Frank A Sinicrope. N Engl J Med 2022
Times Cited: 16
Times Cited: 16
Times Cited
Times Co-cited
Similarity
Screening for Colorectal Cancer: US Preventive Services Task Force Recommendation Statement.
Karina W Davidson, Michael J Barry, Carol M Mangione, Michael Cabana, Aaron B Caughey, Esa M Davis, Katrina E Donahue, Chyke A Doubeni, Alex H Krist, Martha Kubik,[...]. JAMA 2021
Karina W Davidson, Michael J Barry, Carol M Mangione, Michael Cabana, Aaron B Caughey, Esa M Davis, Katrina E Donahue, Chyke A Doubeni, Alex H Krist, Martha Kubik,[...]. JAMA 2021
18
Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries.
Hyuna Sung, Jacques Ferlay, Rebecca L Siegel, Mathieu Laversanne, Isabelle Soerjomataram, Ahmedin Jemal, Freddie Bray. CA Cancer J Clin 2021
Hyuna Sung, Jacques Ferlay, Rebecca L Siegel, Mathieu Laversanne, Isabelle Soerjomataram, Ahmedin Jemal, Freddie Bray. CA Cancer J Clin 2021
18
Changes in colorectal cancer incidence in seven high-income countries: a population-based study.
Marzieh Araghi, Isabelle Soerjomataram, Aude Bardot, Jacques Ferlay, Citadel J Cabasag, David S Morrison, Prithwish De, Hanna Tervonen, Paul M Walsh, Oliver Bucher,[...]. Lancet Gastroenterol Hepatol 2019
Marzieh Araghi, Isabelle Soerjomataram, Aude Bardot, Jacques Ferlay, Citadel J Cabasag, David S Morrison, Prithwish De, Hanna Tervonen, Paul M Walsh, Oliver Bucher,[...]. Lancet Gastroenterol Hepatol 2019
12
Colorectal cancer statistics, 2020.
Rebecca L Siegel, Kimberly D Miller, Ann Goding Sauer, Stacey A Fedewa, Lynn F Butterly, Joseph C Anderson, Andrea Cercek, Robert A Smith, Ahmedin Jemal. CA Cancer J Clin 2020
Rebecca L Siegel, Kimberly D Miller, Ann Goding Sauer, Stacey A Fedewa, Lynn F Butterly, Joseph C Anderson, Andrea Cercek, Robert A Smith, Ahmedin Jemal. CA Cancer J Clin 2020
12
The rising tide of early-onset colorectal cancer: a comprehensive review of epidemiology, clinical features, biology, risk factors, prevention, and early detection.
Swati G Patel, Jordan J Karlitz, Timothy Yen, Christopher H Lieu, C Richard Boland. Lancet Gastroenterol Hepatol 2022
Swati G Patel, Jordan J Karlitz, Timothy Yen, Christopher H Lieu, C Richard Boland. Lancet Gastroenterol Hepatol 2022
12
Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities.
Jiaqi Liu, Qing Xiao, Jiani Xiao, Chenxi Niu, Yuanyuan Li, Xiaojun Zhang, Zhengwei Zhou, Guang Shu, Gang Yin. Signal Transduct Target Ther 2022
Jiaqi Liu, Qing Xiao, Jiani Xiao, Chenxi Niu, Yuanyuan Li, Xiaojun Zhang, Zhengwei Zhou, Guang Shu, Gang Yin. Signal Transduct Target Ther 2022
12
Metagenomic and metabolomic analyses reveal distinct stage-specific phenotypes of the gut microbiota in colorectal cancer.
Shinichi Yachida, Sayaka Mizutani, Hirotsugu Shiroma, Satoshi Shiba, Takeshi Nakajima, Taku Sakamoto, Hikaru Watanabe, Keigo Masuda, Yuichiro Nishimoto, Masaru Kubo,[...]. Nat Med 2019
Shinichi Yachida, Sayaka Mizutani, Hirotsugu Shiroma, Satoshi Shiba, Takeshi Nakajima, Taku Sakamoto, Hikaru Watanabe, Keigo Masuda, Yuichiro Nishimoto, Masaru Kubo,[...]. Nat Med 2019
12
Colorectal cancer screening for average-risk adults: 2018 guideline update from the American Cancer Society.
