shijian Wang, Jiabing Wang. Chem Biol Interact 2020
Jianwei Ruan, Shijian Wang, Jiabing Wang. Chem Biol Interact 2020
16
The Pyroptosis-Related Signature Predicts Prognosis and Indicates Immune Microenvironment Infiltration in Gastric Cancer.
Wei Shao, Zongcheng Yang, Yue Fu, Lixin Zheng, Fen Liu, Li Chai, Jihui Jia. Front Cell Dev Biol 2021
Wei Shao, Zongcheng Yang, Yue Fu, Lixin Zheng, Fen Liu, Li Chai, Jihui Jia. Front Cell Dev Biol 2021
25
NINJ1 mediates plasma membrane rupture during lytic cell death.
Nobuhiko Kayagaki, Opher S Kornfeld, Bettina L Lee, Irma B Stowe, Karen O'Rourke, Qingling Li, Wendy Sandoval, Donghong Yan, Jing Kang, Min Xu,[...]. Nature 2021
Nobuhiko Kayagaki, Opher S Kornfeld, Bettina L Lee, Irma B Stowe, Karen O'Rourke, Qingling Li, Wendy Sandoval, Donghong Yan, Jing Kang, Min Xu,[...]. Nature 2021
12
Gasdermin D Exerts Anti-inflammatory Effects by Promoting Neutrophil Death.
Hiroto Kambara, Fei Liu, Xiaoyu Zhang, Peng Liu, Besnik Bajrami, Yan Teng, Li Zhao, Shiyi Zhou, Hongbo Yu, Weidong Zhou,[...]. Cell Rep 2018
Hiroto Kambara, Fei Liu, Xiaoyu Zhang, Peng Liu, Besnik Bajrami, Yan Teng, Li Zhao, Shiyi Zhou, Hongbo Yu, Weidong Zhou,[...]. Cell Rep 2018
12
GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death.
Lorenzo Sborgi, Sebastian Rühl, Estefania Mulvihill, Joka Pipercevic, Rosalie Heilig, Henning Stahlberg, Christopher J Farady, Daniel J Müller, Petr Broz, Sebastian Hiller. EMBO J 2016
Lorenzo Sborgi, Sebastian Rühl, Estefania Mulvihill, Joka Pipercevic, Rosalie Heilig, Henning Stahlberg, Christopher J Farady, Daniel J Müller, Petr Broz, Sebastian Hiller. EMBO J 2016
12
Pyroptosis: host cell death and inflammation.
Tessa Bergsbaken, Susan L Fink, Brad T Cookson. Nat Rev Microbiol 2009
Tessa Bergsbaken, Susan L Fink, Brad T Cookson. Nat Rev Microbiol 2009
12
ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation.
Sebastian Rühl, Kateryna Shkarina, Benjamin Demarco, Rosalie Heilig, José Carlos Santos, Petr Broz. Science 2018
Sebastian Rühl, Kateryna Shkarina, Benjamin Demarco, Rosalie Heilig, José Carlos Santos, Petr Broz. Science 2018
11
Overexpression of GSDMC is a prognostic factor for predicting a poor outcome in lung adenocarcinoma.
Jie Wei, Zhijie Xu, Xi Chen, Xiang Wang, Shuangshuang Zeng, Long Qian, Xue Yang, Chunlin Ou, Wei Lin, Zhicheng Gong,[...]. Mol Med Rep 2020
Jie Wei, Zhijie Xu, Xi Chen, Xiang Wang, Shuangshuang Zeng, Long Qian, Xue Yang, Chunlin Ou, Wei Lin, Zhicheng Gong,[...]. Mol Med Rep 2020
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Gasdermin (Gsdm) localizing to mouse Chromosome 11 is predominantly expressed in upper gastrointestinal tract but significantly suppressed in human gastric cancer cells.
N Saeki, Y Kuwahara, H Sasaki, H Satoh, T Shiroishi. Mamm Genome 2000
N Saeki, Y Kuwahara, H Sasaki, H Satoh, T Shiroishi. Mamm Genome 2000
11
Channelling inflammation: gasdermins in physiology and disease.
Xing Liu, Shiyu Xia, Zhibin Zhang, Hao Wu, Judy Lieberman. Nat Rev Drug Discov 2021
Xing Liu, Shiyu Xia, Zhibin Zhang, Hao Wu, Judy Lieberman. Nat Rev Drug Discov 2021
14
Single-cell analysis of pyroptosis dynamics reveals conserved GSDMD-mediated subcellular events that precede plasma membrane rupture.
Nathalia M de Vasconcelos, Nina Van Opdenbosch, Hanne Van Gorp, Eef Parthoens, Mohamed Lamkanfi. Cell Death Differ 2019
Nathalia M de Vasconcelos, Nina Van Opdenbosch, Hanne Van Gorp, Eef Parthoens, Mohamed Lamkanfi. Cell Death Differ 2019
11
11
Mechanisms of Gasdermin Family Members in Inflammasome Signaling and Cell Death.
Shouya Feng, Daniel Fox, Si Ming Man. J Mol Biol 2018
Shouya Feng, Daniel Fox, Si Ming Man. J Mol Biol 2018
11
The metabolite α-KG induces GSDMC-dependent pyroptosis through death receptor 6-activated caspase-8.
Jia-Yuan Zhang, Bo Zhou, Ru-Yue Sun, Yuan-Li Ai, Kang Cheng, Fu-Nan Li, Bao-Rui Wang, Fan-Jian Liu, Zhi-Hong Jiang, Wei-Jia Wang,[...]. Cell Res 2021
Jia-Yuan Zhang, Bo Zhou, Ru-Yue Sun, Yuan-Li Ai, Kang Cheng, Fu-Nan Li, Bao-Rui Wang, Fan-Jian Liu, Zhi-Hong Jiang, Wei-Jia Wang,[...]. Cell Res 2021
44
Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries.
Hyuna Sung, Jacques Ferlay, Rebecca L Siegel, Mathieu Laversanne, Isabelle Soerjomataram, Ahmedin Jemal, Freddie Bray. CA Cancer J Clin 2021
Hyuna Sung, Jacques Ferlay, Rebecca L Siegel, Mathieu Laversanne, Isabelle Soerjomataram, Ahmedin Jemal, Freddie Bray. CA Cancer J Clin 2021
11
GSVA: gene set variation analysis for microarray and RNA-seq data.
Sonja Hänzelmann, Robert Castelo, Justin Guinney. BMC Bioinformatics 2013
Sonja Hänzelmann, Robert Castelo, Justin Guinney. BMC Bioinformatics 2013
11
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.