Abhishek Chandra, Anthony B Lagnado, Joshua N Farr, Madison Doolittle, Tamara Tchkonia, James L Kirkland, Nathan K LeBrasseur, Paul D Robbins, Laura J Niedernhofer, Yuji Ikeno, João F Passos, David G Monroe, Robert J Pignolo, Sundeep Khosla. Aging Cell 2022
Times Cited: 3
Times Cited: 3
Times Cited
Times Co-cited
Similarity
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders.
Darren J Baker, Tobias Wijshake, Tamar Tchkonia, Nathan K LeBrasseur, Bennett G Childs, Bart van de Sluis, James L Kirkland, Jan M van Deursen. Nature 2011
Darren J Baker, Tobias Wijshake, Tamar Tchkonia, Nathan K LeBrasseur, Bennett G Childs, Bart van de Sluis, James L Kirkland, Jan M van Deursen. Nature 2011
100
Senolytics improve physical function and increase lifespan in old age.
Ming Xu, Tamar Pirtskhalava, Joshua N Farr, Bettina M Weigand, Allyson K Palmer, Megan M Weivoda, Christina L Inman, Mikolaj B Ogrodnik, Christine M Hachfeld, Daniel G Fraser,[...]. Nat Med 2018
Ming Xu, Tamar Pirtskhalava, Joshua N Farr, Bettina M Weigand, Allyson K Palmer, Megan M Weivoda, Christina L Inman, Mikolaj B Ogrodnik, Christine M Hachfeld, Daniel G Fraser,[...]. Nat Med 2018
100
Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan.
Darren J Baker, Bennett G Childs, Matej Durik, Melinde E Wijers, Cynthia J Sieben, Jian Zhong, Rachel A Saltness, Karthik B Jeganathan, Grace Casaclang Verzosa, Abdulmohammad Pezeshki,[...]. Nature 2016
Darren J Baker, Bennett G Childs, Matej Durik, Melinde E Wijers, Cynthia J Sieben, Jian Zhong, Rachel A Saltness, Karthik B Jeganathan, Grace Casaclang Verzosa, Abdulmohammad Pezeshki,[...]. Nature 2016
100
Targeting senescent cells alleviates obesity-induced metabolic dysfunction.
Allyson K Palmer, Ming Xu, Yi Zhu, Tamar Pirtskhalava, Megan M Weivoda, Christine M Hachfeld, Larissa G Prata, Theo H van Dijk, Esther Verkade, Grace Casaclang-Verzosa,[...]. Aging Cell 2019
Allyson K Palmer, Ming Xu, Yi Zhu, Tamar Pirtskhalava, Megan M Weivoda, Christine M Hachfeld, Larissa G Prata, Theo H van Dijk, Esther Verkade, Grace Casaclang-Verzosa,[...]. Aging Cell 2019
100
Targeting cellular senescence prevents age-related bone loss in mice.
Joshua N Farr, Ming Xu, Megan M Weivoda, David G Monroe, Daniel G Fraser, Jennifer L Onken, Brittany A Negley, Jad G Sfeir, Mikolaj B Ogrodnik, Christine M Hachfeld,[...]. Nat Med 2017
Joshua N Farr, Ming Xu, Megan M Weivoda, David G Monroe, Daniel G Fraser, Jennifer L Onken, Brittany A Negley, Jad G Sfeir, Mikolaj B Ogrodnik, Christine M Hachfeld,[...]. Nat Med 2017
100
Cellular senescence and the senescent secretory phenotype: therapeutic opportunities.
Tamara Tchkonia, Yi Zhu, Jan van Deursen, Judith Campisi, James L Kirkland. J Clin Invest 2013
Tamara Tchkonia, Yi Zhu, Jan van Deursen, Judith Campisi, James L Kirkland. J Clin Invest 2013
66
A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4.
M Serrano, G J Hannon, D Beach. Nature 1993
M Serrano, G J Hannon, D Beach. Nature 1993
66
An inducible p21-Cre mouse model to monitor and manipulate p21-highly-expressing senescent cells in vivo.