Andrew M D Wolf, Elizabeth T H Fontham, Timothy R Church, Christopher R Flowers, Carmen E Guerra, Samuel J LaMonte, Ruth Etzioni, Matthew T McKenna, Kevin C Oeffinger, Ya-Chen Tina Shih,[...]. CA Cancer J Clin 2018
Andrew M D Wolf, Elizabeth T H Fontham, Timothy R Church, Christopher R Flowers, Carmen E Guerra, Samuel J LaMonte, Ruth Etzioni, Matthew T McKenna, Kevin C Oeffinger, Ya-Chen Tina Shih,[...]. CA Cancer J Clin 2018
6
Global patterns and trends in colorectal cancer incidence in young adults.
Rebecca L Siegel, Lindsey A Torre, Isabelle Soerjomataram, Richard B Hayes, Freddie Bray, Thomas K Weber, Ahmedin Jemal. Gut 2019
Rebecca L Siegel, Lindsey A Torre, Isabelle Soerjomataram, Richard B Hayes, Freddie Bray, Thomas K Weber, Ahmedin Jemal. Gut 2019
6
Prevalence and Predictors of Young-Onset Colorectal Neoplasia: Insights From a Nationally Representative Colonoscopy Registry.
Parth D Trivedi, Aditi Mohapatra, Melissa K Morris, Shannon A Thorne, Sandy C Smith, Amanda M Ward, Paul Schroy, Heather Hampel, Lina Jandorf, John W Popp,[...]. Gastroenterology 2022
Parth D Trivedi, Aditi Mohapatra, Melissa K Morris, Shannon A Thorne, Sandy C Smith, Amanda M Ward, Paul Schroy, Heather Hampel, Lina Jandorf, John W Popp,[...]. Gastroenterology 2022
12
Adenoma Detection Rates for 45- to 49-Year-Old Screening Population.
Aasma Shaukat, Douglas K Rex, Michael Shyne, Timothy R Church, David G Perdue. Gastroenterology 2022
Aasma Shaukat, Douglas K Rex, Michael Shyne, Timothy R Church, David G Perdue. Gastroenterology 2022
14
Colonoscopy Outcomes in Average-Risk Screening Equivalent Young Adults: Data From the New Hampshire Colonoscopy Registry.
Lynn F Butterly, Rebecca L Siegel, Stacey Fedewa, Christina M Robinson, Ahmedin Jemal, Joseph C Anderson. Am J Gastroenterol 2021
Lynn F Butterly, Rebecca L Siegel, Stacey Fedewa, Christina M Robinson, Ahmedin Jemal, Joseph C Anderson. Am J Gastroenterol 2021
6
Effect of Robotic-Assisted vs Conventional Laparoscopic Surgery on Risk of Conversion to Open Laparotomy Among Patients Undergoing Resection for Rectal Cancer: The ROLARR Randomized Clinical Trial.
David Jayne, Alessio Pigazzi, Helen Marshall, Julie Croft, Neil Corrigan, Joanne Copeland, Phil Quirke, Nick West, Tero Rautio, Niels Thomassen,[...]. JAMA 2017
David Jayne, Alessio Pigazzi, Helen Marshall, Julie Croft, Neil Corrigan, Joanne Copeland, Phil Quirke, Nick West, Tero Rautio, Niels Thomassen,[...]. JAMA 2017
6
Open versus laparoscopic surgery for mid or low rectal cancer after neoadjuvant chemoradiotherapy (COREAN trial): 10-year follow-up of an open-label, non-inferiority, randomised controlled trial.
Ji Won Park, Sung-Bum Kang, Jie Hao, Seok-Byung Lim, Hyo Seong Choi, Duck-Woo Kim, Hee Jin Chang, Dae Yong Kim, Kyung Hae Jung, Tae-You Kim,[...]. Lancet Gastroenterol Hepatol 2021
Ji Won Park, Sung-Bum Kang, Jie Hao, Seok-Byung Lim, Hyo Seong Choi, Duck-Woo Kim, Hee Jin Chang, Dae Yong Kim, Kyung Hae Jung, Tae-You Kim,[...]. Lancet Gastroenterol Hepatol 2021
6
Impact of radiotherapy on anorectal function in patients with rectal cancer following a watch and wait programme.
