Shuxuan Huang, Zhi Chen, Binglin Fan, Yuan Chen, Liyuan Zhou, Bingjian Jiang, Haiyin Long, Weizhang Zhong, Xiaofeng Li, Yanhua Li. J Neuroimmunol 2021
Times Cited: 7
Times Cited: 7
Times Cited
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Similarity
A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases.
Rebecca C Coll, Avril A B Robertson, Jae Jin Chae, Sarah C Higgins, Raúl Muñoz-Planillo, Marco C Inserra, Irina Vetter, Lara S Dungan, Brian G Monks, Andrea Stutz,[...]. Nat Med 2015
Rebecca C Coll, Avril A B Robertson, Jae Jin Chae, Sarah C Higgins, Raúl Muñoz-Planillo, Marco C Inserra, Irina Vetter, Lara S Dungan, Brian G Monks, Andrea Stutz,[...]. Nat Med 2015
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Small molecule-driven NLRP3 inflammation inhibition via interplay between ubiquitination and autophagy: implications for Parkinson disease.
Xiaojuan Han, Sifan Sun, Yiming Sun, Qiqi Song, Jialei Zhu, Nanshan Song, Miaomiao Chen, Ting Sun, Meiling Xia, Jianhua Ding,[...]. Autophagy 2019
Xiaojuan Han, Sifan Sun, Yiming Sun, Qiqi Song, Jialei Zhu, Nanshan Song, Miaomiao Chen, Ting Sun, Meiling Xia, Jianhua Ding,[...]. Autophagy 2019
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Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice.
Richard Gordon, Eduardo A Albornoz, Daniel C Christie, Monica R Langley, Vinod Kumar, Susanna Mantovani, Avril A B Robertson, Mark S Butler, Dominic B Rowe, Luke A O'Neill,[...]. Sci Transl Med 2018
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NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice.
Michael T Heneka, Markus P Kummer, Andrea Stutz, Andrea Delekate, Stephanie Schwartz, Ana Vieira-Saecker, Angelika Griep, Daisy Axt, Anita Remus, Te-Chen Tzeng,[...]. Nature 2013
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Fyn kinase regulates misfolded α-synuclein uptake and NLRP3 inflammasome activation in microglia.
Nikhil Panicker, Souvarish Sarkar, Dilshan S Harischandra, Matthew Neal, Tae-In Kam, Huajun Jin, Hariharan Saminathan, Monica Langley, Adhithiya Charli, Manikandan Samidurai,[...]. J Exp Med 2019
Nikhil Panicker, Souvarish Sarkar, Dilshan S Harischandra, Matthew Neal, Tae-In Kam, Huajun Jin, Hariharan Saminathan, Monica Langley, Adhithiya Charli, Manikandan Samidurai,[...]. J Exp Med 2019
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Dopamine controls systemic inflammation through inhibition of NLRP3 inflammasome.
Yiqing Yan, Wei Jiang, Lei Liu, Xiaqiong Wang, Chen Ding, Zhigang Tian, Rongbin Zhou. Cell 2015
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Triggering of inflammasome by aggregated α-synuclein, an inflammatory response in synucleinopathies.
Gaia Codolo, Nicoletta Plotegher, Tommaso Pozzobon, Marco Brucale, Isabella Tessari, Luigi Bubacco, Marina de Bernard. PLoS One 2013
Gaia Codolo, Nicoletta Plotegher, Tommaso Pozzobon, Marco Brucale, Isabella Tessari, Luigi Bubacco, Marina de Bernard. PLoS One 2013
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MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition.
Rebecca C Coll, James R Hill, Christopher J Day, Alina Zamoshnikova, Dave Boucher, Nicholas L Massey, Jessica L Chitty, James A Fraser, Michael P Jennings, Avril A B Robertson,[...]. Nat Chem Biol 2019
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AIM2 and NLRC4 inflammasomes contribute with ASC to acute brain injury independently of NLRP3.
Adam Denes, Graham Coutts, Nikolett Lénárt, Sheena M Cruickshank, Pablo Pelegrin, Joanne Skinner, Nancy Rothwell, Stuart M Allan, David Brough. Proc Natl Acad Sci U S A 2015
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NLRP3 inflammasome-driven pathways in depression: Clinical and preclinical findings.
Fernanda N Kaufmann, Ana Paula Costa, Gabriele Ghisleni, Alexandre P Diaz, Ana Lúcia S Rodrigues, Hugo Peluffo, Manuella P Kaster. Brain Behav Immun 2017
Fernanda N Kaufmann, Ana Paula Costa, Gabriele Ghisleni, Alexandre P Diaz, Ana Lúcia S Rodrigues, Hugo Peluffo, Manuella P Kaster. Brain Behav Immun 2017
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Inflammasome signalling in brain function and neurodegenerative disease.