Binsheng Wang, Lichao Wang, Nathan S Gasek, Yueying Zhou, Taewan Kim, Chun Guo, Evan R Jellison, Laura Haynes, Sumit Yadav, Tamar Tchkonia,[...]. Nat Aging 2021
Binsheng Wang, Lichao Wang, Nathan S Gasek, Yueying Zhou, Taewan Kim, Chun Guo, Evan R Jellison, Laura Haynes, Sumit Yadav, Tamar Tchkonia,[...]. Nat Aging 2021
66
Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment.
Ok Hee Jeon, Chaekyu Kim, Remi-Martin Laberge, Marco Demaria, Sona Rathod, Alain P Vasserot, Jae Wook Chung, Do Hun Kim, Yan Poon, Nathaniel David,[...]. Nat Med 2017
Ok Hee Jeon, Chaekyu Kim, Remi-Martin Laberge, Marco Demaria, Sona Rathod, Alain P Vasserot, Jae Wook Chung, Do Hun Kim, Yan Poon, Nathaniel David,[...]. Nat Med 2017
66
Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts.
D A Alcorta, Y Xiong, D Phelps, G Hannon, D Beach, J C Barrett. Proc Natl Acad Sci U S A 1996
D A Alcorta, Y Xiong, D Phelps, G Hannon, D Beach, J C Barrett. Proc Natl Acad Sci U S A 1996
66
Length-independent telomere damage drives post-mitotic cardiomyocyte senescence.
Rhys Anderson, Anthony Lagnado, Damien Maggiorani, Anna Walaszczyk, Emily Dookun, James Chapman, Jodie Birch, Hanna Salmonowicz, Mikolaj Ogrodnik, Diana Jurk,[...]. EMBO J 2019
Rhys Anderson, Anthony Lagnado, Damien Maggiorani, Anna Walaszczyk, Emily Dookun, James Chapman, Jodie Birch, Hanna Salmonowicz, Mikolaj Ogrodnik, Diana Jurk,[...]. EMBO J 2019
66
Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts.
G H Stein, L F Drullinger, A Soulard, V Dulić. Mol Cell Biol 1999
G H Stein, L F Drullinger, A Soulard, V Dulić. Mol Cell Biol 1999
66
Aging, Cell Senescence, and Chronic Disease: Emerging Therapeutic Strategies.
Tamara Tchkonia, James L Kirkland. JAMA 2018
Tamara Tchkonia, James L Kirkland. JAMA 2018
66
The senescence-associated secretory phenotype: the dark side of tumor suppression.
Jean-Philippe Coppé, Pierre-Yves Desprez, Ana Krtolica, Judith Campisi. Annu Rev Pathol 2010
Jean-Philippe Coppé, Pierre-Yves Desprez, Ana Krtolica, Judith Campisi. Annu Rev Pathol 2010
66
The serial cultivation of human diploid cell strains.
L HAYFLICK, P S MOORHEAD. Exp Cell Res 1961
L HAYFLICK, P S MOORHEAD. Exp Cell Res 1961
66
Cellular Senescence Promotes Skin Carcinogenesis through p38MAPK and p44/42MAPK Signaling.
Fatouma Alimirah, Tanya Pulido, Alexis Valdovinos, Sena Alptekin, Emily Chang, Elijah Jones, Diego A Diaz, Jose Flores, Michael C Velarde, Marco Demaria,[...]. Cancer Res 2020
Fatouma Alimirah, Tanya Pulido, Alexis Valdovinos, Sena Alptekin, Emily Chang, Elijah Jones, Diego A Diaz, Jose Flores, Michael C Velarde, Marco Demaria,[...]. Cancer Res 2020
66
Cellular senescence in aging and age-related disease: from mechanisms to therapy.
Bennett G Childs, Matej Durik, Darren J Baker, Jan M van Deursen. Nat Med 2015
Bennett G Childs, Matej Durik, Darren J Baker, Jan M van Deursen. Nat Med 2015
66
An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA.