Marit E van der Sande, Britt J P Hupkens, Maaike Berbée, Sander M J van Kuijk, Monique Maas, Jarno Melenhorst, Geerard L Beets, Stéphanie O Breukink. Radiother Oncol 2019
Marit E van der Sande, Britt J P Hupkens, Maaike Berbée, Sander M J van Kuijk, Monique Maas, Jarno Melenhorst, Geerard L Beets, Stéphanie O Breukink. Radiother Oncol 2019
6
[Complete response after neoadjuvant therapy of rectal cancer: implications for surgery].
Carolin Kastner, Bernhard Petritsch, Joachim Reibetanz, Christoph-Thomas Germer, Armin Wiegering. Chirurg 2022
Carolin Kastner, Bernhard Petritsch, Joachim Reibetanz, Christoph-Thomas Germer, Armin Wiegering. Chirurg 2022
100
Oncological and Survival Outcomes in Watch and Wait Patients With a Clinical Complete Response After Neoadjuvant Chemoradiotherapy for Rectal Cancer: A Systematic Review and Pooled Analysis.
Mit Dattani, Richard J Heald, Ghaleb Goussous, Jack Broadhurst, Guilherme P São Julião, Angelita Habr-Gama, Rodrigo Oliva Perez, Brendan J Moran. Ann Surg 2018
Mit Dattani, Richard J Heald, Ghaleb Goussous, Jack Broadhurst, Guilherme P São Julião, Angelita Habr-Gama, Rodrigo Oliva Perez, Brendan J Moran. Ann Surg 2018
6
Advances in management of adjuvant chemotherapy in rectal cancer: Consequences for clinical practice.
Jeanne Netter, Richard Douard, Catherine Durdux, Bruno Landi, Anne Berger, Julien Taieb. Clin Res Hepatol Gastroenterol 2016
Jeanne Netter, Richard Douard, Catherine Durdux, Bruno Landi, Anne Berger, Julien Taieb. Clin Res Hepatol Gastroenterol 2016
11
Preoperative versus postoperative chemoradiotherapy for locally advanced rectal cancer: results of the German CAO/ARO/AIO-94 randomized phase III trial after a median follow-up of 11 years.
Rolf Sauer, Torsten Liersch, Susanne Merkel, Rainer Fietkau, Werner Hohenberger, Clemens Hess, Heinz Becker, Hans-Rudolf Raab, Marie-Therese Villanueva, Helmut Witzigmann,[...]. J Clin Oncol 2012
Rolf Sauer, Torsten Liersch, Susanne Merkel, Rainer Fietkau, Werner Hohenberger, Clemens Hess, Heinz Becker, Hans-Rudolf Raab, Marie-Therese Villanueva, Helmut Witzigmann,[...]. J Clin Oncol 2012
6
Bowel Obstruction and Ventral Hernia After Laparoscopic Versus Open Surgery for Rectal Cancer in A Randomized Trial (COLOR II).
Josefin Petersson, Thomas W Koedam, H Jaap Bonjer, John Andersson, Eva Angenete, David Bock, Miguel A Cuesta, Charlotte L Deijen, Alois Fürst, Antonio M Lacy,[...]. Ann Surg 2019
Josefin Petersson, Thomas W Koedam, H Jaap Bonjer, John Andersson, Eva Angenete, David Bock, Miguel A Cuesta, Charlotte L Deijen, Alois Fürst, Antonio M Lacy,[...]. Ann Surg 2019
6
Effect of the plane of surgery achieved on local recurrence in patients with operable rectal cancer: a prospective study using data from the MRC CR07 and NCIC-CTG CO16 randomised clinical trial.
Phil Quirke, Robert Steele, John Monson, Robert Grieve, Subhash Khanna, Jean Couture, Chris O'Callaghan, Arthur Sun Myint, Eric Bessell, Lindsay C Thompson,[...]. Lancet 2009
Phil Quirke, Robert Steele, John Monson, Robert Grieve, Subhash Khanna, Jean Couture, Chris O'Callaghan, Arthur Sun Myint, Eric Bessell, Lindsay C Thompson,[...]. Lancet 2009
6
Randomized Phase II Trial of Chemoradiotherapy Plus Induction or Consolidation Chemotherapy as Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer: CAO/ARO/AIO-12.