Michael T Heneka, Róisín M McManus, Eicke Latz. Nat Rev Neurosci 2018
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Development and Characterization of a Hydroxyl-Sulfonamide Analogue, 5-Chloro-N-[2-(4-hydroxysulfamoyl-phenyl)-ethyl]-2-methoxy-benzamide, as a Novel NLRP3 Inflammasome Inhibitor for Potential Treatment of Multiple Sclerosis.
Chunqing Guo, Jacob W Fulp, Yuqi Jiang, Xia Li, Jeremy E Chojnacki, Jingde Wu, Xiang-Yang Wang, Shijun Zhang. ACS Chem Neurosci 2017
Chunqing Guo, Jacob W Fulp, Yuqi Jiang, Xia Li, Jeremy E Chojnacki, Jingde Wu, Xiang-Yang Wang, Shijun Zhang. ACS Chem Neurosci 2017
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Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores.
Xing Liu, Zhibin Zhang, Jianbin Ruan, Youdong Pan, Venkat Giri Magupalli, Hao Wu, Judy Lieberman. Nature 2016
Xing Liu, Zhibin Zhang, Jianbin Ruan, Youdong Pan, Venkat Giri Magupalli, Hao Wu, Judy Lieberman. Nature 2016
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Plasma-borne indicators of inflammasome activity in Parkinson's disease patients.
Faith L Anderson, Katharine M von Herrmann, Angeline S Andrew, Yuliya I Kuras, Alison L Young, Clemens R Scherzer, William F Hickey, Stephen L Lee, Matthew C Havrda. NPJ Parkinsons Dis 2021
Faith L Anderson, Katharine M von Herrmann, Angeline S Andrew, Yuliya I Kuras, Alison L Young, Clemens R Scherzer, William F Hickey, Stephen L Lee, Matthew C Havrda. NPJ Parkinsons Dis 2021
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The role of NLRP3-CASP1 in inflammasome-mediated neuroinflammation and autophagy dysfunction in manganese-induced, hippocampal-dependent impairment of learning and memory ability.
Diya Wang, Jianbin Zhang, Wenkai Jiang, Zipeng Cao, Fang Zhao, Tongjian Cai, Michael Aschner, Wenjing Luo. Autophagy 2017
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Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer's disease.
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The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation.
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MicroRNA-7 targets Nod-like receptor protein 3 inflammasome to modulate neuroinflammation in the pathogenesis of Parkinson's disease.
Yan Zhou, Ming Lu, Ren-Hong Du, Chen Qiao, Chun-Yi Jiang, Ke-Zhong Zhang, Jian-Hua Ding, Gang Hu. Mol Neurodegener 2016
Yan Zhou, Ming Lu, Ren-Hong Du, Chen Qiao, Chun-Yi Jiang, Ke-Zhong Zhang, Jian-Hua Ding, Gang Hu. Mol Neurodegener 2016
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Editor's Highlight: Nlrp3 Is Required for Inflammatory Changes and Nigral Cell Loss Resulting From Chronic Intragastric Rotenone Exposure in Mice.
Eileen M Martinez, Alison L Young, Yash R Patankar, Brent L Berwin, Li Wang, Katharine M von Herrmann, Jaclyn M Weier, Matthew C Havrda. Toxicol Sci 2017
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Mitochondrial impairment in microglia amplifies NLRP3 inflammasome proinflammatory signaling in cell culture and animal models of Parkinson's disease.
Souvarish Sarkar, Emir Malovic, Dilshan S Harishchandra, Shivani Ghaisas, Nikhil Panicker, Adhithiya Charli, Bharathi N Palanisamy, Dharmin Rokad, Huajun Jin, Vellareddy Anantharam,[...]. NPJ Parkinsons Dis 2017
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Rotenone-induced Impairment of Mitochondrial Electron Transport Chain Confers a Selective Priming Signal for NLRP3 Inflammasome Activation.
Ji-Hee Won, Sangjun Park, Sujeong Hong, Seunghwan Son, Je-Wook Yu. J Biol Chem 2015
Ji-Hee Won, Sangjun Park, Sujeong Hong, Seunghwan Son, Je-Wook Yu. J Biol Chem 2015
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The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response.
Alberto Baroja-Mazo, Fatima Martín-Sánchez, Ana I Gomez, Carlos M Martínez, Joaquín Amores-Iniesta, Vincent Compan, Maria Barberà-Cremades, Jordi Yagüe, Estibaliz Ruiz-Ortiz, Jordi Antón,[...]. Nat Immunol 2014
Alberto Baroja-Mazo, Fatima Martín-Sánchez, Ana I Gomez, Carlos M Martínez, Joaquín Amores-Iniesta, Vincent Compan, Maria Barberà-Cremades, Jordi Yagüe, Estibaliz Ruiz-Ortiz, Jordi Antón,[...]. Nat Immunol 2014
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Integrin CD11b mediates locus coeruleus noradrenergic neurodegeneration in a mouse Parkinson's disease model.