Marco Demaria, Naoko Ohtani, Sameh A Youssef, Francis Rodier, Wendy Toussaint, James R Mitchell, Remi-Martin Laberge, Jan Vijg, Harry Van Steeg, Martijn E T Dollé,[...]. Dev Cell 2014
Marco Demaria, Naoko Ohtani, Sameh A Youssef, Francis Rodier, Wendy Toussaint, James R Mitchell, Remi-Martin Laberge, Jan Vijg, Harry Van Steeg, Martijn E T Dollé,[...]. Dev Cell 2014
66
Senescence is a developmental mechanism that contributes to embryonic growth and patterning.
Mekayla Storer, Alba Mas, Alexandre Robert-Moreno, Matteo Pecoraro, M Carmen Ortells, Valeria Di Giacomo, Reut Yosef, Noam Pilpel, Valery Krizhanovsky, James Sharpe,[...]. Cell 2013
Mekayla Storer, Alba Mas, Alexandre Robert-Moreno, Matteo Pecoraro, M Carmen Ortells, Valeria Di Giacomo, Reut Yosef, Noam Pilpel, Valery Krizhanovsky, James Sharpe,[...]. Cell 2013
66
A proteomic atlas of senescence-associated secretomes for aging biomarker development.
Nathan Basisty, Abhijit Kale, Ok Hee Jeon, Chisaka Kuehnemann, Therese Payne, Chirag Rao, Anja Holtz, Samah Shah, Vagisha Sharma, Luigi Ferrucci,[...]. PLoS Biol 2020
Nathan Basisty, Abhijit Kale, Ok Hee Jeon, Chisaka Kuehnemann, Therese Payne, Chirag Rao, Anja Holtz, Samah Shah, Vagisha Sharma, Luigi Ferrucci,[...]. PLoS Biol 2020
66
Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor.
Jean-Philippe Coppé, Christopher K Patil, Francis Rodier, Yu Sun, Denise P Muñoz, Joshua Goldstein, Peter S Nelson, Pierre-Yves Desprez, Judith Campisi. PLoS Biol 2008
Jean-Philippe Coppé, Christopher K Patil, Francis Rodier, Yu Sun, Denise P Muñoz, Joshua Goldstein, Peter S Nelson, Pierre-Yves Desprez, Judith Campisi. PLoS Biol 2008
66
Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity.
Lichao Wang, Binsheng Wang, Nathan S Gasek, Yueying Zhou, Rachel L Cohn, Dominique E Martin, Wulin Zuo, William F Flynn, Chun Guo, Evan R Jellison,[...]. Cell Metab 2022
Lichao Wang, Binsheng Wang, Nathan S Gasek, Yueying Zhou, Rachel L Cohn, Dominique E Martin, Wulin Zuo, William F Flynn, Chun Guo, Evan R Jellison,[...]. Cell Metab 2022
66
Ink4a/Arf expression is a biomarker of aging.
Janakiraman Krishnamurthy, Chad Torrice, Matthew R Ramsey, Grigoriy I Kovalev, Khalid Al-Regaiey, Lishan Su, Norman E Sharpless. J Clin Invest 2004
Janakiraman Krishnamurthy, Chad Torrice, Matthew R Ramsey, Grigoriy I Kovalev, Khalid Al-Regaiey, Lishan Su, Norman E Sharpless. J Clin Invest 2004
66
Cellular senescence and its effector programs.
Rafik Salama, Mahito Sadaie, Matthew Hoare, Masashi Narita. Genes Dev 2014
Rafik Salama, Mahito Sadaie, Matthew Hoare, Masashi Narita. Genes Dev 2014
66
66
Programmed cell senescence during mammalian embryonic development.
Daniel Muñoz-Espín, Marta Cañamero, Antonio Maraver, Gonzalo Gómez-López, Julio Contreras, Silvia Murillo-Cuesta, Alfonso Rodríguez-Baeza, Isabel Varela-Nieto, Jesús Ruberte, Manuel Collado,[...]. Cell 2013
Daniel Muñoz-Espín, Marta Cañamero, Antonio Maraver, Gonzalo Gómez-López, Julio Contreras, Silvia Murillo-Cuesta, Alfonso Rodríguez-Baeza, Isabel Varela-Nieto, Jesús Ruberte, Manuel Collado,[...]. Cell 2013
66
The role of cellular senescence in ageing and endocrine disease.