Emmanouil Fokas, Michael Allgäuer, Bülent Polat, Gunther Klautke, Gerhard G Grabenbauer, Rainer Fietkau, Thomas Kuhnt, Ludger Staib, Thomas Brunner, Anca-Ligia Grosu,[...]. J Clin Oncol 2019
Emmanouil Fokas, Michael Allgäuer, Bülent Polat, Gunther Klautke, Gerhard G Grabenbauer, Rainer Fietkau, Thomas Kuhnt, Ludger Staib, Thomas Brunner, Anca-Ligia Grosu,[...]. J Clin Oncol 2019
6
Patient-reported genitourinary dysfunction after laparoscopic and open rectal cancer surgery in a randomized trial (COLOR II).
J Andersson, G Abis, M Gellerstedt, E Angenete, U Angerås, M A Cuesta, P Jess, J Rosenberg, H J Bonjer, E Haglind. Br J Surg 2014
J Andersson, G Abis, M Gellerstedt, E Angenete, U Angerås, M A Cuesta, P Jess, J Rosenberg, H J Bonjer, E Haglind. Br J Surg 2014
6
Staging of Locally Advanced Rectal Cancer Beyond TME.
Deborah S Keller. Clin Colon Rectal Surg 2020
Deborah S Keller. Clin Colon Rectal Surg 2020
50
Local staging of rectal cancer: a review of imaging.
Regina G H Beets-Tan, Geerard L Beets. J Magn Reson Imaging 2011
Regina G H Beets-Tan, Geerard L Beets. J Magn Reson Imaging 2011
6
Long-term outcomes of clinical complete responders after neoadjuvant treatment for rectal cancer in the International Watch & Wait Database (IWWD): an international multicentre registry study.
Maxime J M van der Valk, Denise E Hilling, Esther Bastiaannet, Elma Meershoek-Klein Kranenbarg, Geerard L Beets, Nuno L Figueiredo, Angelita Habr-Gama, Rodrigo O Perez, Andrew G Renehan, Cornelis J H van de Velde. Lancet 2018
Maxime J M van der Valk, Denise E Hilling, Esther Bastiaannet, Elma Meershoek-Klein Kranenbarg, Geerard L Beets, Nuno L Figueiredo, Angelita Habr-Gama, Rodrigo O Perez, Andrew G Renehan, Cornelis J H van de Velde. Lancet 2018
6
Evolution and Current Status of the Multidisciplinary Management of Locally Advanced Rectal Cancer.
Benjamin W Deschner, Noam A VanderWalde, Axel Grothey, David Shibata. JCO Oncol Pract 2021
Benjamin W Deschner, Noam A VanderWalde, Axel Grothey, David Shibata. JCO Oncol Pract 2021
25
A watch-and-wait approach for locally advanced rectal cancer after a clinical complete response following neoadjuvant chemoradiation: a systematic review and meta-analysis.
Fahima Dossa, Tyler R Chesney, Sergio A Acuna, Nancy N Baxter. Lancet Gastroenterol Hepatol 2017
Fahima Dossa, Tyler R Chesney, Sergio A Acuna, Nancy N Baxter. Lancet Gastroenterol Hepatol 2017
6
Laparoscopic versus open surgery for rectal cancer (COLOR II): short-term outcomes of a randomised, phase 3 trial.
Martijn Hgm van der Pas, Eva Haglind, Miguel A Cuesta, Alois Fürst, Antonio M Lacy, Wim Cj Hop, Hendrik Jaap Bonjer. Lancet Oncol 2013
Martijn Hgm van der Pas, Eva Haglind, Miguel A Cuesta, Alois Fürst, Antonio M Lacy, Wim Cj Hop, Hendrik Jaap Bonjer. Lancet Oncol 2013
6
Short-course radiotherapy followed by chemotherapy before total mesorectal excision (TME) versus preoperative chemoradiotherapy, TME, and optional adjuvant chemotherapy in locally advanced rectal cancer (RAPIDO): a randomised, open-label, phase 3 trial.
