Qinghua Jiang, Mingxue Li, Hua Li, Lixia Chen. Biomed Pharmacother 2022
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Optimization of a novel kinase inhibitor scaffold for the dual inhibition of JAK2 and FAK kinases.
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Design, synthesis, and biological evaluation of novel FAK scaffold inhibitors targeting the FAK-VEGFR3 protein-protein interaction.
Priyanka N Gogate, Manivannan Ethirajan, Elena V Kurenova, Andrew T Magis, Ravindra K Pandey, William G Cance. Eur J Med Chem 2014
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Mitoxantrone targets the ATP-binding site of FAK, binds the FAK kinase domain and decreases FAK, Pyk-2, c-Src, and IGF-1R in vitro kinase activities.
Vita M Golubovskaya, Baotran Ho, Min Zheng, Andrew Magis, David Ostrov, William G Cance. Anticancer Agents Med Chem 2013
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Small molecule chloropyramine hydrochloride (C4) targets the binding site of focal adhesion kinase and vascular endothelial growth factor receptor 3 and suppresses breast cancer growth in vivo.
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FAK activity sustains intrinsic and acquired ovarian cancer resistance to platinum chemotherapy.
Carlos J Diaz Osterman, Duygu Ozmadenci, Elizabeth G Kleinschmidt, Kristin N Taylor, Allison M Barrie, Shulin Jiang, Lisa M Bean, Florian J Sulzmaier, Christine Jean, Isabelle Tancioni,[...]. Elife 2019
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mTOR: from growth signal integration to cancer, diabetes and ageing.
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Selectivity switch between FAK and Pyk2: Macrocyclization of FAK inhibitors improves Pyk2 potency.
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Emerging roles of focal adhesion kinase in cancer.
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TGF-β stimulates Pyk2 expression as part of an epithelial-mesenchymal transition program required for metastatic outgrowth of breast cancer.
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Structure-kinetic relationship reveals the mechanism of selectivity of FAK inhibitors over PYK2.
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Chemically Induced Degradation of FAK-ALK for Application in Cancer Therapeutics.
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FAK-targeted and combination therapies for the treatment of cancer: an overview of phase I and II clinical trials.
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Targeting FAK scaffold functions inhibits human renal cell carcinoma growth.
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The histone deacetylases HDAC1 and HDAC2 are required for the growth and survival of renal carcinoma cells.
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Dynamic interactions between cells and their extracellular matrix mediate embryonic development.
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PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments.
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HDAC2 promotes the migration and invasion of non-small cell lung cancer cells via upregulation of fibronectin.
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Nuclear FAK controls chemokine transcription, Tregs, and evasion of anti-tumor immunity.
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An UPLC-MS/MS method to determine CT-707 and its two metabolites in plasma of ALK-positive advanced non-small cell lung cancer patients.
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Molecular Pathways: Endothelial Cell FAK-A Target for Cancer Treatment.
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FAK and S6K1 Inhibitor, Neferine, Dually Induces Autophagy and Apoptosis in Human Neuroblastoma Cells.
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Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.