Sundeep Khosla, Joshua N Farr, Tamara Tchkonia, James L Kirkland. Nat Rev Endocrinol 2020
Sundeep Khosla, Joshua N Farr, Tamara Tchkonia, James L Kirkland. Nat Rev Endocrinol 2020
33
PTH1-34 alleviates radiotherapy-induced local bone loss by improving osteoblast and osteocyte survival.
Abhishek Chandra, Tiao Lin, Mary Beth Tribble, Ji Zhu, Allison R Altman, Wei-Ju Tseng, Yejia Zhang, Sunday O Akintoye, Keith Cengel, X Sherry Liu,[...]. Bone 2014
Abhishek Chandra, Tiao Lin, Mary Beth Tribble, Ji Zhu, Allison R Altman, Wei-Ju Tseng, Yejia Zhang, Sunday O Akintoye, Keith Cengel, X Sherry Liu,[...]. Bone 2014
33
Potential role of senescence in radiation-induced damage of the aged skeleton.
Abhishek Chandra, Sean S Park, Robert J Pignolo. Bone 2019
Abhishek Chandra, Sean S Park, Robert J Pignolo. Bone 2019
33
Bone Marrow Adiposity in Models of Radiation- and Aging-Related Bone Loss Is Dependent on Cellular Senescence.
Abhishek Chandra, Anthony B Lagnado, Joshua N Farr, Megan Schleusner, David G Monroe, Dominik Saul, João F Passos, Sundeep Khosla, Robert J Pignolo. J Bone Miner Res 2022
Abhishek Chandra, Anthony B Lagnado, Joshua N Farr, Megan Schleusner, David G Monroe, Dominik Saul, João F Passos, Sundeep Khosla, Robert J Pignolo. J Bone Miner Res 2022
100
p21 both attenuates and drives senescence and aging in BubR1 progeroid mice.
Darren J Baker, Robbyn L Weaver, Jan M van Deursen. Cell Rep 2013
Darren J Baker, Robbyn L Weaver, Jan M van Deursen. Cell Rep 2013
33
Targeted Reduction of Senescent Cell Burden Alleviates Focal Radiotherapy-Related Bone Loss.
Abhishek Chandra, Anthony B Lagnado, Joshua N Farr, David G Monroe, Sean Park, Christine Hachfeld, Tamar Tchkonia, James L Kirkland, Sundeep Khosla, João F Passos,[...]. J Bone Miner Res 2020
Abhishek Chandra, Anthony B Lagnado, Joshua N Farr, David G Monroe, Sean Park, Christine Hachfeld, Tamar Tchkonia, James L Kirkland, Sundeep Khosla, João F Passos,[...]. J Bone Miner Res 2020
33
Site-specific integrase-mediated transgenesis in mice via pronuclear injection.
Bosiljka Tasic, Simon Hippenmeyer, Charlene Wang, Matthew Gamboa, Hui Zong, Yanru Chen-Tsai, Liqun Luo. Proc Natl Acad Sci U S A 2011
Bosiljka Tasic, Simon Hippenmeyer, Charlene Wang, Matthew Gamboa, Hui Zong, Yanru Chen-Tsai, Liqun Luo. Proc Natl Acad Sci U S A 2011
33
Identification of Senescent Cells in the Bone Microenvironment.
Joshua N Farr, Daniel G Fraser, Haitao Wang, Katharina Jaehn, Mikolaj B Ogrodnik, Megan M Weivoda, Matthew T Drake, Tamara Tchkonia, Nathan K LeBrasseur, James L Kirkland,[...]. J Bone Miner Res 2016
Joshua N Farr, Daniel G Fraser, Haitao Wang, Katharina Jaehn, Mikolaj B Ogrodnik, Megan M Weivoda, Matthew T Drake, Tamara Tchkonia, Nathan K LeBrasseur, James L Kirkland,[...]. J Bone Miner Res 2016
33
Effects of p21 deletion in mouse models of premature aging.
