Christopher B Ryder, Hannah C Kondolf, Meghan E O'Keefe, Bowen Zhou, Derek W Abbott. J Mol Biol 2022
Times Cited: 7
Times Cited: 7
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Gasdermin E suppresses tumour growth by activating anti-tumour immunity.
Zhibin Zhang, Ying Zhang, Shiyu Xia, Qing Kong, Shunying Li, Xing Liu, Caroline Junqueira, Karla F Meza-Sosa, Temy Mo Yin Mok, James Ansara,[...]. Nature 2020
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Punching Holes in Cellular Membranes: Biology and Evolution of Gasdermins.
Elke De Schutter, Ria Roelandt, Franck B Riquet, Guy Van Camp, Andy Wullaert, Peter Vandenabeele. Trends Cell Biol 2021
Elke De Schutter, Ria Roelandt, Franck B Riquet, Guy Van Camp, Andy Wullaert, Peter Vandenabeele. Trends Cell Biol 2021
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Single-cell analysis of pyroptosis dynamics reveals conserved GSDMD-mediated subcellular events that precede plasma membrane rupture.
Nathalia M de Vasconcelos, Nina Van Opdenbosch, Hanne Van Gorp, Eef Parthoens, Mohamed Lamkanfi. Cell Death Differ 2019
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Pathogenic ubiquitination of GSDMB inhibits NK cell bactericidal functions.
Justin M Hansen, Maarten F de Jong, Qi Wu, Li-Shu Zhang, David B Heisler, Laura T Alto, Neal M Alto. Cell 2021
Justin M Hansen, Maarten F de Jong, Qi Wu, Li-Shu Zhang, David B Heisler, Laura T Alto, Neal M Alto. Cell 2021
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Analysis of rs8067378 Polymorphism in the Risk of Uterine Cervical Cancer from a Polish Population and its Impact on Gasdermin B Expression.
Anna Lutkowska, Andrzej Roszak, Margarita Lianeri, Anna Sowińska, Emianka Sotiri, Pawel P Jagodziński. Mol Diagn Ther 2017
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Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling.
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Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation.
Corey Rogers, Dan A Erkes, Alexandria Nardone, Andrew E Aplin, Teresa Fernandes-Alnemri, Emad S Alnemri. Nat Commun 2019
Corey Rogers, Dan A Erkes, Alexandria Nardone, Andrew E Aplin, Teresa Fernandes-Alnemri, Emad S Alnemri. Nat Commun 2019
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Gene polymorphism linked to increased asthma and IBD risk alters gasdermin-B structure, a sulfatide and phosphoinositide binding protein.
Kinlin L Chao, Liudmila Kulakova, Osnat Herzberg. Proc Natl Acad Sci U S A 2017
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GSDMB promotes non-canonical pyroptosis by enhancing caspase-4 activity.
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Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin.
Yupeng Wang, Wenqing Gao, Xuyan Shi, Jingjin Ding, Wang Liu, Huabin He, Kun Wang, Feng Shao. Nature 2017
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Members of a novel gene family, Gsdm, are expressed exclusively in the epithelium of the skin and gastrointestinal tract in a highly tissue-specific manner.
Masaru Tamura, Shigekazu Tanaka, Tomoaki Fujii, Aya Aoki, Hiromitu Komiyama, Kiyoshi Ezawa, Kenta Sumiyama, Tomoko Sagai, Toshihiko Shiroishi. Genomics 2007
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HMGB1 released from GSDME-mediated pyroptotic epithelial cells participates in the tumorigenesis of colitis-associated colorectal cancer through the ERK1/2 pathway.
Gao Tan, Chongyang Huang, Jiaye Chen, Fachao Zhi. J Hematol Oncol 2020
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PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis.
Junwei Hou, Rongce Zhao, Weiya Xia, Chiung-Wen Chang, Yun You, Jung-Mao Hsu, Lei Nie, Yeh Chen, Yu-Chuan Wang, Chunxiao Liu,[...]. Nat Cell Biol 2020
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FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation.
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The gasdermins, a protein family executing cell death and inflammation.
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Pore-forming activity and structural autoinhibition of the gasdermin family.
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Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells.
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Gasdermin (Gsdm) localizing to mouse Chromosome 11 is predominantly expressed in upper gastrointestinal tract but significantly suppressed in human gastric cancer cells.
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A functional splice variant associated with decreased asthma risk abolishes the ability of gasdermin B to induce epithelial cell pyroptosis.
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GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death.
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GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes.