Liyan Hou, Xingyue Qu, Xiaofei Qiu, Ruixue Huang, Xiulan Zhao, Qingshan Wang. J Neuroinflammation 2020
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Aggregated Tau activates NLRP3-ASC inflammasome exacerbating exogenously seeded and non-exogenously seeded Tau pathology in vivo.
Ilie-Cosmin Stancu, Niels Cremers, Hannah Vanrusselt, Julien Couturier, Alexandre Vanoosthuyse, Sofie Kessels, Chritica Lodder, Bert Brône, François Huaux, Jean-Noël Octave,[...]. Acta Neuropathol 2019
Ilie-Cosmin Stancu, Niels Cremers, Hannah Vanrusselt, Julien Couturier, Alexandre Vanoosthuyse, Sofie Kessels, Chritica Lodder, Bert Brône, François Huaux, Jean-Noël Octave,[...]. Acta Neuropathol 2019
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Microglial autophagy defect causes parkinson disease-like symptoms by accelerating inflammasome activation in mice.
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NLRP3 inflammasome activation drives tau pathology.
Christina Ising, Carmen Venegas, Shuangshuang Zhang, Hannah Scheiblich, Susanne V Schmidt, Ana Vieira-Saecker, Stephanie Schwartz, Shadi Albasset, Róisín M McManus, Dario Tejera,[...]. Nature 2019
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The NLRP3 inflammasome inhibitor OLT1177 rescues cognitive impairment in a mouse model of Alzheimer's disease.
Niklas Lonnemann, Shirin Hosseini, Carlo Marchetti, Damaris B Skouras, Davide Stefanoni, Angelo D'Alessandro, Charles A Dinarello, Martin Korte. Proc Natl Acad Sci U S A 2020
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NLR members NLRC4 and NLRP3 mediate sterile inflammasome activation in microglia and astrocytes.
Leslie Freeman, Haitao Guo, Clément N David, W June Brickey, Sushmita Jha, Jenny P-Y Ting. J Exp Med 2017
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NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component.
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Baicalein Attenuates Neuroinflammation by Inhibiting NLRP3/caspase-1/GSDMD Pathway in MPTP Induced Mice Model of Parkinson's Disease.
Wenjuan Rui, Sheng Li, Hong Xiao, Ming Xiao, Jingping Shi. Int J Neuropsychopharmacol 2020
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MPTP-driven NLRP3 inflammasome activation in microglia plays a central role in dopaminergic neurodegeneration.
Eunju Lee, Inhwa Hwang, Sangjun Park, Sujeong Hong, Boreum Hwang, Yoeseph Cho, Junghyun Son, Je-Wook Yu. Cell Death Differ 2019
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Inhibition of the hepatic Nlrp3 protects dopaminergic neurons via attenuating systemic inflammation in a MPTP/p mouse model of Parkinson's disease.
Chen Qiao, Qian Zhang, Qingling Jiang, Ting Zhang, Miaomiao Chen, Yi Fan, Jianhua Ding, Ming Lu, Gang Hu. J Neuroinflammation 2018
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Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity.
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Diverging inflammasome signals in tumorigenesis and potential targeting.
Rajendra Karki, Thirumala-Devi Kanneganti. Nat Rev Cancer 2019
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The science of stroke: mechanisms in search of treatments.
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Parkin and PINK1 mitigate STING-induced inflammation.
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AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC.
Veit Hornung, Andrea Ablasser, Marie Charrel-Dennis, Franz Bauernfeind, Gabor Horvath, Daniel R Caffrey, Eicke Latz, Katherine A Fitzgerald. Nature 2009
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Multiple inflammasome complexes are activated in autistic spectrum disorders.
Marina Saresella, Federica Piancone, Ivana Marventano, Martina Zoppis, Ambra Hernis, Michela Zanette, Daria Trabattoni, Matteo Chiappedi, Alessandro Ghezzo, Maria Paola Canevini,[...]. Brain Behav Immun 2016
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Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA.
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Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway.
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The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation.
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Post-stroke cognitive impairment is common even after successful clinical recovery.
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Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis.
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Inhibition of AIM2 inflammasome activation by a novel transcript isoform of IFI16.
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The involvement of NLRP3 inflammasome in the treatment of Alzheimer's disease.
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AIM 2 inflammasomes regulate neuronal morphology and influence anxiety and memory in mice.
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Synthetic oligodeoxynucleotides containing suppressive TTAGGG motifs inhibit AIM2 inflammasome activation.
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Summary-Based Methylome-Wide Association Analyses Suggest Potential Genetically Driven Epigenetic Heterogeneity of Alzheimer's Disease.
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20
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.