Sebastian Rühl, Petr Broz. J Mol Biol 2022
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Times Cited: 1
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GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death.
Lorenzo Sborgi, Sebastian Rühl, Estefania Mulvihill, Joka Pipercevic, Rosalie Heilig, Henning Stahlberg, Christopher J Farady, Daniel J Müller, Petr Broz, Sebastian Hiller. EMBO J 2016
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Single-cell analysis of pyroptosis dynamics reveals conserved GSDMD-mediated subcellular events that precede plasma membrane rupture.
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Gasdermin E deficiency attenuates acute kidney injury by inhibiting pyroptosis and inflammation.
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Fiery Cell Death: Pyroptosis in the Central Nervous System.
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Itaconate and fumarate derivatives inhibit priming and activation of the canonical NLRP3 inflammasome in macrophages.
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A Role for the Inflammasome in Spontaneous Preterm Labor With Acute Histologic Chorioamnionitis.
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Intracellular Delivery of an Antibody Targeting Gasdermin-B Reduces HER2 Breast Cancer Aggressiveness.
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Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells.
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Mutations in the gene encoding pejvakin, a newly identified protein of the afferent auditory pathway, cause DFNB59 auditory neuropathy.
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The cleavage of gasdermin D by caspase-11 promotes tubular epithelial cell pyroptosis and urinary IL-18 excretion in acute kidney injury.
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The Gasdermin-D pore acts as a conduit for IL-1β secretion in mice.
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Pyroptosis and its relationship to atherosclerosis.
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Severe Acute Respiratory Syndrome Coronavirus Viroporin 3a Activates the NLRP3 Inflammasome.
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Succination inactivates gasdermin D and blocks pyroptosis.
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Gasdermin E suppresses tumour growth by activating anti-tumour immunity.
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Gasdermin B expression predicts poor clinical outcome in HER2-positive breast cancer.
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SARS-CoV-2 N protein promotes NLRP3 inflammasome activation to induce hyperinflammation.
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SARS-CoV-2 non-structural protein 6 triggers NLRP3-dependent pyroptosis by targeting ATP6AP1.
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SARS-Coronavirus Open Reading Frame-8b triggers intracellular stress pathways and activates NLRP3 inflammasomes.
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Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.