Renu R Bahadoer, Esmée A Dijkstra, Boudewijn van Etten, Corrie A M Marijnen, Hein Putter, Elma Meershoek-Klein Kranenbarg, Annet G H Roodvoets, Iris D Nagtegaal, Regina G H Beets-Tan, Lennart K Blomqvist,[...]. Lancet Oncol 2021
Renu R Bahadoer, Esmée A Dijkstra, Boudewijn van Etten, Corrie A M Marijnen, Hein Putter, Elma Meershoek-Klein Kranenbarg, Annet G H Roodvoets, Iris D Nagtegaal, Regina G H Beets-Tan, Lennart K Blomqvist,[...]. Lancet Oncol 2021
6
Oxaliplatin-Based Adjuvant Chemotherapy for Rectal Cancer After Preoperative Chemoradiotherapy (ADORE): Long-Term Results of a Randomized Controlled Trial.
Yong Sang Hong, Sun Young Kim, Ji Sung Lee, Byung-Ho Nam, Kyu-Pyo Kim, Jeong Eun Kim, Young Suk Park, Joon Oh Park, Ji Yeon Baek, Tae-You Kim,[...]. J Clin Oncol 2019
Yong Sang Hong, Sun Young Kim, Ji Sung Lee, Byung-Ho Nam, Kyu-Pyo Kim, Jeong Eun Kim, Young Suk Park, Joon Oh Park, Ji Yeon Baek, Tae-You Kim,[...]. J Clin Oncol 2019
6
Optimal Imaging Strategies for Rectal Cancer Staging and Ongoing Management.
Svetlana Balyasnikova, Gina Brown. Curr Treat Options Oncol 2016
Svetlana Balyasnikova, Gina Brown. Curr Treat Options Oncol 2016
6
Pre-operative staging of rectal cancer: a review of imaging techniques.
Chris Hunter, Gina Brown. Expert Rev Gastroenterol Hepatol 2016
Chris Hunter, Gina Brown. Expert Rev Gastroenterol Hepatol 2016
11
Clinical lymph node staging in colorectal cancer; a flip of the coin?
Nelleke P M Brouwer, Rutger C H Stijns, Valery E P P Lemmens, Iris D Nagtegaal, Regina G H Beets-Tan, Jurgen J Fütterer, Pieter J Tanis, Rob H A Verhoeven, Johannes H W de Wilt. Eur J Surg Oncol 2018
Nelleke P M Brouwer, Rutger C H Stijns, Valery E P P Lemmens, Iris D Nagtegaal, Regina G H Beets-Tan, Jurgen J Fütterer, Pieter J Tanis, Rob H A Verhoeven, Johannes H W de Wilt. Eur J Surg Oncol 2018
6
Urinary and sexual dysfunction after rectal cancer treatment.
Marilyne M Lange, Cornelis J H van de Velde. Nat Rev Urol 2011
Marilyne M Lange, Cornelis J H van de Velde. Nat Rev Urol 2011
6
Organ preservation in rectal cancer: have all questions been answered?
Corrie A M Marijnen. Lancet Oncol 2015
Corrie A M Marijnen. Lancet Oncol 2015
6
The multidisciplinary management of rectal cancer.
Deborah S Keller, Mariana Berho, Rodrigo O Perez, Steven D Wexner, Manish Chand. Nat Rev Gastroenterol Hepatol 2020
Deborah S Keller, Mariana Berho, Rodrigo O Perez, Steven D Wexner, Manish Chand. Nat Rev Gastroenterol Hepatol 2020
6
Evidence in Favor of Standard Surgical Treatment for Rectal Cancer.
Heidi Nelson, Nikolaos Machairas, Axel Grothey. JAMA Oncol 2017
Heidi Nelson, Nikolaos Machairas, Axel Grothey. JAMA Oncol 2017
25
Preoperative high-resolution magnetic resonance imaging can identify good prognosis stage I, II, and III rectal cancer best managed by surgery alone: a prospective, multicenter, European study.