Erica K Benson, Bo Zhao, David A Sassoon, Sam W Lee, Stuart A Aaronson. Cell Cycle 2009
Erica K Benson, Bo Zhao, David A Sassoon, Sam W Lee, Stuart A Aaronson. Cell Cycle 2009
33
Long-term loss of osteoclasts and unopposed cortical mineral apposition following limited field irradiation.
Megan E Oest, Veerle Franken, Timothy Kuchera, Judy Strauss, Timothy A Damron. J Orthop Res 2015
Megan E Oest, Veerle Franken, Timothy Kuchera, Judy Strauss, Timothy A Damron. J Orthop Res 2015
33
Targeting senescent cells enhances adipogenesis and metabolic function in old age.
Ming Xu, Allyson K Palmer, Husheng Ding, Megan M Weivoda, Tamar Pirtskhalava, Thomas A White, Anna Sepe, Kurt O Johnson, Michael B Stout, Nino Giorgadze,[...]. Elife 2015
Ming Xu, Allyson K Palmer, Husheng Ding, Megan M Weivoda, Tamar Pirtskhalava, Thomas A White, Anna Sepe, Kurt O Johnson, Michael B Stout, Nino Giorgadze,[...]. Elife 2015
33
Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation.
Marzia Fumagalli, Francesca Rossiello, Michela Clerici, Sara Barozzi, Davide Cittaro, Jessica M Kaplunov, Gabriele Bucci, Miryana Dobreva, Valentina Matti, Christian M Beausejour,[...]. Nat Cell Biol 2012
Marzia Fumagalli, Francesca Rossiello, Michela Clerici, Sara Barozzi, Davide Cittaro, Jessica M Kaplunov, Gabriele Bucci, Miryana Dobreva, Valentina Matti, Christian M Beausejour,[...]. Nat Cell Biol 2012
33
Proteasome inhibitor bortezomib is a novel therapeutic agent for focal radiation-induced osteoporosis.
Abhishek Chandra, Luqiang Wang, Tiffany Young, Leilei Zhong, Wei-Ju Tseng, Michael A Levine, Keith Cengel, X Sherry Liu, Yejia Zhang, Robert J Pignolo,[...]. FASEB J 2018
Abhishek Chandra, Luqiang Wang, Tiffany Young, Leilei Zhong, Wei-Ju Tseng, Michael A Levine, Keith Cengel, X Sherry Liu, Yejia Zhang, Robert J Pignolo,[...]. FASEB J 2018
33
Radiation-induced cell cycle arrest compromised by p21 deficiency.
J Brugarolas, C Chandrasekaran, J I Gordon, D Beach, T Jacks, G J Hannon. Nature 1995
J Brugarolas, C Chandrasekaran, J I Gordon, D Beach, T Jacks, G J Hannon. Nature 1995
33
Suppression of Sclerostin Alleviates Radiation-Induced Bone Loss by Protecting Bone-Forming Cells and Their Progenitors Through Distinct Mechanisms.
Abhishek Chandra, Tiao Lin, Tiffany Young, Wei Tong, Xiaoyuan Ma, Wei-Ju Tseng, Ina Kramer, Michaela Kneissel, Michael A Levine, Yejia Zhang,[...]. J Bone Miner Res 2017
Abhishek Chandra, Tiao Lin, Tiffany Young, Wei Tong, Xiaoyuan Ma, Wei-Ju Tseng, Ina Kramer, Michaela Kneissel, Michael A Levine, Yejia Zhang,[...]. J Bone Miner Res 2017
33
Cdkn1a transcript variant 2 is a marker of aging and cellular senescence.