Robin A Aglietti, Alberto Estevez, Aaron Gupta, Monica Gonzalez Ramirez, Peter S Liu, Nobuhiko Kayagaki, Claudio Ciferri, Vishva M Dixit, Erin C Dueber. Proc Natl Acad Sci U S A 2016
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Chemotherapeutic paclitaxel and cisplatin differentially induce pyroptosis in A549 lung cancer cells via caspase-3/GSDME activation.
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Gasdermin-B promotes invasion and metastasis in breast cancer cells.
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Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death.
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Determination of the Potential Tumor-Suppressive Effects of Gsdme in a Chemically Induced and in a Genetically Modified Intestinal Cancer Mouse Model.
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Intracellular Delivery of an Antibody Targeting Gasdermin-B Reduces HER2 Breast Cancer Aggressiveness.
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A bioorthogonal system reveals antitumour immune function of pyroptosis.
Qinyang Wang, Yupeng Wang, Jingjin Ding, Chunhong Wang, Xuehan Zhou, Wenqing Gao, Huanwei Huang, Feng Shao, Zhibo Liu. Nature 2020
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Alu-derived cis-element regulates tumorigenesis-dependent gastric expression of GASDERMIN B (GSDMB).
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Succination inactivates gasdermin D and blocks pyroptosis.
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Gasdermin B expression predicts poor clinical outcome in HER2-positive breast cancer.
Marta Hergueta-Redondo, David Sarrio, Ángela Molina-Crespo, Rocío Vicario, Cristina Bernadó-Morales, Lidia Martínez, Alejandro Rojo-Sebastián, Jordi Serra-Musach, Alba Mota, Ángel Martínez-Ramírez,[...]. Oncotarget 2016
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N-terminal functional domain of Gasdermin A3 regulates mitochondrial homeostasis via mitochondrial targeting.
Pei-Hsuan Lin, Hsien-Yi Lin, Cheng-Chin Kuo, Liang-Tung Yang. J Biomed Sci 2015
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Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.
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ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation.
Sebastian Rühl, Kateryna Shkarina, Benjamin Demarco, Rosalie Heilig, José Carlos Santos, Petr Broz. Science 2018
Sebastian Rühl, Kateryna Shkarina, Benjamin Demarco, Rosalie Heilig, José Carlos Santos, Petr Broz. Science 2018
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Cryo-EM structure of the gasdermin A3 membrane pore.
Jianbin Ruan, Shiyu Xia, Xing Liu, Judy Lieberman, Hao Wu. Nature 2018
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Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion.
Wan-ting He, Haoqiang Wan, Lichen Hu, Pengda Chen, Xin Wang, Zhe Huang, Zhang-Hua Yang, Chuan-Qi Zhong, Jiahuai Han. Cell Res 2015
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Distinctive expression and function of four GSDM family genes (GSDMA-D) in normal and malignant upper gastrointestinal epithelium.
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Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection.
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Transcriptional control of the HERV-H LTR element of the GSDML gene in human tissues and cancer cells.
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IRF2 transcriptionally induces GSDMD expression for pyroptosis.
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Gasdermin C Is Upregulated by Inactivation of Transforming Growth Factor β Receptor Type II in the Presence of Mutated Apc, Promoting Colorectal Cancer Proliferation.
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Gasdermin D Exerts Anti-inflammatory Effects by Promoting Neutrophil Death.
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Loss of conserved Gsdma3 self-regulation causes autophagy and cell death.
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Mitochondrial ROS promote macrophage pyroptosis by inducing GSDMD oxidation.
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The metabolite α-KG induces GSDMC-dependent pyroptosis through death receptor 6-activated caspase-8.
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Chemotherapy-induced pyroptosis is mediated by BAK/BAX-caspase-3-GSDME pathway and inhibited by 2-bromopalmitate.
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USP24-GSDMB complex promotes bladder cancer proliferation via activation of the STAT3 pathway.
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Cathepsin G Inhibition by Serpinb1 and Serpinb6 Prevents Programmed Necrosis in Neutrophils and Monocytes and Reduces GSDMD-Driven Inflammation.
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Gasdermin D plays a vital role in the generation of neutrophil extracellular traps.
Gabriel Sollberger, Axel Choidas, Garth Lawrence Burn, Peter Habenberger, Raffaella Di Lucrezia, Susanne Kordes, Sascha Menninger, Jan Eickhoff, Peter Nussbaumer, Bert Klebl,[...]. Sci Immunol 2018
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Chemical disruption of the pyroptotic pore-forming protein gasdermin D inhibits inflammatory cell death and sepsis.
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Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.