Fiona G M Taylor, Philip Quirke, Richard J Heald, Brendan Moran, Lennart Blomqvist, Ian Swift, David J Sebag-Montefiore, Paris Tekkis, Gina Brown. Ann Surg 2011
Fiona G M Taylor, Philip Quirke, Richard J Heald, Brendan Moran, Lennart Blomqvist, Ian Swift, David J Sebag-Montefiore, Paris Tekkis, Gina Brown. Ann Surg 2011
6
Long-term results of a randomized trial comparing preoperative short-course radiotherapy with preoperative conventionally fractionated chemoradiation for rectal cancer.
K Bujko, M P Nowacki, A Nasierowska-Guttmejer, W Michalski, M Bebenek, M Kryj. Br J Surg 2006
K Bujko, M P Nowacki, A Nasierowska-Guttmejer, W Michalski, M Bebenek, M Kryj. Br J Surg 2006
6
Neoadjuvant chemotherapy with FOLFIRINOX and preoperative chemoradiotherapy for patients with locally advanced rectal cancer (UNICANCER-PRODIGE 23): a multicentre, randomised, open-label, phase 3 trial.
Thierry Conroy, Jean-François Bosset, Pierre-Luc Etienne, Emmanuel Rio, Éric François, Nathalie Mesgouez-Nebout, Véronique Vendrely, Xavier Artignan, Olivier Bouché, Dany Gargot,[...]. Lancet Oncol 2021
Thierry Conroy, Jean-François Bosset, Pierre-Luc Etienne, Emmanuel Rio, Éric François, Nathalie Mesgouez-Nebout, Véronique Vendrely, Xavier Artignan, Olivier Bouché, Dany Gargot,[...]. Lancet Oncol 2021
6
Chemoradiotherapy Plus Induction or Consolidation Chemotherapy as Total Neoadjuvant Therapy for Patients With Locally Advanced Rectal Cancer: Long-term Results of the CAO/ARO/AIO-12 Randomized Clinical Trial.
Emmanouil Fokas, Anke Schlenska-Lange, Bülent Polat, Gunther Klautke, Gerhard G Grabenbauer, Rainer Fietkau, Thomas Kuhnt, Ludger Staib, Thomas Brunner, Anca-Ligia Grosu,[...]. JAMA Oncol 2022
Emmanouil Fokas, Anke Schlenska-Lange, Bülent Polat, Gunther Klautke, Gerhard G Grabenbauer, Rainer Fietkau, Thomas Kuhnt, Ludger Staib, Thomas Brunner, Anca-Ligia Grosu,[...]. JAMA Oncol 2022
6
Advances and challenges in treatment of locally advanced rectal cancer.
J Joshua Smith, Julio Garcia-Aguilar. J Clin Oncol 2015
J Joshua Smith, Julio Garcia-Aguilar. J Clin Oncol 2015
6
The molecular basis of chemoradiosensitivity in rectal cancer: implications for personalized therapies.
Marian Grade, Hendrik A Wolff, Jochen Gaedcke, B Michael Ghadimi. Langenbecks Arch Surg 2012
Marian Grade, Hendrik A Wolff, Jochen Gaedcke, B Michael Ghadimi. Langenbecks Arch Surg 2012
6
Extramural depth of tumor invasion at thin-section MR in patients with rectal cancer: results of the MERCURY study.
. Radiology 2007
. Radiology 2007
6
Rectal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.
R Glynne-Jones, L Wyrwicz, E Tiret, G Brown, C Rödel, A Cervantes, D Arnold. Ann Oncol 2017
R Glynne-Jones, L Wyrwicz, E Tiret, G Brown, C Rödel, A Cervantes, D Arnold. Ann Oncol 2017
6
Targeting hallmarks of cancer to enhance radiosensitivity in gastrointestinal cancers.
Amy M Buckley, Niamh Lynam-Lennon, Hazel O'Neill, Jacintha O'Sullivan. Nat Rev Gastroenterol Hepatol 2020
Amy M Buckley, Niamh Lynam-Lennon, Hazel O'Neill, Jacintha O'Sullivan. Nat Rev Gastroenterol Hepatol 2020
6
Synchronous and "early" metachronous colorectal adenocarcinoma: analysis of prognosis and current trends.
H S Chen, S M Sheen-Chen. Dis Colon Rectum 2000
H S Chen, S M Sheen-Chen. Dis Colon Rectum 2000
6
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.