José Alberto López-Domínguez, Sandra Rodríguez-López, Ulises Ahumada-Castro, Pierre-Yves Desprez, Maria Konovalenko, Remi-Martin Laberge, César Cárdenas, José Manuel Villalba, Judith Campisi. Aging (Albany NY) 2021
José Alberto López-Domínguez, Sandra Rodríguez-López, Ulises Ahumada-Castro, Pierre-Yves Desprez, Maria Konovalenko, Remi-Martin Laberge, César Cárdenas, José Manuel Villalba, Judith Campisi. Aging (Albany NY) 2021
33
WAF1, a potential mediator of p53 tumor suppression.
W S el-Deiry, T Tokino, V E Velculescu, D B Levy, R Parsons, J M Trent, D Lin, W E Mercer, K W Kinzler, B Vogelstein. Cell 1993
W S el-Deiry, T Tokino, V E Velculescu, D B Levy, R Parsons, J M Trent, D Lin, W E Mercer, K W Kinzler, B Vogelstein. Cell 1993
33
Topological control of p21WAF1/CIP1 expression in normal and neoplastic tissues.
W S el-Deiry, T Tokino, T Waldman, J D Oliner, V E Velculescu, M Burrell, D E Hill, E Healy, J L Rees, S R Hamilton. Cancer Res 1995
W S el-Deiry, T Tokino, T Waldman, J D Oliner, V E Velculescu, M Burrell, D E Hill, E Healy, J L Rees, S R Hamilton. Cancer Res 1995
33
The bone-fat interface: basic and clinical implications of marrow adiposity.
Maureen J Devlin, Clifford J Rosen. Lancet Diabetes Endocrinol 2015
Maureen J Devlin, Clifford J Rosen. Lancet Diabetes Endocrinol 2015
33
Senescent cell clearance by the immune system: Emerging therapeutic opportunities.
Larissa G P Langhi Prata, Inna G Ovsyannikova, Tamara Tchkonia, James L Kirkland. Semin Immunol 2018
Larissa G P Langhi Prata, Inna G Ovsyannikova, Tamara Tchkonia, James L Kirkland. Semin Immunol 2018
33
Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence.
Graeme Hewitt, Diana Jurk, Francisco D M Marques, Clara Correia-Melo, Timothy Hardy, Agata Gackowska, Rhys Anderson, Morgan Taschuk, Jelena Mann, João F Passos. Nat Commun 2012
Graeme Hewitt, Diana Jurk, Francisco D M Marques, Clara Correia-Melo, Timothy Hardy, Agata Gackowska, Rhys Anderson, Morgan Taschuk, Jelena Mann, João F Passos. Nat Commun 2012
33
Impairment of osteoblast differentiation due to proliferation-independent telomere dysfunction in mouse models of accelerated aging.
Haitao Wang, Qijun Chen, Seoung-Hoon Lee, Yongwon Choi, Frederick Brad Johnson, Robert J Pignolo. Aging Cell 2012
Haitao Wang, Qijun Chen, Seoung-Hoon Lee, Yongwon Choi, Frederick Brad Johnson, Robert J Pignolo. Aging Cell 2012
33
Fat apoptosis through targeted activation of caspase 8: a new mouse model of inducible and reversible lipoatrophy.
Utpal B Pajvani, Maria E Trujillo, Terry P Combs, Puneeth Iyengar, Linda Jelicks, Kevin A Roth, Richard N Kitsis, Philipp E Scherer. Nat Med 2005
Utpal B Pajvani, Maria E Trujillo, Terry P Combs, Puneeth Iyengar, Linda Jelicks, Kevin A Roth, Richard N Kitsis, Philipp E Scherer. Nat Med 2005
33
The influence of therapeutic radiation on the patterns of bone marrow in ovary-intact and ovariectomized mice.
Susanta K Hui, Leslie Sharkey, Louis S Kidder, Yan Zhang, Greg Fairchild, Kayti Coghill, Cory J Xian, Douglas Yee. PLoS One 2012
Susanta K Hui, Leslie Sharkey, Louis S Kidder, Yan Zhang, Greg Fairchild, Kayti Coghill, Cory J Xian, Douglas Yee. PLoS One 2012
33
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.