Sayantan Chatterjee, Yelena Kan, Mateusz Brzezinski, Kaloian Koynov, Roshan Mammen Regy, Anastasia C Murthy, Kathleen A Burke, Jasper J Michels, Jeetain Mittal, Nicolas L Fawzi, Sapun H Parekh. Adv Sci (Weinh) 2022
Times Cited: 2
Times Cited: 2
Times Cited
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Structure of FUS Protein Fibrils and Its Relevance to Self-Assembly and Phase Separation of Low-Complexity Domains.
Dylan T Murray, Masato Kato, Yi Lin, Kent R Thurber, Ivan Hung, Steven L McKnight, Robert Tycko. Cell 2017
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RNA buffers the phase separation behavior of prion-like RNA binding proteins.
Shovamayee Maharana, Jie Wang, Dimitrios K Papadopoulos, Doris Richter, Andrey Pozniakovsky, Ina Poser, Marc Bickle, Sandra Rizk, Jordina Guillén-Boixet, Titus M Franzmann,[...]. Science 2018
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Molecular interactions underlying liquid-liquid phase separation of the FUS low-complexity domain.
Anastasia C Murthy, Gregory L Dignon, Yelena Kan, Gül H Zerze, Sapun H Parekh, Jeetain Mittal, Nicolas L Fawzi. Nat Struct Mol Biol 2019
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Phosphorylation of the FUS low-complexity domain disrupts phase separation, aggregation, and toxicity.
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Residue-by-Residue View of In Vitro FUS Granules that Bind the C-Terminal Domain of RNA Polymerase II.
Kathleen A Burke, Abigail M Janke, Christy L Rhine, Nicolas L Fawzi. Mol Cell 2015
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Application of Nile red, a fluorescent hydrophobic probe, for the detection of neutral lipid deposits in tissue sections: comparison with oil red O.
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ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function.
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The RNA binding protein TLS is translocated to dendritic spines by mGluR5 activation and regulates spine morphology.
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Phase transitions in the assembly of multivalent signalling proteins.
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Nile red fluorescence for quantitative monitoring of micropolarity and microviscosity of pluronic F127 in aqueous media.
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A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation.
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Raman spectroscopic characterization of secondary structure in natively unfolded proteins: alpha-synuclein.
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The C-terminal threonine of Aβ43 nucleates toxic aggregation via structural and dynamical changes in monomers and protofibrils.
Alexander E Conicella, Nicolas L Fawzi. Biochemistry 2014
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Probing exchange kinetics and atomic resolution dynamics in high-molecular-weight complexes using dark-state exchange saturation transfer NMR spectroscopy.
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Partitioning of cancer therapeutics in nuclear condensates.
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Stress- and ubiquitylation-dependent phase separation of the proteasome.
Sayaka Yasuda, Hikaru Tsuchiya, Ai Kaiho, Qiang Guo, Ken Ikeuchi, Akinori Endo, Naoko Arai, Fumiaki Ohtake, Shigeo Murata, Toshifumi Inada,[...]. Nature 2020
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Self-assembled FUS binds active chromatin and regulates gene transcription.
Liuqing Yang, Jozsef Gal, Jing Chen, Haining Zhu. Proc Natl Acad Sci U S A 2014
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Position-dependent FUS-RNA interactions regulate alternative splicing events and transcriptions.
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Atomic-resolution dynamics on the surface of amyloid-β protofibrils probed by solution NMR.
Nicolas L Fawzi, Jinfa Ying, Rodolfo Ghirlando, Dennis A Torchia, G Marius Clore. Nature 2011
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Particle-tracking microrheology of living cells: principles and applications.
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RNA Controls PolyQ Protein Phase Transitions.
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Therapeutics-how to treat phase separation-associated diseases.
Richard John Wheeler. Emerg Top Life Sci 2020
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Cell-free formation of RNA granules: low complexity sequence domains form dynamic fibers within hydrogels.
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Misregulated RNA processing in amyotrophic lateral sclerosis.
Magdalini Polymenidou, Clotilde Lagier-Tourenne, Kasey R Hutt, C Frank Bennett, Don W Cleveland, Gene W Yeo. Brain Res 2012
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A genetically engineered protein responsive to multiple stimuli.
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Spontaneous driving forces give rise to protein-RNA condensates with coexisting phases and complex material properties.
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Different Material States of Pub1 Condensates Define Distinct Modes of Stress Adaptation and Recovery.
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RNA seeds higher-order assembly of FUS protein.
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Hydrogen bond guidance and aromatic stacking drive liquid-liquid phase separation of intrinsically disordered histidine-rich peptides.
Bartosz Gabryelczyk, Hao Cai, Xiangyan Shi, Yue Sun, Piet J M Swinkels, Stefan Salentinig, Konstantin Pervushin, Ali Miserez. Nat Commun 2019
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Pi-Pi contacts are an overlooked protein feature relevant to phase separation.
Robert McCoy Vernon, Paul Andrew Chong, Brian Tsang, Tae Hun Kim, Alaji Bah, Patrick Farber, Hong Lin, Julie Deborah Forman-Kay. Elife 2018
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Phase separation by low complexity domains promotes stress granule assembly and drives pathological fibrillization.
Amandine Molliex, Jamshid Temirov, Jihun Lee, Maura Coughlin, Anderson P Kanagaraj, Hong Joo Kim, Tanja Mittag, J Paul Taylor. Cell 2015
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ALS Mutations Disrupt Phase Separation Mediated by α-Helical Structure in the TDP-43 Low-Complexity C-Terminal Domain.
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RNA-binding proteins with prion-like domains in health and disease.
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Probing the transient dark state of substrate binding to GroEL by relaxation-based solution NMR.
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Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.