Karl J Harber, Kyra E de Goede, Sanne G S Verberk, Elisa Meinster, Helga E de Vries, Michel van Weeghel, Menno P J de Winther, Jan Van den Bossche. Metabolites 2020
Times Cited: 17
Times Cited: 17
Times Cited
Times Co-cited
Similarity
Succinate is an inflammatory signal that induces IL-1β through HIF-1α.
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Network integration of parallel metabolic and transcriptional data reveals metabolic modules that regulate macrophage polarization.
Abhishek K Jha, Stanley Ching-Cheng Huang, Alexey Sergushichev, Vicky Lampropoulou, Yulia Ivanova, Ekaterina Loginicheva, Karina Chmielewski, Kelly M Stewart, Juliet Ashall, Bart Everts,[...]. Immunity 2015
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α-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming.
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Cancer-Derived Succinate Promotes Macrophage Polarization and Cancer Metastasis via Succinate Receptor.
Jing-Yiing Wu, Tsai-Wang Huang, Yi-Ting Hsieh, Yi-Fu Wang, Chia-Chien Yen, Guan-Lin Lee, Chang-Ching Yeh, Yi-Jen Peng, Ya-Yi Kuo, Hsiu-Ting Wen,[...]. Mol Cell 2020
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Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages.
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SUCNR1 controls an anti-inflammatory program in macrophages to regulate the metabolic response to obesity.
Noelia Keiran, Victoria Ceperuelo-Mallafré, Enrique Calvo, Maria Isabel Hernández-Alvarez, Miriam Ejarque, Catalina Núñez-Roa, Daniel Horrillo, Elsa Maymó-Masip, M Mar Rodríguez, Rosa Fradera,[...]. Nat Immunol 2019
Noelia Keiran, Victoria Ceperuelo-Mallafré, Enrique Calvo, Maria Isabel Hernández-Alvarez, Miriam Ejarque, Catalina Núñez-Roa, Daniel Horrillo, Elsa Maymó-Masip, M Mar Rodríguez, Rosa Fradera,[...]. Nat Immunol 2019
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Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation.
Vicky Lampropoulou, Alexey Sergushichev, Monika Bambouskova, Sharmila Nair, Emma E Vincent, Ekaterina Loginicheva, Luisa Cervantes-Barragan, Xiucui Ma, Stanley Ching-Cheng Huang, Takla Griss,[...]. Cell Metab 2016
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Functional polarization of tumour-associated macrophages by tumour-derived lactic acid.
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Metabolic Reprogramming Mediated by the mTORC2-IRF4 Signaling Axis Is Essential for Macrophage Alternative Activation.
Stanley Ching-Cheng Huang, Amber M Smith, Bart Everts, Marco Colonna, Erika L Pearce, Joel D Schilling, Edward J Pearce. Immunity 2016
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Pyruvate kinase M2 regulates Hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in LPS-activated macrophages.
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"Of mice and men": arginine metabolism in macrophages.
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Mitochondrial Dysfunction Prevents Repolarization of Inflammatory Macrophages.
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Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels.
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Immunometabolism governs dendritic cell and macrophage function.
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Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.
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Mitochondrial TCA cycle metabolites control physiology and disease.
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Succinate: a metabolic signal in inflammation.
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Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages.
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Metabolic regulation of gene expression by histone lactylation.
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Macrophage Immunometabolism: Where Are We (Going)?
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Triggering the succinate receptor GPR91 on dendritic cells enhances immunity.
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GPR91 senses extracellular succinate released from inflammatory macrophages and exacerbates rheumatoid arthritis.
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Nitric Oxide Modulates Metabolic Remodeling in Inflammatory Macrophages through TCA Cycle Regulation and Itaconate Accumulation.
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Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase.
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Commitment to glycolysis sustains survival of NO-producing inflammatory dendritic cells.
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Substrate fate in activated macrophages: a comparison between innate, classic, and alternative activation.
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Succinate dehydrogenase inhibition leads to epithelial-mesenchymal transition and reprogrammed carbon metabolism.
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Tumor-derived lactate induces M2 macrophage polarization via the activation of the ERK/STAT3 signaling pathway in breast cancer.
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HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia.
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Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition.
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Pharmacologic or Genetic Targeting of Glutamine Synthetase Skews Macrophages toward an M1-like Phenotype and Inhibits Tumor Metastasis.
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Macrophage-Derived Extracellular Succinate Licenses Neural Stem Cells to Suppress Chronic Neuroinflammation.
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Succinate receptor mediates intestinal inflammation and fibrosis.
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The succinate receptor as a novel therapeutic target for oxidative and metabolic stress-related conditions.
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A guide to immunometabolism for immunologists.
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Coupling Krebs cycle metabolites to signalling in immunity and cancer.
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SUCNR1-mediated chemotaxis of macrophages aggravates obesity-induced inflammation and diabetes.
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Comparative evaluation of itaconate and its derivatives reveals divergent inflammasome and type I interferon regulation in macrophages.
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Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.